• 36415 Citations
  • 92 Scopus h-Index
1989 …2019
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Research Output 1989 2019

  • 36415 Citations
  • 92 Scopus h-Index
  • 344 Article
  • 8 Review article
  • 2 Letter
  • 1 Chapter
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Article
2019
46 Citations (Scopus)

Angiotensin–neprilysin inhibition in heart failure with preserved ejection fraction

Solomon, S. D., McMurray, J. J. V., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., Redfield, M. M., Rouleau, J. L., Van Veldhuisen, D. J., Zannad, F., Zile, M. R., Desai, A. S., Claggett, B., Jhund, P. S., Boytsov, S. A., Comin-Colet, J. & 14 others, Cleland, J., Düngen, H. D., Goncalvesova, E., Katova, T., Kerr Saraiva, J. F., Lelonek, M., Merkely, B., Senni, M., Shah, S. J., Zhou, J., Rizkala, A. R., Gong, J., Shi, V. C. & Lefkowitz, M. P., Oct 24 2019, In : New England Journal of Medicine. 381, 17, p. 1609-1620 12 p.

Research output: Contribution to journalArticle

Valsartan
Heart Failure
Confidence Intervals
Cause of Death
Hospitalization
1 Citation (Scopus)

Characterization of the Obese Phenotype of Heart Failure With Preserved Ejection Fraction: A RELAX Trial Ancillary Study

Reddy, Y. N. V., Lewis, G. D., Shah, S. J., Obokata, M., Abou-Ezzedine, O. F., Fudim, M., Sun, J. L., Chakraborty, H., McNulty, S., LeWinter, M. M., Mann, D. L., Stevenson, L. W., Redfield, M. M. & Borlaug, B. A., Jul 1 2019, In : Mayo Clinic proceedings. 94, 7, p. 1199-1209 11 p.

Research output: Contribution to journalArticle

Open Access
Heart Failure
Phenotype
Exercise
Body Mass Index
Quality of Life
2 Citations (Scopus)

Circulating Neprilysin in Patients With Heart Failure and Preserved Ejection Fraction

Lyle, M. A., Iyer, S. R., Redfield, M. M., Reddy, Y. N. V., Felker, G. M., Cappola, T. P., Hernandez, A. F., Scott, C. G., Burnett, J. C. & Pereira, N. L., Jan 1 2019, (Accepted/In press) In : JACC: Heart Failure.

Research output: Contribution to journalArticle

Neprilysin
Heart Failure
Confidence Intervals
Body Mass Index
Smoking
2 Citations (Scopus)

Health-Related Quality of Life in Heart Failure With Preserved Ejection Fraction: The PARAGON-HF Trial

PARAGON-HF Investigators, Oct 2019, In : JACC: Heart Failure. 7, 10, p. 862-874 13 p.

Research output: Contribution to journalArticle

Heart Failure
Quality of Life
Cardiomyopathies
Valsartan
Random Allocation

History of Atrial Fibrillation and Trajectory of Decongestion in Acute Heart Failure

Patel, R. B., Vaduganathan, M., Rikhi, A., Chakraborty, H., Greene, S. J., Hernandez, A. F., Felker, G. M., Redfield, M. M., Butler, J. & Shah, S. J., Jan 1 2019, In : JACC: Heart Failure. 7, 1, p. 47-55 9 p.

Research output: Contribution to journalArticle

Atrial Flutter
Atrial Fibrillation
Heart Failure
Natriuretic Peptides
Logistic Models
5 Citations (Scopus)

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction

Chaanine, A. H., Joyce, L. D., Stulak, J. M., Maltais, S., Joyce, D. L., Dearani, J. A., Klaus, K., Nair, K. S., Hajjar, R. J. & Redfield, M. M., Feb 1 2019, In : Circulation. Heart failure. 12, 2, p. e005131

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Myocardial Ischemia
Heart Failure
Pressure
Organelle Biogenesis

Myocardial Energetics in Heart Failure With Preserved Ejection Fraction

AbouEzzeddine, O. F., Kemp, B. J., Borlaug, B. A., Mullan, B. P., Behfar, A., Pislaru, S. V., Fudim, M., Redfield, M. M. & Chareonthaitawee, P., Oct 1 2019, In : Circulation. Heart failure. 12, 10, p. e006240

Research output: Contribution to journalArticle

Open Access
Heart Failure
Dobutamine
Left Ventricular Hypertrophy
Blood Group Antigens
Positron-Emission Tomography

Physical Activity, Quality of Life, and Biomarkers in Atrial Fibrillation and Heart Failure With Preserved Ejection Fraction (from the NEAT-HFpEF Trial)

Patel, R. B., Vaduganathan, M., Felker, G. M., Butler, J., Redfield, M. M. & Shah, S. J., May 15 2019, In : American Journal of Cardiology. 123, 10, p. 1660-1666 7 p.

Research output: Contribution to journalArticle

Atrial Flutter
Nitrates
Atrial Fibrillation
Heart Failure
Biomarkers

Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease

Reddy, Y. N. V., Iyer, S. R., Scott, C. G., Rodeheffer, R. J., Bailey, K., Jenkins, G., Batzler, A., Redfield, M. M., Burnett, J. C. & Pereira, N. L., Aug 6 2019, In : Journal of the American Heart Association. 8, 15, p. e012943

Research output: Contribution to journalArticle

Open Access
Neprilysin
Cardiovascular Diseases
Population
Natriuretic Peptides
Heart Failure
2018
4 Citations (Scopus)

Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population

Cannone, V., Buglioni, A., Sangaralingham, S. J., Scott, C., Bailey, K. R., Rodeheffer, R., Redfield, M. M., Sarzani, R. & Burnett, J. C. J., Aug 1 2018, In : Mayo Clinic Proceedings. 93, 8, p. 980-990 11 p.

Research output: Contribution to journalArticle

Aldosterone
Antihypertensive Agents
Hypertension
Population
Atrial Natriuretic Factor
59 Citations (Scopus)

A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction

Reddy, Y. N. V., Carter, R. E., Obokata, M., Redfield, M. M. & Borlaug, B. A., Aug 28 2018, In : Circulation. 138, 9, p. 861-870 10 p.

Research output: Contribution to journalArticle

Heart Failure
Dyspnea
Area Under Curve
Hemodynamics
Exercise
30 Citations (Scopus)

Baseline characteristics of patients with heart failure and preserved ejection fraction in the PARAGON-HF trial

Solomon, S. D., Rizkala, A. R., Lefkowitz, M. P., Shi, V. C., Gong, J., Anavekar, N., Anker, S. D., Arango, J. L., Arenas, J. L., Atar, D., Ben-Gal, T., Boytsov, S. A., Chen, C. H., Chopra, V. K., Cleland, J., Comin-Colet, J., Duengen, H. D., Echeverría Correa, L. E., Filippatos, G., Flammer, A. J. & 44 others, Galinier, M., Godoy, A., Goncalvesova, E., Janssens, S., Katova, T., Køber, L., Lelonek, M., Linssen, G., Lund, L. H., O'Meara, E., Merkely, B., Milicic, D., Oh, B. H., Perrone, S. V., Ranjith, N., Saito, Y., Saraiva, J. F., Shah, S., Seferovic, P. M., Senni, M., Sibulo, A. S., Sim, D., Sweitzer, N. K., Taurio, J., Vinereanu, D., Vrtovec, B., Widimský, J., Yilmaz, M. B., Zhou, J., Zweiker, R., Anand, I. S., Ge, J., Lam, C. S. P., Maggioni, A. P., Martinez, F., Packer, M., Pfeffer, M. A., Pieske, B., Redfield, M. M., Rouleau, J. L., Van Veldhuisen, D. J., Zannad, F., Zile, M. R. & McMurray, J. J. V., Jul 1 2018, In : Circulation: Heart Failure. 11, 7, e004962.

Research output: Contribution to journalArticle

Heart Failure
Angiotensin Receptor Antagonists
Valsartan
Stroke Volume
Mineralocorticoid Receptor Antagonists
2 Citations (Scopus)

Clinical Significance of Early Fluid and Weight Change During Acute Heart Failure Hospitalization

Groarke, J. D., Stevens, S. R., Mentz, R. J., Cooper, L. B., Vader, J. M., Abou Ezzeddine, O., Grodin, J. L., Joyce, E., Anstrom, K. J., Felker, G. M., Redfield, M. M., Stevenson, L. W. & Lala, A., Jan 1 2018, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

Hospitalization
Heart Failure
Weight Loss
Weights and Measures
Therapeutics
5 Citations (Scopus)

Comparing Measures to Assess Health-Related Quality of Life in Heart Failure With Preserved Ejection Fraction

Napier, R., McNulty, S. E., Eton, D. T., Redfield, M. M., Abou Ezzeddine, O. & Dunlay, S. M., Jan 1 2018, (Accepted/In press) In : JACC: Heart Failure.

Research output: Contribution to journalArticle

Heart Failure
Quality of Life
Cardiomyopathies
Surveys and Questionnaires
Reproducibility of Results
22 Citations (Scopus)

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity among Patients with Heart Failure with Preserved Ejection Fraction: The INDIE-HFpEF Randomized Clinical Trial

Borlaug, B. A., Anstrom, K. J., Lewis, G. D., Shah, S. J., Levine, J. A., Koepp, G. A., Givertz, M. M., Felker, G. M., Lewinter, M. M., Mann, D. L., Margulies, K. B., Smith, A. L., Tang, W. H. W., Whellan, D. J., Chen, H. H., Davila-Roman, V. G., McNulty, S., Desvigne-Nickens, P., Hernandez, A. F., Braunwald, E. & 1 others, Redfield, M. M., Nov 6 2018, In : JAMA - Journal of the American Medical Association. 320, 17, p. 1764-1773 10 p.

Research output: Contribution to journalArticle

Nitrites
Randomized Controlled Trials
Heart Failure
Placebos
Exercise
39 Citations (Scopus)

Global pulmonary vascular remodeling in pulmonary hypertension associated with heart failure and preserved or reduced ejection fraction

Fayyaz, A. U., Edwards, W. D., Maleszewski, J., Konik, E. A., DuBrock, H. M., Borlaug, B. A., Frantz, R., Jenkins, S. M. & Redfield, M. M., Jan 1 2018, In : Circulation. 137, 17, p. 1796-1810 15 p.

Research output: Contribution to journalArticle

Pulmonary Hypertension
Heart Failure
Lung
Pulmonary Artery
Blood Pressure
13 Citations (Scopus)

High-sensitivity C-reactive protein in heart failure with preserved ejection fraction

DuBrock, H. M., Abou Ezzeddine, O. & Redfield, M. M., Aug 1 2018, In : PLoS One. 13, 8, e0201836.

Research output: Contribution to journalArticle

C-reactive protein
heart failure
C-Reactive Protein
Heart Failure
Comorbidity
5 Citations (Scopus)

High-sensitivity troponin I in hospitalized and ambulatory patients with heart failure with preserved ejection fraction: Insights from the heart failure clinical research network

Fudim, M., Ambrosy, A. P., Sun, J. L., Anstrom, K. J., Bart, B. A., Butler, J., Abou Ezzeddine, O., Greene, S. J., Mentz, R. J., Redfield, M. M., Reddy, Y. N. V., Vaduganathan, M., Braunwald, E., Hernandez, A. F., Borlaug, B. A. & Felker, G. M., Dec 1 2018, In : Journal of the American Heart Association. 7, 24, e010364.

Research output: Contribution to journalArticle

Troponin I
Heart Failure
Research
Troponin
Type 5 Cyclic Nucleotide Phosphodiesterases
2 Citations (Scopus)

Is mild asymptomatic left ventricular systolic dysfunction always predictive of adverse events in high-risk populations? Insights from the DAVID-Berg study

Gori, M., Redfield, M. M., Calabrese, A., Canova, P., Cioffi, G., De Maria, R., Grosu, A., Fontana, A., Iacovoni, A., Ferrari, P., Parati, G., Gavazzi, A. & Senni, M., Nov 1 2018, In : European Journal of Heart Failure. 20, 11, p. 1540-1548 9 p.

Research output: Contribution to journalArticle

Left Ventricular Dysfunction
Stroke Volume
Heart Failure
Population
Control Groups
10 Citations (Scopus)

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes

Krysiak, J., Unger, A., Beckendorf, L., Hamdani, N., Von Frieling-Salewsky, M., Redfield, M. M., Dos Remedios, C. G., Sheikh, F., Gergs, U., Boknik, P. & Linke, W. A., Dec 1 2018, In : Nature Communications. 9, 1, 262.

Research output: Contribution to journalArticle

Connectin
Sarcomeres
phosphorylation
Phosphorylation
phosphatases
2017
1 Citation (Scopus)

Abundance, localization, and functional correlates of the advanced glycation end-product carboxymethyl lysine in human myocardium

LeWinter, M. M., Taatjes, D., Ashikaga, T., Palmer, B., Bishop, N., VanBuren, P., Bell, S., Donaldson, C., Meyer, M., Margulies, K. B., Redfield, M. M., Bull, D. A. & Zile, M., Nov 1 2017, In : Physiological Reports. 5, 20, e13462.

Research output: Contribution to journalArticle

Advanced Glycosylation End Products
Myocardium
Hypertension
Diabetes Mellitus
Collagen
12 Citations (Scopus)

Accelerometer-Measured Daily Activity in Heart Failure with Preserved Ejection Fraction: Clinical Correlates and Association with Standard Heart Failure Severity Indices

Snipelisky, D., Kelly, J., Levine, J. A., Koepp, G. A., Anstrom, K. J., McNulty, S. E., Zakeri, R., Michael Felker, G., Hernandez, A. F., Braunwald, E. & Redfield, M. M., Jun 1 2017, In : Circulation: Heart Failure. 10, 6, e003878.

Research output: Contribution to journalArticle

Heart Failure
isosorbide-5-mononitrate
Quality of Life
Brain Natriuretic Peptide
Nitrates
46 Citations (Scopus)

Ambulatory Hemodynamic Monitoring Reduces Heart Failure Hospitalizations in “Real-World” Clinical Practice

Desai, A. S., Bhimaraj, A., Bharmi, R., Jermyn, R., Bhatt, K., Shavelle, D., Redfield, M. M., Hull, R., Pelzel, J., Davis, K., Dalal, N., Adamson, P. B. & Heywood, J. T., May 16 2017, In : Journal of the American College of Cardiology. 69, 19, p. 2357-2365 9 p.

Research output: Contribution to journalArticle

Ambulatory Monitoring
Hospitalization
Heart Failure
Hemodynamics
Costs and Cost Analysis
2 Citations (Scopus)

A modifier screen identifies DNAJB6 as a cardiomyopathy susceptibility gene

Ding, Y., Long, P. A., Bos, J. M., Shih, Y. H., Ma, X., Sundsbak, R. S., Chen, J., Jiang, Y., Zhao, L., Hu, X., Wang, J., Shi, Y., Ackerman, M. J., Lin, X., Ekker, S. C., Redfield, M. M., Olson, T. M. & Xu, X. H., Apr 20 2017, In : JCI insight. 2, 8

Research output: Contribution to journalArticle

Open Access
Cardiomyopathies
Genes
8 Citations (Scopus)

Aortic Waveform Analysis to Individualize Treatment in Heart Failure

Wohlfahrt, P., Melenovsky, V., Redfield, M. M., Olson, T. P., Lin, G. D., Abdelmoneim, S. S., Hametner, B., Wassertheurer, S. & Borlaug, B. A., Feb 1 2017, In : Circulation: Heart Failure. 10, 2, e003516.

Research output: Contribution to journalArticle

Heart Failure
Pressure
Arterial Pressure
Therapeutics
Brachial Artery
93 Citations (Scopus)

Effect of oral iron repletion on exercise capacity in patients with heart failure with reduced ejection fraction and iron deficiency the IRONOUT HF randomized clinical trial

Lewis, G. D., Malhotra, R., Hernandez, A. F., McNulty, S. E., Smith, A., Michael Felker, G., Wilson Tang, W. H., LaRue, S. J., Redfield, M. M., Semigran, M. J., Givertz, M. M., Van Buren, P., Whellan, D., Anstrom, K. J., Shah, M. R., Desvigne-Nickens, P., Butler, J. & Braunwald, E., May 16 2017, In : JAMA - Journal of the American Medical Association. 317, 19, p. 1958-1966 9 p.

Research output: Contribution to journalArticle

Iron
Randomized Controlled Trials
Heart Failure
Exercise
Stroke Volume
45 Citations (Scopus)

Efficacy and safety of spironolactone in acute heart failure: The ATHENA-HF randomized clinical trial

National Heart Lung and Blood Institute Heart Failure Clinical Research Network, Sep 1 2017, In : JAMA Cardiology. 2, 9, p. 950-958 9 p.

Research output: Contribution to journalArticle

Spironolactone
Brain Natriuretic Peptide
Randomized Controlled Trials
Heart Failure
Safety
5 Citations (Scopus)

End-of-Life Discussions in Patients With Heart Failure

Young, K. A., Redfield, M. M., Strand, J. J. & Dunlay, S. M., 2017, (Accepted/In press) In : Journal of Cardiac Failure.

Research output: Contribution to journalArticle

Heart Failure
Advance Directives
Hospices
Physicians
Advance Care Planning
11 Citations (Scopus)

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction

Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C. J., Russell, S. J. & Redfield, M. M., Aug 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H392-H407

Research output: Contribution to journalArticle

Ventricular Dysfunction
Heart Failure
Cardiac Myocytes
Oxidative Stress
Fibrosis
36 Citations (Scopus)

Impaired left ventricular global longitudinal strain in patients with heart failure with preserved ejection fraction: Insights from the RELAX trial

Devore, A. D., Mcnulty, S., Alenezi, F., Ersboll, M., Vader, J. M., Oh, J. K., Lin, G. D., Redfield, M. M., Lewis, G., Semigran, M. J., Anstrom, K. J., Hernandez, A. F. & Velazquez, E. J., 2017, (Accepted/In press) In : European Journal of Heart Failure.

Research output: Contribution to journalArticle

Heart Failure
Collagen
Brain Natriuretic Peptide
Stroke Volume
Biomarkers
23 Citations (Scopus)

INDIE-HFpEF (Inorganic Nitrite Delivery to Improve Exercise Capacity in Heart Failure with Preserved Ejection Fraction): Rationale and Design

Reddy, Y. N. V., Lewis, G. D., Shah, S. J., LeWinter, M., Semigran, M., Davila-Roman, V. G., Anstrom, K., Hernandez, A., Braunwald, E., Redfield, M. M. & Borlaug, B. A., May 1 2017, In : Circulation: Heart Failure. 10, 5, e003862.

Research output: Contribution to journalArticle

Nitrites
Heart Failure
Exercise
Nitric Oxide
National Heart, Lung, and Blood Institute (U.S.)
3 Citations (Scopus)

Inpatient Mortality Risk Scores and Postdischarge Events in Hospitalized Heart Failure Patients: A Community-Based Study

Win, S., Hussain, I., Hebl, V. B., Dunlay, S. M. & Redfield, M. M., Jul 1 2017, In : Circulation: Heart Failure. 10, 7, e003926.

Research output: Contribution to journalArticle

Inpatients
Heart Failure
Registries
Mortality
Guidelines
8 Citations (Scopus)

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload-Induced Left Ventricular Remodeling

Chaanine, A. H., Nair, K. S., Bergen, R. H., Klaus, K., Guenzel, A. J., Hajjar, R. J. & Redfield, M. M., Jun 15 2017, In : Journal of the American Heart Association. 6, 6

Research output: Contribution to journalArticle

Ventricular Remodeling
Organelle Biogenesis
Sodium-Calcium Exchanger
Pressure
Autophagy
2 Citations (Scopus)

Pulmonary Pressure Assessment with the Total Artificial Heart

Joyce, D. L., Redfield, M. M., Kushwaha, S. S., Behfar, A., Borlaug, B. A., Daly, R. C., Sandhu, G. S. & Joyce, L. D., Jul 24 2017, (Accepted/In press) In : ASAIO Journal.

Research output: Contribution to journalArticle

Artificial heart
Artificial Heart
Transplants
Pulmonary Artery
Pressure
51 Citations (Scopus)

Risk of Heart Failure with Preserved Ejection Fraction in Older Women After Contemporary Radiotherapy for Breast Cancer

Saiki, H., Petersen, I. A., Scott, C. G., Bailey, K. R., Dunlay, S. M., Finley, R. R., Ruddy, K. J., Yan, E. & Redfield, M. M., Feb 20 2017, (Accepted/In press) In : Circulation.

Research output: Contribution to journalArticle

Radiotherapy
Heart Failure
Breast Neoplasms
Radiation
Tomography
4 Citations (Scopus)

Sildenafil treatment in heart failure with preserved ejection fraction: Targeted metabolomic profiling in the RELAX trial

Wang, H., Anstrom, K., Ilkayeva, O., Muehlbauer, M. J., Bain, J. R., McNulty, S., Newgard, C. B., Kraus, W. E., Hernandez, A., Felker, G. M., Redfield, M. M. & Shah, S. H., Aug 1 2017, In : JAMA Cardiology. 2, 8, p. 896-901 6 p.

Research output: Contribution to journalArticle

Metabolomics
Carnitine
Heart Failure
Type 5 Cyclic Nucleotide Phosphodiesterases
Asparagine
19 Citations (Scopus)

Suppression of tumorigenicity 2 in heart failure with preserved ejection fraction

Abou Ezzeddine, O., McKie, P., Dunlay, S. M., Stevens, S. R., Felker, G. M., Borlaug, B. A., Chen, H. H., Tracy, R. P., Braunwald, E. & Redfield, M. M., 2017, In : Journal of the American Heart Association. 6, 2, e004382.

Research output: Contribution to journalArticle

Heart Failure
Biomarkers
Inflammation
Ventricular Dysfunction
Ventricular Pressure
39 Citations (Scopus)

Temporal relation between myocardial fibrosis and heart failure with preserved ejection fraction: Association with baseline disease severity and subsequent outcome

Schelbert, E. B., Fridman, Y., Wong, T. C., Abu Daya, H., Piehler, K. M., Kadakkal, A., Miller, C. A., Ugander, M., Maanja, M., Kellman, P., Shah, D. J., Abebe, K. Z., Simon, M. A., Quarta, G., Senni, M., Butler, J., Diez, J., Redfield, M. M. & Gheorghiade, M., Sep 1 2017, In : JAMA Cardiology. 2, 9, p. 995-1006 12 p.

Research output: Contribution to journalArticle

Fibrosis
Heart Failure
Brain Natriuretic Peptide
Magnetic Resonance Spectroscopy
Linear Models
2016
13 Citations (Scopus)

Biomarker-based risk prediction in the community

Abou Ezzeddine, O., McKie, P., Scott, C. G., Rodeheffer, R. J., Chen, H. H., Michael Felker, G., Jaffe, A. S., Burnett, J. C. J. & Redfield, M. M., Nov 1 2016, In : European Journal of Heart Failure. 18, 11, p. 1342-1350 9 p.

Research output: Contribution to journalArticle

Biomarkers
Brain Natriuretic Peptide
Heart Failure
Troponin I
Galectin 3
14 Citations (Scopus)

Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure)

Wan, S. H., McKie, P., Schirger, J. A., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. J. & Chen, H. H., Jul 1 2016, In : JACC: Heart Failure. 4, 7, p. 539-547 9 p.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Heart Failure
Peptides
Tachyphylaxis
Therapeutics
16 Citations (Scopus)

Chronic subcutaneous brain natriuretic peptide therapy in asymptomatic systolic heart failure

McKie, P., Schirger, J. A., Benike, S. L., Harstad, L. K., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. J. & Chen, H. H., 2016, (Accepted/In press) In : European Journal of Heart Failure.

Research output: Contribution to journalArticle

Systolic Heart Failure
Brain Natriuretic Peptide
Placebos
Glomerular Filtration Rate
Sodium
15 Citations (Scopus)

Differential response to low-dose dopamine or low-dose nesiritide in acute heart failure with reduced or preserved ejection fraction

Wan, S. H., Stevens, S. R., Borlaug, B. A., Anstrom, K. J., Deswal, A., Felker, G. M., Givertz, M. M., Bart, B. A., Tang, W. H. W., Redfield, M. M. & Chen, H. H., Aug 1 2016, In : Circulation: Heart Failure. 9, 8, e002593.

Research output: Contribution to journalArticle

Brain Natriuretic Peptide
Dopamine
Heart Failure
Placebos
Urine
198 Citations (Scopus)

Effects of liraglutide on clinical stability among patients with advanced heart failure and reduced ejection fraction: A randomized clinical trial

NHLBI Heart Failure Clinical Research Network, Aug 2 2016, In : JAMA - Journal of the American Medical Association. 316, 5, p. 500-508 9 p.

Research output: Contribution to journalArticle

Randomized Controlled Trials
Heart Failure
Placebos
Stroke Volume
Glucagon-Like Peptide 1
6 Citations (Scopus)

Evaluation of a provocative dyspnea severity score in acute heart failure

Abou Ezzeddine, O., Lala, A., Khazanie, P. P., Shah, R., Ho, J. E., Chen, H. H., Pang, P. S., McNulty, S. E., Anstrom, K. J., Hernandez, A. F. & Redfield, M. M., Feb 1 2016, In : American Heart Journal. 172, p. 34-41 8 p.

Research output: Contribution to journalArticle

Dyspnea
Heart Failure
Visual Analog Scale
Exercise
Oxygen
4 Citations (Scopus)

Evaluation of Novel Metrics of Symptom Relief in Acute Heart Failure: The Worst Symptom Score

Abou Ezzeddine, O., Wong, Y. W., Mentz, R. J., Raza, S. S., Nativi-Nicolau, J., Kociol, R. D., McNulty, S. E., Anstrom, K. J., Hernandez, A. F. & Redfield, M. M., Nov 1 2016, In : Journal of Cardiac Failure. 22, 11, p. 853-858 6 p.

Research output: Contribution to journalArticle

Visual Analog Scale
Dyspnea
Heart Failure
Fatigue
Natriuretic Peptides
16 Citations (Scopus)

FOXO3A regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

Chaanine, A. H., Kohlbrenner, E., Gamb, S. I., Guenzel, A. J., Klaus, K., Fayyaz, A. U., Nair, K. S., Hajjar, R. J. & Redfield, M. M., Dec 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 6, p. H1540-H1559

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Phenylephrine
Heart Failure
Cardiac Myocytes
Calcium
8 Citations (Scopus)
Brain Natriuretic Peptide
Heart Failure
Heart-Assist Devices
Registries
Comorbidity
178 Citations (Scopus)

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Pattaro, C., Teumer, A., Gorski, M., Chu, A. Y., Li, M., Mijatovic, V., Garnaas, M., Tin, A., Sorice, R., Li, Y., Taliun, D., Olden, M., Foster, M., Yang, Q., Chen, M. H., Pers, T. H., Johnson, A. D., Ko, Y. A., Fuchsberger, C., Tayo, B. & 678 others, Nalls, M., Feitosa, M. F., Isaacs, A., Dehghan, A., D'Adamo, P., Adeyemo, A., Dieffenbach, A. K., Zonderman, A. B., Nolte, I. M., Van Der Most, P. J., Wright, A. F., Shuldiner, A. R., Morrison, A. C., Hofman, A., Smith, A. V., Dreisbach, A. W., Franke, A., Uitterlinden, A. G., Metspalu, A., Tonjes, A., Lupo, A., Robino, A., Johansson, Å., Demirkan, A., Kollerits, B., Freedman, B. I., Ponte, B., Oostra, B. A., Paulweber, B., Krämer, B. K., Mitchell, B. D., Buckley, B. M., Peralta, C. A., Hayward, C., Helmer, C., Rotimi, C. N., Shaffer, C. M., Müller, C., Sala, C., Van Duijn, C. M., Saint-Pierre, A., Ackermann, D., Shriner, D., Ruggiero, D., Toniolo, D., Lu, Y., Cusi, D., Czamara, D., Ellinghaus, D., Siscovick, D. S., Ruderfer, D., Gieger, C., Grallert, H., Rochtchina, E., Atkinson, E. J., Holliday, E. G., Boerwinkle, E., Salvi, E., Bottinger, E. P., Murgia, F., Rivadeneira, F., Ernst, F., Kronenberg, F., Hu, F. B., Navis, G. J., Curhan, G. C., Ehret, G. B., Homuth, G., Coassin, S., Thun, G. A., Pistis, G., Gambaro, G., Malerba, G., Montgomery, G. W., Eiriksdottir, G., Jacobs, G., Li, G., Wichmann, H. E., Campbell, H., Schmidt, H., Wallaschofski, H., Völzke, H., Brenner, H., Kroemer, H. K., Kramer, H., Lin, H., Leach, I. M., Ford, I., Guessous, I., Rudan, I., Prokopenko, I., Borecki, I., Heid, I. M., Kolcic, I., Persico, I., Jukema, J. W., Wilson, J. F., Felix, J. F., Divers, J., Lambert, J. C., Stafford, J. M., Gaspoz, J. M., Smith, J. A., Faul, J. D., Wang, J. J., Ding, J., Hirschhorn, J. N., Attia, J., Whitfield, J. B., Chalmers, J., Viikari, J., Coresh, J., Denny, J. C., Karjalainen, J., Fernandes, J. K., Endlich, K., Butterbach, K., Keene, K. L., Lohman, K., Portas, L., Launer, L. J., Lyytikäinen, L. P., Yengo, L., Franke, L., Ferrucci, L., Rose, L. M., Kedenko, L., Rao, M., Struchalin, M., Kleber, M. E., Cavalieri, M., Haun, M., Cornelis, M. C., Ciullo, M., Pirastu, M., De Andrade, M., McEvoy, M. A., Woodward, M., Adam, M., Cocca, M., Nauck, M., Imboden, M., Waldenberger, M., Pruijm, M., Metzger, M., Stumvoll, M., Evans, M. K., Sale, M. M., Kähönen, M., Boban, M., Bochud, M., Rheinberger, M., Verweij, N., Bouatia-Naji, N., Martin, N. G., Hastie, N., Probst-Hensch, N., Soranzo, N., Devuyst, O., Raitakari, O., Gottesman, O., Franco, O. H., Polasek, O., Gasparini, P., Munroe, P. B., Ridker, P. M., Mitchell, P., Muntner, P., Meisinger, C., Smit, J. H., Abecasis, G. R., Adair, L. S., Alexander, M., Altshuler, D., Amin, N., Arking, D. E., Arora, P., Aulchenko, Y., Bakker, S. J. L., Bandinelli, S., Barroso, I., Beckmann, J. S., Beilby, J. P., Bergman, R. N., Bergmann, S., Bis, J. C., Boehnke, M., Bonnycastle, L. L., Bornstein, S. R., Bots, M. L., Bragg-Gresham, J. L., Brand, S. M., Brand, E., Braund, P. S., Brown, M. J., Burton, P. R., Casas, J. P., Caulfield, M. J., Chakravarti, A., Chambers, J. C., Chandak, G. R., Chang, Y. P. C., Charchar, F. J., Chaturvedi, N., Cho, Y. S., Clarke, R., Collins, F. S., Collins, R., Connell, J. M., Cooper, J. A., Cooper, M. N., Cooper, R. S., Corsi, A. M., Dörr, M., Dahgam, S., Danesh, J., Smith, G. D., Day, I. N. M., Deloukas, P., Denniff, M., Dominiczak, A. F., Dong, Y., Doumatey, A., Elliott, P., Elosua, R., Erdmann, J., Eyheramendy, S., Farrall, M., Fava, C., Forrester, T., Fowkes, F. G. R., Fox, E. R., Frayling, T. M., Galan, P., Ganesh, S. K., Garcia, M., Gaunt, T. R., Glazer, N. L., Go, M. J., Goel, A., Grässler, J., Grobbee, D. E., Groop, L., Guarrera, S., Guo, X., Hadley, D., Hamsten, A., Han, B. G., Hardy, R., Hartikainen, A. L., Heath, S., Heckbert, S. R., Hedblad, B., Hercberg, S., Hernandez, D., Hicks, A. A., Hilton, G., Hingorani, A. D., Hoffman Bolton, J. A., Hopewell, J. C., Howard, P., Humphries, S. E., Hunt, S. C., Hveem, K., Ikram, M. A., Islam, M., Iwai, N., Jarvelin, M. R., Jackson, A. U., Jafar, T. H., Janipalli, C. S., Johnson, T., Kathiresan, S., Khaw, K. T., Kim, H. L., Kinra, S., Kita, Y., Kivimaki, M., Kooner, J. S., Kumar, M. J. K., Kuh, D., Kulkarni, S. R., Kumari, M., Kuusisto, J., Kuznetsova, T., Laakso, M., Laan, M., Laitinen, J., Lakatta, E. G., Langefeld, C. D., Larson, M. G., Lathrop, M., Lawlor, D. A., Lawrence, R. W., Lee, J. Y., Lee, N. R., Levy, D., Li, Y., Longstreth, W. T., Luan, J., Lucas, G., Ludwig, B., Mangino, M., Mani, K. R., Marmot, M. G., Mattace-Raso, F. U. S., Matullo, G., McArdle, W. L., McKenzie, C. A., Meitinger, T., Melander, O., Meneton, P., Meschia, J. F., Miki, T., Milaneschi, Y., Mohlke, K. L., Mooser, V., Morken, M. A., Morris, R. W., Mosley, T. H., Najjar, S., Narisu, N., Newton-Cheh, C., Nguyen, K. D. H., Nilsson, P., Nyberg, F., O'Donnell, C. J., Ogihara, T., Ohkubo, T., Okamura, T., Ong, R. T. H., Ongen, H., Onland-Moret, N. C., O'Reilly, P. F., Org, E., Orru, M., Palmas, W., Palmen, J., Palmer, L. J., Palmer, N. D., Parker, A. N., Peden, J. F., Peltonen, L., Perola, M., Pihur, V., Platou, C. G. P., Plump, A., Prabhakaran, D., Psaty, B. M., Raffel, L. J., Rao, D. C., Rasheed, A., Ricceri, F., Rice, K. M., Rosengren, A., Rotter, J. I., Rudock, M. E., Sõber, S., Salako, T., Saleheen, D., Salomaa, V., Samani, N. J., Schwartz, S. M., Schwarz, P. E. H., Scott, L. J., Scott, J., Scuteri, A., Sehmi, J. S., Seielstad, M., Seshadri, S., Sharma, P., Shaw-Hawkins, S., Shi, G., Shrine, N. R. G., Sijbrands, E. J. G., Sim, X., Singleton, A., Sjögren, M., Smith, N. L., Artigas, M. S., Spector, T. D., Staessen, J. A., Stancakova, A., Steinle, N. I., Strachan, D. P., Stringham, H. M., Sun, Y. V., Swift, A. J., Tabara, Y., Tai, E. S., Talmud, P. J., Taylor, A., Terzic, J., Thelle, D. S., Tobin, M. D., Tomaszewski, M., Tripathy, V., Tuomilehto, J., Tzoulaki, I., Uda, M., Ueshima, H., Uiterwaal, C. S. P. M., Umemura, S., Van Der Harst, P., Van Der Schouw, Y. T., Van Gilst, W. H., Vartiainen, E., Vasan, R. S., Veldre, G., Verwoert, G. C., Viigimaa, M., Vinay, D. G., Vineis, P., Voight, B. F., Vollenweider, P., Wagenknecht, L. E., Wain, L. V., Wang, X., Wang, T. J., Wareham, N. J., Watkins, H., Weder, A. B., Whincup, P. H., Wiggins, K. L., Witteman, J. C. M., Wong, A., Wu, Y., Yajnik, C. S., Yao, J., Young, J. H., Zelenika, D., Zhai, G., Zhang, W., Zhang, F., Zhao, J. H., Zhu, H., Zhu, X., Zitting, P., Zukowska-Szczechowska, E., Okada, Y., Wu, J. Y., Gu, D., Takeuchi, F., Takahashi, A., Maeda, S., Tsunoda, T., Chen, P., Lim, S. C., Wong, T. Y., Liu, J., Young, T. L., Aung, T., Teo, Y. Y., Kim, Y. J., Kang, D., Chen, C. H., Tsai, F. J., Chang, L. C., Fann, S. J. C., Mei, H., Hixson, J. E., Chen, S., Katsuya, T., Isono, M., Albrecht, E., Yamamoto, K., Kubo, M., Nakamura, Y., Kamatani, N., Kato, N., He, J., Chen, Y. T., Tanaka, T., Reilly, M. P., Schunkert, H., Assimes, T. L., Hall, A., Hengstenberg, C., König, I. R., Laaksonen, R., McPherson, R., Thompson, J. R., Thorsteinsdottir, U., Ziegler, A., Absher, D., Chen, L., Cupples, L. A., Halperin, E., Li, M., Musunuru, K., Preuss, M., Schillert, A., Thorleifsson, G., Wells, G. A., Holm, H., Roberts, R., Stewart, A. F. R., Fortmann, S., Go, A., Hlatky, M., Iribarren, C., Knowles, J., Myers, R., Quertermous, T., Sidney, S., Risch, N., Tang, H., Blankenberg, S., Schnabel, R., Sinning, C., Lackner, K. J., Tiret, L., Nicaud, V., Cambien, F., Bickel, C., Rupprecht, H. J., Perret, C., Proust, C., Münzel, T. F., Barbalic, M., Chen, I. Y. D., Demissie-Banjaw, S., Folsom, A., Lumley, T., Marciante, K., Taylor, K. D., Volcik, K., Gretarsdottir, S., Gulcher, J. R., Kong, A., Stefansson, K., Thorgeirsson, G., Andersen, K., Fischer, M., Grosshennig, A., Linsel-Nitschke, P., Stark, K., Schreiber, S., Aherrahrou, Z., Bruse, P., Doering, A., Klopp, N., Diemert, P., Loley, C., Medack, A., Nahrstedt, J., Peters, A., Wagner, A. K., Willenborg, C., Böhm, B. O., Dobnig, H., Grammer, T. B., Hoffmann, M. M., Meinitzer, A., Winkelmann, B. R., Pilz, S., Renner, W., Scharnagl, H., Stojakovic, T., Tomaschitz, A., Winkler, K., Guiducci, C., Burtt, N., Gabriel, S. B., Dandona, S., Jarinova, O., Qu, L., Wilensky, R., Matthai, W., Hakonarson, H. H., Devaney, J., Burnett, M. S., Pichard, A. D., Kent, K. M., Satler, L., Lindsay, J. M., Waksman, R., Knouff, C. W., Waterworth, D. M., Walker, M. C., Epstein, S. E., Rader, D. J., Nelson, C. P., Wright, B. J., Balmforth, A. J., Ball, S. G., Loehr, L. R., Rosamond, W. D., Benjamin, E., Haritunians, T., Couper, D., Murabito, J., Wang, Y. A., Stricker, B. H., Chang, P. P., Willerson, J. T., Felix, S. B., Watzinger, N., Aragam, J., Zweiker, R., Lind, L., Rodeheffer, R. J., Greiser, K. H., Deckers, J. W., Stritzke, J., Ingelsson, E., Kullo, I. J., Haerting, J., Reffelmann, T., Redfield, M. M., Werdan, K., Mitchell, G. F., Arnett, D. K., Gottdiener, J. S., Blettner, M., Friedrich, N., Kovacs, P., Wild, P. S., Froguel, P., Rettig, R., Mägi, R., Biffar, R., Schmidt, R., Middelberg, R. P. S., Carroll, R. J., Penninx, B. W., Scott, R. J., Katz, R., Sedaghat, S., Wild, S. H., Kardia, S. L. R., Ulivi, S., Hwang, S. J., Enroth, S., Kloiber, S., Trompet, S., Stengel, B., Hancock, S. J., Turner, S. T., Rosas, S. E., Stracke, S., Harris, T. B., Zeller, T., Zemunik, T., Lehtimäki, T., Illig, T., Aspelund, T., Nikopensius, T., Esko, T., Tanaka, T., Gyllensten, U., Völker, U., Emilsson, V., Vitart, V., Aalto, V., Gudnason, V., Chouraki, V., Chen, W. M., Igl, W., März, W., Koenig, W., Lieb, W., Loos, R. J. F., Liu, Y., Snieder, H., Pramstaller, P. P., Parsa, A., O'Connell, J. R., Susztak, K., Hamet, P., Tremblay, J., De Boer, I. H., Böger, C. A., Goessling, W., Chasman, D. I., Köttgen, A., Kao, W. H. L. & Fox, C. S., Jan 21 2016, In : Nature Communications. 7, 10023.

Research output: Contribution to journalArticle

kidneys
loci
Glomerular Filtration Rate
Kidney
cells
50 Citations (Scopus)

High-Output Heart Failure: A 15-Year Experience

Reddy, Y. N. V., Melenovsky, V., Redfield, M. M., Nishimura, R. A. & Borlaug, B. A., Aug 2 2016, In : Journal of the American College of Cardiology. 68, 5, p. 473-482 10 p.

Research output: Contribution to journalArticle

Heart Failure
Hemodynamics
Vascular Resistance
Liver Diseases
Obesity
32 Citations (Scopus)

Impaired right ventricular-pulmonary arterial coupling and effect of sildenafil in heart failure with preserved ejection fraction

Hussain, I., Mohammed, S. F., Forfia, P. R., Lewis, G. D., Borlaug, B. A., Gallup, D. S. & Redfield, M. M., Apr 1 2016, In : Circulation: Heart Failure. 9, 4, e002729.

Research output: Contribution to journalArticle

Heart Failure
Right Ventricular Dysfunction
Lung
Oxygen Consumption
Right Ventricular Function