Matthew Philip Goetz, MD

  • 7918 Citations
  • 41 Scopus h-Index
20022021
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Research Output 2002 2019

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4 Citations (Scopus)

A combinatorial biomarker predicts pathologic complete response to neoadjuvant lapatinib and trastuzumab without chemotherapy in patients with HER2+ breast cancer

Veeraraghavan, J., De Angelis, C., Mao, R., Wang, T., Herrera, S., Pavlick, A. C., Contreras, A., Nuciforo, P., Mayer, I. A., Forero, A., Nanda, R., Goetz, M. P., Chang, J. C., Wolff, A. C., Krop, I. E., Fuqua, S. A. W., Prat, A., Hilsenbeck, S. G., Weigelt, B., Reis-Filho, J. S. & 4 others, Gutierrez, C., Osborne, C. K., Rimawi, M. F. & Schiff, R., Jun 1 2019, In : Annals of Oncology. 30, 6, p. 927-933 7 p., mdz076.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Biomarkers
Breast Neoplasms
Drug Therapy
Fluorescence In Situ Hybridization
9 Citations (Scopus)

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N. D., Jeraldo, P. R., Walther-Antonio, M., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L. M., Weinshilboum, R. M., Boughey, J. C., Kocher, J-P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PLoS One. 12, 11, e0188873.

Research output: Contribution to journalArticle

Microbiota
Gene expression
breast neoplasms
Tumors
Breast Neoplasms
8 Citations (Scopus)

Activation of PI3K/Akt/mTOR signaling in the tumor stroma drives endocrine therapy-dependent breast tumor regression

Polo, M. L., Riggio, M., May, M., Rodríguez, M. J., Perrone, M. C., Stallings-Mann, M., Kaen, D., Frost, M., Goetz, M. P., Boughey, J. C., Lanari, C., Radisky, D. C. & Novaro, V., 2015, In : Oncotarget. 6, 26, p. 22081-22097 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinases
Breast Neoplasms
Neoadjuvant Therapy
Neoplasms
S 6
283 Citations (Scopus)

Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer

Sparano, J. A., Gray, R. J., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Goetz, M. P., Olson, J. A., Lively, T., Badve, S. S., Saphner, T. J., Wagner, L. I., Whelan, T. J., Ellis, M. J., Paik, S., Wood, W. C., Ravdin, P. M., Keane, M. M. & 10 others, Gomez Moreno, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Brufsky, A. M., Toppmeyer, D. L., Kaklamani, V. G., Berenberg, J. L., Abrams, J. & Sledge, G. W., Jul 12 2018, In : New England Journal of Medicine. 379, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

Adjuvant Chemotherapy
Breast Neoplasms
Gene Expression
Recurrence
Drug Therapy
25 Citations (Scopus)

A first-in-human phase i study of the oral p38 MAPK inhibitor, ralimetinib (LY2228820 Dimesylate), in patients with advanced cancer

Patnaik, A., Haluska, P., Tolcher, A. W., Erlichman, C., Papadopoulos, K. P., Lensing, J. L., Beeram, M., Molina, J. R., Rasco, D. W., Arcos, R. R., Kelly, C. S., Wijayawardana, S. R., Zhang, X., Stancato, L. F., Bell, R., Shi, P., Kulanthaivel, P., Pitou, C., Mulle, L. B., Farrington, D. L. & 2 others, Chan, E. M. & Goetz, M. P., Mar 1 2016, In : Clinical Cancer Research. 22, 5, p. 1095-1102 8 p.

Research output: Contribution to journalArticle

LY2228820
p38 Mitogen-Activated Protein Kinases
Tamoxifen
Neoplasms
Safety
17 Citations (Scopus)

A hot flash on tamoxifen metabolism

Goetz, M. P. & Loprinzi, C. L., Dec 3 2003, In : Journal of the National Cancer Institute. 95, 23, p. 1734-1735 2 p.

Research output: Contribution to journalArticle

Hormonal Antineoplastic Agents
Second-Generation Antidepressive Agents
Cyclohexanols
Hot Flashes
Selective Estrogen Receptor Modulators
39 Citations (Scopus)

A multidisciplinary approach to the management of breast cancer, part 1: Prevention and diagnosis

Pruthi, S., Brandt, K. R., Degnim, A. C., Goetz, M. P., Perez, E. A., Reynolds, C. A., Schomberg, P. J., Dy, G. K. & Ingle, J. N., 2007, In : Mayo Clinic Proceedings. 82, 8, p. 999-1012 14 p.

Research output: Contribution to journalArticle

Breast
Breast Neoplasms
Patient Care
Textbooks
Genetic Testing
24 Citations (Scopus)

A multidisciplinary approach to the management of breast cancer, part 2: Therapeutic considerations

Pruthi, S., Boughey, J. C., Brandt, K. R., Degnim, A. C., Dy, G. K., Goetz, M. P., Perez, E. A., Reynolds, C. A., Schomberg, P. J. & Ingle, J. N., 2007, In : Mayo Clinic Proceedings. 82, 9, p. 1131-1140 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Therapeutics
Pharmacogenetics
Tamoxifen
Standard of Care

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. M. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms
72 Citations (Scopus)

Androgen receptor-positive triple negative breast cancer: A unique breast cancer subtype

McGhan, L. J., McCullough, A. E., Protheroe, C. A., Dueck, A., Lee, J. J., Nunez-Nateras, R., Castle, E. P., Gray, R. J., Wasif, N., Goetz, M. P., Hawse, J. R., Henry, T. J., Barrett, M., Cunliffe, H. E. & Pockaj, B. A., Feb 2014, In : Annals of Surgical Oncology. 21, 2, p. 361-367 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Androgen Receptors
Breast Neoplasms
Lymph Nodes
Carcinoma, Intraductal, Noninfiltrating
22 Citations (Scopus)

A phase II trial of neoadjuvant MK-2206, an AKT inhibitor, with anastrozole in clinical stage II or III PIK3CA-mutant ER-positive and HER2-negative breast cancer

Ma, C. X., Suman, V. J., Goetz, M. P., Northfelt, D. W., Burkard, M. E., Ademuyiwa, F., Naughton, M., Margenthaler, J., Aft, R., Gray, R., Tevaarwerk, A., Wilke, L., Haddad, T. C., Moynihan, T., Loprinzi, C. L., Hieken, T. J., Barnell, E. K., Skidmore, Z. L., Feng, Y. Y., Krysiak, K. & 14 others, Hoog, J., Guo, Z., Nehring, L., Wisinski, K. B., Mardis, E., Hagemann, I. S., Vij, K., Sanati, S., Al-Kateb, H., Griffith, O. L., Griffith, M., Doyle, L., Erlichman, C. & Ellis, M. J., Nov 15 2017, In : Clinical Cancer Research. 23, 22, p. 6823-6832 10 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Estrogens
Phosphorylation
Goserelin
Apoptosis
12 Citations (Scopus)

A phase I study of cilengitide and paclitaxel in patients with advanced solid tumors

Haddad, T. C., Qin, R., Lupu, R., Satele, D., Eadens, M., Goetz, M. P., Erlichman, C. & Molina, J. R., Jun 1 2017, In : Cancer Chemotherapy and Pharmacology. 79, 6, p. 1221-1227 7 p.

Research output: Contribution to journalArticle

Paclitaxel
Tumors
Neoplasms
Clinical Trials, Phase I
Maximum Tolerated Dose
tipifarnib
Farnesyltranstransferase
Epidermal Growth Factor
Protein-Tyrosine Kinases
Maximum Tolerated Dose
45 Citations (Scopus)

A phase i trial of the IGF-1R antibody Cixutumumab in combination with temsirolimus in patients with metastatic breast cancer

Ma, C. X., Suman, V. J., Goetz, M. P., Haluska, P., Moynihan, T., Nanda, R., Olopade, O., Pluard, T., Guo, Z., Chen, H. X., Erlichman, C., Ellis, M. J. & Fleming, G. F., May 2013, In : Breast Cancer Research and Treatment. 139, 1, p. 145-153 9 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Maximum Tolerated Dose
Breast Neoplasms
Antibodies
Insulin-Like Growth Factor Binding Protein 3
14 Citations (Scopus)

A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2

Vachon, C. M., Schaid, D. J., Ingle, J. N., Wickerham, D. L., Kubo, M., Mushiroda, T., Goetz, M. P., Carlson, E. E., Paik, S., Wolmark, N., Nakamura, Y., Wang, L. M., Weinshilboum, R. M. & Couch, F. J., 2015, In : Breast Cancer Research and Treatment. 149, 2, p. 517-523 7 p.

Research output: Contribution to journalArticle

Tamoxifen
Breast Neoplasms
Selective Estrogen Receptor Modulators
Raloxifene Hydrochloride
Single Nucleotide Polymorphism
1 Citation (Scopus)

Aromatase inhibitors and tamoxifen: Where do we go from here? Commentary

Goetz, M. P. & Loprinzi, C. L., Nov 2007, In : Nature Clinical Practice Oncology. 4, 11, p. 626-627 2 p.

Research output: Contribution to journalArticle

Aromatase Inhibitors
Tamoxifen
413 Citations (Scopus)

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen

Schroth, W., Goetz, M. P., Hamann, U., Fasching, P. A., Schmidt, M., Winter, S., Fritz, P., Simon, W., Suman, V. J., Ames, M. M., Safgren, S. L., Kuffel, M. J., Ulmer, H. U., Boländer, J., Strick, R., Beckmann, M. W., Koelbl, H., Weinshilboum, R. M., Ingle, J. N., Eichelbaum, M. & 2 others, Schwab, M. & Brauch, H., 2009, In : JAMA - Journal of the American Medical Association. 302, 13, p. 1429-1436 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Breast Neoplasms
Disease-Free Survival
Confidence Intervals
3 Citations (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
136 Citations (Scopus)

A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen

Goetz, M. P., Suman, V. J., Ingle, J. N., Nibbe, A. M., Visscher, D. W., Reynolds, C. A., Lingle, W. L., Erlander, M., Ma, X. J., Sgroi, D. C., Perez, E. A. & Couch, F. J., Apr 1 2006, In : Clinical Cancer Research. 12, 7 I, p. 2080-2087 8 p.

Research output: Contribution to journalArticle

Interleukin Receptors
Interleukin-17
Homeobox Genes
Tamoxifen
Gene Expression
13 Citations (Scopus)

Aurora-A mitotic kinase induces endocrine resistance through down-regulation of ERα expression in initially ERα+ breast cancer cells

Opyrchal, M., Salisbury, J. L., Zhang, S., McCubrey, J., Hawse, J. R., Goetz, M. P., Lomberk, G. A., Haddad, T. C., Degnim, A. C., Lange, C., Ingle, J. N., Galanis, E. & D'Assoro, A., May 9 2014, In : PLoS One. 9, 5, e96995.

Research output: Contribution to journalArticle

Aurora Kinase A
Estrogen Receptor alpha
breast neoplasms
phosphotransferases (kinases)
Phosphotransferases
17 Citations (Scopus)
Electronic Health Records
Drug Discovery
Breast Neoplasms
Tamoxifen
Aromatase Inhibitors
92 Citations (Scopus)

Breast cancer, version 1.2016 featured updates to the NCCN guidelines

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Hudis, C. A., Isakoff, S. J., Marcom, P. K., Mayer, I. A., McCormick, B., Moran, M., Patel, S. A., Pierce, L. J. & 11 others, Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M., Ward, J. H., Shead, D. A. & Kumar, R., Dec 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 12, p. 1475-1485 11 p.

Research output: Contribution to journalArticle

Guidelines
Breast Neoplasms
Therapeutics
Hormones
12 Citations (Scopus)

Breast cancer, version 3.2018 featured updates to the NCCN guidelines

Goetz, M. P., Gradishar, W. J., Anderson, B. O., Abraham, J., Aft, R., Allison, K. H., Blair, S. L., Burstein, H. J., Dang, C., Elias, A. D., Farrar, W. B., Giordano, S. H., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., Moran, M. S., Mortimer, J., O’Regan, R. M. & 13 others, Patel, S. A., Pierce, L. J., Reed, E. C., Rugo, H. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Telli, M. L., Ward, J. H., Young, J. S., Shead, D. A. & Kumar, R., Feb 1 2019, In : JNCCN Journal of the National Comprehensive Cancer Network. 17, 2, p. 118-126 9 p.

Research output: Contribution to journalArticle

Open Access
Adjuvant Chemotherapy
Hormones
Guidelines
Breast Neoplasms
Therapeutics
106 Citations (Scopus)

Breast cancer version 2.2015: Clinical practice guidelines in oncology

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Hudis, C. A., Isakoff, S. J., Marcom, P. K., Mayer, I. A., McCormick, B., Moran, M., Patel, S. A., Pierce, L. J. & 11 others, Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M., Ward, J. H., Shead, D. A. & Kumar, R., Apr 1 2015, In : JNCCN Journal of the National Comprehensive Cancer Network. 13, 4, p. 448-475 28 p.

Research output: Contribution to journalArticle

Practice Guidelines
Breast Neoplasms
Neoplasms
Biological Therapy
Cause of Death
20 Citations (Scopus)

Breast medical oncologists' use of standard prognostic factors to predict a 21-gene recurrence score

Kamal, A. H., Loprinzi, C. L., Reynolds, C., Dueck, A., Geiger, X. J., Ingle, J. N., Carlson, R. W., Hobday, T. J., Winer, E. P. & Goetz, M. P., 2011, In : Oncologist. 16, 10, p. 1359-1366 8 p.

Research output: Contribution to journalArticle

Breast
Recurrence
Genes
Oncologists
Drug Therapy
10 Citations (Scopus)

Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity

Kurmi, K., Hitosugi, S., Wiese, E. K., Boakye-Agyeman, F., Gonsalves, W., Lou, Z., Karnitz, L. M., Goetz, M. P. & Hitosugi, T. D., Feb 6 2018, In : Cell Reports. 22, 6, p. 1365-1373 9 p.

Research output: Contribution to journalArticle

Carnitine O-Palmitoyltransferase
Lysine
Phosphopyruvate Hydratase
Isotope Labeling
Mutation
41 Citations (Scopus)

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L. M., Boughey, J. C. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature Communications. 8, 13923.

Research output: Contribution to journalArticle

metastasis
Tumors
breast
cancer
Chemical activation
17 Citations (Scopus)

Clinical and genomic risk to guide the use of adjuvant therapy for breast cancer

Sparano, J. A., Gray, R. J., Ravdin, P. M., Makower, D. F., Pritchard, K. I., Albain, K. S., Hayes, D. F., Geyer, C. E., Dees, E. C., Goetz, M. P., Olson, J. A., Lively, T., Badve, S. S., Saphner, T. J., Wagner, L. I., Whelan, T. J., Ellis, M. J., Paik, S., Wood, W. C., Keane, M. M. & 10 others, Gomez Moreno, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Brufsky, A. M., Toppmeyer, D. L., Kaklamani, V. G., Berenberg, J. L., Abrams, J. & Sledge, G. W., Jun 20 2019, In : New England Journal of Medicine. 380, 25, p. 2395-2405 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Recurrence
Therapeutics
Drug Therapy
Confidence Intervals
68 Citations (Scopus)

Clinical implementation of pharmacogenomics: Overcoming genetic exceptionalism

Relling, M. V., Altman, R. B., Goetz, M. P. & Evans, W. E., Jun 2010, In : The Lancet Oncology. 11, 6, p. 507-509 3 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Pharmacogenetics
Methyltransferases
Genetic Testing
Precursor Cell Lymphoblastic Leukemia-Lymphoma
1 Citation (Scopus)

Clinical Outcomes in Early Breast Cancer with a High 21-Gene Recurrence Score of 26 to 100 Assigned to Adjuvant Chemotherapy plus Endocrine Therapy: A Secondary Analysis of the TAILORx Randomized Clinical Trial

Sparano, J. A., Gray, R. J., Makower, D. F., Albain, K. S., Saphner, T. J., Badve, S. S., Wagner, L. I., Kaklamani, V. G., Keane, M. M., Gomez, H. L., Reddy, P. S., Goggins, T. F., Mayer, I. A., Toppmeyer, D. L., Brufsky, A. M., Goetz, M. P., Berenberg, J. L., Mahalcioiu, C., Desbiens, C., Hayes, D. F. & 9 others, Dees, E. C., Geyer, C. E., Olson, J. A., Wood, W. C., Lively, T., Paik, S., Ellis, M. J., Abrams, J. & Sledge, G. W., Jan 1 2019, (Accepted/In press) In : JAMA Oncology.

Research output: Contribution to journalArticle

Open Access
Adjuvant Chemotherapy
Randomized Controlled Trials
Breast Neoplasms
Recurrence
Genes
48 Citations (Scopus)

Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for CYP2D6 and Tamoxifen Therapy

Goetz, M. P., Sangkuhl, K., Guchelaar, H. J., Schwab, M., Province, M., Whirl-Carrillo, M., Symmans, W. F., Mcleod, H. L., Ratain, M. J., Zembutsu, H., Gaedigk, A., van Schaik, R. H., Ingle, J. N., Caudle, K. E. & Klein, T. E., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Pharmacogenetics
Tamoxifen
Guidelines
Genetic Polymorphisms
72 Citations (Scopus)

Clinical practice guidelines in oncology

Gradishar, W. J., Anderson, B. O., Balassanian, R., Blair, S. L., Burstein, H. J., Cyr, A., Elias, A. D., Farrar, W. B., Forero, A., Giordano, S. H., Goetz, M. P., Goldstein, L. J., Isakoff, S. J., Lyons, J., Kelly Marcom, P., Mayer, I. A., McCormick, B., Moran, M. S., O’Regan, R. M., Patel, S. A. & 13 others, Pierce, L. J., Reed, E. C., Salerno, K. E., Schwartzberg, L. S., Sitapati, A., Smith, K. L., Smith, M. L., Soliman, H., Somlo, G., Telli, M. L., Ward, J. H., Kumar, R. & Shead, D. A., Mar 1 2018, In : JNCCN Journal of the National Comprehensive Cancer Network. 16, 3, p. 310-320 11 p.

Research output: Contribution to journalArticle

Carcinoma, Intraductal, Noninfiltrating
Practice Guidelines
Breast
Risk Reduction Behavior
Guidelines
40 Citations (Scopus)

Clinical trial designs for prospective validation of biomarkers

Mandrekar, S. J., Grothey, A. F., Goetz, M. P. & Sargent, D. J., 2005, In : American Journal of PharmacoGenomics. 5, 5, p. 317-325 9 p.

Research output: Contribution to journalArticle

Biomarkers
Clinical Trials
Therapeutics
Patient Selection
Disease-Free Survival
16 Citations (Scopus)

Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy

Park, J. H., Jang, M., Tarhan, Y. E., Katagiri, T., Sasa, M., Miyoshi, Y., Kalari, K. R., Suman, V. J., Weinshilboum, R. M., Wang, L. M., Boughey, J. C., Goetz, M. P. & Nakamura, Y., Aug 1 2016, In : International Journal of Oncology. 49, 2, p. 471-478 8 p.

Research output: Contribution to journalArticle

Breast Neoplasms
T-Lymphocytes
Drug Therapy
T-Cell Antigen Receptor
Neoplasms
42 Citations (Scopus)

Colonic polyposis and neoplasia in Cowden syndrome

Stanich, P. P., Owens, V. L., Sweetser, S., Khambatta, S., Smyrk, T. C., Richardson, R. L., Goetz, M. P. & Patnaik, M. M., 2011, In : Mayo Clinic Proceedings. 86, 6, p. 489-492 4 p.

Research output: Contribution to journalArticle

Multiple Hamartoma Syndrome
Polyps
Colon
Neoplasms
Colectomy
10 Citations (Scopus)

Comparative uterotrophic effects of endoxifen and tamoxifen in ovariectomized sprague-dawley rats

Schweikart, K. M., Eldridge, S. R., Safgren, S. L., Parman, T., Reid, J. M., Ames, M. M., Goetz, M. P. & Davis, M. A., Dec 29 2014, In : Toxicologic Pathology. 42, 8, p. 1188-1196 9 p.

Research output: Contribution to journalArticle

Tamoxifen
Sprague Dawley Rats
Rats
Estradiol
Estrogen Antagonists
1 Citation (Scopus)
Technetium Tc 99m Sestamibi
Molecular Imaging
Breast
Breast Neoplasms
Drug Therapy
98 Citations (Scopus)

Coprescription of tamoxifen and medications that inhibit CYP2D6

Sideras, K., Ingle, J. N., Ames, M. M., Loprinzi, C. L., Mrazek, D. P., Black, J. L., Weinshilboum, R. M., Hawse, J. R., Spelsberg, T. C. & Goetz, M. P., Jun 1 2010, In : Journal of Clinical Oncology. 28, 16, p. 2768-2776 9 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Breast Neoplasms
Recurrence
Enzymes
13 Citations (Scopus)

CYP2D6 and tamoxifen: Awaiting the denouement

Brauch, H. B., Schroth, W., Ingle, J. N. & Goetz, M. P., Dec 1 2011, In : Journal of Clinical Oncology. 29, 34, p. 4589-4590 2 p.

Research output: Contribution to journalArticle

110 Citations (Scopus)

CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations

Province, M. A., Goetz, M. P., Brauch, H., Flockhart, D. A., Hebert, J. M., Whaley, R., Suman, V. J., Schroth, W., Winter, S., Zembutsu, H., Mushiroda, T., Newman, W. G., Lee, M. T. M., Ambrosone, C. B., Beckmann, M. W., Choi, J. Y., Dieudonné, A. S., Fasching, P. A., Ferraldeschi, R., Gong, L. & 89 others, Haschke-Becher, E., Howell, A., Jordan, L. B., Hamann, U., Kiyotani, K., Krippl, P., Lambrechts, D., Latif, A., Langsenlehner, U., Lorizio, W., Neven, P., Nguyen, A. T., Park, B. W., Purdie, C. A., Quinlan, P., Renner, W., Schmidt, M., Schwab, M., Shin, J. G., Stingl, J. C., Wegman, P., Wingren, S., Wu, A. H. B., Ziv, E., Zirpoli, G., Thompson, A. M., Jordan, V. C., Nakamura, Y., Ingle, J. N., Ames, M. M., Weinshilboum, R. M., Eichelbaum, M., Ingle, J. N., Klein, T. E., Hamann, U., Boländer, J., Ulmer, H. U., Fischer-Bosch, M., Brauch, H., Schroth, W., Schwab, M., Winter, S., Eichelbaum, M., Fritz, P., Simon, W., Stingl, J. C., Flockhart, D. A., Nguyen, A. T., Shin, J. G., Choi, J. Y., Goetz, M. P., Ingle, J. N., Suman, V. J., Weinshilboum, R. M., Purdie, C. A., Jordan, L. B., Wegman, P., Zembutsu, H., Mushiroda, T., Kiyotani, K., Ambrosone, C. B., Fasching, P. A., Strick, R., Beckmann, M. W., Neven, P., Dieudonné, A. S., Haschke-Becher, E., Wu, A. H. B., Lorizio, W., Ziv, E., Quinlan, P., Schmidt, M., Koelbl, H., Newman, W. G., Ferraldeschi, R., Howell, A., Latif, A., Lambrechts, D., Park, B. W., Klein, T. E., Whaley, R., Province, M. A., Hebert, J. M., Gong, L., Altman, R. B., Ambrosone, C. A., Thompson, A. M., Wingren, S. & H, E. Z., Feb 2014, In : Clinical Pharmacology and Therapeutics. 95, 2, p. 216-227 12 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Meta-Analysis
Genotype
Population
9 Citations (Scopus)

CYP2D6 genotype and tamoxifen: Considerations for proper nonprospective studies

Goetz, M. P. & Ingle, J. N., 2014, In : Clinical Pharmacology and Therapeutics. 96, 2, p. 141-144 4 p.

Research output: Contribution to journalArticle

Hormonal Antineoplastic Agents
Cytochrome P-450 CYP2D6
Tamoxifen
Genotype
Neoplasms
14 Citations (Scopus)

CYP2D6 genotype and tamoxifen response.

Rae, J. M., Goetz, M. P., Hayes, D. F., Ingle, J. N., Li, L., Storniolo, A. M., Stearns, V. & Flockhart, D. A., 2005, In : Breast cancer research : BCR. 7, 5

Research output: Contribution to journalArticle

Hormonal Antineoplastic Agents
Postmenopause
Cytochrome P-450 CYP2D6
Tamoxifen
Genotype
79 Citations (Scopus)

CYP2D6 metabolism and patient outcome in the Austrian breast and colorectal cancer study group trial (ABCSG) 8

Goetz, M. P., Suman, V. J., Hoskin, T. L., Gnant, M., Filipits, M., Safgren, S. L., Kuffel, M., Jakesz, R., Rudas, M., Greil, R., Dietze, O., Lang, A., Offner, F., Reynolds, C. A., Weinshilboum, R. M., Ames, M. M. & Ingle, J. N., Jan 15 2013, In : Clinical Cancer Research. 19, 2, p. 500-507 8 p.

Research output: Contribution to journalArticle

Cytochrome P-450 CYP2D6
Tamoxifen
Colorectal Neoplasms
Alleles
Breast Neoplasms
21 Citations (Scopus)

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: Combining inherited and tumor gene markers for prediction of tamoxifen resistance

Goetz, M. P., Suman, V. J., Couch, F. J., Ames, M. M., Rae, J. M., Erlander, M. G., Ma, X. J., Sgroi, D. C., Reynolds, C. A., Lingle, W. L., Weinshilboum, R. M., Flockhart, D. A., Desta, Z., Perez, E. A. & Ingle, J. N., Sep 15 2008, In : Clinical Cancer Research. 14, 18, p. 5864-5868 5 p.

Research output: Contribution to journalArticle

Interleukin Receptors
Cytochrome P-450 CYP2D6
Interleukin-17
Homeobox Genes
Tamoxifen

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer

Ingle, J. N., Kalari, K. R., Momozawa, Y., Kubo, M., Furukawa, Y., Shepherd, L. E., Ellis, M. J., Goss, P. E., Barman, P., Carlson, E. E., Sinnwell, J. P., Tang, X., Goetz, M. P., Chen, B. E., Cairns, J., Weinshilboum, R. M. & Wang, L. M., Oct 1 2019, In : Pharmacogenetics and genomics. 29, 8, p. 183-191 9 p.

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Breast Neoplasms
33 Citations (Scopus)

Development, characterization, and applications of a novel estrogen receptor beta monoclonal antibody

Wu, X., Subramaniam, M., Negron, V., Cicek, M., Reynolds, C., Lingle, W. L., Goetz, M. P., Ingle, J. N., Spelsberg, T. C. & Hawse, J. R., Feb 2012, In : Journal of Cellular Biochemistry. 113, 2, p. 711-723 13 p.

Research output: Contribution to journalArticle

Estrogen Receptor beta
Estrogen Receptor alpha
Monoclonal Antibodies
Antibodies
Breast Neoplasms
8 Citations (Scopus)

Developments in combination chemotheraphy for colorectal cancer

Goetz, M. P. & Grothey, A. F., Aug 2004, In : Expert Review of Anticancer Therapy. 4, 4, p. 627-637 11 p.

Research output: Contribution to journalArticle

oxaliplatin
irinotecan
Colorectal Neoplasms
Combination Drug Therapy
Fluorouracil
5 Citations (Scopus)

Discovery of a glucocorticoid receptor (gr) activity signature using selective gr antagonis in er-negative breast cancer

West, D. C., Kocherginsky, M., Tonsing-Carter, E. Y., Dolcen, D. N., Hosfield, D. J., Lastra, R. R., Sinnwell, J. P., Thompson, K. J., Bowie, K. R., Harkless, R. V., Skor, M. N., Pierce, C. F., Styke, S. C., Kim, C. R., De Wet, L., Greene, G. L., Boughey, J. C., Goetz, M. P., Kalari, K. R., Wang, L. M. & 3 others, Fleming, G. F., Gyorffy, B. & Conzen, S. D., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Breast Neoplasms
Estrogen Receptors
Genes
Gene Expression
13 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers
3 Citations (Scopus)

Early discontinuation of tamoxifen: A lesson for oncologists [3]

Goetz, M. P. & Ingle, J., Dec 1 2007, In : Cancer. 110, 11, p. 2595-2596 2 p.

Research output: Contribution to journalArticle

Hormonal Antineoplastic Agents
Treatment Refusal
Polypharmacy
Fluoxetine
Tamoxifen