• 13057 Citations
  • 59 Scopus h-Index
1982 …2020

Research output per year

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Research Output

2020

Dynamin 2 interacts with α-actinin 4 to drive tumor cell invasion

Burton, K. M., Cao, H., Chen, J., Qiang, L., Krueger, E. W., Johnson, K. M., Bamlet, W. R., Zhang, L., McNiven, M. A. & Razidlo, G. L., Mar 15 2020, In : Molecular biology of the cell. 31, 6, p. 439-451 13 p.

Research output: Contribution to journalArticle

Maturation of Lipophagic Organelles in Hepatocytes Is Dependent Upon a Rab10/Dynamin-2 Complex

Li, Z., Weller, S. G., Drizyte-Miller, K., Chen, J., Krueger, E. W., Mehall, B., Casey, C. A., Cao, H. & McNiven, M. A., Jan 1 2020, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

The anti-viral dynamin family member MxB participates in mitochondrial integrity

Cao, H., Krueger, E. W., Chen, J., Drizyte-Miller, K., Schulz, M. E. & McNiven, M. A., Dec 1 2020, In : Nature communications. 11, 1, 1048.

Research output: Contribution to journalArticle

Open Access
2019

Ethanol withdrawal mitigates fatty liver by normalizing lipid catabolism

Thomes, P. G., Rasineni, K., Yang, L., Donohue, T. M., Kubik, J. L., McNiven, M. A. & Casey, C. A., Apr 2019, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 316, 4, p. G509-G518

Research output: Contribution to journalArticle

4 Scopus citations

Fasting Inhibits the Recruitment of Kinesin-1 to Lipid Droplets and Stalls Hepatic Triglyceride Secretion

Schulze, R. J. & McNiven, M. A., Jan 2019, In : Hepatology. 69, 1, p. 444-446 3 p.

Research output: Contribution to journalArticle

1 Scopus citations

Lipid Droplet Formation and Lipophagy in Fatty Liver Disease

Schulze, R. J. & McNiven, M. A., Jan 1 2019, In : Seminars in liver disease. 39, 3, p. 283-290 8 p.

Research output: Contribution to journalArticle

Open Access

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

Schott, M. B., Weller, S. G., Schulze, R. J., Krueger, E. W., Drizyte-Miller, K., Casey, C. A. & McNiven, M. A., Oct 7 2019, In : Journal of Cell Biology. 218, 10, p. 3320-3335 16 p.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

Lipophagy and alcohol-induced fatty liver

Yang, L., Yang, C., Thomes, P. G., Kharbanda, K. K., Casey, C. A., McNiven, M. A. & Donohue, T. M., Jan 1 2019, In : Frontiers in Pharmacology. 10, MAY, 495.

Research output: Contribution to journalReview article

Open Access
5 Scopus citations

Pancreatic tumor cell metastasis is restricted by MT1-MMP binding protein MTCBP-1

Qiang, L., Cao, H., Chen, J., Weller, S. G., Krueger, E. W., Zhang, L., Razidlo, G. & Mc Niven, M. A., Jan 7 2019, In : The Journal of cell biology. 218, 1, p. 317-332 16 p.

Research output: Contribution to journalArticle

7 Scopus citations

RINT1 Bi-allelic Variations Cause Infantile-Onset Recurrent Acute Liver Failure and Skeletal Abnormalities

Cousin, M. A., Conboy, E., Wang, J. S., Lenz, D., Schwab, T. L., Williams, M., Abraham, R. S., Barnett, S., El-Youssef, M., Graham, R. P., Gutierrez Sanchez, L. H., Hasadsri, L., Hoffmann, G. F., Hull, N. C., Kopajtich, R., Kovacs-Nagy, R., Li, J. Q., Marx-Berger, D., McLin, V., McNiven, M. A. & 9 others, Mounajjed, T., Prokisch, H., Rymen, D., Schulze, R. J., Staufner, C., Yang, Y., Clark, K. J., Lanpher, B. C. & Klee, E. W., Jul 3 2019, In : American journal of human genetics. 105, 1, p. 108-121 14 p.

Research output: Contribution to journalArticle

3 Scopus citations

Small Interfering RNA Screening for the Small GTPase Rab Proteins Identifies Rab5B as a Major Regulator of Hepatitis B Virus Production

Inoue, J., Ninomiya, M., Umetsu, T., Nakamura, T., Kogure, T., Kakazu, E., Iwata, T., Takai, S., Sano, A., Fukuda, M., Watashi, K., Isogawa, M., Tanaka, Y., Shimosegawa, T., Mc Niven, M. A. & Masamune, A., Aug 1 2019, In : Journal of virology. 93, 15

Research output: Contribution to journalArticle

3 Scopus citations

The cell biology of the hepatocyte: A membrane trafficking machine

Schulze, R. J., Schott, M. B., Casey, C. A., Tuma, P. L. & McNiven, M. A., Jan 1 2019, In : Journal of Cell Biology. 218, 7, p. 2096-2112 17 p.

Research output: Contribution to journalReview article

Open Access
2 Scopus citations
2018

Cellular Membrane Trafficking Machineries Used by the Hepatitis Viruses

Inoue, J., Ninomiya, M., Shimosegawa, T. & Mc Niven, M. A., Aug 1 2018, In : Hepatology. 68, 2, p. 751-762 12 p.

Research output: Contribution to journalReview article

5 Scopus citations

Interleukin-6 promotes pancreatic cancer cell migration by rapidly activating the small GTPase CDC42

Razidlo, G., Burton, K. M. & Mc Niven, M. A., Jan 1 2018, In : Journal of Biological Chemistry. 293, 28, p. 11143-11153 11 p.

Research output: Contribution to journalArticle

11 Scopus citations
2017

Herpes simplex virus type 1 neuronal infection perturbs golgi apparatus integrity through activation of src tyrosine kinase and Dyn-2 GTPase

Martin, C., Leyton, L., Hott, M., Arancibia, Y., Spichiger, C., Mc Niven, M. A., Court, F. A., Concha, M. I., Burgos, P. V. & Otth, C., Aug 22 2017, In : Frontiers in cellular and infection microbiology. 7, AUG, 371.

Research output: Contribution to journalArticle

9 Scopus citations

LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

Zhu, S., Zhang, X., Weichert-Leahey, N., Dong, Z., Zhang, C., Lopez, G., Tao, T., He, S., Wood, A. C., Oldridge, D., Ung, C. Y., van Ree, J. H., Khan, A., Salazar, B. M., Lummertz da Rocha, E., Zimmerman, M. W., Guo, F., Cao, H., Hou, X., Weroha, S. J. & 8 others, Perez-Atayde, A. R., Neuberg, D. S., Meves, A., McNiven, M. A., van Deursen, J. M., Li, H., Maris, J. M. & Look, A. T., Sep 11 2017, In : Cancer cell. 32, 3, p. 310-323.e5

Research output: Contribution to journalArticle

28 Scopus citations

Structure, function and metabolism of hepatic and adipose tissue lipid droplets: Implications in alcoholic liver disease

Natarajan, S. K., Rasineni, K., Ganesan, M., Feng, D., McVicker, B. L., McNiven, M. A., Osna, N. A., Mott, J. L., Casey, C. A. & Kharbanda, K. K., Aug 1 2017, In : Current Molecular Pharmacology. 10, 3, p. 237-248 12 p.

Research output: Contribution to journalReview article

3 Scopus citations

β-adrenergic induction of lipolysis in hepatocytes is inhibited by ethanol exposure

Schott, M. B., Rasineni, K., Weller, S. G., Schulze, R. J., Sletten, A. C., Casey, C. A. & Mc Niven, M. A., Jul 14 2017, In : Journal of Biological Chemistry. 292, 28, p. 11815-11828 14 p.

Research output: Contribution to journalArticle

16 Scopus citations
2016

Alcoholic vs non-alcoholic fatty liver in rats: Distinct differences in endocytosis and vesicle trafficking despite similar pathology

Rasineni, K., Penrice, D. D., Natarajan, S. K., McNiven, M. A., McVicker, B. L., Kharbanda, K. K., Casey, C. A. & Harris, E. N., Feb 29 2016, In : BMC Gastroenterology. 16, 1, 27.

Research output: Contribution to journalArticle

8 Scopus citations

A novel rab10-EHBP1-EHD2 complex essential for the autophagic engulfment of lipid droplets

Li, Z., Schulze, R. J., Weller, S. G., Krueger, E. W., Schott, M. B., Zhang, X., Casey, C. A., Liu, J., Stöckli, J., James, D. E. & Mc Niven, M. A., Dec 1 2016, In : Science advances. 2, 12, 1601470.

Research output: Contribution to journalArticle

42 Scopus citations

Integrated mate-pair and RNA sequencing identifies novel, targetable gene fusions in peripheral T-cell lymphoma

Boddicker, R. L., Razidlo, G. L., Dasari, S., Zeng, Y., Hu, G., Knudson, R. A., Greipp, P. T., Davila, J. I., Johnson, S. H., Porcher, J. C., Smadbeck, J. B., Eckloff, B. W., Billadeau, D. D., Kurtin, P. J., McNiven, M. A., Link, B. K., Ansell, S. M., Cerhan, J. R., Asmann, Y. W., Vasmatzis, G. & 1 others, Feldman, A. L., Sep 1 2016, In : Blood. 128, 9, p. 1234-1245 12 p.

Research output: Contribution to journalArticle

48 Scopus citations

Stromal fibroblasts facilitate cancer cell invasion by a novel invadopodia-independent matrix degradation process

Cao, H., Eppinga, R. D., Razidlo, G. L., Krueger, E. W., Chen, J., Qiang, L. & McNiven, M. A., Mar 3 2016, In : Oncogene. 35, 9, p. 1099-1110 12 p.

Research output: Contribution to journalArticle

13 Scopus citations

The endocytic fate of the transferrin receptor is regulated by c-Abl kinase

Cao, H., Schroeder, B., Chen, J., Schott, M. B. & Mc Niven, M. A., Aug 5 2016, In : Journal of Biological Chemistry. 291, 32, p. 16424-16437 14 p.

Research output: Contribution to journalArticle

9 Scopus citations
2015

HBV secretion is regulated through the activation of endocytic and autophagic compartments mediated by Rab7 stimulation

Inoue, J., Krueger, E. W., Chen, J., Cao, H., Ninomiya, M. & Mc Niven, M. A., 2015, In : Journal of Cell Science. 128, 9, p. 1696-1706 11 p.

Research output: Contribution to journalArticle

23 Scopus citations

Hdac3 Deficiency Increases Marrow Adiposity and Induces Lipid Storage and Glucocorticoid Metabolism in Osteochondroprogenitor Cells

McGee-Lawrence, M. E., Carpio, L. R., Schulze, R. J., Pierce, J. L., Mc Niven, M. A., Farr, J., Khosla, S., Oursler, M. J. & Westendorf, J. J., 2015, (Accepted/In press) In : Journal of Bone and Mineral Research.

Research output: Contribution to journalArticle

30 Scopus citations

Regulation of Cell Migration

Mc Niven, M. A. & Razidlo, G., Jan 1 2015, Functional Cell Biology. Elsevier Inc., Vol. 3. p. 208-215 8 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Targeting pancreatic cancer metastasis by inhibition of Vav1, a Driver of Tumor Cell Invasion

Razidlo, G., Magnine, C., Sletten, A. C., Hurley, R. M., Almada, L. L., Fernandez-Zapico, M. E., Ji, B. D. & Mc Niven, M. A., Jul 15 2015, In : Cancer Research. 75, 14, p. 2907-2915 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

Schroeder, B., Schulze, R. J., Weller, S. G., Sletten, A. C., Casey, C. A. & Mc Niven, M. A., Jun 1 2015, In : Hepatology. 61, 6, p. 1896-1907 12 p.

Research output: Contribution to journalArticle

91 Scopus citations
2014

A well-oiled machine DNM2/dynamin 2 helps keep hepatocyte lipophagy running smoothly

Schulze, R. J. & McNiven, M. A., Feb 2014, In : Autophagy. 10, 2, p. 388-389 2 p.

Research output: Contribution to journalShort survey

7 Scopus citations

Importance of endocytic pathways in liver function and disease

Schroeder, B. & Mc Niven, M. A., Oct 1 2014, In : Comprehensive Physiology. 4, 4, p. 1403-1417 15 p.

Research output: Contribution to journalArticle

10 Scopus citations

Preclinical evaluation of the supercritical extract of azadirachta indica (neem) leaves in vitro and in vivo on inhibition of prostate cancer tumor growth

Wu, Q., Kohli, M., Bergen, H. R., Cheville, J. C., Karnes, R. J., Cao, H., Young, C. Y. F., Tindall, D. J., McNiven, M. A. & Donkena, K. V., May 2014, In : Molecular cancer therapeutics. 13, 5, p. 1067-1077 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Rab GTPases Associate with Isolated Lipid Droplets (LDs) and Show Altered Content After Ethanol Administration: Potential Role in Alcohol-Impaired LD Metabolism

Rasineni, K., Mcvicker, B. L., Tuma, D. J., Mcniven, M. A. & Casey, C. A., Feb 1 2014, In : Alcoholism: Clinical and Experimental Research. 38, 2, p. 327-335 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Vav1 as a central regulator of invadopodia assembly

Razidlo, G. L., Schroeder, B., Chen, J., Billadeau, D. D. & McNiven, M. A., Jan 6 2014, In : Current Biology. 24, 1, p. 86-93 8 p.

Research output: Contribution to journalArticle

34 Scopus citations
2013

Breaking away: Matrix remodeling from the leading edge

McNiven, M. A., Jan 1 2013, In : Trends in Cell Biology. 23, 1, p. 16-21 6 p.

Research output: Contribution to journalReview article

45 Scopus citations

Dynamin 2 Potentiates Invasive Migration of Pancreatic Tumor Cells through Stabilization of the Rac1 GEF Vav1

Razidlo, G. L., Wang, Y., Chen, J., Krueger, E. W., Billadeau, D. D. & McNiven, M. A., Mar 25 2013, In : Developmental Cell. 24, 6, p. 573-585 13 p.

Research output: Contribution to journalArticle

40 Scopus citations

Lipid droplet breakdown requires dynamin 2 for vesiculation of autolysosomal tubules in hepatocytes

Schulze, R. J., Weller, S. G., Schroeder, B., Krueger, E. W., Chi, S., Casey, C. A. & McNiven, M. A., Oct 28 2013, In : Journal of Cell Biology. 203, 2, p. 315-326 12 p.

Research output: Contribution to journalArticle

65 Scopus citations
2012

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies

Schroeder, B., Srivatsan, S., Shaw, A., Billadeau, D. & McNiven, M. A., Sep 15 2012, In : Molecular biology of the cell. 23, 18, p. 3602-3611 10 p.

Research output: Contribution to journalArticle

13 Scopus citations

Dynamin 2 mediates PDGFRα-SHP-2-promoted glioblastoma growth and invasion

Feng, H., Liu, K. W., Guo, P., Zhang, P., Cheng, T., McNiven, M. A., Johnson, G. R., Hu, B. & Cheng, S. Y., May 1 2012, In : Oncogene. 31, 21, p. 2691-2702 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

Increased expression of the large GTPase dynamin 2 potentiates metastatic migration and invasion of pancreatic ductal carcinoma

Eppinga, R. D., Krueger, E. W., Weller, S. G., Zhang, L., Cao, H. & McNiven, M. A., Mar 8 2012, In : Oncogene. 31, 10, p. 1228-1241 14 p.

Research output: Contribution to journalArticle

33 Scopus citations

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK-p130Cas complex

Wang, Y. & McNiven, M. A., Feb 6 2012, In : Journal of Cell Biology. 196, 3, p. 375-385 11 p.

Research output: Contribution to journalArticle

134 Scopus citations
2011

A direct interaction between the large GTPase dynamin-2 and FAK regulates focal adhesion dynamics in response to active Src

Wang, Y., Cao, H., Chen, J. & McNiven, M. A., May 1 2011, In : Molecular biology of the cell. 22, 9, p. 1529-1538 10 p.

Research output: Contribution to journalArticle

42 Scopus citations

Alcohol and lipid traffic don't mix

Mcniven, M. A. & Casey, C. A., Apr 1 2011, In : Hepatology. 53, 4, p. 1073-1075 3 p.

Research output: Contribution to journalComment/debate

4 Scopus citations

Calcineurin selectively docks with the dynamin Ixb splice variant to regulate activity-dependent bulk endocytosis

Xue, J., Graham, M. E., Novelle, A. E., Sue, N., Gray, N., McNiven, M. A., Smillie, K. J., Cousin, M. A. & Robinson, P. J., Sep 2 2011, In : Journal of Biological Chemistry. 286, 35, p. 30295-30303 9 p.

Research output: Contribution to journalArticle

26 Scopus citations

Growth cone morphology and spreading are regulated by a dynamin-cortactin complex at point contacts in hippocampal neurons

Kurklinsky, S., Chen, J. & McNiven, M. A., Apr 1 2011, In : Journal of neurochemistry. 117, 1, p. 48-60 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Hepatocytes internalize trophic receptors at large endocytic "Hot Spots"

Cao, H., Krueger, E. W. & Mcniven, M. A., Nov 1 2011, In : Hepatology. 54, 5, p. 1819-1829 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Recycling of the epidermal growth factor receptor is mediated by a novel form of the clathrin adaptor protein Eps15

Chi, S., Cao, H., Wang, Y. & McNiven, M. A., Oct 7 2011, In : Journal of Biological Chemistry. 286, 40, p. 35196-35208 13 p.

Research output: Contribution to journalArticle

27 Scopus citations
2010

A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding

Schroeder, B., Weller, S. G., Chen, J., Billadeau, D. & McNiven, M. A., Sep 1 2010, In : EMBO Journal. 29, 18, p. 3039-3053 15 p.

Research output: Contribution to journalArticle

38 Scopus citations

FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth

Zhang, J., Zhao, D., Park, H. K., Wang, H., Dyer, R. B., Liu, W., Klee, G. G., McNiven, M. A., Tindall, D. J., Molina, J. R. & Fei, P., May 3 2010, In : Journal of Clinical Investigation. 120, 5, p. 1524-1534 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Nanoconjugation modulates the trafficking and mechanism of antibody induced receptor endocytosis

Bhattacharyya, S., Bhattacharya, R., Curley, S., McNiven, M. A. & Mukherjee, P., Aug 17 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 33, p. 14541-14546 6 p.

Research output: Contribution to journalArticle

103 Scopus citations

Src kinase regulates the integrity and function of the Golgi apparatus via activation of dynamin 2

Weller, S. G., Capitani, M., Cao, H., Micaroni, M., Luini, A., Sallese, M. & McNiven, M. A., Mar 30 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 13, p. 5863-5868 6 p.

Research output: Contribution to journalArticle

66 Scopus citations