Marta Chesi, PhD

  • 8938 Citations
  • 38 Scopus h-Index
19962020
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Research Output 1996 2019

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Article
2019
6 Citations (Scopus)

Bone marrow transplantation generates T cell-dependent control of myeloma in mice

Vuckovic, S., Minnie, S. A., Smith, D., Gartlan, K. H., Watkins, T. S., Markey, K. A., Mukhopadhyay, P., Guillerey, C., Kuns, R. D., Locke, K. R., Pritchard, A. L., Johansson, P. A., Varelias, A., Zhang, P., Huntington, N. D., Waddell, N., Chesi, M., Miles, J. J., Smyth, M. J. & Hill, G. R., Jan 2 2019, In : Journal of Clinical Investigation. 129, 1, CI98888.

Research output: Contribution to journalArticle

Bone Marrow Transplantation
T-Lymphocytes
Autologous Transplantation
Tissue Donors
Multiple Myeloma
1 Citation (Scopus)

Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model

Guillerey, C., Nakamura, K., Pichler, A. C., Barkauskas, D., Krumeich, S., Stannard, K., Miles, K., Harjunpää, H., Yu, Y., Casey, M., Doban, A. I., Lazar, M., Hartel, G., Smith, D., Vuckovic, S., Teng, M. W. L., Bergsagel, P. L., Chesi, M., Hill, G. R., Martinet, L. & 1 others, Smyth, M. J., Jul 25 2019, In : JCI Insight. 4, 14, :e125932.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Immunotherapy
Drug Therapy
T-Lymphocytes
Therapeutics
1 Citation (Scopus)

Dynamic CD138 surface expression regulates switch between myeloma growth and dissemination

Akhmetzyanova, I., McCarron, M. J., Parekh, S., Chesi, M., Bergsagel, P. L. & Fooksman, D. R., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Growth
Syndecan-1
Bone and Bones
Plasma Cells
Cell Movement
1 Citation (Scopus)

Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model

Thirukkumaran, C. M., Shi, Z. Q., Nuovo, G. J., Luider, J., Kopciuk, K. A., Dong, Y., Mostafa, A. A., Thakur, S., Gratton, K., Yang, A., Chin, A. C., Coffey, M. C., Jimenez-Zepeda, V. H., Stewart, D., Chesi, M., Bergsagel, P. L. & Morris, D., Mar 12 2019, In : Blood advances. 3, 5, p. 797-812 16 p.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Immunotherapy
Survival
Neoplasms
Therapeutics
2018
4 Citations (Scopus)

Antigen-mediated regulation in monoclonal gammopathies and myeloma

Nair, S., Sng, J., Boddupalli, C. S., Seckinger, A., Chesi, M., Fulciniti, M., Zhang, L., Rauniyar, N., Lopez, M., Neparidze, N., Parker, T., Munshi, N. C., Sexton, R., Barlogie, B., Orlowski, R., Bergsagel, P. L., Hose, D., Flavell, R. A., Mistry, P. K., Meffre, E. & 1 others, Dhodapkar, M. V., Apr 19 2018, In : JCI insight. 3, 8

Research output: Contribution to journalArticle

Open Access
Paraproteinemias
Antigens
Gaucher Disease
Plasma Cells
Multiple Myeloma
9 Citations (Scopus)

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression

Kawano, Y., Zavidij, O., Park, J., Moschetta, M., Kokubun, K., Mouhieddine, T. H., Manier, S., Mishima, Y., Murakami, N., Bustoros, M., Pistofidis, R. S., Reidy, M., Shen, Y. J., Rahmat, M., Lukyanchykov, P., Karreci, E. S., Tsukamoto, S., Shi, J., Takagi, S., Huynh, D. & 7 others, Sacco, A., Tai, Y. T., Chesi, M., Bergsagel, P. L., Roccaro, A. M., Azzi, J. & Ghobrial, I. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2487-2499 13 p.

Research output: Contribution to journalArticle

Interferon Type I
Immunosuppressive Agents
Multiple Myeloma
Immunosuppression
Regulatory T-Lymphocytes
14 Citations (Scopus)

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

Nakamura, K., Kassem, S., Cleynen, A., Chrétien, M. L., Guillerey, C., Putz, E. M., Bald, T., Förster, I., Vuckovic, S., Hill, G. R., Masters, S. L., Chesi, M., Bergsagel, P. L., Avet-Loiseau, H., Martinet, L. & Smyth, M. J., Jan 1 2018, (Accepted/In press) In : Cancer Cell.

Research output: Contribution to journalArticle

Interleukin-18
Multiple Myeloma
Immunosuppression
Therapeutics
T-Lymphocytes
1 Citation (Scopus)

Importin-β and exportin-5 are strong biomarkers of productive reoviral infection of cancer cells

Nuovo, G., Tran, H., Gutierrez, A., Fadda, P., Pichiorri, F., Caserta, E., Hofmeister, C. C., Chesi, M., Bergsagel, P. L., Morris, D., Shi, Q., Coffey, M. & Thirukkumaran, C., Feb 1 2018, In : Annals of Diagnostic Pathology. 32, p. 28-34 7 p.

Research output: Contribution to journalArticle

Karyopherins
Biomarkers
Capsid Proteins
Infection
Caspase 3
3 Citations (Scopus)

Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma

Robinson, R. M., Reyes, L., Duncan, R. M., Bian, H., Reitz, A. B., Manevich, Y., McClure, J. J., Champion, M. M., Chou, C. J., Sharik, M. E., Chesi, M., Bergsagel, P. L. & Dolloff, N. G., Jan 1 2018, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Multiple Myeloma
Proteasome Inhibitors
Click Chemistry
Small Molecule Libraries
11 Citations (Scopus)

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

Calcinotto, A., Brevi, A., Chesi, M., Ferrarese, R., Garcia Perez, L., Grioni, M., Kumar, S. K., Garbitt, V. M., Sharik, M. E., Henderson, K. J., Tonon, G., Tomura, M., Miwa, Y., Esplugues, E., Flavell, R. A., Huber, S., Canducci, F., Rajkumar, S. V., Bergsagel, P. L. & Bellone, M., Dec 1 2018, In : Nature Communications. 9, 1, 4832.

Research output: Contribution to journalArticle

eosinophils
interleukins
Interleukin-17
Microbiota
Multiple Myeloma
2017
8 Citations (Scopus)

Multiple myeloma cells' capacity to decompose H2O2 determines lenalidomide sensitivity

Sebastian, S., Zhu, Y. X., Braggio, E. D., Shi, C. X., Panchabhai, S. C., Van Wier, S. A., Ahmann, G. J., Chesi, M., Bergsagel, P. L., Stewart, A. K. & Fonseca, R., Feb 23 2017, In : Blood. 129, 8, p. 991-1007 17 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Multiple Myeloma
Cytotoxicity
Thioredoxins
Cells
29 Citations (Scopus)

Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control

Pawlyn, C., Bright, M. D., Buros, A. F., Stein, C. K., Walters, Z., Aronson, L. I., Mirabella, F., Jones, J. R., Kaiser, M. F., Walker, B. A., Jackson, G. H., Clarke, P. A., Bergsagel, P. L., Workman, P., Chesi, M., Morgan, G. J. & Davies, F. E., Jan 1 2017, In : Blood Cancer Journal. 7, 3, e549.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Multiple Myeloma
Epigenomics
Cyclin-Dependent Kinases
Therapeutics
11 Citations (Scopus)

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

López-Iglesias, A. A., Herrero, A. B., Chesi, M., San-Segundo, L., González-Méndez, L., Hernández-García, S., Misiewicz-Krzeminska, I., Quwaider, D., Martín-Sánchez, M., Primo, D., Paíno, T., Bergsagel, P. L., Mehrling, T., González-Díaz, M., San-Miguel, J. F., Mateos, M. V., Gutiérrez, N. C., Garayoa, M. & Ocio, E. M., Jun 20 2017, In : Journal of Hematology and Oncology. 10, 1, 127.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Multiple Myeloma
Cell Line
Pharmaceutical Preparations
23 Citations (Scopus)

The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma

Le Moigne, R., Aftab, B. T., Djakovic, S., Dhimolea, E., Valle, E., Murnane, M., King, E. M., Soriano, F., Menon, M. K., Wu, Z. Y., Wong, S. T., Lee, G. J., Yao, B., Wiita, A. P., Lam, C., Rice, J., Wang, J., Chesi, M., Bergsagel, P. L., Kraus, M. & 11 others, Driessen, C., Von Soly, S. K., Yakes, F. M., Wustrow, D., Shawver, L., Zhou, H. J., Martin, T. G., Wolf, J. L., Mitsiades, C. S., Anderson, D. J. & Rolfe, M., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Homeostasis
Proteins
Proteasome Inhibitors
Proteasome Endopeptidase Complex
2016
13 Citations (Scopus)

Chromogranin a is preferentially cleaved into proangiogenic peptides in the bone marrow of multiple myeloma patients

Bianco, M., Gasparri, A. M., Colombo, B., Curnis, F., Girlanda, S., Ponzoni, M., Bertilaccio, M. T. S., Calcinotto, A., Sacchi, A., Ferrero, E., Ferrarini, M., Chesi, M., Bergsagel, P. L., Bellone, M., Tonon, G., Ciceri, F., Marcatti, M., Caligaris-Cappio, F. & Corti, A., Apr 1 2016, In : Cancer Research. 76, 7, p. 1781-1791 11 p.

Research output: Contribution to journalArticle

Chromogranins
Multiple Myeloma
Bone Marrow
Peptides
Chromogranin A
53 Citations (Scopus)

IAP antagonists induce anti-tumor immunity in multiple myeloma

Chesi, M., Mirza, N. N., Garbitt, V. M., Sharik, M. E., Dueck, A., Asmann, Y., Akhmetzyanova, I., Kosiorek, H. E., Calcinotto, A., Riggs, D. L., Keane, N., Ahmann, G. J., Morrison, K. M., Fonseca, R., Lacy, M., Dingli, D. M., Kumar, S. K., Ailawadhi, S., Dispenzieri, A., Buadi, F. & 7 others, Gertz, M., Reeder, C. B., Lin, Y., Chanan Khan, A. A., Stewart, A. K., Fooksman, D. & Bergsagel, P. L., Dec 1 2016, In : Nature Medicine. 22, 12, p. 1411-1420 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Immunity
Apoptosis
Neoplasms

Induction of iron excess restricts malignant plasma cells expansion and potentiates bortezomib effect in models of multiple myeloma

Bordini, J., Galvan, S., Ponzoni, M., Bertilaccio, M. T. S., Chesi, M., Bergsagel, P. L., Camaschella, C. & Campanella, A., Dec 13 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Plasma Cells
Multiple Myeloma
Iron
Bortezomib
19 Citations (Scopus)

Targeting vasculogenesis to prevent progression in multiple myeloma

Moschetta, M., Mishima, Y., Kawano, Y., Manier, S., Paiva, B., Palomera, L., Aljawai, Y., Calcinotto, A., Unitt, C., Sahin, I., Sacco, A., Glavey, S., Shi, J., Reagan, M. R., Prosper, F., Bellone, M., Chesi, M., Bergsagel, P. L., Vacca, A., Roccaro, A. M. & 1 others, Ghobrial, I. M., May 1 2016, In : Leukemia. 30, 5, p. 1103-1115 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Neoplasms
Hematologic Neoplasms
Endothelial Cells
RNA Sequence Analysis
2015
21 Citations (Scopus)

Advances in the pathogenesis and diagnosis of multiple myeloma

Chesi, M. & Bergsagel, P. L., May 1 2015, In : International Journal of Laboratory Hematology. 37, S1, p. 108-114 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Neoplasms
Immunoglobulin Heavy Chain Genes
Immunoglobulin Heavy Chains
34 Citations (Scopus)

Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

Desantis, A., Bruno, T., Catena, V., De Nicola, F., Goeman, F., Iezzi, S., Sorino, C., Ponzoni, M., Bossi, G., Federico, V., La Rosa, F., Ricciardi, M. R., Lesma, E., De Meo, P. D. O., Castrignanò, T., Petrucci, M. T., Pisani, F., Chesi, M., Bergsagel, P. L., Floridi, A. & 4 others, Tonon, G., Passananti, C., Blandino, G. & Fanciulli, M., May 5 2015, In : EMBO Journal. 34, 9, p. 1214-1230 17 p.

Research output: Contribution to journalArticle

Autophagy
Sirolimus
Cell growth
Multiple Myeloma
RNA-Binding Proteins
6 Citations (Scopus)

Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent (Journal of Clinical Investigation (2015) 125:5 (2077-2089) DOI:10.1172/JCI77181)

Guillerey, C., De Andrade, L. F., Vuckovic, S., Miles, K., Ngiow, S. F., Yong, M. C. R., Teng, M. W. L., Colonna, M., Ritchie, D. S., Chesi, M., Bergsagel, P. L., Hill, G. R., Smyth, M. J. & Martinet, L., Jul 1 2015, In : Journal of Clinical Investigation. 125, 7, p. 2904 1 p.

Research output: Contribution to journalArticle

Immunologic Monitoring
Multiple Myeloma
Therapeutics
4 Citations (Scopus)

Erythroblast apoptosis and microenvironmental iron restriction trigger anemia in the VK*MYC model of multiple myeloma

Bordini, J., Bertilaccio, M. T. S., Ponzoni, M., Fermo, I., Chesi, M., Bergsagel, P. L., Camaschella, C. & Campanella, A., 2015, In : Haematologica. 100, 6, p. 834-841 8 p.

Research output: Contribution to journalArticle

Erythroblasts
Multiple Myeloma
Anemia
Iron
Apoptosis
41 Citations (Scopus)

Immunosurveillance and therapy of multiple myeloma are CD226 dependent

Guillerey, C., De Andrade, L. F., Vuckovic, S., Miles, K., Ngiow, S. F., Yong, M. C. R., Teng, M. W. L., Colonna, M., Ritchie, D. S., Chesi, M., Bergsagel, P. L., Hill, G. R., Smyth, M. J. & Martinet, L., May 1 2015, In : Journal of Clinical Investigation. 125, 5, p. 2077-2089 13 p.

Research output: Contribution to journalArticle

Immunologic Monitoring
Multiple Myeloma
Therapeutics
Programmed Cell Death 1 Receptor
Perforin
12 Citations (Scopus)

Modifications of the mouse bone marrow microenvironment favor angiogenesis and correlate with disease progression from asymptomatic to symptomatic multiple myeloma

Calcinotto, A., Ponzoni, M., Ria, R., Grioni, M., Cattaneo, E., Villa, I., Bertilaccio, M. T. S., Chesi, M., Rubinacci, A., Tonon, G., Bergsagel, P. L., Vacca, A. & Bellone, M., Jan 1 2015, In : OncoImmunology. 4, 6

Research output: Contribution to journalArticle

Multiple Myeloma
Disease Progression
Monoclonal Gammopathy of Undetermined Significance
Bone Marrow
Microvessels
28 Citations (Scopus)

Transcriptional repression by the HDAC4-RelB-p52 complex regulates multiple myeloma survival and growth

Vallabhapurapu, S. D., Noothi, S. K., Pullum, D. A., Lawrie, C. H., Pallapati, R., Potluri, V., Kuntzen, C., Khan, S., Plas, D. R., Orlowski, R. Z., Chesi, M., Kuehl, W. M., Bergsagel, P. L., Karin, M. & Vallabhapurapu, S., Oct 12 2015, In : Nature Communications. 6, 8428.

Research output: Contribution to journalArticle

Multiple Myeloma
Chemical activation
activation
Growth
cells
15 Citations (Scopus)

Tumoricidal effects of macrophage-activating immunotherapy in a murine model of relapsed/refractory multiple myeloma

Jensen, J. L., Rakhmilevich, A., Heninger, E., Broman, A. T., Hope, C., Phan, F., Miyamoto, S., Maroulakou, I., Callander, N., Hematti, P., Chesi, M., Bergsagel, P. L., Sondel, P. & Asimakopoulos, F., Aug 1 2015, In : Cancer immunology research. 3, 8, p. 881-890 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Immunotherapy
Macrophage Activation
Macrophages
Residual Neoplasm
17 Citations (Scopus)

UCHL1 is a biomarker of aggressive multiple myeloma required for disease progression

Hussain, S., Bedekovics, T., Chesi, M., Bergsagel, P. L. & Galardy, P. J., 2015, In : Oncotarget. 6, 38, p. 40704-40718 15 p.

Research output: Contribution to journalArticle

Proteasome Endopeptidase Complex
Ubiquitin
Multiple Myeloma
Disease Progression
Biomarkers
2014
33 Citations (Scopus)

A structurally distinct human mycoplasma protein that generically blocks antigen-antibody union

Grover, R. K., Zhu, X., Nieusma, T., Jones, T., Boero, I., MacLeod, A. S., Mark, A., Niessen, S., Kim, H. J., Kong, L., Assad-Garcia, N., Kwon, K., Chesi, M., Smider, V. V., Salomon, D. R., Jelinek, D. F., Kyle, R. A., Pyles, R. B., Glass, J. I., Ward, A. B. & 2 others, Wilson, I. A. & Lerner, R. A., 2014, In : Science. 343, 6171, p. 656-661 6 p.

Research output: Contribution to journalArticle

Antigens
Antibodies
Proteins
Carrier Proteins
Staphylococcal Protein A
41 Citations (Scopus)

CD28-mediated pro-survival signaling induces chemotherapeutic resistance in multiple myeloma

Murray, M. E., Gavile, C. M., Nair, J. R., Koorella, C., Carlson, L. M., Buac, D., Utley, A., Chesi, M., Bergsagel, P. L., Boise, L. H. & Lee, K. P., Jun 12 2014, In : Blood. 123, 24, p. 3770-3779 10 p.

Research output: Contribution to journalArticle

Chemotherapy
Multiple Myeloma
Costimulatory and Inhibitory T-Cell Receptors
Drug Therapy
Molecules
7 Citations (Scopus)

Combination anti-CD137 and anti-CD40 antibody therapy in murine myc-driven hematological cancers

Westwood, J. A., Matthews, G. M., Shortt, J., Faulkner, D., Pegram, H. J., Duong, C. P. M., Chesi, M., Bergsagel, P. L., Sharp, L. L., Huhn, R. D., Darcy, P. K., Johnstone, R. W. & Kershaw, M. H., 2014, In : Leukemia Research. 38, 8, p. 948-954 7 p.

Research output: Contribution to journalArticle

Anti-Idiotypic Antibodies
Neoplasms
Multiple Myeloma
Therapeutics
Lymphoma

Enter protein m

Grover, R. K., Zhu, X., Nieusma, T., Jones, T., Boero, I., MacLeod, A. S., Mark, A., Niessen, S., Kim, H. J., Kong, L., Assad-Garcia, N., Kwon, K., Chesi, M., Smider, V. V., Salomon, D. R., Jelinek, D. F., Kyle, R. A., Pyles, R. B., Glass, J. I., Ward, A. B. & 2 others, Wilson, I. A. & Lerner, R. A., May 1 2014, In : Assay and Drug Development Technologies. 12, 4, p. 204-206 3 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells

Tanno, T., Lim, Y., Wang, Q., Chesi, M., Bergsagel, P. L., Matthews, G., Johnstone, R. W., Ghosh, N., Borrello, I., Huff, C. A. & Matsui, W., Jan 30 2014, In : Blood. 123, 5, p. 725-733 9 p.

Research output: Contribution to journalArticle

Growth Differentiation Factor 15
Multiple Myeloma
Tumors
Intercellular Signaling Peptides and Proteins
Neoplasms
121 Citations (Scopus)

Promiscuous MYC locus rearrangements hijack enhancers but mostly super-enhancers to dysregulate MYC expression in multiple myeloma

Affer, M., Chesi, M., Chen, W. D., Keats, J. J., Demchenko, Y. N., Tamizhmani, K., Garbitt, V. M., Riggs, D. L., Brents, L. A., Roschke, A. V., Van Wier, S., Fonseca, R., Bergsagel, P. L. & Kuehl, W. M., 2014, In : Leukemia. 28, 8, p. 1725-1735 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Monoclonal Gammopathy of Undetermined Significance
Germinal Center
Immunoglobulin Genes
Neoplasms
18 Citations (Scopus)

The drug vehicle and solvent N-Methylpyrrolidone is an immunomodulator and antimyeloma compound

Shortt, J., Hsu, A. K., Martin, B. P., Doggett, K., Matthews, G. M., Doyle, M. A., Ellul, J., Jockel, T. E., Andrews, D. M., Hogg, S. J., Reitsma, A., Faulkner, D., Bergsagel, P. L., Chesi, M., Heath, J. K., Denny, W. A., Thompson, P. E., Neeson, P. J., Ritchie, D. S., McArthur, G. A. & 1 others, Johnstone, R. W., May 22 2014, In : Cell Reports. 7, 4, p. 1009-1019 11 p.

Research output: Contribution to journalArticle

Immunologic Factors
Pharmaceutical Preparations
Literature
N-methylpyrrolidone
Immunomodulation
26 Citations (Scopus)

The PI3K inhibitor GDC-0941 combines with existing clinical regimens for superior activity in multiple myeloma

Munugalavadla, V., Mariathasan, S., Slaga, D., Du, C., Berry, L., Del Rosario, G., Yan, Y., Boe, M., Sun, L., Friedman, L. S., Chesi, M., Bergsagel, P. L. & Ebens, A., Jan 16 2014, In : Oncogene. 33, 3, p. 316-325 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 3-Kinase
Multiple Myeloma
Class I Phosphatidylinositol 3-Kinases
Cell Cycle Checkpoints
Heterografts
45 Citations (Scopus)

TPL2 kinase regulates the inflammatory milieu of the myeloma niche

Hope, C., Ollar, S. J., Heninger, E., Hebron, E., Jensen, J. L., Kim, J., Maroulakou, I., Miyamoto, S., Leith, C., Yang, D. T., Callander, N., Hematti, P., Chesi, M., Bergsagel, P. L. & Asimakopoulos, F., May 22 2014, In : Blood. 123, 21, p. 3305-3315 11 p.

Research output: Contribution to journalArticle

Macrophages
Versicans
Phosphotransferases
Monocytes
Plasma Cells
2013
66 Citations (Scopus)

Genome-wide studies in multiple myeloma identify XPO1/CRM1 as a critical target validated using the selective nuclear export inhibitor KPT-276

Schmidt, J., Braggio, E. D., Kortuem, K. M., Egan, J. B., Zhu, Y. X., Xin, C. S., Tiedemann, R. E., Palmer, S. E., Garbitt, V. M., McCauley, D., Kauffman, M., Shacham, S., Chesi, M., Bergsagel, P. L. & Stewart, A. K., Dec 2013, In : Leukemia. 27, 12, p. 2357-2365 9 p.

Research output: Contribution to journalArticle

Cell Nucleus Active Transport
Multiple Myeloma
Genome
Cell Cycle
Monoclonal Gammopathy of Undetermined Significance
67 Citations (Scopus)

Molecular pathogenesis of multiple myeloma: Basic and clinical updates

Chesi, M. & Bergsagel, P. L., Mar 2013, In : International Journal of Hematology. 97, 3, p. 313-323 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Chromosomes
Cyclin D
Chromosomes, Human, Pair 5
Immunoglobulin Genes
22 Citations (Scopus)

Preclinical screening of histone deacetylase inhibitors combined with ABT-737, rhTRAIL/MD5-1 or 5-azacytidine using syngeneic Vk*MYC multiple myeloma

Matthews, G. M., Lefebure, M., Doyle, M. A., Shortt, J., Ellul, J., Chesi, M., Banks, K. M., Vidacs, E., Faulkner, D., Atadja, P., Bergsagel, P. L. & Johnstone, R. W., Sep 2013, In : Cell Death and Disease. 4, 9, e798.

Research output: Contribution to journalArticle

Azacitidine
Histone Deacetylase Inhibitors
Multiple Myeloma
Apoptosis
Cell Line
23 Citations (Scopus)

V. Molecular classification and risk stratification of myeloma

Bergsagel, P. L. & Chesi, M., Jun 2013, In : Hematological Oncology. 31, SUPPL 2, p. 38-41 4 p.

Research output: Contribution to journalArticle

Neoplastic Gene Expression Regulation
Proto-Oncogene Proteins c-maf
Histone-Lysine N-Methyltransferase
Receptor, Fibroblast Growth Factor, Type 3
Monoclonal Gammopathy of Undetermined Significance
2012
390 Citations (Scopus)

Clonal competition with alternating dominance in multiple myeloma

Keats, J. J., Chesi, M., Egan, J. B., Garbitt, V. M., Palmer, S. E., Braggio, E. D., Van Wier, S., Blackburn, P. R., Baker, A. S., Dispenzieri, A., Kumar, S. K., Rajkumar, S. V., Carpten, J. D., Barrett, M., Fonseca, R., Stewart, A. K. & Bergsagel, P. L., Aug 2 2012, In : Blood. 120, 5, p. 1067-1076 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Clone Cells
Genes
Neoplasms
102 Citations (Scopus)

Drug response in a genetically engineered mouse model of multiple myeloma is predictive of clinical efficacy

Chesi, M., Matthews, G. M., Garbitt, V. M., Palmer, S. E., Shortt, J., Lefebure, M., Stewart, A. K., Johnstone, R. W. & Bergsagel, P. L., Jul 12 2012, In : Blood. 120, 2, p. 376-385 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Pharmaceutical Preparations
Clinical Trials
Histone Deacetylase Inhibitors
Prodrugs
43 Citations (Scopus)

NKT cell adjuvant-based tumor vaccine for treatment of myc oncogene-driven mouse B-cell lymphoma

Mattarollo, S. R., West, A. C., Steegh, K., Duret, H., Paget, C., Martin, B., Matthews, G. M., Shortt, J., Chesi, M., Bergsagel, P. L., Bots, M., Zuber, J., Lowe, S. W., Johnstone, R. W. & Smyth, M. J., Oct 11 2012, In : Blood. 120, 15, p. 3019-3029 11 p.

Research output: Contribution to journalArticle

Cancer Vaccines
Natural Killer T-Cells
myc Genes
B-Cell Lymphoma
T-cells
2011
1511 Citations (Scopus)

BET bromodomain inhibition as a therapeutic strategy to target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., Chesi, M., Schinzel, A. C., McKeown, M. R., Heffernan, T. P., Vakoc, C. R., Bergsagel, P. L., Ghobrial, I. M., Richardson, P. G., Young, R. A., Hahn, W. C. & 4 others, Anderson, K. C., Kung, A. L., Bradner, J. E. & Mitsiades, C. S., Sep 16 2011, In : Cell. 146, 6, p. 904-917 14 p.

Research output: Contribution to journalArticle

Transcription
Multiple Myeloma
Down-Regulation
Genes
Signal transduction
151 Citations (Scopus)

Clinical and biological implications of MYC activation: A common difference between MGUS and newly diagnosed multiple myeloma

Chng, W. J., Huang, G. F., Chung, T. H., Ng, S. B., Gonzalez-Paz, N., Troska-Price, T., Mulligan, G., Chesi, M., Bergsagel, P. L. & Fonseca, R., Jun 2011, In : Leukemia. 25, 6, p. 1026-1035 10 p.

Research output: Contribution to journalArticle

Monoclonal Gammopathy of Undetermined Significance
Multiple Myeloma
Immunohistochemistry
cdc Genes
Polyploidy
40 Citations (Scopus)
Multiple Myeloma
Polyploidy
Cyclin D
Immunoglobulin Genes
Gene Expression Profiling
273 Citations (Scopus)

MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites

Pei, H., Zhang, L., Luo, K., Qin, Y., Chesi, M., Fei, F., Bergsagel, P. L., Wang, L. M., You, Z. & Lou, Z., Feb 3 2011, In : Nature. 470, 7332, p. 124-129 6 p.

Research output: Contribution to journalArticle

Histones
Methylation
DNA Damage
DNA Breaks
Lysine
40 Citations (Scopus)

Role of Pirh2 in mediating the regulation of p53 and c-Myc

Hakem, A., Bohgaki, M., Lemmers, B., Tai, E., Salmena, L., Matysiak-Zablocki, E., Jung, Y. S., Karaskova, J., Kaustov, L., Duan, S., Madore, J., Boutros, P., Sheng, Y., Chesi, M., Bergsagel, P. L., Perez-Ordonez, B., Mes-Masson, A. M., Penn, L., Squire, J., Chen, X. & 5 others, Jurisica, I., Arrowsmith, C., Sanchez, O., Benchimol, S. & Hakem, R., Nov 2011, In : PLoS Genetics. 7, 11, e1002360.

Research output: Contribution to journalArticle

carcinogenesis
Carcinogenesis
mice
Ubiquitin-Protein Ligases
ovarian neoplasms
2010
10 Citations (Scopus)

Epigenetics and MicroRNAs combine to modulate the MDM2/p53 axis in myeloma

Chesi, M. & Bergsagel, P. L., Oct 19 2010, In : Cancer Cell. 18, 4, p. 299-300 2 p.

Research output: Contribution to journalArticle

Multiple Myeloma
MicroRNAs
Epigenomics
Neoplasms
Growth
2009
24 Citations (Scopus)

High-resolution genomic analysis in Waldenström's macroglobulinemia identifies disease-specific and common abnormalities with marginal zone lymphomas

Braggio, E. D., Keats, J., Leleu, X., Wier, S. V., Jimenez-Zepeda, V. H., Schop, R., Chesi, M., Barrett, M., Stewart, A. K., Dogan, A., Bergsagel, P. L., Ghobrial, I. & Fonseca, R., 2009, In : Clinical Lymphoma and Myeloma. 9, 1, p. 39-42 4 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Lymphoma
Chromosome Aberrations
Comparative Genomic Hybridization
Cytogenetic Analysis