Matthew T Auton, PhD

  • 150 3rd Street SW, 6-56 Stabile Building

    55905 Rochester

    United States

  • 1448 Citations
  • 17 Scopus h-Index
20042019
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Research Output 2004 2019

  • 1448 Citations
  • 17 Scopus h-Index
  • 37 Article
  • 1 Chapter
  • 1 Comment/debate
2019

Arabinose Alters Both Local and Distal H-D Exchange Rates in the Escherichia coli AraC Transcriptional Regulator

Tischer, A., Brown, M. J., Schleif, R. F. & Auton, M. T., Jan 1 2019, In : Biochemistry.

Research output: Contribution to journalArticle

AraC Transcription Factor
Arabinose
Escherichia coli
Dimerization
DNA

Glycosylation sterically inhibits platelet adhesion to von Willebrand factor without altering intrinsic conformational dynamics

Tischer, A., Machha, V. R., Moon-Tasson, L., Benson, L. M. & Auton, M., Jan 1 2019, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

von Willebrand Factor
Glycosylation
Blood Platelets
Platelet Glycoprotein GPIb-IX Complex
Thermodynamics

Platelet-type von Willebrand disease: Local disorder of the platelet GPIbα β-switch drives high-affinity binding to von Willebrand factor

Tischer, A., Machha, V. R., Moon-Tasson, L. & Auton, M., Jan 1 2019, (Accepted/In press) In : Journal of Thrombosis and Haemostasis.

Research output: Contribution to journalArticle

von Willebrand Factor
Hydrogen
Blood Platelets
Deuterium
Mutation
7 Citations (Scopus)

The von Willebrand factor Tyr2561 allele is a gain-of-function variant and a risk factor for early myocardial infarction

Schneppenheim, R., Hellermann, N., Brehm, M. A., Klemm, U., Obser, T., Huck, V., Schneider, S. W., Denis, C. V., Tischer, A., Auton, M. T., März, W., Xu, E. R., Wilmanns, M. & Zotz, R. B., Jan 24 2019, In : Blood. 133, 4, p. 356-365 10 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Alleles
Myocardial Infarction
Platelets
Blood Platelets
2018
2 Citations (Scopus)

“Cooperative collapse” of the denatured state revealed through Clausius-Clapeyron analysis of protein denaturation phase diagrams

Tischer, A., Machha, V. R., Rösgen, J. & Auton, M. T., Aug 1 2018, In : Biopolymers. 109, 8, e23106.

Research output: Contribution to journalArticle

Protein Denaturation
Denaturation
Urea
Phase diagrams
Proteins
2017
3 Citations (Scopus)

A novel Kleefstra syndrome-associated variant that affects the conserved TPLX motif within the ankyrin repeat of EHMT1 leads to abnormal protein folding

Blackburn, P. R., Tischer, A., Zimmermann, M. T., Kemppainen, J. L., Sastry, S., Knight Johnson, A. E., Cousin, M. A., Boczek, N. J., Oliver, G., Misra, V. K., Gavrilova, R. M., Lomberk, G., Auton, M. T., Urrutia, R. & Klee, E. W., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3866-3876 11 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Protein folding
Protein Folding
Histone Code
Intellectual Disability
5 Citations (Scopus)

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping

Tischer, A., Machha, V. R., Frontroth, J. P., Brehm, M. A., Obser, T., Schneppenheim, R., Mayne, L., Walter Englander, S. & Auton, M. T., Jul 7 2017, In : Journal of Molecular Biology. 429, 14, p. 2161-2177 17 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Blood Platelets
Disulfides
Thrombocytopenia
von Willebrand Diseases
4 Citations (Scopus)

The Von Willebrand Factor A1–Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype

Machha, V. R., Tischer, A., Moon-Tasson, L. & Auton, M. T., Jan 6 2017, In : Journal of Molecular Biology. 429, 1, p. 32-47 16 p.

Research output: Contribution to journalArticle

Type 2 von Willebrand Disease
von Willebrand Factor
Collagen
Phenotype
Blood Platelets
2016
3 Citations (Scopus)

Chaperonin-Based Biolayer Interferometry to Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins

Lea, W. A., O'Neil, P. T., Machen, A. J., Naik, S., Chaudhri, T., McGinn-Straub, W., Tischer, A., Auton, M. T., Burns, J. R., Baldwin, M. R., Khar, K. R., Karanicolas, J. & Fisher, M. T., Sep 6 2016, In : Biochemistry. 55, 35, p. 4885-4908 24 p.

Research output: Contribution to journalArticle

Interferometry
Chaperonins
Agglomeration
Kinetics
Immobilized Proteins
2 Citations (Scopus)
Protein folding
Monoclonal Antibodies
Thermodynamics
Water
Proteins
6 Citations (Scopus)

Data on the purification and crystallization of the loss-of-function von Willebrand disease variant (p.Gly1324Ser) of the von Willebrand factor A1 domain

Cambell, J., Tischer, A., Machha, V., Moon-Tasson, L., Sankaran, B., Kim, C. & Auton, M. T., Jun 1 2016, In : Data in Brief. 7, p. 1700-1706 7 p.

Research output: Contribution to journalArticle

loss of function
inclusion
Disease
data bank
quality control
14 Citations (Scopus)

Mutational constraints on local unfolding inhibit the rheological adaptation of von willebrand factor

Tischer, A., Campbell, J. C., Machha, V. R., Moon-Tasson, L., Benson, L. M., Sankaran, B., Kim, C. & Auton, M. T., Feb 19 2016, In : Journal of Biological Chemistry. 291, 8, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Platelets
Blood Platelets
Shear flow
Mutation

Osmophobics and hydrophobics: The changing landscape of protein folding

Auton, M. T. & Pettitt, B. M., Apr 19 2016, Fluctuation Theory of Solutions: Applications in Chemistry, Chemical Engineering, and Biophysics. CRC Press, p. 309-323 15 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Protein folding
Protein Stability
Fluorescence Spectrometry
Protein Folding
Thermodynamics

Untangling a Structurally Resolved Protein Folding Intermediate

Auton, M. T., Mar 29 2016, In : Biophysical Journal. 110, 6, p. 1205-1206 2 p.

Research output: Contribution to journalArticle

Secondary Protein Structure
Protein Denaturation
Molecular Models
Protein Folding
Proteins
2015
8 Citations (Scopus)

Structural Origins of Misfolding Propensity in the Platelet Adhesive von Willebrand Factor A1 Domain

Zimmermann, M. T., Tischer, A., Whitten, S. T. & Auton, M. T., Jul 22 2015, In : Biophysical Journal. 109, 2, p. 398-406 9 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Blood Platelets
von Willebrand Diseases
Energy Transfer
Hemostasis
20 Citations (Scopus)

Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding

Blancas-Mejía, L. M., Horn, T. J., Marin-Argany, M., Auton, M. T., Tischer, A. & Ramirez-Alvarado, M., Aug 12 2015, In : Biophysical Chemistry. 207, p. 13-20 8 p., 5846.

Research output: Contribution to journalArticle

Immunoglobulin Light Chains
Thermodynamics
Amyloid
Hot Temperature
Light
2014
11 Citations (Scopus)

Alanine and proline content modulate global sensitivity to discrete perturbations in disordered proteins

Perez, R. B., Tischer, A., Auton, M. T. & Whitten, S. T., 2014, In : Proteins: Structure, Function and Bioinformatics. 82, 12, p. 3373-3384 12 p.

Research output: Contribution to journalArticle

Proline
Alanine
Intrinsically Disordered Proteins
Proteins
Substitution reactions
14 Citations (Scopus)

A molten globule intermediate of the Von Willebrand factor A1 domain firmly tethers platelets under shear flow

Tischer, A., Madde, P., Blancas-Mejia, L. M. & Auton, M. T., 2014, In : Proteins: Structure, Function and Bioinformatics. 82, 5, p. 867-878 12 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Shear flow
Platelets
Disulfides
Molten materials
28 Citations (Scopus)

Kinetic control in protein folding for light chain amyloidosis and the differential effects of somatic mutations

Blancas-Mejía, L. M., Tischer, A., Thompson, J. R., Tai, J., Wang, L., Auton, M. T. & Ramirez-Alvarado, M., Jan 23 2014, In : Journal of Molecular Biology. 426, 2, p. 347-361 15 p.

Research output: Contribution to journalArticle

Protein Folding
Amyloidosis
Light
Mutation
Thermodynamics
18 Citations (Scopus)

Misfolding of vWF to pathologically disordered conformations impacts the severity of von willebrand disease

Tischer, A., Madde, P., Moon-Tasson, L. & Auton, M. T., Sep 2 2014, In : Biophysical Journal. 107, 5, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

von Willebrand Diseases
von Willebrand Factor
Blood Platelets
Thrombocytopenia
Platelet Adhesiveness
1 Citation (Scopus)

Oxidative refolding of rPA in l -ArgHCl and in ionic liquids: A correlation between hydrophobicity, salt effects, and refolding yield

Tischer, A., Lilie, H., Auton, M. T. & Lange, C., 2014, In : Biopolymers. 101, 11, p. 1129-1140 12 p.

Research output: Contribution to journalArticle

Ionic Liquids
Protein Refolding
Hydrophobicity
Hydrophobic and Hydrophilic Interactions
Ionic liquids
4 Citations (Scopus)

The effects of N-ethyl-N′-methyl imidazolium chloride on the solubility, stability and aggregation of tc-rPA

Tischer, A., Pultke, H., Topf, A., Auton, M. T., Lange, C. & Lilie, H., 2014, In : FEBS Journal. 281, 7, p. 1738-1749 12 p.

Research output: Contribution to journalArticle

Methyl Chloride
Solubility
Agglomeration
Ionic Liquids
Protein Unfolding
2013
5 Citations (Scopus)

Free cholesterol determines reassembled high-density lipoprotein phospholipid phase structure and stability

Auton, M. T., Bassett, G. R., Gillard, B. K. & Pownall, H. J., Jun 25 2013, In : Biochemistry. 52, 25, p. 4324-4330 7 p.

Research output: Contribution to journalArticle

Phase stability
HDL Lipoproteins
Phase structure
Dimyristoylphosphatidylcholine
Phospholipids
21 Citations (Scopus)

The linker between the D3 and A1 domains of vWF suppresses A1-GPIba catch bonds by site-specific binding to the A1 domain

Tischer, A., Cruz, M. A. & Auton, M. T., Aug 2013, In : Protein Science. 22, 8, p. 1049-1059 11 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Platelets
Binding Sites
Blood Platelets
Stabilization
12 Citations (Scopus)

Ureaerature phase diagrams capture the thermodynamics of denatured state expansion that accompany protein unfolding

Tischer, A. & Auton, M. T., Sep 2013, In : Protein Science. 22, 9, p. 1147-1160 14 p.

Research output: Contribution to journalArticle

Protein Unfolding
Thermodynamics
Phase diagrams
Urea
Hot Temperature
2012
30 Citations (Scopus)

N-terminal flanking region of A1 domain in von Willebrand factor stabilizes structure of A1A2A3 complex and modulates platelet activation under shear stress

Auton, M. T., Sowa, K. E., Behymer, M. & Cruz, M. A., Apr 27 2012, In : Journal of Biological Chemistry. 287, 18, p. 14579-14585 7 p.

Research output: Contribution to journalArticle

Platelet Activation
von Willebrand Factor
Platelets
Shear stress
Blood Platelets
2011
130 Citations (Scopus)

Osmolyte effects on protein stability and solubility: A balancing act between backbone and side-chains

Auton, M. T., Rösgen, J., Sinev, M., Holthauzen, L. M. F. & Bolen, D. W., Nov 2011, In : Biophysical Chemistry. 159, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

Protein Stability
Solubility
Energy Transfer
Proteins
Free energy
21 Citations (Scopus)

Protein stability in the presence of cosolutes

Holthauzen, L. M. F., Auton, M. T., Sinev, M. & Rösgen, J., 2011, In : Methods in Enzymology. 492, p. 61-125 65 p.

Research output: Contribution to journalArticle

Protein Stability
Proteins
Urea
Temperature
2010
31 Citations (Scopus)

Destabilization of the A1 domain in von Willebrand factor dissociates the A1A2A3 tri-domain and provokes spontaneous binding to glycoprotein Ibα and platelet activation under shear stress

Auton, M. T., Sowa, K. E., Smith, S. M., Sedlák, E., Vijayan, K. V. & Cruz, M. A., Jul 23 2010, In : Journal of Biological Chemistry. 285, 30, p. 22831-22839 9 p.

Research output: Contribution to journalArticle

Platelet Glycoprotein GPIb-IX Complex
Ristocetin
Platelet Activation
von Willebrand Factor
Platelets
25 Citations (Scopus)

The mechanism of VWF-mediated platelet GPIbα binding

Auton, M. T., Zhu, C. & Cruz, M. A., Aug 9 2010, In : Biophysical Journal. 99, 4, p. 1192-1201 10 p.

Research output: Contribution to journalArticle

Blood Platelets
von Willebrand Factor
Thermodynamics
von Willebrand Diseases
Protein Unfolding
2009
30 Citations (Scopus)

Changes in thermodynamic stability of von Willebrand factor differentially affect the force-dependent binding to platelet GPIbα

Auton, M. T., Sedlák, E., Marek, J., Wu, T., Zhu, C. & Cruz, M. A., 2009, In : Biophysical Journal. 97, 2, p. 618-627 10 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Thermodynamics
Blood Platelets
Mutation
Type 2 von Willebrand Disease
2008
129 Citations (Scopus)

Structural thermodynamics of protein preferential solvation: Osmolyte solvation of proteins, aminoacids, and peptides

Auton, M. T., Bolen, D. W. & Rösgen, J., Dec 2008, In : Proteins: Structure, Function and Genetics. 73, 4, p. 802-813 12 p.

Research output: Contribution to journalArticle

Solvation
Thermodynamics
Hydration
Peptides
Water
2007
203 Citations (Scopus)

Anatomy of energetic changes accompanying urea-induced protein denaturation

Auton, M. T., Holthauzen, L. M. F. & Bolen, D. W., Sep 25 2007, In : Proceedings of the National Academy of Sciences of the United States of America. 104, 39, p. 15317-15322 6 p.

Research output: Contribution to journalArticle

Protein Denaturation
Urea
Anatomy
Protein Unfolding
Energy Transfer
71 Citations (Scopus)

Application of the Transfer Model to Understand How Naturally Occurring Osmolytes Affect Protein Stability

Auton, M. T. & Bolen, D. W., 2007, In : Methods in Enzymology. 428, p. 397-418 22 p.

Research output: Contribution to journalArticle

Protein Unfolding
Protein Stability
Energy Transfer
Protein Folding
Thermodynamics
63 Citations (Scopus)

Conformational Stability and Domain Unfolding of the Von Willebrand Factor A Domains

Auton, M. T., Cruz, M. A. & Moake, J., Feb 23 2007, In : Journal of Molecular Biology. 366, 3, p. 986-1000 15 p.

Research output: Contribution to journalArticle

von Willebrand Factor
varespladib methyl
Urea
Platelet Glycoprotein GPIb-IX Complex
Metalloproteases
2006
2 Citations (Scopus)

Attack of the acronyms: TTP, VWF, ADAMTS-13 and SELDI-TOF-MS

Auton, M. T. & Moake, J., Feb 2006, In : Journal of Thrombosis and Haemostasis. 4, 2, p. 329-332 4 p.

Research output: Contribution to journalArticle

ADAM Proteins
Recombinant Fusion Proteins
Thrombotic Thrombocytopenic Purpura
Protein Array Analysis
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
59 Citations (Scopus)

Metrics that Differentiate the Origins of Osmolyte Effects on Protein Stability: A Test of the Surface Tension Proposal

Auton, M. T., Ferreon, A. C. M. & Bolen, D. W., Sep 1 2006, In : Journal of Molecular Biology. 361, 5, p. 983-992 10 p.

Research output: Contribution to journalArticle

Surface Tension
Protein Stability
Proteins
Static Electricity
Membrane Proteins
2005
304 Citations (Scopus)

Prediction the energetics of osmolyte-induced protein folding/unfolding

Auton, M. T. & Bolen, D. W., Oct 18 2005, In : Proceedings of the National Academy of Sciences of the United States of America. 102, 42, p. 15065-15068 4 p.

Research output: Contribution to journalArticle

Protein Unfolding
Protein Folding
Thermodynamics
Biochemistry
Dissection
2004
162 Citations (Scopus)

Additive Transfer Free Energies of the Peptide Backbone Unit That Are Independent of the Model Compound and the Choice of Concentration Scale

Auton, M. T. & Bolen, D. W., Feb 10 2004, In : Biochemistry. 43, 5, p. 1329-1342 14 p.

Research output: Contribution to journalArticle

Energy Transfer
Free energy
Peptides
Protein Unfolding
Activity coefficients