Michael Deture

  • 2938 Citations
  • 22 Scopus h-Index
19962019
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Research Output 1996 2019

  • 2938 Citations
  • 22 Scopus h-Index
  • 47 Article
  • 1 Comment/debate
  • 1 Review article
2019
6 Citations (Scopus)

Association of MAPT Subhaplotypes with Risk of Progressive Supranuclear Palsy and Severity of Tau Pathology

Heckman, M. G., Brennan, R. R., Labbé, C., Soto, A. I., Koga, S., Deture, M., Murray, M. E., Petersen, R. C., Boeve, B. F., Van Gerpen, J. A., Uitti, R. J., Wszolek, Z. K., Rademakers, R. V., Dickson, D. W. & Ross, O. A., Jan 1 2019, In : JAMA neurology.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Microtubule-Associated Proteins
Pathology
Haplotypes
Odds Ratio

Coexistence of Progressive Supranuclear Palsy with Pontocerebellar Atrophy and Myotonic Dystrophy Type 1

Koga, S., Eric Ahlskog, J., DeTure, M. A., Baker, M., Roemer, S. F., Konno, T., Rademakers, R., Ross, O. A. & Dickson, D. W., Jan 1 2019, In : Journal of Neuropathology and Experimental Neurology. 78, 8, p. 756-762 7 p.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Myotonic Dystrophy
Atrophy
Multiple System Atrophy
Cerebellar Ataxia

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R. V., Deture, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta neuropathologica communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Dependovirus
Phosphorylation
Tauopathies
Brain
Progressive Supranuclear Palsy
1 Citation (Scopus)

Erratum: Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease (Neuron (2018) 99(5) (925–940.e7), (S0896627318306378) (10.1016/j.neuron.2018.07.039))

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennett, R. E., Tepper, K., Deture, M., Vanderburg, C. R., Corjuc, B. T., DeVos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S. & 10 others, Gage, F. H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. & Hyman, B. T., Jan 16 2019, In : Neuron. 101, 2, 1 p.

Research output: Contribution to journalComment/debate

tau Proteins
Cell Nucleus Active Transport
Names
Publications
Alzheimer Disease
16 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins
3 Citations (Scopus)

rAAV-based brain slice culture models of Alzheimer’s and Parkinson’s disease inclusion pathologies

Croft, C. L., Cruz, P. E., Ryu, D. H., Ceballos-Diaz, C., Strang, K. H., Woody, B. M., Lin, W. L., Deture, M., Rodríguez-Lebrón, E., Dickson, D. W., Chakrabarty, P., Levites, Y., Giasson, B. I. & Golde, T. E., Mar 1 2019, In : Journal of Experimental Medicine. 216, 3, p. 539-555 17 p.

Research output: Contribution to journalArticle

Open Access
Dependovirus
Parkinson Disease
Alzheimer Disease
Pathology
Brain

Structure-based inhibitors halt prion-like seeding by Alzheimer's disease-and tauopathy-derived brain tissue samples

Seidler, P. M., Boyer, D. R., Murray, K. A., Yang, T. P., Bentzel, M., Sawaya, M. R., Rosenberg, G., Cascio, D., Williams, C. K., Newell, K. L., Ghetti, B., DeTure, M. A., Dickson, D. W., Vinters, H. V. & Eisenberg, D. S., Jan 1 2019, In : Journal of Biological Chemistry. 294, 44, p. 16451-16464 14 p.

Research output: Contribution to journalArticle

Tauopathies
Prions
Polymorphism
Brain
Alzheimer Disease
4 Citations (Scopus)

Tau exhibits unique seeding properties in globular glial tauopathy

Chung, D. E. C., Carlomagno, Y., Cook, C., Jansen-West, K., Daughrity, L., Lewis-Tuffin, L. J., Castanedes-Casey, M., Deture, M., Dickson, D. W. & Petrucelli, L., Mar 7 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Tauopathies
Neuroglia
tau Proteins
Inclusion Bodies
Biosensing Techniques
5 Citations (Scopus)

The neuropathological diagnosis of Alzheimer's disease

Deture, M. & Dickson, D. W., Aug 2 2019, In : Molecular neurodegeneration. 14, 1, 32.

Research output: Contribution to journalReview article

Open Access
Alzheimer Disease
Cerebrovascular Disorders
Lewy Body Disease
Pathology
TDP-43 Proteinopathies
2018

Relationships between lewy and tau pathologies in 375 consecutive non-Alzheimer's olfactory bulbs

Kasanuki, K., Ross, O. A., Deture, M., Walton, R. L., Sanchez-Contreras, M., Koga, S., Murray, M. E., Rademakers, R. V. & Dickson, D. W., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Lewy Body Disease
alpha-Synuclein
Olfactory Bulb
Immunohistochemistry
Pathology
34 Citations (Scopus)

Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease

Eftekharzadeh, B., Daigle, J. G., Kapinos, L. E., Coyne, A., Schiantarelli, J., Carlomagno, Y., Cook, C., Miller, S. J., Dujardin, S., Amaral, A. S., Grima, J. C., Bennett, R. E., Tepper, K., Deture, M., Vanderburgh, C. R., Corjuc, B. T., DeVos, S. L., Gonzalez, J. A., Chew, J., Vidensky, S. & 10 others, Gage, F. H., Mertens, J., Troncoso, J., Mandelkow, E., Salvatella, X., Lim, R. Y. H., Petrucelli, L., Wegmann, S., Rothstein, J. D. & Hyman, B. T., Sep 5 2018, In : Neuron. 99, 5, p. 925-940.e7

Research output: Contribution to journalArticle

Nuclear Pore
tau Proteins
Cell Nucleus Active Transport
Alzheimer Disease
Nuclear Pore Complex Proteins
2017
28 Citations (Scopus)

An Acetylation–phosphorylation switch that regulates tau aggregation propensity and function

Carlomagno, Y., Chung, D. E. C., Yue, M., Castanedes-Casey, M., Madden, B. J., Dunmore, J., Tong, J., Deture, M., Dickson, D. W., Petrucelli, L. & Cook, C., 2017, In : Journal of Biological Chemistry. 292, 37, p. 15277-15286 10 p.

Research output: Contribution to journalArticle

Phosphorylation
Acetylation
Histone Deacetylases
Agglomeration
Switches
19 Citations (Scopus)
Tauopathies
Frontotemporal Dementia
Chromosomes, Human, Pair 17
Microtubule-Associated Proteins
Parkinsonian Disorders
25 Citations (Scopus)

Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients

Prudencio, M., Gonzales, P. K., Cook, C., Gendron, T. D., Daughrity, L. M., Song, Y., Ebbert, M. T. W., Van Blitterswijk, M., Zhang, Y., Jansen-West, K., Baker, M. C., Deture, M., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Petrucelli, L. & Link, C. D., Sep 1 2017, In : Human Molecular Genetics. 26, 17, p. 3421-3431 11 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Amyotrophic Lateral Sclerosis
Brain
RNA Polymerase II
RNA Sequence Analysis
2016
5 Citations (Scopus)

FTDP-17 with Pick body-like inclusions associated with a novel tau mutation, p.E372G

Tacik, P., Deture, M., Carlomagno, Y., Lin, W. L., Murray, M. E., Baker, M. C., Josephs, K. A., Boeve, B. F., Wszolek, Z. K., Graff Radford, N. R., Parisi, J. E., Petrucelli, L., Rademakers, R. V., Isaacson, R. S., Heilman, K. M., Petersen, R. C., Dickson, D. W. & Kouri, N., 2016, (Accepted/In press) In : Brain Pathology.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Inclusion Bodies
Mutation
Microtubule-Associated Proteins
Exons
24 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
2015
26 Citations (Scopus)

A novel tau mutation, p.K317N, causes globular glial tauopathy

Tacik, P., Deture, M., Lin, W. L., Sanchez Contreras, M., Wojtas, A., Hinkle, K. M., Fujioka, S., Baker, M. C., Walton, R. L., Carlomagno, Y., Brown, P. H., Strongosky, A. J., Kouri, N., Murray, M. E., Petrucelli, L., Josephs, K. A., Rademakers, R. V., Ross, O. A., Wszolek, Z. K. & Dickson, D. W., Apr 22 2015, In : Acta Neuropathologica. 130, 2, p. 199-214 16 p.

Research output: Contribution to journalArticle

Tauopathies
Microtubule-Associated Proteins
Neuroglia
Mutation
Dementia
11 Citations (Scopus)

A novel Tau Mutation in exon 12, P. Q336H, causes hereditary pick disease

Tacik, P., Deture, M., Hinkle, K. M., Lin, W. L., Sanchez-Contreras, M., Carlomagno, Y., Pedraza, O. D., Rademakers, R. V., Ross, O. A., Wszolek, Z. K. & Dickson, D. W., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 11, p. 1042-1052 11 p.

Research output: Contribution to journalArticle

Pick Disease of the Brain
Inborn Genetic Diseases
Exons
Mutation
Microtubules
135 Citations (Scopus)

Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS

Prudencio, M., Belzil, V., Batra, R., Ross, C. A., Gendron, T. D., Pregent, L. J., Murray, M. E., Overstreet, K. K., Piazza-Johnston, A. E., Desaro, P., Bieniek, K. F., Deture, M., Lee, W. C., Biendarra, S. M., Davis, M. D., Baker, M. C., Perkerson, R. B., Van Blitterswijk, M., Stetler, C. T., Rademakers, R. V. & 5 others, Link, C. D., Dickson, D. W., Boylan, K. B., Li, H. & Petrucelli, L., Aug 30 2015, In : Nature Neuroscience. 18, 8, p. 1175-1182 8 p.

Research output: Contribution to journalArticle

Alternative Splicing
Transcriptome
Polyadenylation
Amyotrophic Lateral Sclerosis
Brain
16 Citations (Scopus)

Transmission of soluble and insoluble α-synuclein to mice

Jones, D. R., Delenclos, M., Baine, A. M. T., Deture, M., Murray, M. E., Dickson, D. W. & McLean, P. J., 2015, In : Journal of Neuropathology and Experimental Neurology. 74, 12, p. 1158-1169 12 p.

Research output: Contribution to journalArticle

Synucleins
Lewy Body Disease
Protein Isoforms
Multiple System Atrophy
Lewy Bodies
140 Citations (Scopus)

Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease

Pottier, C., Bieniek, K. F., Finch, N. C., van de Vorst, M., Baker, M., Perkersen, R., Brown, P., Ravenscroft, T., Van Blitterswijk, M., Nicholson, A. M., Deture, M., Knopman, D. S., Josephs, K. A., Parisi, J. E., Petersen, R. C., Boylan, K. B., Boeve, B. F., Graff Radford, N. R., Veltman, J. A., Gilissen, C. & 3 others, Murray, M. E., Dickson, D. W. & Rademakers, R. V., May 6 2015, In : Acta Neuropathologica. 130, 1, p. 77-92 16 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Motor Neuron Disease
DNA-Binding Proteins
Phosphotransferases
Genome
2014
112 Citations (Scopus)

Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance

Cook, C., Carlomagno, Y., Gendron, T. D., Dunmore, J., Scheffel, K., Stetler, C., Davis, M., Dickson, D. W., Jarpe, M., Deture, M. & Petrucelli, L., Jan 2014, In : Human Molecular Genetics. 23, 1, p. 104-116 13 p., ddt402.

Research output: Contribution to journalArticle

Acetylation
Tauopathies
Alzheimer Disease
Phosphorylation
tau Proteins
151 Citations (Scopus)

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

Zhang, Y., Jansen-West, K., Xu, Y. F., Gendron, T. D., Bieniek, K. F., Lin, W. L., Sasaguri, H., Caulfield, T., Hubbard, J., Daughrity, L., Chew, J., Belzil, V., Prudencio, M., Stankowski, J. N., Castanedes-Casey, M., Whitelaw, E., Ash, P. E. A., Deture, M., Rademakers, R. V., Boylan, K. B. & 2 others, Dickson, D. W. & Petrucelli, L., 2014, In : Acta Neuropathologica. 128, 4, p. 505-524 20 p.

Research output: Contribution to journalArticle

Endoplasmic Reticulum Stress
Proteins
Proteasome Endopeptidase Complex
Caspase 3
Endoplasmic Reticulum
20 Citations (Scopus)

Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins

Carlomagno, Y., Zhang, Y., Davis, M., Lin, W. L., Cook, C., Dunmore, J., Tay, W., Menkosky, K., Cao, X., Petrucelli, L. & Deture, M., Mar 4 2014, In : PLoS One. 9, 3, e90452.

Research output: Contribution to journalArticle

Casein Kinase II
Heat-Shock Proteins
heat shock proteins
Polymerization
polymerization
46 Citations (Scopus)

Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration

Kouri, N., Carlomagno, Y., Baker, M., Liesinger, A. M., Caselli, R. J., Wszolek, Z. K., Petrucelli, L., Boeve, B. F., Parisi, J. E., Josephs, K. A., Uitti, R. J., Ross, O. A., Graff Radford, N. R., Deture, M., Dickson, D. W. & Rademakers, R. V., Feb 2014, In : Acta Neuropathologica. 127, 2, p. 271-282 12 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Exons
Mutation
Genes
Autopsy
2013
53 Citations (Scopus)

Characteristics of TBS-extractable hyperphosphorylated tau species: Aggregation intermediates in rTg4510 mouse brain

Sahara, N., Deture, M., Ren, Y., Ebrahim, A. S., Kang, D., Knight, J., Volbracht, C., Pedersen, J. T., Dickson, D. W., Yen, S. H. & Lewis, J., 2013, In : Journal of Alzheimer's Disease. 33, 1, p. 249-263 15 p.

Research output: Contribution to journalArticle

Tauopathies
Brain
Frontotemporal Dementia
Neurofibrillary Tangles
Immunoelectron Microscopy
2012
80 Citations (Scopus)

Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation

Cook, C., Gendron, T. D., Scheffel, K., Carlomagno, Y., Dunmore, J., Deture, M. & Petrucelli, L., Jul 2012, In : Human Molecular Genetics. 21, 13, p. 2936-2945 10 p., dds125.

Research output: Contribution to journalArticle

Histone Deacetylases
Proteins
Microtubule Proteins
Molecular Chaperones
Triage
2010
19 Citations (Scopus)

Characterization and localization of a hybrid non-ribosomal peptide synthetase and polyketide synthase gene from the toxic dinoflagellate Karenia brevis

López-Legentil, S., Song, B., Deture, M. & Baden, D. G., Feb 2010, In : Marine Biotechnology. 12, 1, p. 32-41 10 p.

Research output: Contribution to journalArticle

Peptide Synthases
Polyketide Synthases
polyketide synthases
Dinoflagellida
Poisons
8 Citations (Scopus)

Targeting heat shock proteins in tauopathies.

Deture, M., Hicks, C. & Petrucelli, L., Dec 2010, In : Current Alzheimer Research. 7, 8, p. 677-684 8 p.

Research output: Contribution to journalArticle

Tauopathies
Heat-Shock Proteins
Heat-Shock Response
Protein Folding
Alzheimer Disease
52 Citations (Scopus)

Three repeat isoforms of tau inhibit assembly of four repeat tau filaments

Adams, S. J., Deture, M., McBride, M., Dickson, D. W. & Petrucelli, L., 2010, In : PLoS One. 5, 5, e10810.

Research output: Contribution to journalArticle

microtubules
Protein Isoforms
exons
Tauopathies
alternative splicing
2009
40 Citations (Scopus)

Overexpression of wild-type murine tau results in progressive tauopathy and neurodegeneration

Adams, S. J., Crook, R. J. P., Deture, M., Randle, S. J., Innes, A. E., Yu, X. Z., Lin, W. L., Dugger, B. N., McBride, M., Hutton, M., Dickson, D. W. & McGowan, E., 2009, In : American Journal of Pathology. 175, 4, p. 1598-1609 12 p.

Research output: Contribution to journalArticle

Tauopathies
Transgenes
Pathology
tau Proteins
Gliosis
2008
162 Citations (Scopus)

Autophagic-lysosomal perturbation enhances tau aggregation in transfectants with induced wild-type tau expression

Hamano, T., Gendron, T. D., Causevic, E., Yen, S. H., Lin, W. L., Isidoro, C., Deture, M. & Ko, L. W., Mar 2008, In : European Journal of Neuroscience. 27, 5, p. 1119-1130 12 p.

Research output: Contribution to journalArticle

Chloroquine
Tauopathies
Cathepsin L
Cathepsin B
Cathepsin D
2006
9 Citations (Scopus)

Evidence for independent mechanisms and a multiple-hit model of tau assembly

Deture, M., Granger, B., Grover, A., Hutton, M. & Yen, S. H., Jan 20 2006, In : Biochemical and Biophysical Research Communications. 339, 3, p. 858-864 7 p.

Research output: Contribution to journalArticle

Polymerization
Heparin
Arachidonic Acid
tau Proteins
Frontotemporal Dementia
2005
1250 Citations (Scopus)

Medicine: Tau suppression in a neurodegenerative mouse model improves memory function

Santacruz, K., Lewis, J., Spires, T., Paulson, J., Kotilinek, L., Ingelsson, M., Guimaraes, A., Deture, M., Ramsden, M., McCowan, E., Forster, C., Yue, M., Orne, J., Janus, C., Mariash, A., Kuskowski, M., Hyman, B., Hutton, M. & Ashe, K. H., Jul 15 2005, In : Science. 309, 5733, p. 476-481 6 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Medicine
Tauopathies
Neurodegenerative Diseases
Neurons
19 Citations (Scopus)

Recent advances in experimental modeling of the assembly of tau filaments

Ko, L. W., Deture, M., Sahara, N., Chihab, R., Vega, I. E. & Yen, S. H., Jan 3 2005, In : Biochimica et Biophysica Acta - Molecular Basis of Disease. 1739, 2, p. 125-139 15 p.

Research output: Contribution to journalArticle

Tauopathies
Microtubule-Associated Proteins
Post Translational Protein Processing
Alzheimer Disease
Animal Models
22 Citations (Scopus)
mutagenesis
tau Proteins
Mutagenesis
site-directed mutagenesis
Site-Directed Mutagenesis
2004
25 Citations (Scopus)

Assembly of filamentous tau aggregates in human neuronal cells

Ko, L. W., Rush, T., Sahara, N., Kersh, J. S., Easson, C., Deture, M., Lin, W. L., Connor, Y. D. & Yen, S. H. C., 2004, In : Journal of Alzheimer's Disease. 6, 6, p. 605-622 18 p.

Research output: Contribution to journalArticle

Tauopathies
Alzheimer Disease
Protein Isoforms
Ecdysone
Microtubule-Associated Proteins
2003
45 Citations (Scopus)

A novel tau mutation in exon 9 (1260V) causes a four-repeat tauopathy

Grover, A., England, E., Baker, M., Sahara, N., Adamson, J., Granger, B., Houlden, H., Passant, U., Yen, S. H., Deture, M. & Hutton, M., Nov 2003, In : Experimental Neurology. 184, 1, p. 131-140 10 p.

Research output: Contribution to journalArticle

Tauopathies
Exons
Microtubules
Mutation
Protein Isoforms
2002
96 Citations (Scopus)

Assembly of tau in transgenic animals expressing P301L tau: Alteration of phosphorylation and solubility

Sahara, N., Lewis, J., Deture, M., McGowan, E., Dickson, D. W., Hutton, M. & Yen, S. H., Dec 2002, In : Journal of Neurochemistry. 83, 6, p. 1498-1508 11 p.

Research output: Contribution to journalArticle

Genetically Modified Animals
Phosphorylation
Solubility
Animals
Buffers
12 Citations (Scopus)

Cellular models for tau filament assembly

Ko, L. W., Deture, M., Sahara, N., Chihab, R. & Yen, S. H., Dec 2002, In : Journal of Molecular Neuroscience. 19, 3, p. 311-316 6 p.

Research output: Contribution to journalArticle

Cognition
Disease Progression
Alzheimer Disease
Agglomeration
Cell Culture Techniques
15 Citations (Scopus)

In vitro assembly of Alzheimer-like filaments: How a small cluster of charged residues in Tau and MAP2 controls filament morphology

Deture, M., Di Noto, L. & Purich, D. L., Sep 20 2002, In : Journal of Biological Chemistry. 277, 38, p. 34755-34759 5 p.

Research output: Contribution to journalArticle

Microtubules
Frontotemporal Dementia
Mutagenesis
Self assembly
Electron microscopy
56 Citations (Scopus)

Tau Assembly in inducible transfectants expressing wild-type or FTDP-17 tau

Deture, M., Ko, L. W., Easson, C. & Yen, S. H., Nov 1 2002, In : American Journal of Pathology. 161, 5, p. 1711-1722 12 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Mutation
Chromosomes, Human, Pair 17
Octoxynol
Centrifugation
2000
72 Citations (Scopus)

Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions

Deture, M., Ko, L. W., Yen, S., Nacharaju, P., Easson, C., Lewis, J., Van Slegtenhorst, M., Hutton, M. & Yen, S. H., Jan 17 2000, In : Brain Research. 853, 1, p. 5-14 10 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Missense Mutation
Microtubules
Aptitude
Neurons
1999
12 Citations (Scopus)

Disulfide-cross-linked Tau and MAP2 homodimers readily promote microtubule assembly

Di Noto, L., Deture, M. & Purich, D. L., Jul 1999, In : Molecular Cell Biology Research Communications. 2, 1, p. 71-76 6 p.

Research output: Contribution to journalArticle

Microtubules
Disulfides
tau Proteins
Pronase
Intermediate Filaments
40 Citations (Scopus)

Fibrillogenesis of tau: Insights from Tau missense mutations in FTDP-17

Yen, S. H., Hutton, M., Deture, M., Ko, L. W. & Nacharaju, P., Oct 1999, In : Brain Pathology. 9, 4, p. 695-705 11 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Missense Mutation
Mutation
Exons
RNA Splice Sites
1998

Promotion and stabilization of microtubule self-assembly by disulfide cross-linked TAU-TAU dimers and MAP2-MAP2 dimers

Purich, D. L., DiNoto, L. & Deture, M., 1998, In : FASEB Journal. 12, 8

Research output: Contribution to journalArticle

sulfides
Microtubules
Disulfides
Dimers
Self assembly
1997

MAP-2 Polymerization into Alzheimer-like Filaments

Li, D., Purich, E., Zhang, Y. & Deture, M., 1997, In : FASEB Journal. 11, 9

Research output: Contribution to journalArticle

Polymerization
polymerization
Neurofibrillary Tangles
Alzheimer disease
microtubules
1996
14 Citations (Scopus)

In vitro polymerization of embryonic MAP-2c and fragments of the MAP-2 microtubule binding region into structures resembling paired helical filaments

Deture, M., Zhang, E. Y., Bubb, M. R. & Purich, D. L., 1996, In : Journal of Biological Chemistry. 271, 51, p. 32702-32706 5 p.

Research output: Contribution to journalArticle

Microtubule-Associated Proteins
Microtubules
Polymerization
Coloring Agents
Pronase
10 Citations (Scopus)

Self-assembly of the brain MAP-2 microtubule-binding region into polymeric structures resembling Alzheimer filaments

Zhang, E. Y., Deture, M., Bubb, M. R., Caviston, T. L., Erdos, G. W., Whittaker, S. D. & Purich, D. L., Dec 4 1996, In : Biochemical and Biophysical Research Communications. 229, 1, p. 176-181 6 p.

Research output: Contribution to journalArticle

Neurofibrillary Tangles
Microtubules
Self assembly
Brain
Alzheimer Disease