Michael John Ackerman, MD, PhD, FACC

  • 38100 Citations
  • 108 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Article

Maternal mosaicism confounds the neonatal diagnosis of type 1 timothy syndrome

Dufendach, K. A., Giudicessi, J. R., Boczek, N. J. & Ackerman, M. J., Jun 2013, In : Pediatrics. 131, 6, p. e1991-e1995

Research output: Contribution to journalArticle

17 Scopus citations

Mechanical Dysfunction in Extreme QT Prolongation

Vyas, H., O'Leary, P. W., Earing, M. G., Cetta, F. & Ackerman, M. J., May 2008, In : Journal of the American Society of Echocardiography. 21, 5, p. 511.e15-511.e17

Research output: Contribution to journalArticle

15 Scopus citations

Mechanism of loss of Kv11.1 K+ current in mutant T421M-Kv11.1-expressing rat ventricular myocytes: Interaction of trafficking and gating

Balijepalli, S. Y., Lim, E., Concannon, S. P., Chew, C. L., Holzem, K. E., Tester, D. J., Ackerman, M. J., Delisle, B. P., Balijepalli, R. C. & January, C. T., Dec 11 2012, In : Circulation. 126, 24, p. 2809-2818 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Medicina personalizada: diagnóstico genético de cardiopatías/canalopatías hereditarias

Translated title of the contribution: Personalized medicine: Genetic diagnosis for inherited cardiomyopathies/ channelopathiesAckerman, M. J., Marcou, C. A. & Tester, D. J., Apr 2013, In : Revista Espanola de Cardiologia. 66, 4, p. 298-307 10 p.

Research output: Contribution to journalArticle

Mexiletine rescues a mixed biophysical phenotype of the cardiac sodium channel arising from the SCN5a mutation, N406K, found in LQT3 patients

Hu, R. M., Tester, D. J., Li, R., Sun, T., Peterson, B. Z., Ackerman, M. J., Makielski, J. C. & Tan, B. H., Jan 1 2018, In : Channels. 12, 1, p. 176-186 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Mexiletine Shortens the QT Interval in Patients with Potassium Channel-Mediated Type 2 Long QT Syndrome

Bos, J. M., Crotti, L., Rohatgi, R. K., Castelletti, S., Dagradi, F., Schwartz, P. J. & Ackerman, M. J., May 1 2019, In : Circulation: Arrhythmia and Electrophysiology. 12, 5, e007280.

Research output: Contribution to journalArticle

12 Scopus citations

Microvascular function is selectively impaired in patients with hypertrophic cardiomyopathy and sarcomere myofilament gene mutations

Olivotto, I., Girolami, F., Sciagr, R., Ackerman, M. J., Sotgia, B., Bos, J. M., Nistri, S., Sgalambro, A., Grifoni, C., Torricelli, F., Camici, P. G. & Cecchi, F., Aug 16 2011, In : Journal of the American College of Cardiology. 58, 8, p. 839-848 10 p.

Research output: Contribution to journalArticle

87 Scopus citations

Minimally invasive epicardial implantable cardioverter-defibrillator placement for infants and children: An effective alternative to the transvenous approach

Schneider, A. E., Burkhart, H. M., Ackerman, M. J., Dearani, J. A., Wackel, P. & Cannon, B. C., 2016, (Accepted/In press) In : Heart Rhythm.

Research output: Contribution to journalArticle

6 Scopus citations

Molecular and functional characterization of a human frataxin mutation found in hypertrophic cardiomyopathy

Van Driest, S. L., Gakh, O., Ommen, S. R., Isaya, G. & Ackerman, M. J., Aug 2005, In : Molecular genetics and metabolism. 85, 4, p. 280-285 6 p.

Research output: Contribution to journalArticle

18 Scopus citations

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels

Anson, B. D., Ackerman, M. J., Tester, D. J., Will, M. L., Delisle, B. P., Anderson, C. L. & January, C. T., Jun 1 2004, In : American Journal of Physiology - Heart and Circulatory Physiology. 286, 6 55-6, p. H2434-H2441

Research output: Contribution to journalArticle

110 Scopus citations

Molecular and functional characterization of novel glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) mutations in sudden infant death syndrome

Van Norstrand, D. W., Valdivia, C. R., Tester, D. J., Ueda, K., London, B., Makielski, J. C. & Ackerman, M. J., Nov 2007, In : Circulation. 116, 20, p. 2253-2259 7 p.

Research output: Contribution to journalArticle

140 Scopus citations

Molecular and functional characterization of novel hypertrophic cardiomyopathy susceptibility mutations in TNNC1-encoded troponin C

Landstrom, A. P., Parvatiyar, M. S., Pinto, J. R., Marquardt, M. L., Bos, J. M., Tester, D. J., Ommen, S. R., Potter, J. D. & Ackerman, M. J., Aug 2008, In : Journal of Molecular and Cellular Cardiology. 45, 2, p. 281-288 8 p.

Research output: Contribution to journalArticle

76 Scopus citations

Molecular and Functional Characterization of Rare CACNA1C Variants in Sudden Unexplained Death in the Young

Sutphin, B. S., Boczek, N. J., Barajas-Martínez, H., Hu, D., Ye, D., Tester, D. J., Antzelevitch, C. & Ackerman, M. J., Nov 1 2016, In : Congenital Heart Disease. 11, 6, p. 683-692 10 p.

Research output: Contribution to journalArticle

12 Scopus citations

Molecular autopsy of sudden unexplained death in the young

Ackerman, M. J., Tester, D. J. & Driscoll, D. J., Jun 11 2001, In : American Journal of Forensic Medicine and Pathology. 22, 2, p. 105-111 7 p.

Research output: Contribution to journalArticle

111 Scopus citations

Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations

Purevjav, E., Arimura, T., Augustin, S., Huby, A. C., Takagi, K., Nunoda, S., Kearney, D. L., Taylor, M. D., Terasaki, F., Bos, J. M., Ommen, S. R., Shibata, H., Takahashi, M., Itoh-satoh, M., Mckenna, W. J., Murphy, R. T., Labeit, S., Yamanaka, Y., Machida, N., Park, J. E. & 6 others, Alexander, P. M. A., Weintraub, R. G., Kitaura, Y., Ackerman, M. J., Kimura, A. & Towbin, J. A., May 2012, In : Human molecular genetics. 21, 9, p. 2039-2053 15 p., dds022.

Research output: Contribution to journalArticle

49 Scopus citations

Molecular basis of congenital and acquired long QT syndromes

Ackerman, M. J., Oct 1 2004, In : Journal of Electrocardiology. 37, SUPPL., p. 1-6 6 p.

Research output: Contribution to journalArticle

17 Scopus citations

Molecular characterization of a swelling-induced chloride conductance regulatory protein, plCIn

Krapivinsky, G. B., Ackerman, M. J., Gordon, E. A., Krapivinsky, L. D. & Clapham, D. E., Feb 11 1994, In : Cell. 76, 3, p. 439-448 10 p.

Research output: Contribution to journalArticle

183 Scopus citations

Molecular characterization of the calcium release channel deficiency syndrome

Tester, D. J., John Kim, C. S., Hamrick, S. K., Ye, D., O’Hare, B. J., Bombei, H. M., Fitzgerald, K. K., Haglund-Turnquist, C. M., Atkins, D. L., Ochoa Nunez, L. A., Law, I., Temple, J. & Ackerman, M. J., Aug 6 2020, In : JCI Insight. 5, 15, e135952.

Research output: Contribution to journalArticle

Open Access

Molecular diagnosis of the inherited long-QT syndrome in a woman who died after near-drowning

Ackerman, M. J., Tester, D. J., Porter, C. B. J. & Edwards, W. D., Oct 7 1999, In : New England Journal of Medicine. 341, 15, p. 1121-1125 5 p.

Research output: Contribution to journalArticle

110 Scopus citations

Molecular evolution of the junctophilin gene family

Garbino, A., Van Oort, R. J., Dixit, S. S., Landstrom, A. P., Ackerman, M. J. & Wehrens, X. H. T., May 2009, In : Physiological Genomics. 37, 3, p. 175-186 12 p.

Research output: Contribution to journalArticle

51 Scopus citations

Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism

Anderson, C. L., Delisle, B. P., Anson, B. D., Kilby, J. A., Will, M. L., Tester, D. J., Gong, Q., Zhou, Z., Ackerman, M. J. & January, C. T., Jan 2006, In : Circulation. 113, 3, p. 365-373 9 p.

Research output: Contribution to journalArticle

299 Scopus citations

Mothers with long QT syndrome are at increased risk for fetal death: findings from a multicenter international study

Fetal LQTS Consortium, Jan 1 2019, (Accepted/In press) In : American journal of obstetrics and gynecology.

Research output: Contribution to journalArticle

3 Scopus citations

Mutant caveolin-3 induces persistent late sodium current and is associated with long-QT syndrome

Vatta, M., Ackerman, M. J., Ye, B., Makielski, J. C., Ughanze, E. E., Taylor, E. W., Tester, D. J., Balijepalli, R. C., Foell, J. D., Li, Z., Kamp, T. J. & Towbin, J. A., Nov 2006, In : Circulation. 114, 20, p. 2104-2112 9 p.

Research output: Contribution to journalArticle

388 Scopus citations

Mutation and gender-specific risk in type 2 long QT syndrome: Implications for risk stratification for life-threatening cardiac events in patients with long QT syndrome

Migdalovich, D., Moss, A. J., Lopes, C. M., Costa, J., Ouellet, G., Barsheshet, A., McNitt, S., Polonsky, S., Robinson, J. L., Zareba, W., Ackerman, M. J., Benhorin, J., Kaufman, E. S., Platonov, P. G., Shimizu, W., Towbin, J. A., Vincent, G. M., Wilde, A. A. M. & Goldenberg, I., Oct 2011, In : Heart rhythm. 8, 10, p. 1537-1543 7 p.

Research output: Contribution to journalArticle

76 Scopus citations

Mutation detection in congenital long QT syndrome: cardiac channel gene screen using PCR, dHPLC, and direct DNA sequencing.

Tester, D. J., Will, M. L. & Ackerman, M. J., 2006, In : Methods in molecular medicine. 128, p. 181-207 27 p.

Research output: Contribution to journalArticle

24 Scopus citations

Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization

Beavers, D. L., Wang, W., Ather, S., Voigt, N., Garbino, A., Dixit, S. S., Landstrom, A. P., Li, N., Wang, Q., Olivotto, I., Dobrev, D., Ackerman, M. J. & Wehrens, X. H. T., Nov 19 2013, In : Journal of the American College of Cardiology. 62, 21, p. 2010-2019 10 p.

Research output: Contribution to journalArticle

97 Scopus citations

Mutation in glycerol-3-phosphate dehydrogenase 1-like gene (GPD1-L) decreases cardiac Na+ current and causes inherited arrhythmias

London, B., Michalec, M., Mehdi, H., Zhu, X., Kerchner, L., Sanyal, S., Viswanathan, P. C., Pfahnl, A. E., Shang, L. L., Madhusudanan, M., Baty, C. J., Lagana, S., Aleong, R., Gutmann, R., Ackerman, M. J., McNamara, D. M., Weiss, R. & Dudley, S. C., Nov 2007, In : Circulation. 116, 20, p. 2260-2268 9 p.

Research output: Contribution to journalArticle

344 Scopus citations

Mutation of an A-kinase-anchoring protein causes long-QT syndrome

Chen, L., Marquardt, M. L., Tester, D. J., Sampson, K. J., Ackerman, M. J. & Kass, R. S., Dec 26 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 52, p. 20990-20995 6 p.

Research output: Contribution to journalArticle

239 Scopus citations

Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome

Jons, C., Moss, A. J., Lopes, C. M., McNitt, S., Zareba, W., Goldenberg, I., Qi, M., Wilde, A. A. M., Shimizu, W., Kanters, J. K., Towbin, J. A., Ackerman, M. J. & Robinson, J. L., Aug 2009, In : Journal of cardiovascular electrophysiology. 20, 8, p. 859-865 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Mutations in cytoplasmic loops of the KCNQ1 channel and the risk of life-threatening events: Implications for mutation-specific response to β-blocker therapy in type 1 long-QT syndrome

Barsheshet, A., Goldenberg, I., O-Uchi, J., Moss, A. J., Jons, C., Shimizu, W., Wilde, A. A., McNitt, S., Peterson, D. R., Zareba, W., Robinson, J. L., Ackerman, M. J., Cypress, M., Gray, D. A., Hofman, N., Kanters, J. K., Kaufman, E. S., Platonov, P. G., Qi, M., Towbin, J. A. & 2 others, Vincent, G. M. & Lopes, C. M., Apr 24 2012, In : Circulation. 125, 16, p. 1988-1996 9 p.

Research output: Contribution to journalArticle

120 Scopus citations

Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans

Landstrom, A. P., Weisleder, N., Batalden, K. B., Martijn Bos, J., Tester, D. J., Ommen, S. R., Wehrens, X. H. T., Claycomb, W. C., Ko, J. K., Hwang, M., Pan, Z., Ma, J. & Ackerman, M. J., Jun 2007, In : Journal of Molecular and Cellular Cardiology. 42, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

118 Scopus citations

Mutation-Specific Risk in Two Genetic Forms of Type 3 Long QT Syndrome

Liu, J. F., Moss, A. J., Jons, C., Benhorin, J., Schwartz, P. J., Spazzolini, C., Crotti, L., Ackerman, M. J., McNitt, S., Robinson, J. L., Qi, M., Goldenberg, I. & Zareba, W., Jan 15 2010, In : American Journal of Cardiology. 105, 2, p. 210-213 4 p.

Research output: Contribution to journalArticle

21 Scopus citations

MYBPC3 mutations are associated with a reduced super-relaxed state in patients with hypertrophic cardiomyopathy

McNamara, J. W., Li, A., Lal, S., Bos, J. M., Harris, S. P., Van Der Velden, J., Ackerman, M. J., Cooke, R. & Dos Remedios, C. G., Jun 2017, In : PloS one. 12, 6, e0180064.

Research output: Contribution to journalArticle

36 Scopus citations

My child just fainted: no big deal or sudden-death warning?

Tipton, M. L. & Ackerman, M. J., Jul 2004, In : Emergency medical services. 33, 7, p. 41-45 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Myofilament protein gene mutation screening and outcome of patients with hypertrophic cardiomyopathy

Olivotto, I., Girolami, F., Ackerman, M. J., Nistri, S., Bos, J. M., Zachara, E., Ommen, S. R., Theis, J. L., Vaubel, R. A., Re, F., Armentano, C., Poggesi, C., Torricelli, F. & Cecchi, F., Jun 2008, In : Mayo Clinic proceedings. 83, 6, p. 630-638 9 p.

Research output: Contribution to journalArticle

261 Scopus citations

Myosin binding protein C mutations and compound heterozygosity in hypertrophic cardiomyopathy

Van Driest, S. L., Vasile, V. C., Ommen, S. R., Will, M. L., Tajik, A. J., Gersh, B. J. & Ackerman, M. J., Nov 2 2004, In : Journal of the American College of Cardiology. 44, 9, p. 1903-1910 8 p.

Research output: Contribution to journalArticle

314 Scopus citations

New mammalian chloride channel identified by expression cloning

Paulmichl, M., Li, Y., Wickman, K., Ackerman, M., Peralta, E. & Clapham, D., Jan 1 1992, In : Nature. 356, 6366, p. 238-241 4 p.

Research output: Contribution to journalArticle

298 Scopus citations

Noncardiac genetic predisposition in sudden infant death syndrome

Gray, B., Tester, D. J., Wong, L. C., Chanana, P., Jaye, A., Evans, J. M., Baruteau, A. E., Evans, M., Fleming, P., Jeffrey, I., Cohen, M., Tfelt-Hansen, J., Simpson, M. A., Ackerman, M. J. & Behr, E. R., Mar 1 2019, In : Genetics in Medicine. 21, 3, p. 641-649 9 p.

Research output: Contribution to journalArticle

3 Scopus citations
5 Scopus citations

Noninvasive blood potassium measurement using signal-processed, single-lead ecg acquired from a handheld smartphone

Yasin, O. Z., Attia, Z., Dillon, J. J., DeSimone, C. V., Sapir, Y., Dugan, J., Somers, V. K., Ackerman, M. J., Asirvatham, S. J., Scott, C. G., Bennet, K. E., Ladewig, D. J., Sadot, D., Geva, A. B. & Friedman, P. A., Sep 2017, In : Journal of Electrocardiology. 50, 5, p. 620-625 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Noninvasive potassium determination using a mathematically processed ECG: Proof of concept for a novel "blood-less, blood test"

Dillon, J. J., Desimone, C. V., Sapir, Y., Somers, V. K., Dugan, J. L., Bruce, C. J., Ackerman, M. J., Asirvatham, S. J., Striemer, B. L., Bukartyk, J., Scott, C. G., Bennet, K. E., Mikell, S. B., Ladewig, D. J., Gilles, E. J., Geva, A., Sadot, D. & Friedman, P. A., Jan 1 2015, In : Journal of Electrocardiology. 48, 1, p. 12-18 7 p.

Research output: Contribution to journalArticle

21 Scopus citations

Normal electrocardiographic findings: Recognizing physiological adaptations in athletes

Drezner, J. A., Fischbach, P., Froelicher, V., Marek, J., Pelliccia, A., Prutkin, J. M., Schmied, C. M., Sharma, S., Wilson, M. G., Ackerman, M. J., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., Cannon, B. C., Corrado, D., DiFiori, J. P., Harmon, K. G., Heidbuchel, H. & 5 others, Owens, D. S., Paul, S., Salerno, J. C., Stein, R. & Vetter, V. L., May 2013, In : Sport en Geneeskunde. 46, 2, p. 24-34 11 p.

Research output: Contribution to journalArticle

Normal electrocardiographic findings: Recognising physiological adaptations in athletes

Drezner, J. A., Fischbach, P., Froelicher, V., Marek, J., Pelliccia, A., Prutkin, J. M., Schmied, C. M., Sharma, S., Wilson, M. G., Ackerman, M. J., Anderson, J., Ashley, E., Asplund, C. A., Baggish, A. L., Börjesson, M., Cannon, B. C., Corrado, D., DiFiori, J. P., Harmon, K. G., Heidbuchel, H. & 5 others, Owens, D. S., Paul, S., Salerno, J. C., Stein, R. & Vetter, V. L., Feb 1 2013, In : British journal of sports medicine. 47, 3, p. 125-136 12 p.

Research output: Contribution to journalArticle

120 Scopus citations

Not all beta-blockers are equal in the management of long QT syndrome types 1 and 2: Higher recurrence of events under metoprolol

Chockalingam, P., Crotti, L., Girardengo, G., Johnson, J. N., Harris, K. M., Van Der Heijden, J. F., Hauer, R. N. W., Beckmann, B. M., Spazzolini, C., Rordorf, R., Rydberg, A., Clur, S. A. B., Fischer, M., Van Den Heuvel, F., Kääb, S., Blom, N. A., Ackerman, M. J., Schwartz, P. J. & Wilde, A. A. M., Nov 13 2012, In : Journal of the American College of Cardiology. 60, 20, p. 2092-2099 8 p.

Research output: Contribution to journalArticle

129 Scopus citations

Novel bloodless potassium determination using a signal-processed single-lead ECG

Attia, Z. I., DeSimone, C. V., Dillon, J. J., Sapir, Y., Somers, V. K., Dugan, J. L., Bruce, C. J., Ackerman, M. J., Asirvatham, S. J., Striemer, B. L., Bukartyk, J., Scott, C. G., Bennet, K. E., Ladewig, D. J., Gilles, E. J., Sadot, D., Geva, A. B. & Friedman, P. A., Jan 1 2016, In : Journal of the American Heart Association. 5, 1, e002746.

Research output: Contribution to journalArticle

18 Scopus citations

Novel CPVT-Associated Calmodulin Mutation in CALM3 (CALM3-A103V) Activates Arrhythmogenic Ca Waves and Sparks

Gomez-Hurtado, N., Boczek, N. J., Kryshtal, D. O., Johnson, C. N., Sun, J., Nitu, F. R., Cornea, R. L., Chazin, W. J., Calvert, M. L., Tester, D. J., Ackerman, M. J. & Knollmann, B. C., Aug 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 8, e004161.

Research output: Contribution to journalArticle

33 Scopus citations

Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction

Quick, A. P., Landstrom, A. P., Wang, Q., Beavers, D. L., Reynolds, J. O., Barreto-Torres, G., Tran, V., Showell, J., Philippen, L. E., Morris, S. A., Skapura, D., Bos, J. M., Pedersen, S. E., Pautler, R. G., Ackerman, M. J. & Wehrens, X. H. T., 2017, In : JACC: Basic to Translational Science. 2, 1, p. 56-67 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Novel long QT syndrome-associated missense mutation, L762F, in CACNA1C-encoded L-type calcium channel imparts a slower inactivation tau and increased sustained and window current

Landstrom, A. P., Boczek, N. J., Ye, D., Miyake, C. Y., De la Uz, C. M., Allen, H. D., Ackerman, M. J. & Kim, J. J., Oct 1 2016, In : International Journal of Cardiology. 220, p. 290-298 9 p.

Research output: Contribution to journalArticle

19 Scopus citations