Michael John Ackerman

2024

Artificial intelligence-enhanced electrocardiogram for arrhythmogenic right ventricular cardiomyopathy detection

Haq, I. U., Liu, K., Giudicessi, J. R., Siontis, K. C., Asirvatham, S. J., Attia, Z. I., Ackerman, M. J., Friedman, P. A. & Killu, A. M., Mar 1 2024, In: European Heart Journal - Digital Health. 5, 2, p. 192-194 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Continuous variant reclassification: An effective tool in the ongoing quest to escape genetic purgatory

Ackerman, M. J. & Giudicessi, J. R., 2024, (Accepted/In press) In: Heart rhythm.

Research output: Contribution to journal › Editorial › peer-review

Decision Support System Detecting Patients at Risk of Prolonged QT and Associated Mortality

Caraballo, P. J., Bos, J. M., Qian, R., Fischer, K. M., Johnsen, P. J., Schreie, D. J., Simon, G. & Ackerman, M. J., Jan 25 2024, In: Studies in health technology and informatics. 310, p. 1378-1379 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Effect of Mavacamten on Hypertrophic Cardiomyopathy Patients With Left Ventricular Outflow Tract Obstruction Provoked Only Postexercise or With Amyl Nitrite

Roehl, K., Suppah, M., Geske, J., Newman, D., Giudicessi, J., Ackerman, M., Ommen, S. & Alsidawi, S., 2024, (Accepted/In press) In: Journal of the American Society of Echocardiography.

Research output: Contribution to journal › Article › peer-review

Genotype Influences Mavacamten Responsiveness in Obstructive Hypertrophic Cardiomyopathy

Giudicessi, J. R., Alsidawi, S., Geske, J. B., Newman, D. B., Arruda-Olson, A. M., Bos, J. M., Ommen, S. R. & Ackerman, M. J., Feb 2024, In: Mayo Clinic proceedings. 99, 2, p. 341-343 3 p.

Research output: Contribution to journal › Article › peer-review

Insights into adherence to medication and lifestyle recommendations in an international cohort of patients with catecholaminergic polymorphic ventricular tachycardia

Peltenburg, P. J., van den Heuvel, L. M., Kallas, D., Bell, C., Denjoy, I., Behr, E. R., Field, E., Kammeraad, J. A. E., Yap, S. C., Probst, V., Ackerman, M. J., Blom, N. A., Wilde, A. A. M., Clur, S. A. B. & van der Werf, C., Feb 1 2024, In: Europace. 26, 2, euae044.

Research output: Contribution to journal › Article › peer-review

Open Access

Precision therapy in congenital long QT syndrome

Neves, R., Bains, S., Bos, J. M., MacIntyre, C., Giudicessi, J. R. & Ackerman, M. J., Jan 2024, In: Trends in cardiovascular medicine. 34, 1, p. 39-47 9 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

Proceed with caution: Standard protocol exercise stress tests fail to replicate the diagnostic utility of supine-stand tests for long QT syndrome

Pinsky, A. M., Kulkarni, V. K., Bos, J. M., Neves, R., Allison, T. G. & Ackerman, M. J., Mar 2024, In: PACE - Pacing and Clinical Electrophysiology. 47, 3, p. 455-461 7 p.

Research output: Contribution to journal › Article › peer-review

Risk Prediction in Male Adolescents With Congenital Long QT Syndrome: Implications for Sex-Specific Risk Stratification in Potassium Channel-Mediated Long QT Syndrome

Bjelic, M., Goldenberg, I., Younis, A., Chen, A. Y., Huang, D. T., Yoruk, A., Aktas, M. K., Rosero, S., Cutter, K., McNitt, S., Sotoodehnia, N., Kudenchuk, P. J., Rea, T. D., Arking, D. E., Zareba, W., Ackerman, M. J. & Goldenberg, I., Feb 6 2024, In: Journal of the American Heart Association. 13, 3, e028902.

Research output: Contribution to journal › Article › peer-review

Open Access

Sports Participation by Athletes With Cardiovascular Disease

Martinez, M. W., Ackerman, M. J., Annas, G. J., Baggish, A. L., Day, S. M., Harmon, K. G., Kim, J. H., Levine, B. D., Putukian, M. & Lampert, R., Feb 27 2024, In: Journal of the American College of Cardiology. 83, 8, p. 865-868 4 p.

Research output: Contribution to journal › Article › peer-review

State of Gene Therapy for Monogenic Cardiovascular Diseases

Bains, S., Giudicessi, J. R., Odening, K. E. & Ackerman, M. J., Apr 2024, In: Mayo Clinic proceedings. 99, 4, p. 610-629 20 p.

Research output: Contribution to journal › Review article › peer-review

Sudden Cardiac Death in National Collegiate Athletic Association Athletes: A 20-Year Study

Petek, B. J., Churchill, T. W., Moulson, N., Kliethermes, S. A., Baggish, A. L., Drezner, J. A., Patel, M. R., Ackerman, M. J., Kucera, K. L., Siebert, D. M., Salerno, L., Zigman Suchsland, M., Asif, I. M., Maleszewski, J. J. & Harmon, K. G., Jan 9 2024, In: Circulation. 149, 2, p. 80-90 11 p.

Research output: Contribution to journal › Article › peer-review

Temporal Association Between Vaping and Risk of Cardiac Events

Bains, S., Garmany, R., Neves, R., Giudicessi, J. R., Gao, X., Tester, D. J., Bos, J. M. & Ackerman, M. J., Feb 2024, In: Mayo Clinic proceedings. 99, 2, p. 241-248 8 p.

Research output: Contribution to journal › Article › peer-review

Utility of routine follow-up defibrillation safety margin testing in young patients with epicardial implantable cardioverter-defibrillators

Leng, T., Griffeth, E., Stephens, E. H., Dearani, J., Cannon, B. C., Ackerman, M. J. & Wackel, P. L., Mar 2024, In: PACE - Pacing and Clinical Electrophysiology. 47, 3, p. 392-397 6 p.

Research output: Contribution to journal › Article › peer-review

2023

Arrhythmic sudden death survival prediction model for hypertrophic cardiomyopathy patients: An interpretable machine learning analysis

Farahani, N. Z., Enayati, M., Pumarejo, A., Aguirre, M. A., Scott, C., Siontis, K., Bos, M., Geske, J. B., Ackerman, M. J. & Arruda-Olson, A. M., 2023, Proceedings of the 2023 Design of Medical Devices Conference, DMD 2023. American Society of Mechanical Engineers, v001t01a004. (Proceedings of the 2023 Design of Medical Devices Conference, DMD 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Artificial intelligence in cardiovascular genetics

Bos, J. M. & Ackerman, M. J., Jan 1 2023, Intelligence-Based Cardiology and Cardiac Surgery: Artificial Intelligence and Human Cognition in Cardiovascular Medicine. Elsevier, p. 271-277 7 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Association between Syncope Trigger Type and Risk of Subsequent Life-Threatening Events in Patients with Long QT Syndrome

Younis, A., Bos, J. M., Zareba, W., Aktas, M. K., Wilde, A. A. M., Tabaja, C., Bodurian, C., Tobert, K. E., McNitt, S., Polonsky, B., Shimizu, W., Ackerman, M. J. & Goldenberg, I., Aug 9 2023, In: JAMA cardiology. 8, 8, p. 775-783 9 p.

Research output: Contribution to journal › Article › peer-review

Asymptomatic Apical Hypertrophic Cardiomyopathy in an Elite Competitive Athlete

Huang, A. L., MacNamara, J., Link, M. S., Martinez, M., Dearani, J. A., Cannon, B. C., Levine, B. D. & Ackerman, M. J., Jan 18 2023, In: JACC: Case Reports. 6, 101705.

Research output: Contribution to journal › Article › peer-review

Open Access

Bilateral cardiac sympathetic denervation in patients with congenital long QT syndrome

Tobert, K. E., Bos, J. M., Moir, C., Polites, S. F. & Ackerman, M. J., Jul 2023, In: Heart rhythm. 20, 7, p. 1033-1038 6 p.

Research output: Contribution to journal › Article › peer-review

Cardiac fludeoxyglucose-18 positron emission tomography in genotype-positive arrhythmogenic cardiomyopathy

Neves, R., Tseng, A. S., Garmany, R., Fink, A. L., McLeod, C. J., Cooper, L. T., MacIntyre, C. J., Homb, A. C., Rosenbaum, A. N., Bois, J. P., Abou Ezzeddine, O. F., Siontis, K. C., Pereira, N. L., Ackerman, M. J. & Giudicessi, J. R., Oct 15 2023, In: International Journal of Cardiology. 389, 131173.

Research output: Contribution to journal › Article › peer-review

Cardiopulmonary Exercise Testing in Athletes With Hypertrophic Cardiomyopathy

Newman, D. B., Garmany, R., Contreras, A. M., Bos, J. M., Johnson, J. N., Geske, J. B., Allison, T. G., Ommen, S. R. & Ackerman, M. J., Feb 15 2023, In: American Journal of Cardiology. 189, p. 49-55 7 p.

Research output: Contribution to journal › Article › peer-review

Cellular and electrophysiological characterization of triadin knockout syndrome using induced pluripotent stem cell-derived cardiomyocytes

Clemens, D. J., Ye, D., Wang, L., Kim, C. S. J., Zhou, W., Dotzler, S. M., Tester, D. J., Marty, I., Knollmann, B. C. & Ackerman, M. J., May 9 2023, In: Stem Cell Reports. 18, 5, p. 1075-1089 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical course of patients with hypertrophic cardiomyopathy away from tertiary referral care

Garmany, R., Bos, J. M., Ommen, S. R., Ackerman, M. J. & Geske, J. B., Jun 2023, In: ESC Heart Failure. 10, 3, p. 1919-1927 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Clinical presentation of calmodulin mutations: the International Calmodulinopathy Registry

Crotti, L., Spazzolini, C., Nyegaard, M., Overgaard, M. T., Kotta, M. C., Dagradi, F., Sala, L., Aiba, T., Ayers, M. D., Baban, A., Barc, J., Beach, C. M., Behr, E. R., Bos, J. M., Cerrone, M., Covi, P., Cuneo, B., Denjoy, I., Donner, B., Elbert, A., & 35 othersEliasson, H., Etheridge, S. P., Fukuyama, M., Girolami, F., Hamilton, R., Horie, M., Iascone, M., Jaimez, J. J., Jensen, H. K., Kannankeril, P. J., Kaski, J. P., Makita, N., Muñoz-Esparza, C., Odland, H. H., Ohno, S., Papagiannis, J., Porretta, A. P., Prandstetter, C., Probst, V., Robyns, T., Rosenthal, E., Rosés-Noguer, F., Sekarski, N., Singh, A., Spentzou, G., Stute, F., Tfelt-Hansen, J., Till, J., Tobert, K. E., Vinocur, J. M., Webster, G., Wilde, A. A. M., Wolf, C. M., Ackerman, M. J. & Schwartz, P. J., Sep 14 2023, In: European heart journal. 44, 35, p. 3357-3370 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Counterpoint: Ablation in long QT syndrome

Wilde, A. A. M. & Ackerman, M. J., Dec 2023, In: Heart rhythm. 20, 12, p. 1785-1786 2 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Curcumin, a dietary natural supplement, prolongs the action potential duration of KCNE1-D85N–induced pluripotent stem cell–derived cardiomyocytes

Martinez, K., Smith, A., Ye, D., Zhou, W., Tester, D. J. & Ackerman, M. J., Apr 2023, In: Heart rhythm. 20, 4, p. 580-586 7 p.

Research output: Contribution to journal › Article › peer-review

Effects of cohort, genotype, variant, and maternal β-blocker treatment on foetal heart rate predictors of inherited long QT syndrome

Kaizer, A. M., Winbo, A., Clur, S. A. B., Etheridge, S. P., Ackerman, M. J., Horigome, H., Herberg, U., Dagradi, F., Spazzolini, C., Killen, S. A. S., Wacker-Gussmann, A., Wilde, A. A. M., Sinkovskaya, E., Abuhamad, A., Torchio, M., Ng, C. A., Rydberg, A., Schwartz, P. J. & Cuneo, B. F., Nov 1 2023, In: Europace. 25, 11, euad319.

Research output: Contribution to journal › Article › peer-review

Open Access

Elucidation of ALG10B as a Novel Long-QT Syndrome-Susceptibility Gene

Zhou, W., Ye, D., Tester, D. J., Bains, S., Giudicessi, J. R., Haglund-Turnquist, C. M., Orland, K. M., January, C. T., Eckhardt, L. L., Maginot, K. R. & Ackerman, M. J., Apr 1 2023, In: Circulation: Genomic and Precision Medicine. 16, 2, p. E003726

Research output: Contribution to journal › Article › peer-review

Open Access

European Society of Cardiology quality indicators for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death

Aktaa, S., Tzeis, S., Gale, C. P., Ackerman, M. J., Arbelo, E., Behr, E. R., Crotti, L., D'Avila, A., De Chillou, C., Deneke, T., Figueiredo, M., Friede, T., Leclercq, C., Merino, J. L., Semsarian, C., Verstrael, A., Zeppenfeld, K., Tfelt-Hansen, J. & Reichlin, T., Jan 1 2023, In: Europace. 25, 1, p. 199-210 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Fatal Cardiac Arrhythmias During Electronic Gaming in Patients With Genetically Mediated Heart Diseases

Neves, R., Bains, S., Bos, J. M., MacIntyre, C. J., Giudicessi, J. R. & Ackerman, M. J., Aug 15 2023, In: Journal of the American College of Cardiology. 82, 7, p. 603-611 9 p.

Research output: Contribution to journal › Article › peer-review

Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia

Bergeman, A. T., Lieve, K. V. V., Kallas, D., Bos, J. M., Rosés I Noguer, F., Denjoy, I., Zorio, E., Kammeraad, J. A. E., Peltenburg, P. J., Tobert, K., Aiba, T., Atallah, J., Drago, F., Batra, A. S., Brugada, R., Borggrefe, M., Clur, S. A. B., Cox, M. G. P. J., Davis, A., Dhillon, S., & 30 othersEtheridge, S. P., Fischbach, P., Franciosi, S., Haugaa, K., Horie, M., Johnsrude, C., Kane, A. M., Krause, U., Kwok, S. Y., Lapage, M. J., Ohno, S., Probst, V., Roberts, J. D., Robyns, T., Sacher, F., Semsarian, C., Skinner, J. R., Swan, H., Tavacova, T., Tisma-Dupanovic, S., Tfelt-Hansen, J., Yap, S. C., Kannankeril, P. J., Leenhardt, A., Till, J., Sanatani, S., Tanck, M. W. T., Ackerman, M. J., Wilde, A. A. M. & Van Der Werf, C., Dec 19 2023, In: Circulation. 148, 25, p. 2029-2037 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Functional characterization and identification of a therapeutic for a novel SCN5A-F1760C variant causing type 3 long QT syndrome refractory to all guideline-directed therapies

Stutzman, M. J., Gao, X., Kim, M., Ye, D., Zhou, W., Tester, D. J., Giudicessi, J. R., Shannon, K. & Ackerman, M. J., May 2023, In: Heart rhythm. 20, 5, p. 709-717 9 p.

Research output: Contribution to journal › Article › peer-review

High-Sensitivity Cardiac Troponin T Elevation in Hypertrophic Cardiomyopathy Is Associated With Ventricular Arrhythmias

Burczak, D. R., Newman, D. B., Jaffe, A. S., Ackerman, M. J., Ommen, S. R. & Geske, J. B., Mar 2023, In: Mayo Clinic proceedings. 98, 3, p. 410-418 9 p.

Research output: Contribution to journal › Article › peer-review

Injectable contraceptive Depo-Provera induces erratic beating patterns in patient-specific induced pluripotent stem cell–derived cardiomyocytes with long QT syndrome type 2

Pinsky, A. M., Gao, X., Bains, S., Kim, C. J., Louradour, J., Odening, K. E., Tester, D. J., Giudicessi, J. R. & Ackerman, M. J., Jun 2023, In: Heart rhythm. 20, 6, p. 910-917 8 p.

Research output: Contribution to journal › Article › peer-review

Interpreting Incidentally Identified Variants in Genes Associated with Heritable Cardiovascular Disease: A Scientific Statement from the American Heart Association

Landstrom, A. P., Chahal, A. A., Ackerman, M. J., Cresci, S., Milewicz, D. M., Morris, A. A., Sarquella-Brugada, G., Semsarian, C., Shah, S. H. & Sturm, A. C., Apr 1 2023, In: Circulation: Genomic and Precision Medicine. 16, 2, p. E000092

Research output: Contribution to journal › Review article › peer-review

Open Access

Multi-Omic Architecture of Obstructive Hypertrophic Cardiomyopathy

Garmany, R., Bos, J. M., Tester, D. J., Giudicessi, J. R., Dos Remedios, C. G., Dasari, S., Nagaraj, N. K., Nair, A. A., Johnson, K. L., Ryan, Z. C., Maleszewski, J. J., Ommen, S. R., Dearani, J. A. & Ackerman, M. J., Apr 1 2023, In: Circulation: Genomic and Precision Medicine. 16, 2, p. E003756

Research output: Contribution to journal › Article › peer-review

Open Access

Pediatric Epicardial Devices: Early and Midterm Outcomes

Griffeth, E. M., Krishnan, P., Dearani, J. A., Pahwa, S., Ackerman, M. J., Wackel, P. L., Todd, A. & Cannon, B. C., Jul 2023, In: World Journal for Pediatric and Congenital Heart Surgery. 14, 4, p. 451-458 8 p.

Research output: Contribution to journal › Article › peer-review

Personalized Care in Long QT Syndrome: Better Management, More Sports, and Fewer Devices

MacIntyre, C. J. & Ackerman, M. J., Sep 2023, In: Cardiac Electrophysiology Clinics. 15, 3, p. 285-291 7 p.

Research output: Contribution to journal › Review article › peer-review

Phenotypes of Overdiagnosed Long QT Syndrome

Bains, S., Neves, R., Bos, J. M., Giudicessi, J. R., MacIntyre, C. & Ackerman, M. J., Feb 7 2023, In: Journal of the American College of Cardiology. 81, 5, p. 477-486 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Proteomic and phosphoproteomic analyses of myectomy tissue reveals difference between sarcomeric and genotype-negative hypertrophic cardiomyopathy

Garmany, R., Bos, J. M., Dasari, S., Johnson, K. L., Tester, D. J., Giudicessi, J. R., dos Remedios, C., Maleszewski, J. J., Ommen, S. R., Dearani, J. A. & Ackerman, M. J., Dec 2023, In: Scientific reports. 13, 1, 14341.

Research output: Contribution to journal › Article › peer-review

Open Access

RASopathy-Associated Cardiac Hypertrophy: A Shocking Gap in Care

Ackerman, M. J. & Garmany, R., Mar 21 2023, In: Journal of the American College of Cardiology. 81, 11, p. 1046-1048 3 p.

Research output: Contribution to journal › Editorial › peer-review

Open Access

Rationale and Design of the ORCCA (Outcomes Registry for Cardiac Conditions in Athletes) Study

Moulson, N., Petek, B. J., Ackerman, M. J., Churchill, T. W., Day, S. M., Kim, J. H., Kliethermes, S. A., Lampert, R., Levine, B. D., Martinez, M. W., Patel, M. R., Phelan, D., Harmon, K. G., Baggish, A. L. & Drezner, J. A., Jun 6 2023, In: Journal of the American Heart Association. 12, 11, e029052.

Research output: Contribution to journal › Article › peer-review

Open Access

Repeatability of ventricular arrhythmia characteristics on the exercise-stress test in RYR2-mediated catecholaminergic polymorphic ventricular tachycardia

Peltenburg, P. J., Pultoo, S. N. J., Tobert, K. E., Bos, J. M., Lieve, K. V. V., Tanck, M., Clur, S. A. B., Blom, N. A., Ackerman, M. J., Wilde, A. A. M. & Van Der Werf, C., Feb 1 2023, In: Europace. 25, 2, p. 619-626 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

Return-to-Play for Elite Athletes With Genetic Heart Diseases Predisposing to Sudden Cardiac Death

Martinez, K. A., Bos, J. M., Baggish, A. L., Phelan, D. M., Tobert, K. E., Newman, D. B., Scherer, E., Petek, B. J., Ackerman, M. J. & Martinez, M. W., Aug 22 2023, In: Journal of the American College of Cardiology. 82, 8, p. 661-670 10 p.

Research output: Contribution to journal › Article › peer-review

Saliency maps provide insights into artificial intelligence-based electrocardiography models for detecting hypertrophic cardiomyopathy

Siontis, K. C., Suárez, A. B., Sehrawat, O., Ackerman, M. J., Attia, Z. I., Friedman, P. A., Noseworthy, P. A. & Maanja, M., Nov 1 2023, In: Journal of Electrocardiology. 81, p. 286-291 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

SARS-CoV-2 spike protein-mediated cardiomyocyte fusion may contribute to increased arrhythmic risk in COVID-19

Clemens, D. J., Ye, D., Zhou, W., John Kim, C. S., Pease, D. R., Navaratnarajah, C. K., Barkhymer, A., Tester, D. J., Nelson, T. J., Cattaneo, R., Schneider, J. W. & Ackerman, M. J., Mar 2023, In: PloS one. 18, 3 March, e0282151.

Research output: Contribution to journal › Article › peer-review

Open Access

Septal Myectomy Outcomes in Children and Adolescents With Obstructive Hypertrophic Cardiomyopathy

Griffeth, E. M., Dearani, J. A., Schaff, H. V., Johnson, J. N., Ackerman, M. J., Bos, J. M., Alzate-Aguirre, M., Todd, A., Cannon, B. C., Wackel, P. L. & Stephens, E. H., Sep 2023, In: Annals of Thoracic Surgery. 116, 3, p. 499-507 9 p.

Research output: Contribution to journal › Article › peer-review

SGK1 inhibition attenuated the action potential duration in patient- and genotype-specific re-engineered heart cells with congenital long QT syndrome

Kim, M., Das, S., Tester, D. J., Pradhananga, S., Hamrick, S. K., Gao, X., Srinivasan, D., Sager, P. T. & Ackerman, M. J., Apr 2023, In: Heart Rhythm O2. 4, 4, p. 268-274 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

SGK1 inhibition attenuates the action potential duration in reengineered heart cell models of drug-induced QT prolongation

Kim, M., Sager, P. T., Tester, D. J., Pradhananga, S., Hamrick, S. K., Srinivasan, D., Das, S. & Ackerman, M. J., Apr 2023, In: Heart rhythm. 20, 4, p. 589-595 7 p.

Research output: Contribution to journal › Article › peer-review

Michael John Ackerman, MD, PhD, FACC

Research output

Search results