• 4209 Citations
  • 36 Scopus h-Index
1991 …2019
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Research Output 1991 2019

  • 4209 Citations
  • 36 Scopus h-Index
  • 159 Article
  • 1 Chapter
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Article
2019

An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant

Whitwell, J. L., Stevens, C. A., Duffy, J. R., Clark, H., Machulda, M. M., Strand, E. A., Martin, P. R., Utianski, R., Botha, H., Spychalla, A. J., Senjem, M. L., Schwarz, C., Jack, C. R. J., Ali, F., Hassan, A. & Josephs, K. A., Jan 1 2019, In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Language
Parkinsonian Disorders
Mesencephalon
Language Disorders
Open Access
Apolipoprotein E4
Genotype
hard labor
Independent Living
manual labor
3 Citations (Scopus)
Amyloid
Dementia
Biomarkers
Positron-Emission Tomography
National Institute on Aging (U.S.)

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R., Botha, H., Martin, P. R., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Butts, A., Lowe, V., Jack, C. R. J., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 1 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
speech disorder
Neuroimaging
diagnostic
visualization
1 Citation (Scopus)
Intelligence Tests
Dementia
Alzheimer Disease
Referral and Consultation
Research
1 Citation (Scopus)

Cortical β-amyloid burden, neuropsychiatric symptoms, and cognitive status: the Mayo Clinic Study of Aging

Krell-Roesch, J., Vassilaki, M., Mielke, M. M., Kremers, W. K., Lowe, V., Vemuri, P. D., Machulda, M. M., Christianson, T. J., Syrjanen, J. A., Stokin, G. B., Butler, L. M., Traber, M., Jack, C. R. J., Knopman, D. S., Roberts, R. O., Petersen, R. C. & Geda, Y. E., Dec 1 2019, In : Translational psychiatry. 9, 1, 123.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amyloid
Equipment and Supplies
Anxiety
Cognitive Dysfunction

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M., Murray, M. E., Kantarci, K. M., Jones, D. T., Vemuri, P. D., Graff-Radford, J., Schwarz, C., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R. J., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain
6 Citations (Scopus)
Entorhinal Cortex
Amyloid
Biomarkers
Repression (Psychology)
Verbal Learning
Dementia
Lewy Body Disease
Alzheimer Disease
Frontotemporal Dementia
Phosphatidylcholines
Neuroimaging
Cognition
Alzheimer Disease
Amyloid
1 Citation (Scopus)

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C., Machulda, M. M., Spychalla, A. J., Drubach, D., Knopman, D. S., Petersen, R. C., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Frontal Lobe
Occipital Lobe
Disease Progression
Neuroimaging
Alzheimer Disease
Cognitive Dysfunction
ROC Curve
Cluster Analysis
1 Citation (Scopus)

Predicting Progression to Mild Cognitive Impairment

Petersen, R. C., Lundt, E. S., Therneau, T. M., Weigand, S. D., Knopman, D. S., Mielke, M. M., Roberts, R. O., Lowe, V., Machulda, M. M., Kremers, W. K., Geda, Y. E. & Jack, C. R. J., Jan 1 2019, In : Annals of Neurology. 85, 1, p. 155-160 6 p.

Research output: Contribution to journalArticle

Biomarkers
Amyloid
Cognitive Dysfunction
Alzheimer Disease
Population
1 Citation (Scopus)
National Institute on Aging (U.S.)
Alzheimer Disease
Amyloid
Research
Positron-Emission Tomography

Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome

Tetzloff, K. A., Duffy, J. R., Clark, H., Utianski, R., Strand, E. A., Machulda, M. M., Botha, H., Martin, P. R., Schwarz, C., Senjem, M. L., Reid, R. I., Gunter, J. L., Spychalla, A. J., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V., Josephs, K. A. & Whitwell, J. L., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2466-2482 17 p.

Research output: Contribution to journalArticle

Apraxias
Aphasia
Broca Aphasia
Parkinsonian Disorders
Neuroimaging
2 Citations (Scopus)
Primary Progressive Aphasia
Agnosia
Language
Apraxias
Deafness

Quantity and quality of mental activities and the risk of incident mild cognitive impairment

Krell-Roesch, J., Syrjanen, J. A., Vassilaki, M., Machulda, M. M., Mielke, M. M., Knopman, D. S., Kremers, W. K., Petersen, R. C. & Geda, Y. E., Aug 6 2019, In : Neurology. 93, 6, p. e548-e558

Research output: Contribution to journalArticle

Open Access
Independent Living
Cognitive Dysfunction
Reading
Cohort Studies
Prospective Studies
1 Citation (Scopus)
Open Access
Comorbidity
Biomarkers
Alzheimer Disease
Medical Record Linkage
Logistic Models
2 Citations (Scopus)
Open Access
Tumor Necrosis Factor-alpha
Interleukin-10
Interleukin-6
Cytokines
Independent Living
3 Citations (Scopus)
alpha-Synuclein
Amyloid
Blood Vessels
Pathology
Apolipoprotein E4
1 Citation (Scopus)

The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia

Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H., Machulda, M. M., Schwarz, C., Weigand, S. D., Sintini, I., Senjem, M. L., Taner, N., Botha, H., Utianski, R., Graff-Radford, J., Jones, D. T., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Feb 12 2019, In : Neurology. 92, 7, p. e710-e722

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Amyloid
Alzheimer Disease
Temporal Lobe
1 Citation (Scopus)

The metabolic brain signature of cognitive resilience in the 80+: beyond Alzheimer pathologies

Arenaza-Urquijo, E. M., Przybelski, S. A., Lesnick, T. L., Graff-Radford, J., Machulda, M. M., Knopman, D. S., Schwarz, C., Lowe, V., Mielke, M. M., Petersen, R. C., Jack, C. R. J. & Vemuri, P. D., Apr 1 2019, In : Brain : a journal of neurology. 142, 4, p. 1134-1147 14 p.

Research output: Contribution to journalArticle

Cognition
Alzheimer Disease
Pathology
Brain
Biomarkers

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Whitwell, J. L., Martin, P., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Schwarz, C., Weigand, S. D., Spychalla, A. J., Drubach, D., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jan 1 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Amyloid
Atrophy
Alzheimer Disease
Parietal Lobe
Positron-Emission Tomography
2018
13 Citations (Scopus)

[18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

Whitwell, J. L., Graff-Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C., Spychalla, A. J., Jones, D. T., Drubach, D., Knopman, D. S., Boeve, B. F., Taner, N., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., Feb 1 2018, In : Annals of Neurology. 83, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

Cluster Analysis
Alzheimer Disease
Apolipoprotein E4
Entorhinal Cortex
Neocortex
13 Citations (Scopus)

[18F]AV-1451 tau-PET and primary progressive aphasia

Josephs, K. A., Martin, P. R., Botha, H., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Graff-Radford, J., Weigand, S. D., Senjem, M. L., Utianski, R., Drubach, D., Boeve, B. F., Jones, D. T., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Whitwell, J. L., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Principal Component Analysis
2 Citations (Scopus)
Dementia
Alzheimer Disease
Biomarkers
Amyloid
Neuroimaging
4 Citations (Scopus)
Metformin
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Population
Propensity Score
25 Citations (Scopus)
Gyrus Cinguli
Amyloid
Dementia
Parietal Lobe
Sleep
2 Citations (Scopus)

Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration

Tetzloff, K. A., Duffy, J. R., Strand, E. A., Machulda, M. M., Boland, S. M., Utianski, R., Botha, H., Senjem, M. L., Schwarz, C., Josephs, K. A. & Whitwell, J. L., May 26 2018, (Accepted/In press) In : Neurocase. p. 1-10 10 p.

Research output: Contribution to journalArticle

Apraxias
Autopsy
Motor Cortex
Neuroimaging
Broca Aphasia

Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech

Utianski, R., Duffy, J. R., Clark, H., Strand, E. A., Boland, S. M., Machulda, M. M., Whitwell, J. L. & Josephs, K. A., Nov 21 2018, In : American Journal of Speech-Language Pathology. 27, 4, p. 1303-1318 16 p.

Research output: Contribution to journalArticle

Apraxias
Aphasia
speech disorder
Dysarthria
Phonetics
1 Citation (Scopus)
Lewy Body Disease
Single-Photon Emission-Computed Tomography
Dementia
Corpus Striatum
Putamen
Neuropsychological Tests
Microcomputers
Maze Learning
Equivalence
Battery
3 Citations (Scopus)

Development of a cerebrovascular magnetic resonance imaging biomarker for cognitive aging

Vemuri, P. D., Lesnick, T. G., Przybelski, S. A., Graff-Radford, J., Reid, R. I., Lowe, V., Zuk, S. M., Senjem, M. L., Schwarz, C., Gunter, J. L., Kantarci, K. M., Machulda, M. M., Mielke, M. M., Petersen, R. C., Knopman, D. S. & Jack, C. R. J., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Biomarkers
Magnetic Resonance Imaging
Health
Blood Vessels
Amyloid
1 Citation (Scopus)

Disrupted functional connectivity in primary progressive apraxia of speech

Botha, H., Utianski, R., Whitwell, J. L., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Tosakulwong, N., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Josephs, K. A. & Jones, D. T., Jan 1 2018, In : NeuroImage: Clinical. 18, p. 617-629 13 p.

Research output: Contribution to journalArticle

Apraxias
Motor Cortex
Language
Short-Term Memory
Speech Disorders
Primary Progressive Aphasia
Apraxias
speech disorder
Electroencephalography
Aphasia
7 Citations (Scopus)

FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

Botha, H., Mantyh, W. G., Murray, M. E., Knopman, D. S., Przybelski, S. A., Wiste, H. J., Graff-Radford, J., Josephs, K. A., Schwarz, C., Kremers, W. K., Boeve, B. F., Petersen, R. C., Machulda, M. M., Parisi, J. E., Dickson, D. W., Lowe, V., Jack, C. R. J. & Jones, D. T., Apr 1 2018, In : Brain. 141, 4, p. 1201-1217 17 p.

Research output: Contribution to journalArticle

Sclerosis
Dementia
Autopsy
Amyloid
Fluorodeoxyglucose F18

Functional Activity and Neuropsychiatric Symptoms in Normal Aging and Mild Cognitive Impairment: The Mayo Clinic Study of Aging

Krell-Roesch, J., Cerhan, L. P., Machulda, M. M., Roberts, R. O., Mielke, M. M., Knopman, D. S., Syrjanen, J. A., Christianson, T. J., Petersen, R. C. & Geda, Y. E., Jan 1 2018, (Accepted/In press) In : Alzheimer Disease and Associated Disorders.

Research output: Contribution to journalArticle

Case-Control Studies
Cognitive Dysfunction
11 Citations (Scopus)
Amyloid
Positron-Emission Tomography
Atrophy
Alzheimer Disease
Neuroimaging
6 Citations (Scopus)

Joint associations of β-amyloidosis and cortical thickness with cognition

Knopman, D. S., Lundt, E. S., Therneau, T. M., Vemuri, P. D., Lowe, V., Kantarci, K. M., Gunter, J. L., Senjem, M. L., Mielke, M. M., Machulda, M. M., Roberts, R. O., Boeve, B. F., Jones, D. T., Petersen, R. C. & Jack, C. R. J., May 1 2018, In : Neurobiology of Aging. 65, p. 121-131 11 p.

Research output: Contribution to journalArticle

Amyloidosis
Amyloid
Cognition
Positron-Emission Tomography
Alzheimer Disease
7 Citations (Scopus)

Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia

Tetzloff, K. A., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Schwarz, C., Senjem, M. L., Reid, R. I., Spychalla, A. J., Tosakulwong, N., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2018, In : Brain. 141, 1, p. 302-317 16 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Apraxias
Neuroimaging
Aphasia
Motor Cortex
33 Citations (Scopus)

Longitudinal tau PET in ageing and Alzheimer's disease

Jack, C. R. J., Wiste, H. J., Schwarz, C., Lowe, V., Senjem, M. L., Vemuri, P. D., Weigand, S. D., Therneau, T. M., Knopman, D. S., Gunter, J. L., Jones, D. T., Graff-Radford, J., Kantarci, K. M., Roberts, R. O., Mielke, M. M., Machulda, M. M. & Petersen, R. C., May 1 2018, In : Brain. 141, 5, p. 1517-1528 12 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Sample Size
Brain
Outcome Assessment (Health Care)
2 Citations (Scopus)

Mediterranean Diet, Its Components, and Amyloid Imaging Biomarkers

Vassilaki, M., Aakre, J. A., Syrjanen, J. A., Mielke, M. M., Geda, Y. E., Kremers, W. K., Machulda, M. M., Alhurani, R. E., Staubo, S. C., Knopman, D. S., Petersen, R. C., Lowe, V., Jack, C. R. J. & Roberts, R. O., Jan 1 2018, In : Journal of Alzheimer's Disease. 64, 1, p. 281-290 10 p.

Research output: Contribution to journalArticle

Mediterranean Diet
Amyloid
Biomarkers
Food
Apolipoprotein E4

Molecular neuroimaging in primary progressive aphasia with predominant agraphia

Utianski, R., Duffy, J. R., Savica, R., Whitwell, J. L., Machulda, M. M. & Josephs, K. A., Mar 25 2018, (Accepted/In press) In : Neurocase. p. 1-3 3 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Agraphia
Neuroimaging
Positron-Emission Tomography
Tauopathies

Non-right handed primary progressive apraxia of speech

Botha, H., Duffy, J. R., Whitwell, J. L., Strand, E. A., Machulda, M. M., Spychalla, A. J., Tosakulwong, N., Senjem, M. L., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jul 15 2018, In : Journal of the Neurological Sciences. 390, p. 246-254 9 p.

Research output: Contribution to journalArticle

Apraxias
Functional Laterality
Research
Population
1 Citation (Scopus)

Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia

Owens, T. E., Machulda, M. M., Duffy, J. R., Strand, E. A., Clark, H., Boland, S., Martin, P. R., Lowe, V., Jack, C. R. J., Whitwell, J. L. & Josephs, K. A., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Aphasia
Atrophy
Language
Occipital Lobe
22 Citations (Scopus)

Plasma phospho-tau181 increases with Alzheimer's disease clinical severity and is associated with tau- and amyloid-positron emission tomography

Mielke, M. M., Hagen, C. E., Xu, J., Chai, X., Vemuri, P. D., Lowe, V., Airey, D. C., Knopman, D. S., Roberts, R. O., Machulda, M. M., Jack, C. R. J., Petersen, R. C. & Dage, J. L., Jan 1 2018, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Amyloid
Positron-Emission Tomography
Alzheimer Disease
Brain
Apolipoproteins E
14 Citations (Scopus)

Prevalence and outcomes of amyloid positivity among persons without dementia in a longitudinal, population-based setting

Roberts, R. O., Aakre, J. A., Kremers, W. K., Vassilaki, M., Knopman, D. S., Mielke, M. M., Alhurani, R., Geda, Y. E., Machulda, M. M., Coloma, P., Schauble, B., Lowe, V., Jack, C. R. J. & Petersen, R. C., Aug 1 2018, In : JAMA Neurology. 75, 8, p. 970-979 10 p.

Research output: Contribution to journalArticle

Amyloid
Dementia
Population
Alzheimer Disease
Positron-Emission Tomography
7 Citations (Scopus)

Prosodic and phonetic subtypes of primary progressive apraxia of speech

Utianski, R., Duffy, J. R., Clark, H., Strand, E. A., Botha, H., Schwarz, C., Machulda, M. M., Senjem, M. L., Spychalla, A. J., Jack, C. R. J., Petersen, R. C., Lowe, V., Whitwell, J. L. & Josephs, K. A., Sep 1 2018, In : Brain and Language. 184, p. 54-65 12 p.

Research output: Contribution to journalArticle

Apraxias
Phonetics
phonetics
Motor Cortex
Frontal Lobe

Quantitative assessment of grammar in amyloid-negative logopenic aphasia

Tetzloff, K. A., Whitwell, J. L., Utianski, R., Duffy, J. R., Clark, H., Machulda, M. M., Strand, E. A. & Josephs, K. A., Nov 1 2018, In : Brain and Language. 186, p. 26-31 6 p.

Research output: Contribution to journalArticle

Aphasia
speech disorder
Linguistics
Amyloid
grammar
semantics
anxiety
Primary Progressive Aphasia