Michael John Ackerman, MD, PhD, FACC

  • 38100 Citations
  • 108 Scopus h-Index
1991 …2020

Research output per year

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Research Output

Article

Genetic testing for potentially lethal, highly treatable inherited cardiomyopathies/channelopathies in clinical practice

Tester, D. J. & Ackerman, M. J., Mar 8 2011, In : Circulation. 123, 9, p. 1021-1037 17 p.

Research output: Contribution to journalArticle

146 Scopus citations

Genomic Triangulation and Coverage Analysis in Whole-Exome Sequencing-Based Molecular Autopsies

Shanks, G. W., Tester, D. J., Nishtala, S., Evans, J. M. & Ackerman, M. J., Oct 1 2017, In : Circulation: Cardiovascular Genetics. 10, 5, e001828.

Research output: Contribution to journalArticle

7 Scopus citations

Genotype- and Phenotype-Guided Management of Congenital Long QT Syndrome

Giudicessi, J. R. & Ackerman, M. J., Oct 2013, In : Current Problems in Cardiology. 38, 10, p. 417-455 39 p.

Research output: Contribution to journalArticle

78 Scopus citations

Genotype-Phenotype Aspects of Type 2 Long QT Syndrome

Shimizu, W., Moss, A. J., Wilde, A. A. M., Towbin, J. A., Ackerman, M. J., January, C. T., Tester, D. J., Zareba, W., Robinson, J. L., Qi, M., Vincent, G. M., Kaufman, E. S., Hofman, N., Noda, T., Kamakura, S., Miyamoto, Y., Shah, S., Amin, V., Goldenberg, I., Andrews, M. L. & 1 others, McNitt, S., Nov 24 2009, In : Journal of the American College of Cardiology. 54, 22, p. 2052-2062 11 p.

Research output: Contribution to journalArticle

173 Scopus citations

Genotype-Phenotype Correlation of SCN5A Mutation for the Clinical and Electrocardiographic Characteristics of Probands with Brugada Syndrome: A Japanese Multicenter Registry

Yamagata, K., Horie, M., Aiba, T., Ogawa, S., Aizawa, Y., Ohe, T., Yamagishi, M., Makita, N., Sakurada, H., Tanaka, T., Shimizu, A., Hagiwara, N., Kishi, R., Nakano, Y., Takagi, M., Makiyama, T., Ohno, S., Fukuda, K., Watanabe, H., Morita, H. & 9 others, Hayashi, K., Kusano, K., Kamakura, S., Yasuda, S., Ogawa, H., Miyamoto, Y., Kapplinger, J. D., Ackerman, M. J. & Shimizu, W., Jun 6 2017, In : Circulation. 135, 23, p. 2255-2270 16 p.

Research output: Contribution to journalArticle

50 Scopus citations

Genotype-Phenotype Correlations in Apical Variant Hypertrophic Cardiomyopathy

Towe, E. C., Bos, J. M., Ommen, S. R., Gersh, B. J. & Ackerman, M. J., May 1 2015, In : Congenital Heart Disease. 10, 3, p. E139-E145

Research output: Contribution to journalArticle

10 Scopus citations

Genotype-phenotype Correlations of Hypertrophic Cardiomyopathy When Diagnosed in Children, Adolescents, and Young Adults

Loar, R. W., Bos, J. M., Will, M. L., Ommen, S. R. & Ackerman, M. J., Nov 1 2015, In : Congenital Heart Disease. 10, 6, p. 529-536 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Genotype-phenotype relationships in congenital long QT syndrome

Ackerman, M. J., Oct 1 2005, In : Journal of Electrocardiology. 38, 4 SUPPL., p. 64-68 5 p.

Research output: Contribution to journalArticle

22 Scopus citations

Genotype-phenotype relationships involving hypertrophic cardiomyopathy-associated mutations in titin, muscle LIM protein, and telethonin

Bos, J. M., Poley, R. N., Ny, M., Tester, D. J., Xu, X., Vatta, M., Towbin, J. A., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., May 2006, In : Molecular genetics and metabolism. 88, 1, p. 78-85 8 p.

Research output: Contribution to journalArticle

141 Scopus citations

Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome

Barsheshet, A., Peterson, D. R., Moss, A. J., Schwartz, P. J., Kaufman, E. S., McNitt, S., Polonsky, S., Buber, J., Zareba, W., Robinson, J. L., Ackerman, M. J., Benhorin, J., Towbin, J. A., Vincent, G. M., Zhang, L. & Goldenberg, I., Aug 2011, In : Heart rhythm. 8, 8, p. 1207-1213 7 p.

Research output: Contribution to journalArticle

15 Scopus citations

Genotypic heterogeneity and phenotypic mimicry among unrelated patients referred for catecholaminergic polymorphic ventricular tachycardia genetic testing

Tester, D. J., Arya, P., Will, M., Haglund, C. M., Farley, A. L., Makielski, J. C. & Ackerman, M. J., Jul 2006, In : Heart rhythm. 3, 7, p. 800-805 6 p.

Research output: Contribution to journalArticle

99 Scopus citations

GPD1L links redox state to cardiac excitability by PKC-dependent phosphorylation of the sodium channel SCN5A

Valdivia, C. R., Ueda, K., Ackerman, M. J. & Makielski, J. C., Oct 2009, In : American Journal of Physiology - Heart and Circulatory Physiology. 297, 4, p. H1446-H1452

Research output: Contribution to journalArticle

79 Scopus citations

Green Tea Catechin Normalizes the Enhanced Ca2+ Sensitivity of Myofilaments Regulated by a Hypertrophic Cardiomyopathy-Associated Mutation in Human Cardiac Troponin i (K206I)

Warren, C. M., Karam, C. N., Wolska, B. M., Kobayashi, T., De Tombe, P. P., Arteaga, G. M., Bos, J. M., Ackerman, M. J. & Solaro, R. J., Dec 1 2015, In : Circulation: Cardiovascular Genetics. 8, 6, p. 765-773 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels

Larson, N. B., McDonnell, S., Cannon Albright, L., Teerlink, C., Stanford, J., Ostrander, E. A., Isaacs, W. B., Xu, J., Cooney, K. A., Lange, E., Schleutker, J., Carpten, J. D., Powell, I., Bailey-Wilson, J. E., Cussenot, O., Cancel-Tassin, G., Giles, G. G., MacInnis, R. J., Maier, C., Whittemore, A. S. & 12 others, Hsieh, C. L., Wiklund, F., Catolona, W. J., Foulkes, W., Mandal, D., Eeles, R., Kote-Jarai, Z., Ackerman, M. J., Olson, T. M., Klein, C. J., Thibodeau, S. N. & Schaid, D. J., May 2017, In : Genetic epidemiology. 41, 4, p. 297-308 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Heart-Rate-Corrected QT Interval Evolution in Premature Infants During the First Week of Life

Ulrich, T. J. B., Ellsworth, M. A., Carey, W. A., Zubair, A. S., MacQueen, B. C., Colby, C. E. & Ackerman, M. J., 2014, In : Pediatric Cardiology. 35, 8, p. 1363-1369 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Heart rate dependence of the QT interval duration: Differences among congenital long QT syndrome subtypes

Němec, J., Buncová, M., Bůlková, V., Hejlik, J., Winter, B., Shen, W. K. & Ackerman, M. J., May 2004, In : Journal of cardiovascular electrophysiology. 15, 5, p. 550-556 7 p.

Research output: Contribution to journalArticle

32 Scopus citations

Heart Rate Recovery after Exercise Is Associated with Arrhythmic Events in Patients with Catecholaminergic Polymorphic Ventricular Tachycardia

Lieve, K. V. V., Dusi, V., Van Der Werf, C., Bos, J. M., Lane, C. M., Stokke, M. K., Roston, T. M., Djupsjöbacka, A., Wada, Y., Denjoy, I., Bundgaard, H., Noguer, F. R. I., Semsarian, C., Robyns, T., Hofman, N., Tanck, M. W., Van Den Berg, M. P., Kammeraad, J. A. E., Krahn, A. D., Clur, S. A. B. & 14 others, Sacher, F., Till, J., Skinner, J. R., Tfelt-Hansen, J., Probst, V., Leenhardt, A., Horie, M., Swan, H., Roberts, J. D., Sanatani, S., Haugaa, K. H., Schwartz, P. J., Ackerman, M. J. & Wilde, A. A. M., 2020, (Accepted/In press) In : Circulation: Arrhythmia and Electrophysiology. e007471.

Research output: Contribution to journalArticle

Heritability in genetic heart disease: The role of genetic background

Jansweijer, J. A., Van Spaendonck-Zwarts, K. Y., Tanck, M. W. T., Peter Van Tintelen, J., Christiaans, I., Van Der Smagt, J., Vermeer, A., Bos, J. M., Moss, A. J., Swan, H., Priori, S., Rydberg, A., Tfelt-Hansen, J., Ackerman, M., Olivotto, I., Charron, P., Gimeno, J. R., Van Den Berg, M., Wilde, A. & Pinto, Y. M., May 1 2019, In : Open Heart. 6, 1, e000929.

Research output: Contribution to journalArticle

Open Access

Heterogeneity of ryanodine receptor dysfunction in a mouse model of catecholaminergic polymorphic ventricular tachycardia

Loaiza, R., Benkusky, N. A., Powers, P. P., Hacker, T., Noujaim, S., Ackerman, M. J., Jalife, J. & Valdivia, H. H., Jan 18 2013, In : Circulation research. 112, 2, p. 298-308 11 p.

Research output: Contribution to journalArticle

34 Scopus citations

High-risk long QT syndrome mutations in the Kv7.1 (KCNQ1) pore disrupt the molecular basis for rapid K+ permeation

Burgess, D. E., Bartos, D. C., Reloj, A. R., Campbell, K. S., Johnson, J. N., Tester, D. J., Ackerman, M. J., Fressart, V., Denjoy, I., Guicheney, P., Moss, A. J., Ohno, S., Horie, M. & Delisle, B. P., Nov 13 2012, In : Biochemistry. 51, 45, p. 9076-9085 10 p.

Research output: Contribution to journalArticle

10 Scopus citations

Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations

McLeod, C. J., Bos, J. M., Theis, J. L., Edwards, W. D., Gersh, B. J., Ommen, S. R. & Ackerman, M. J., Nov 2009, In : American heart journal. 158, 5, p. 799-805 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Holter monitoring in the evaluation of congenital long QT syndrome

Mauriello, D. A., Johnson, J. N. & Ackerman, M. J., Sep 1 2011, In : PACE - Pacing and Clinical Electrophysiology. 34, 9, p. 1100-1104 5 p.

Research output: Contribution to journalArticle

19 Scopus citations

Homozygous/compound heterozygous triadin mutations associated with autosomal-recessive long-QT syndrome and pediatric sudden cardiac arrest: Elucidation of the triadin knockout syndrome

Altmann, H. M., Tester, D. J., Will, M. L., Middha, S., Evans, J. M., Eckloff, B. W. & Ackerman, M. J., 2015, In : Circulation. 131, 23, p. 2051-2060 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 2 others, Zipes, D. P. & Olson, S., Aug 2011, In : Europace. 13, 8, p. 1077-1109 33 p.

Research output: Contribution to journalArticle

462 Scopus citations

HRS/EHRA expert consensus statement on the state of genetic testing for the channelopathies and cardiomyopathies: This document was developed as a partnership between the Heart Rhythm Society (HRS) and the European Heart Rhythm Association (EHRA)

Ackerman, M. J., Priori, S. G., Willems, S., Berul, C., Brugada, R., Calkins, H., Camm, A. J., Ellinor, P. T., Gollob, M., Hamilton, R., Hershberger, R. E., Judge, D. P., Le Marec, H., McKenna, W. J., Schulze-Bahr, E., Semsarian, C., Towbin, J. A., Watkins, H., Wilde, A., Wolpert, C. & 1 others, Zipes, D. P., Aug 1 2011, In : Heart rhythm. 8, 8, p. 1308-1339 32 p.

Research output: Contribution to journalArticle

625 Scopus citations

HRS policy statement: Clinical cardiac electrophysiology fellowship curriculum: Update 2011

Link, M. S., Exner, D. V., Anderson, M., Ackerman, M., Al-Ahmad, A., Knight, B. P., Markowitz, S. M., Kaufman, E. S., Haines, D., Asirvatham, S. J., Callans, D. J., Mounsey, J. P., Bogun, F., Narayan, S. M., Krahn, A. D., Mittal, S., Singh, J., Fisher, J. D. & Chugh, S. S., Aug 2011, In : Heart rhythm. 8, 8, p. 1340-1356 17 p.

Research output: Contribution to journalArticle

9 Scopus citations

Human Fibrinogen for Maintenance and Differentiation of Induced Pluripotent Stem Cells in Two Dimensions and Three Dimensions

Gandhi, J. K., Knudsen, T., Hill, M., Roy, B., Bachman, L., Pfannkoch-Andrews, C., Schmidt, K. N., Metko, M. M., Ackerman, M. J., Resch, Z., Pulido, J. S. & Marmorstein, A. D., Jun 2019, In : Stem Cells Translational Medicine. 8, 6, p. 512-521 10 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Hypotonicity activates a native chloride current in Xenopus oocytes

Ackerman, M. J., Wickman, K. D. & Clapham, D. E., Feb 1 1994, In : Journal of General Physiology. 103, 2, p. 153-179 27 p.

Research output: Contribution to journalArticle

Open Access
202 Scopus citations

Identification and Functional Characterization of a Novel CACNA1C -Mediated Cardiac Disorder Characterized by Prolonged QT Intervals with Hypertrophic Cardiomyopathy, Congenital Heart Defects, and Sudden Cardiac Death

Boczek, N. J., Ye, D., Jin, F., Tester, D. J., Huseby, A., Bos, J. M., Johnson, A. J., Kanter, R. & Ackerman, M. J., Oct 1 2015, In : Circulation: Arrhythmia and Electrophysiology. 8, 5, p. 1122-1132 11 p.

Research output: Contribution to journalArticle

37 Scopus citations

Identification of a common genetic substrate underlying postpartum cardiac events in congenital long QT syndrome

Khositseth, A., Tester, D. J., Will, M. L., Bell, C. M. & Ackerman, M. J., May 2004, In : Heart rhythm. 1, 1, p. 60-64 5 p.

Research output: Contribution to journalArticle

83 Scopus citations

Identification of a family with inherited long QT syndrome after a pediatric near-drowning

Ackerman, M. J. & Porter, C. B. J., Feb 1998, In : Pediatrics. 101, 2, p. 306-308 3 p.

Research output: Contribution to journalArticle

26 Scopus citations

Identification of a metavinculin missense mutation, R975W, associated with both hypertrophic and dilated cardiomyopathy

Vasile, V. C., Will, M. L., Ommen, S. R., Edwards, W. D., Olson, T. M. & Ackerman, M. J., Feb 1 2006, In : Molecular genetics and metabolism. 87, 2, p. 169-174 6 p.

Research output: Contribution to journalArticle

76 Scopus citations

Identification of a Novel Homozygous Multi-Exon Duplication in RYR2 among Children with Exertion-Related Unexplained Sudden Deaths in the Amish Community

Tester, D. J., Bombei, H. M., Fitzgerald, K. K., Giudicessi, J. R., Pitel, B. A., Thorland, E. C., Russell, B. G., Hamrick, S. K., Kim, C. S. J., Haglund-Turnquist, C. M., Johnsrude, C. L., Atkins, D. L., Ochoa Nunez, L. A., Law, I., Temple, J. & Ackerman, M. J., Mar 2020, In : JAMA cardiology. 5, 3, p. 340-345 6 p.

Research output: Contribution to journalArticle

3 Scopus citations

Identification of a possible pathogenic link between congenital long QT syndrome and epilepsy

Johnson, J. N., Hofman, N., Haglund, C. M., Cascino, G. D., Wilde, A. A. M. & Ackerman, M. J., Jan 20 2009, In : Neurology. 72, 3, p. 224-231 8 p.

Research output: Contribution to journalArticle

172 Scopus citations

Identification of concealed and manifest long QT syndrome using a novel T wave analysis program

Sugrue, A., Noseworthy, P. A., Kremen, V., Bos, J. M., Qiang, B., Rohatgi, R. K., Sapir, Y., Attia, Z. I., Brady, P., Asirvatham, S. J., Friedman, P. A. & Ackerman, M. J., Jul 1 2016, In : Circulation: Arrhythmia and Electrophysiology. 9, 7

Research output: Contribution to journalArticle

9 Scopus citations

Idiopathic Restrictive Cardiomyopathy in Children and Young Adults

Anderson, H. N., Cetta, F., Driscoll, D. J., Olson, T. M., Ackerman, M. J. & Johnson, J. N., May 15 2018, In : American Journal of Cardiology. 121, 10, p. 1266-1270 5 p.

Research output: Contribution to journalArticle

2 Scopus citations
17 Scopus citations

Impact of Genotype on the Occurrence of Atrial Fibrillation in Patients With Hypertrophic Cardiomyopathy

Bongini, C., Ferrantini, C., Girolami, F., Coppini, R., Arretini, A., Targetti, M., Bardi, S., Castelli, G., Torricelli, F., Cecchi, F., Ackerman, M. J., Padeletti, L., Poggesi, C. & Olivotto, I., Sep 22 2015, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journalArticle

8 Scopus citations

Impact of left ventricular hypertrophy on QT prolongation and associated mortality

Haugaa, K. H., Bos, J. M., Borkenhagen, E. J., Tarrell, R. F., Morlan, B. W., Caraballo, P. & Ackerman, M. J., Nov 1 2014, In : Heart Rhythm. 11, 11, p. 1957-1965 9 p.

Research output: Contribution to journalArticle

9 Scopus citations

Impact of Septal Myectomy on Left Atrial Volume and Left Ventricular Diastolic Filling Patterns: An Echocardiographic Study of Young Patients with Obstructive Hypertrophic Cardiomyopathy

Menon, S. C., Ackerman, M. J., Ommen, S. R., Cabalka, A. K., Hagler, D. J., O'Leary, P. W., Dearani, J. A., Cetta, F. & Eidem, B. W., Jun 1 2008, In : Journal of the American Society of Echocardiography. 21, 6, p. 684-688 5 p.

Research output: Contribution to journalArticle

25 Scopus citations

Implantable cardioverter-defibrillator explantation for overdiagnosed or overtreated congenital long QT syndrome

Gaba, P., Martijn Bos, J., Cannon, B. C., Cha, Y-M., Friedman, P. A., Asirvatham, S. J. & Ackerman, M. J., Apr 1 2016, In : Heart Rhythm. 13, 4, p. 879-885 7 p.

Research output: Contribution to journalArticle

18 Scopus citations

Implantable cardioverter-defibrillators in previously undiagnosed patients with catecholaminergic polymorphic ventricular tachycardia resuscitated from sudden cardiac arrest

Van Der Werf, C., Lieve, K. V., Bos, J. M., Lane, C. M., Denjoy, I., Roses-Noguer, F., Aiba, T., Wada, Y., Ingles, J., Leren, I. S., Rudic, B., Schwartz, P. J., Maltret, A., Sacher, F., Skinner, J. R., Krahn, A. D., Roston, T. M., Tfelt-Hansen, J., Swan, H., Robyns, T. & 17 others, Ohno, S., Roberts, J. D., Van Den Berg, M. P., Kammeraad, J. A., Probst, V., Kannankeril, P. J., Blom, N. A., Behr, E. R., Borggrefe, M., Haugaa, K. H., Semsarian, C., Horie, M., Shimizu, W., Till, J. A., Leenhardt, A., Ackerman, M. J. & Wilde, A. A., Sep 14 2019, In : European heart journal. 40, 35, p. 2953-2961 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Implantable cardioverter defibrillator therapy for congenital long QT syndrome: A single-center experience

Horner, J. M., Kinoshita, M., Webster, T. L., Haglund, C. M., Friedman, P. A. & Ackerman, M. J., Nov 1 2010, In : Heart rhythm. 7, 11, p. 1616-1622 7 p.

Research output: Contribution to journalArticle

66 Scopus citations

Implantable cardioverter-defibrillator use in catecholaminergic polymorphic ventricular tachycardia: A systematic review

Roston, T. M., Jones, K., Hawkins, N. M., Bos, J. M., Schwartz, P. J., Perry, F., Ackerman, M. J., Laksman, Z. W. M., Kaul, P., Lieve, K. V. V., Atallah, J., Krahn, A. D. & Sanatani, S., Dec 1 2018, In : Heart Rhythm. 15, 12, p. 1791-1799 9 p.

Research output: Contribution to journalArticle

17 Scopus citations

Importance of Variant Interpretation in Whole-Exome Molecular Autopsy: Population-Based Case Series

Shanks, G. W., Tester, D. J., Ackerman, J. P., Simpson, M. A., Behr, E. R., White, S. M. & Ackerman, M. J., Jun 19 2018, In : Circulation. 137, 25, p. 2705-2715 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Inaccurate diagnosis of Brugada syndrome in a healthy woman based on SCN5A mutation classification

Warring, S. K., Anderson, H. N., Bos, J. M. & Ackerman, M. J., Oct 2017, In : HeartRhythm Case Reports. 3, 10, p. 450-454 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Incidence, cause, and comparative frequency of sudden cardiac death in national collegiate athletic association athletes a decade in review

Harmon, K. G., Asif, I. M., Maleszewski, J. J., Owens, D. S., Prutkin, J. M., Salerno, J. C., Zigman, M. L., Ellenbogen, R., Rao, A. L., Ackerman, M. J. & Drezner, J. A., 2015, In : Circulation. 132, 1, p. 10-19 10 p.

Research output: Contribution to journalArticle

203 Scopus citations

Incidence and Etiology of Sudden Cardiac Arrest and Death in High School Athletes in the United States

Harmon, K. G., Asif, I. M., Maleszewski, J., Owens, D. S., Prutkin, J. M., Salerno, J. C., Zigman, M. L., Ellenbogen, R., Rao, A. L., Ackerman, M. J. & Drezner, J. A., Nov 1 2016, In : Mayo Clinic Proceedings. 91, 11, p. 1493-1502 10 p.

Research output: Contribution to journalArticle

33 Scopus citations

Induced Pluripotent Stem Cell–Derived Cardiomyocytes from a Patient with MYL2-R58Q-Mediated Apical Hypertrophic Cardiomyopathy Show Hypertrophy, Myofibrillar Disarray, and Calcium Perturbations

Zhou, W., Bos, J. M., Ye, D., Tester, D. J., Hrstka, S., Maleszewski, J. J., Ommen, S. R., Nishimura, R. A., Schaff, H. V., Kim, C. S. & Ackerman, M. J., Oct 1 2019, In : Journal of cardiovascular translational research. 12, 5, p. 394-403 10 p.

Research output: Contribution to journalArticle

4 Scopus citations

Inherited and de novo mutations in the cardiac actin gene cause hypertrophic cardiomyopathy

Olson, T. M., Doan, T. P., Kishimoto, N. Y., Whitby, F. G., Ackerman, M. J. & Fananapazir, L., Jan 1 2000, In : Journal of Molecular and Cellular Cardiology. 32, 9, p. 1687-1694 8 p.

Research output: Contribution to journalArticle

166 Scopus citations