Matthew T Auton, PhD

  • 150 3rd Street SW, 6-56 Stabile Building

    55905 Rochester

    United States

  • 1521 Citations
  • 17 Scopus h-Index
20042020

Research output per year

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Research Output

  • 1521 Citations
  • 17 Scopus h-Index
  • 37 Article
  • 3 Chapter
  • 1 Comment/debate
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Article
2020

Evidence for the Misfolding of the A1 Domain within Multimeric von Willebrand Factor in Type 2 von Willebrand Disease

Tischer, A., Brehm, M. A., Machha, V. R., Moon-Tasson, L., Benson, L. M., Nelton, K. J., Leger, R. R., Obser, T., Martinez-Vargas, M., Whitten, S. T., Chen, D., Pruthi, R. K., Bergen, H. R., Cruz, M. A., Schneppenheim, R. & Auton, M., Jan 17 2020, In : Journal of Molecular Biology. 432, 2, p. 305-323 19 p.

Research output: Contribution to journalArticle

Modulating the rate of fibrin formation and clot structure attenuates microvascular thrombosis in systemic inflammation

Valladolid, C., Martinez-Vargas, M., Sekhar, N., Lam, F., Brown, C., Palzkill, T., Tischer, A., Auton, M., Vinod Vijayan, K., Rumbaut, R. E., Nguyen, T. C. & Cruz, M. A., Apr 14 2020, In : Blood Advances. 4, 7, p. 1340-1349 10 p.

Research output: Contribution to journalArticle

Open Access
2019

Arabinose Alters Both Local and Distal H-D Exchange Rates in the Escherichia coli AraC Transcriptional Regulator

Tischer, A., Brown, M. J., Schleif, R. F. & Auton, M., Jul 2 2019, In : Biochemistry. 58, 26, p. 2875-2882 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Glycosylation sterically inhibits platelet adhesion to von Willebrand factor without altering intrinsic conformational dynamics

Tischer, A., Machha, V. R., Moon-Tasson, L., Benson, L. M. & Auton, M., Jan 1 2019, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

Platelet-type von Willebrand disease: Local disorder of the platelet GPIbα β-switch drives high-affinity binding to von Willebrand factor

Tischer, A., Machha, V. R., Moon-Tasson, L. & Auton, M., Jan 1 2019, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Schneppenheim, R., Hellermann, N., Brehm, M. A., Klemm, U., Obser, T., Huck, V., Schneider, S. W., Denis, C. V., Tischer, A., Auton, M., März, W., Xu, E. R., Wilmanns, M. & Zotz, R. B., Jan 24 2019, In : Blood. 133, 4, p. 356-365 10 p.

Research output: Contribution to journalArticle

8 Scopus citations
2018

“Cooperative collapse” of the denatured state revealed through Clausius-Clapeyron analysis of protein denaturation phase diagrams

Tischer, A., Machha, V. R., Rösgen, J. & Auton, M. T., Aug 1 2018, In : Biopolymers. 109, 8, e23106.

Research output: Contribution to journalArticle

2 Scopus citations
2017

A novel Kleefstra syndrome-associated variant that affects the conserved TPLX motif within the ankyrin repeat of EHMT1 leads to abnormal protein folding

Blackburn, P. R., Tischer, A., Zimmermann, M. T., Kemppainen, J. L., Sastry, S., Knight Johnson, A. E., Cousin, M. A., Boczek, N. J., Oliver, G., Misra, V. K., Gavrilova, R. M., Lomberk, G., Auton, M. T., Urrutia, R. & Klee, E. W., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3866-3876 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping

Tischer, A., Machha, V. R., Frontroth, J. P., Brehm, M. A., Obser, T., Schneppenheim, R., Mayne, L., Walter Englander, S. & Auton, M. T., Jul 7 2017, In : Journal of Molecular Biology. 429, 14, p. 2161-2177 17 p.

Research output: Contribution to journalArticle

7 Scopus citations

The Von Willebrand Factor A1–Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype

Machha, V. R., Tischer, A., Moon-Tasson, L. & Auton, M. T., Jan 6 2017, In : Journal of Molecular Biology. 429, 1, p. 32-47 16 p.

Research output: Contribution to journalArticle

4 Scopus citations
2016

Chaperonin-Based Biolayer Interferometry to Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins

Lea, W. A., O'Neil, P. T., Machen, A. J., Naik, S., Chaudhri, T., McGinn-Straub, W., Tischer, A., Auton, M. T., Burns, J. R., Baldwin, M. R., Khar, K. R., Karanicolas, J. & Fisher, M. T., Sep 6 2016, In : Biochemistry. 55, 35, p. 4885-4908 24 p.

Research output: Contribution to journalArticle

3 Scopus citations

Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain

Cambell, J., Tischer, A., Machha, V., Moon-Tasson, L., Sankaran, B., Kim, C. & Auton, M., Jun 1 2016, In : Data in Brief. 7, p. 1700-1706 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

Mutational constraints on local unfolding inhibit the rheological adaptation of von willebrand factor

Tischer, A., Campbell, J. C., Machha, V. R., Moon-Tasson, L., Benson, L. M., Sankaran, B., Kim, C. & Auton, M. T., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Untangling a Structurally Resolved Protein Folding Intermediate

Auton, M. T., Mar 29 2016, In : Biophysical Journal. 110, 6, p. 1205-1206 2 p.

Research output: Contribution to journalArticle

2015

Structural Origins of Misfolding Propensity in the Platelet Adhesive von Willebrand Factor A1 Domain

Zimmermann, M. T., Tischer, A., Whitten, S. T. & Auton, M. T., Jul 22 2015, In : Biophysical Journal. 109, 2, p. 398-406 9 p.

Research output: Contribution to journalArticle

8 Scopus citations

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

Blancas-Mejía, L. M., Horn, T. J., Marin-Argany, M., Auton, M., Tischer, A. & Ramirez-Alvarado, M., Aug 12 2015, In : Biophysical Chemistry. 207, p. 13-20 8 p., 5846.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins

Perez, R. B., Tischer, A., Auton, M. T. & Whitten, S. T., 2014, In : Proteins: Structure, Function and Bioinformatics. 82, 12, p. 3373-3384 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

A molten globule intermediate of the Von Willebrand factor A1 domain firmly tethers platelets under shear flow

Tischer, A., Madde, P., Blancas-Mejia, L. M. & Auton, M., May 2014, In : Proteins: Structure, Function and Bioinformatics. 82, 5, p. 867-878 12 p.

Research output: Contribution to journalArticle

14 Scopus citations

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations

Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. & Ramirez-Alvarado, M., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 347-361 15 p.

Research output: Contribution to journalArticle

29 Scopus citations

Misfolding of vWF to pathologically disordered conformations impacts the severity of von willebrand disease

Tischer, A., Madde, P., Moon-Tasson, L. & Auton, M. T., Sep 2 2014, In : Biophysical Journal. 107, 5, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

21 Scopus citations

Oxidative refolding of rPA in l -ArgHCl and in ionic liquids: A correlation between hydrophobicity, salt effects, and refolding yield

Tischer, A., Lilie, H., Auton, M. & Lange, C., Nov 2014, In : Biopolymers. 101, 11, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

The effects of N-ethyl-N′-methyl imidazolium chloride on the solubility, stability and aggregation of tc-rPA

Tischer, A., Pultke, H., Topf, A., Auton, M., Lange, C. & Lilie, H., Apr 2014, In : FEBS Journal. 281, 7, p. 1738-1749 12 p.

Research output: Contribution to journalArticle

5 Scopus citations
2013

Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability

Auton, M., Bassett, G. R., Gillard, B. K. & Pownall, H. J., Jun 25 2013, In : Biochemistry. 52, 25, p. 4324-4330 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

The linker between the D3 and A1 domains of vWF suppresses A1-GPIba catch bonds by site-specific binding to the A1 domain

Tischer, A., Cruz, M. A. & Auton, M., Aug 2013, In : Protein Science. 22, 8, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

22 Scopus citations

Ureaerature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding

Tischer, A. & Auton, M., Sep 1 2013, In : Protein Science. 22, 9, p. 1147-1160 14 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress

Auton, M., Sowa, K. E., Behymer, M. & Cruz, M. A., Apr 27 2012, In : Journal of Biological Chemistry. 287, 18, p. 14579-14585 7 p.

Research output: Contribution to journalArticle

31 Scopus citations
2011

Osmolyte effects on protein stability and solubility: A balancing act between backbone and side-chains

Auton, M., Rösgen, J., Sinev, M., Holthauzen, L. M. F. & Bolen, D. W., Nov 1 2011, In : Biophysical Chemistry. 159, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

139 Scopus citations
2010

Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibα and platelet activation under shear stress

Auton, M., Sowa, K. E., Smith, S. M., Sedlák, E., Vijayan, K. V. & Cruz, M. A., Jul 23 2010, In : Journal of Biological Chemistry. 285, 30, p. 22831-22839 9 p.

Research output: Contribution to journalArticle

32 Scopus citations

The mechanism of VWF-mediated platelet GPIbα binding

Auton, M., Zhu, C. & Cruz, M. A., Aug 9 2010, In : Biophysical Journal. 99, 4, p. 1192-1201 10 p.

Research output: Contribution to journalArticle

26 Scopus citations
2009

Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbα

Auton, M., Sedlák, E., Marek, J., Wu, T., Zhu, C. & Cruz, M. A., Jan 1 2009, In : Biophysical Journal. 97, 2, p. 618-627 10 p.

Research output: Contribution to journalArticle

30 Scopus citations
2008

Structural thermodynamics of protein preferential solvation: Osmolyte solvation of proteins, aminoacids, and peptides

Auton, M., Bolen, D. W. & Rösgen, J., Dec 1 2008, In : Proteins: Structure, Function and Genetics. 73, 4, p. 802-813 12 p.

Research output: Contribution to journalArticle

136 Scopus citations
2007

Anatomy of energetic changes accompanying urea-induced protein denaturation

Auton, M., Holthauzen, L. M. F. & Bolen, D. W., Sep 25 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 39, p. 15317-15322 6 p.

Research output: Contribution to journalArticle

211 Scopus citations

Conformational Stability and Domain Unfolding of the Von Willebrand Factor A Domains

Auton, M., Cruz, M. A. & Moake, J., Feb 23 2007, In : Journal of Molecular Biology. 366, 3, p. 986-1000 15 p.

Research output: Contribution to journalArticle

64 Scopus citations
2006

Attack of the acronyms: TTP, VWF, ADAMTS-13 and SELDI-TOF-MS

Auton, M. & Moake, J., Feb 1 2006, In : Journal of Thrombosis and Haemostasis. 4, 2, p. 329-332 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Metrics that Differentiate the Origins of Osmolyte Effects on Protein Stability: A Test of the Surface Tension Proposal

Auton, M., Ferreon, A. C. M. & Bolen, D. W., Sep 1 2006, In : Journal of Molecular Biology. 361, 5, p. 983-992 10 p.

Research output: Contribution to journalArticle

60 Scopus citations
2005

Prediction the energetics of osmolyte-induced protein folding/unfolding

Auton, M. & Bolen, D. W., Oct 18 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 42, p. 15065-15068 4 p.

Research output: Contribution to journalArticle

318 Scopus citations
2004

Additive Transfer Free Energies of the Peptide Backbone Unit That Are Independent of the Model Compound and the Choice of Concentration Scale

Auton, M. & Bolen, D. W., Feb 10 2004, In : Biochemistry. 43, 5, p. 1329-1342 14 p.

Research output: Contribution to journalArticle

171 Scopus citations