Matthew T Auton, PhD

Assistant Professor

  • 150 3rd Street SW, 6-56 Stabile Building

    55905 Rochester

    United States

  • 1311 Citations
  • 15 h-Index
20042018
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Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

von Willebrand Factor Medicine & Life Sciences
Thermodynamics Medicine & Life Sciences
Blood Platelets Medicine & Life Sciences
Protein Folding Medicine & Life Sciences
Protein Stability Medicine & Life Sciences
Protein Unfolding Medicine & Life Sciences
Proteins Chemical Compounds
Platelets Chemical Compounds

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Projects 2011 2016

von Willebrand Factor
Thermodynamics
Blood Platelets
von Willebrand Diseases
Mutation

Research Output 2004 2018

  • 1311 Citations
  • 15 h-Index
  • 33 Article
  • 1 Chapter
  • 1 Comment/debate

“Cooperative collapse” of the denatured state revealed through Clausius-Clapeyron analysis of protein denaturation phase diagrams

Tischer, A., Machha, V. R., Rösgen, J. & Auton, M. T., Aug 1 2018, In : Biopolymers. 109, 8, e23106.

Research output: Contribution to journalArticle

Protein Denaturation
Denaturation
Urea
Phase diagrams
Proteins

A novel Kleefstra syndrome-associated variant that affects the conserved TPLX motif within the ankyrin repeat of EHMT1 leads to abnormal protein folding

Blackburn, P. R., Tischer, A., Zimmermann, M. T., Kemppainen, J. L., Sastry, S., Knight Johnson, A. E., Cousin, M. A., Boczek, N. J., Oliver, G., Misra, V. K., Gavrilova, R. M., Lomberk, G., Auton, M. T., Urrutia, R. & Klee, E. W., Mar 3 2017, In : Journal of Biological Chemistry. 292, 9, p. 3866-3876 11 p.

Research output: Contribution to journalArticle

Ankyrin Repeat
Protein folding
Protein Folding
Histone Code
Intellectual Disability

Enhanced Local Disorder in a Clinically Elusive von Willebrand Factor Provokes High-Affinity Platelet Clumping

Tischer, A., Machha, V. R., Frontroth, J. P., Brehm, M. A., Obser, T., Schneppenheim, R., Mayne, L., Walter Englander, S. & Auton, M. T., Jul 7 2017, In : Journal of Molecular Biology. 429, 14, p. 2161-2177 17 p.

Research output: Contribution to journalArticle

von Willebrand Factor
Blood Platelets
Disulfides
Thrombocytopenia
von Willebrand Diseases
1 Citations

The Von Willebrand Factor A1–Collagen III Interaction Is Independent of Conformation and Type 2 Von Willebrand Disease Phenotype

Machha, V. R., Tischer, A., Moon-Tasson, L. & Auton, M. T., Jan 6 2017, In : Journal of Molecular Biology. 429, 1, p. 32-47 16 p.

Research output: Contribution to journalArticle

Type 2 von Willebrand Disease
von Willebrand Factor
Collagen
Phenotype
Blood Platelets
2 Citations

Chaperonin-Based Biolayer Interferometry to Assess the Kinetic Stability of Metastable, Aggregation-Prone Proteins

Lea, W. A., O'Neil, P. T., Machen, A. J., Naik, S., Chaudhri, T., McGinn-Straub, W., Tischer, A., Auton, M. T., Burns, J. R., Baldwin, M. R., Khar, K. R., Karanicolas, J. & Fisher, M. T., Sep 6 2016, In : Biochemistry. 55, 35, p. 4885-4908 24 p.

Research output: Contribution to journalArticle

Interferometry
Chaperonins
Agglomeration
Kinetics
Immobilized Proteins