Research output per year
Research output per year
- 44 results
Search results
-
2022
A p.Arg127Gln variant in GPIba LRR5 allosterically enhances affinity for VWF: a novel form of platelet-type VWD
Bury, L., Falcinelli, E., Bhotla, H. K., Mezzasoma, A. M., Guglielmini, G., Tischer, A., Moon-Tasson, L., Auton, M. & Gresele, P., Apr 12 2022, In: Blood Advances. 6, 7, p. 2236-2246 11 p.Research output: Contribution to journal › Article › peer-review
Open Access -
Gain-of-Function Variant pPro2555Arg of von Willebrand Factor Increases Aggregate Size through Altering Stem Dynamics
Huck, V., Chen, P. C., Xu, E. R., Tischer, A., Klemm, U., Aponte-Santamaría, C., Mess, C., Obser, T., Kutzki, F., König, G., Denis, C. V., Gräter, F., Wilmanns, M., Auton, M., Schneider, S. W., Schneppenheim, R., Hennig, J. & Brehm, M. A., Feb 1 2022, In: Thrombosis and Haemostasis. 122, 2, p. 226-239 14 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2021
Biomarkers of thromboinflammation correlate to COVID-19 infection and admission status in emergency department patients
Goswami, J., MacArthur, T. A., Sridharan, M., Tange, J., Kirmse, A. J., Lundell, K. A., Chen, D., Auton, M. T., Chon, T. Y., Hurt, R. T., Salonen, B. R., Ganesh, R., Erben, Y. M., Marquez, C. P., Dong, J. F., Kozar, R. A., Heller, S. F., Loomis, E. A., Johnstone, A. L., Bailey, K. R., & 2 others, Dec 2021, In: Thrombosis Update. 5, 100090.Research output: Contribution to journal › Article › peer-review
Open Access -
MeV-Stealth: A CD46-specific oncolytic measles virus resistant to neutralization by measles-immune human serum
Muñoz-Aliá, M. Á., Nace, R. A., Tischer, A., Zhang, L., Bah, E. S., Auton, M. & Russell, S. J., Feb 3 2021, In: PLoS pathogens. 17, 2, e1009283.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Neutrophil Extracellular Trap Formation and Syndecan-1 Shedding Are Increased After Trauma
Goswami, J., MacArthur, T., Bailey, K., Spears, G., Kozar, R. A., Auton, M., Dong, J. F., Key, N. S., Heller, S., Loomis, E., Hall, N. W., Johnstone, A. L. & Park, M. S., Sep 1 2021, In: Shock (Augusta, Ga.). 56, 3, p. 433-439 7 p.Research output: Contribution to journal › Article › peer-review
-
Quantification of von Willebrand factor and ADAMTS-13 after traumatic injury: A pilot study
Macarthur, T. A., Goswami, J., Moon Tasson, L., Tischer, A., Bailey, K. R., Spears, G. M., Dong, J. F., Auton, M., Kozar, R. & Park, M. S., Apr 5 2021, In: Trauma Surgery and Acute Care Open. 6, 1, e000703.Research output: Contribution to journal › Article › peer-review
Open Access -
Thrombin Generation Kinetics are Predictive of Rapid Transfusion in Trauma Patients Meeting Critical Administration Threshold
MacArthur, T. A., Spears, G. M., Kozar, R. A., Dong, J. F., Auton, M., Jenkins, D. H., Bailey, K. R., Ashrani, A. A., Ferrara, M. J., Immermann, J. M., Halling, T. M. & Park, M. S., Mar 1 2021, In: Shock (Augusta, Ga.). 55, 3, p. 321-325 5 p.Research output: Contribution to journal › Article › peer-review
Open Access -
2020
Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease
Tischer, A., Brehm, M. A., Machha, V. R., Moon-Tasson, L., Benson, L. M., Nelton, K. J., Leger, R. R., Obser, T., Martinez-Vargas, M., Whitten, S. T., Chen, D., Pruthi, R. K., Bergen, H. R., Cruz, M. A., Schneppenheim, R. & Auton, M., Jan 17 2020, In: Journal of Molecular Biology. 432, 2, p. 305-323 19 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Glycosylation sterically inhibits platelet adhesion to von Willebrand factor without altering intrinsic conformational dynamics
Tischer, A., Machha, V. R., Moon-Tasson, L., Benson, L. M. & Auton, M., Jan 1 2020, In: Journal of Thrombosis and Haemostasis. 18, 1, p. 79-90 12 p.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation
Valladolid, C., Martinez-Vargas, M., Sekhar, N., Lam, F., Brown, C., Palzkill, T., Tischer, A., Auton, M., Vinod Vijayan, K., Rumbaut, R. E., Nguyen, T. C. & Cruz, M. A., Apr 14 2020, In: Blood Advances. 4, 7, p. 1340-1349 10 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
2019
Arabinose Alters Both Local and Distal H-D Exchange Rates in the Escherichia coli AraC Transcriptional Regulator
Tischer, A., Brown, M. J., Schleif, R. F. & Auton, M., Jul 2 2019, In: Biochemistry. 58, 26, p. 2875-2882 8 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Platelet-type von Willebrand disease: Local disorder of the platelet GPIbα β-switch drives high-affinity binding to von Willebrand factor
Tischer, A., Machha, V. R., Moon-Tasson, L. & Auton, M., Dec 1 2019, In: Journal of Thrombosis and Haemostasis. 17, 12, p. 2022-2034 13 p.Research output: Contribution to journal › Article › peer-review
Open Access -
The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction
Schneppenheim, R., Hellermann, N., Brehm, M. A., Klemm, U., Obser, T., Huck, V., Schneider, S. W., Denis, C. V., Tischer, A., Auton, M., März, W., Xu, E. R., Wilmanns, M. & Zotz, R. B., Jan 24 2019, In: Blood. 133, 4, p. 356-365 10 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Scopus citations -
2018
The Chaperonin GroEL: A Versatile Tool for Applied Biotechnology Platforms
O'Neil, P. T., Machen, A. J., Deatherage, B. C., Trecazzi, C., Tischer, A., Machha, V. R., Auton, M. T., Baldwin, M. R., White, T. A. & Fisher, M. T., May 15 2018, In: Frontiers in Molecular Biosciences. 5, 46.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
“Cooperative collapse” of the denatured state revealed through Clausius-Clapeyron analysis of protein denaturation phase diagrams
Tischer, A., Machha, V. R., Rösgen, J. & Auton, M., Aug 2018, In: Biopolymers. 109, 8, e23106.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
2017
A novel Kleefstra syndrome-associated variant that affects the conserved TPLX motif within the ankyrin repeat of EHMT1 leads to abnormal protein folding
Blackburn, P. R., Tischer, A., Zimmermann, M. T., Kemppainen, J. L., Sastry, S., Knight Johnson, A. E., Cousin, M. A., Boczek, N. J., Oliver, G., Misra, V. K., Gavrilova, R. H., Lomberk, G., Auton, M., Urrutia, R. & Klee, E. W., Mar 3 2017, In: Journal of Biological Chemistry. 292, 9, p. 3866-3876 11 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping
Tischer, A., Machha, V. R., Frontroth, J. P., Brehm, M. A., Obser, T., Schneppenheim, R., Mayne, L., Walter Englander, S. & Auton, M., Jul 7 2017, In: Journal of Molecular Biology. 429, 14, p. 2161-2177 17 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
The Von Willebrand Factor A1–Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype
Machha, V. R., Tischer, A., Moon-Tasson, L. & Auton, M., Jan 6 2017, In: Journal of Molecular Biology. 429, 1, p. 32-47 16 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2016
Chaperonin-Based Biolayer Interferometry to Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins
Lea, W. A., O'Neil, P. T., Machen, A. J., Naik, S., Chaudhri, T., McGinn-Straub, W., Tischer, A., Auton, M. T., Burns, J. R., Baldwin, M. R., Khar, K. R., Karanicolas, J. & Fisher, M. T., Sep 6 2016, In: Biochemistry. 55, 35, p. 4885-4908 24 p.Research output: Contribution to journal › Article › peer-review
5 Scopus citations -
Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain
Cambell, J., Tischer, A., Machha, V., Moon-Tasson, L., Sankaran, B., Kim, C. & Auton, M., Jun 1 2016, In: Data in Brief. 7, p. 1700-1706 7 p.Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
Mutational constraints on local unfolding inhibit the rheological adaptation of von willebrand factor
Tischer, A., Campbell, J. C., Machha, V. R., Moon-Tasson, L., Benson, L. M., Sankaran, B., Kim, C. & Auton, M., Feb 19 2016, In: Journal of Biological Chemistry. 291, 8, p. 3848-3859 12 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Scopus citations -
2015
Structural Origins of Misfolding Propensity in the Platelet Adhesive von Willebrand Factor A1 Domain
Zimmermann, M. T., Tischer, A., Whitten, S. T. & Auton, M., Jul 22 2015, In: Biophysical Journal. 109, 2, p. 398-406 9 p.Research output: Contribution to journal › Article › peer-review
9 Scopus citations -
Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding
Blancas-Mejía, L. M., Horn, T. J., Marin-Argany, M., Auton, M., Tischer, A. & Ramirez-Alvarado, M., Aug 12 2015, In: Biophysical Chemistry. 207, p. 13-20 8 p., 5846.Research output: Contribution to journal › Article › peer-review
29 Scopus citations -
2014
Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins
Perez, R. B., Tischer, A., Auton, M. & Whitten, S. T., Dec 2014, In: Proteins: Structure, Function and Bioinformatics. 82, 12, p. 3373-3384 12 p.Research output: Contribution to journal › Article › peer-review
12 Scopus citations -
A molten globule intermediate of the Von Willebrand factor A1 domain firmly tethers platelets under shear flow
Tischer, A., Madde, P., Blancas-Mejia, L. M. & Auton, M., May 2014, In: Proteins: Structure, Function and Bioinformatics. 82, 5, p. 867-878 12 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations
Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. & Ramirez-Alvarado, M., Jan 23 2014, In: Journal of Molecular Biology. 426, 2, p. 347-361 15 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
Misfolding of vWF to pathologically disordered conformations impacts the severity of von willebrand disease
Tischer, A., Madde, P., Moon-Tasson, L. & Auton, M., Sep 2 2014, In: Biophysical Journal. 107, 5, p. 1185-1195 11 p.Research output: Contribution to journal › Article › peer-review
25 Scopus citations -
Oxidative refolding of rPA in l -ArgHCl and in ionic liquids: A correlation between hydrophobicity, salt effects, and refolding yield
Tischer, A., Lilie, H., Auton, M. & Lange, C., Nov 2014, In: Biopolymers. 101, 11, p. 1129-1140 12 p.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
The effects of N-ethyl-N′-methyl imidazolium chloride on the solubility, stability and aggregation of tc-rPA
Tischer, A., Pultke, H., Topf, A., Auton, M., Lange, C. & Lilie, H., Apr 2014, In: FEBS Journal. 281, 7, p. 1738-1749 12 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
2013
Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability
Auton, M., Bassett, G. R., Gillard, B. K. & Pownall, H. J., Jun 25 2013, In: Biochemistry. 52, 25, p. 4324-4330 7 p.Research output: Contribution to journal › Article › peer-review
7 Scopus citations -
The linker between the D3 and A1 domains of vWF suppresses A1-GPIba catch bonds by site-specific binding to the A1 domain
Tischer, A., Cruz, M. A. & Auton, M., Aug 2013, In: Protein Science. 22, 8, p. 1049-1059 11 p.Research output: Contribution to journal › Article › peer-review
26 Scopus citations -
Ureaerature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding
Tischer, A. & Auton, M., Sep 2013, In: Protein Science. 22, 9, p. 1147-1160 14 p.Research output: Contribution to journal › Article › peer-review
13 Scopus citations -
2012
N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress
Auton, M., Sowa, K. E., Behymer, M. & Cruz, M. A., Apr 27 2012, In: Journal of Biological Chemistry. 287, 18, p. 14579-14585 7 p.Research output: Contribution to journal › Article › peer-review
33 Scopus citations -
2011
Osmolyte effects on protein stability and solubility: A balancing act between backbone and side-chains
Auton, M., Rösgen, J., Sinev, M., Holthauzen, L. M. F. & Bolen, D. W., Nov 2011, In: Biophysical Chemistry. 159, 1, p. 90-99 10 p.Research output: Contribution to journal › Article › peer-review
160 Scopus citations -
2010
Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibα and platelet activation under shear stress
Auton, M., Sowa, K. E., Smith, S. M., Sedlák, E., Vijayan, K. V. & Cruz, M. A., Jul 23 2010, In: Journal of Biological Chemistry. 285, 30, p. 22831-22839 9 p.Research output: Contribution to journal › Article › peer-review
35 Scopus citations -
The mechanism of VWF-mediated platelet GPIbα binding
Auton, M., Zhu, C. & Cruz, M. A., Aug 9 2010, In: Biophysical Journal. 99, 4, p. 1192-1201 10 p.Research output: Contribution to journal › Article › peer-review
28 Scopus citations -
2009
Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbα
Auton, M., Sedlák, E., Marek, J., Wu, T., Zhu, C. & Cruz, M. A., 2009, In: Biophysical Journal. 97, 2, p. 618-627 10 p.Research output: Contribution to journal › Article › peer-review
32 Scopus citations -
2008
Structural thermodynamics of protein preferential solvation: Osmolyte solvation of proteins, aminoacids, and peptides
Auton, M., Bolen, D. W. & Rösgen, J., Dec 2008, In: Proteins: Structure, Function and Genetics. 73, 4, p. 802-813 12 p.Research output: Contribution to journal › Article › peer-review
144 Scopus citations -
2007
Anatomy of energetic changes accompanying urea-induced protein denaturation
Auton, M., Holthauzen, L. M. F. & Bolen, D. W., Sep 25 2007, In: Proceedings of the National Academy of Sciences of the United States of America. 104, 39, p. 15317-15322 6 p.Research output: Contribution to journal › Article › peer-review
Open Access223 Scopus citations -
Conformational Stability and Domain Unfolding of the Von Willebrand Factor A Domains
Auton, M., Cruz, M. A. & Moake, J., Feb 23 2007, In: Journal of Molecular Biology. 366, 3, p. 986-1000 15 p.Research output: Contribution to journal › Article › peer-review
65 Scopus citations -
2006
Attack of the acronyms: TTP, VWF, ADAMTS-13 and SELDI-TOF-MS
Auton, M. & Moake, J., Feb 2006, In: Journal of Thrombosis and Haemostasis. 4, 2, p. 329-332 4 p.Research output: Contribution to journal › Article › peer-review
2 Scopus citations -
Metrics that Differentiate the Origins of Osmolyte Effects on Protein Stability: A Test of the Surface Tension Proposal
Auton, M., Ferreon, A. C. M. & Bolen, D. W., Sep 1 2006, In: Journal of Molecular Biology. 361, 5, p. 983-992 10 p.Research output: Contribution to journal › Article › peer-review
64 Scopus citations -
2005
Prediction the energetics of osmolyte-induced protein folding/unfolding
Auton, M. & Bolen, D. W., Oct 18 2005, In: Proceedings of the National Academy of Sciences of the United States of America. 102, 42, p. 15065-15068 4 p.Research output: Contribution to journal › Article › peer-review
333 Scopus citations -
2004
Additive Transfer Free Energies of the Peptide Backbone Unit That Are Independent of the Model Compound and the Choice of Concentration Scale
Auton, M. & Bolen, D. W., Feb 10 2004, In: Biochemistry. 43, 5, p. 1329-1342 14 p.Research output: Contribution to journal › Article › peer-review
177 Scopus citations