Long-Jun Wu, PhD

  • 5419 Citations
  • 42 Scopus h-Index
20012019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 2001 2019

  • 5419 Citations
  • 42 Scopus h-Index
  • 94 Article
  • 18 Review article
  • 1 Comment/debate
  • 1 Editorial
2019
5 Citations (Scopus)

Dual Functions of Microglia in Ischemic Stroke

Qin, C., Zhou, L. Q., Ma, X. T., Hu, Z. W., Yang, S., Chen, M., Bosco, D. B., Wu, L. & Tian, D. S., Jan 1 2019, In : Neuroscience Bulletin.

Research output: Contribution to journalReview article

Microglia
Stroke
Neurogenesis
Oligodendroglia
Brain
1 Citation (Scopus)

Efficacy and safety of rituximab for relapsing-remitting multiple sclerosis: A systematic review and meta-analysis

Hu, Y., Nie, H., Yu, H. H., Qin, C., Wu, L., Tang, Z. P. & Tian, D. S., Jan 1 2019, In : Autoimmunity Reviews.

Research output: Contribution to journalReview article

Relapsing-Remitting Multiple Sclerosis
Meta-Analysis
Safety
Confidence Intervals
Recurrence

Fingolimod promotes angiogenesis and attenuates ischemic brain damage via modulating microglial polarization

Shang, K., He, J., Zou, J., Qin, C., Lin, L., Zhou, L. Q., Yang, L. L., Wu, L. J., Wang, W., Zhan, K. B. & Tian, D. S., Jan 1 2019, (Accepted/In press) In : Brain Research. 146509.

Research output: Contribution to journalArticle

Open Access
Stroke
Brain
Neuroprotective Agents
Phenotype
Immunomodulation

Gene Expression Does Not Support the Developmental Hourglass Model in Three Animals with Spiralian Development

Wu, L., Ferger, K. E. & Lambert, J. D., Jul 1 2019, In : Molecular biology and evolution. 36, 7, p. 1373-1383 11 p.

Research output: Contribution to journalArticle

Mollusca
Annelida
molluscs
Polychaeta
gene expression
4 Citations (Scopus)

Microglia: Lifelong patrolling immune cells of the brain

Eyo, U. B. & Wu, L., Jan 1 2019, In : Progress in Neurobiology. 101614.

Research output: Contribution to journalReview article

Microglia
Brain
Mesoderm
Embryonic Development
Health
1 Citation (Scopus)

Microglia Are Indispensable for Synaptic Plasticity in the Spinal Dorsal Horn and Chronic Pain

Zhou, L. J., Peng, J., Xu, Y. N., Zeng, W. J., Zhang, J., Wei, X., Mai, C. L., Lin, Z. J., Liu, Y., Murugan, M., Eyo, U. B., Umpierre, A. D., Xin, W. J., Chen, T., Li, M., Wang, H., Richardson, J. R., Tan, Z., Liu, X. G. & Wu, L., Jun 25 2019, In : Cell reports. 27, 13, p. 3844-3859.e6

Research output: Contribution to journalArticle

Open Access
Neuronal Plasticity
Long-Term Potentiation
Brain-Derived Neurotrophic Factor
Microglia
Chronic Pain

Microglial P2Y12 receptor regulates ventral hippocampal CA1 neuronal excitability and innate fear in mice

Peng, J., Liu, Y., Umpierre, A. D., Xie, M., Tian, D. S., Richardson, J. R. & Wu, L., Aug 19 2019, In : Molecular brain. 12, 1, 71.

Research output: Contribution to journalArticle

Open Access
Fear
Knockout Mice
Instinct
Hippocampus
Neurons
3 Citations (Scopus)

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus

Feng, L., Murugan, M., Bosco, D. B., Liu, Y., Peng, J., Worrell, G. A., Wang, H. L., Ta, L. E., Richardson, J. R., Shen, Y. & Wu, L., Jan 1 2019, In : Glia.

Research output: Contribution to journalArticle

Status Epilepticus
Microglia
Monocytes
Seizures
Colony-Stimulating Factor Receptors
2 Citations (Scopus)

Neuronal network activity controls microglial process surveillance in awake mice via norepinephrine signaling

Liu, Y. U., Ying, Y., Li, Y., Eyo, U. B., Chen, T., Zheng, J., Umpierre, A. D., Zhu, J., Bosco, D. B., Dong, H. & Wu, L. J., Nov 1 2019, In : Nature Neuroscience. 22, 11, p. 1771-1781 11 p.

Research output: Contribution to journalArticle

Norepinephrine
Microglia
Optogenetics
Sensory Deprivation
General Anesthesia

Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion

Qin, C., Zhao, X. L., Ma, X. T., Zhou, L. Q., Wu, L., Shang, K., Wang, W. & Tian, D. S., Jul 1 2019, In : Journal of Translational Medicine. 17, 1, 214.

Research output: Contribution to journalArticle

Open Access
Biomarkers
Proteomics
Stroke
Plasmas
Proteins
2 Citations (Scopus)

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

Liu, Y., Cheng, A., Li, Y. J., Yang, Y., Kishimoto, Y., Zhang, S., Wang, Y., Wan, R., Raefsky, S. M., Lu, D., Saito, T., Saido, T., Zhu, J., Wu, L. & Mattson, M. P., Dec 1 2019, In : Nature communications. 10, 1, 1886.

Research output: Contribution to journalArticle

Open Access
fasting
Neurons
mice
Fasting
Mitochondrial Proteins

The clinical value of complement proteins in differentiating AQP4-IgG-positive from MOG-IgG-positive neuromyelitis optica spectrum disorders

Qin, C., Chen, B., Tao, R., Chen, M., Ma, X., Shang, K., Wu, L., Wang, W., Bu, B. T. & Tian, D. S., Oct 1 2019, In : Multiple Sclerosis and Related Disorders. 35, p. 1-4 4 p.

Research output: Contribution to journalArticle

Myelin-Oligodendrocyte Glycoprotein
Aquaporin 4
Neuromyelitis Optica
Complement System Proteins
Immunoglobulin G
2018
8 Citations (Scopus)

Microglial interactions with the neurovascular system in physiology and pathology

Zhao, X., Eyo, U. B., Murugan, M. & Wu, L., Jun 1 2018, In : Developmental Neurobiology. 78, 6, p. 604-617 14 p.

Research output: Contribution to journalReview article

Microglia
Pathology
Central Nervous System
Brain Diseases
Research
4 Citations (Scopus)

Microglial TLR4-dependent autophagy induces ischemic white matter damage via STAT1/6 pathway

Qin, C., Liu, Q., Hu, Z. W., Zhou, L. Q., Shang, K., Bosco, D. B., Wu, L., Tian, D. S. & Wang, W., Jan 1 2018, In : Theranostics. 8, 19, p. 5434-5451 18 p.

Research output: Contribution to journalArticle

Autophagy
Microglia
Phenotype
Lipopolysaccharides
Anti-Inflammatory Agents
2 Citations (Scopus)

Microglia Receptors in Animal Models of Traumatic Brain Injury

Younger, D., Murugan, M., Rama Rao, K. V., Wu, L. & Chandra, N., Jan 1 2018, (Accepted/In press) In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Microglia
Animal Models
Interleukin Receptors
Purinergic Receptors
Complement Receptors
14 Citations (Scopus)

P2Y12R-Dependent Translocation Mechanisms Gate the Changing Microglial Landscape

Eyo, U. B., Mo, M., Yi, M. H., Murugan, M., Liu, J., Yarlagadda, R., Margolis, D. J., Xu, P. & Wu, L., Jan 1 2018, (Accepted/In press) In : Cell Reports.

Research output: Contribution to journalArticle

Microglia
Sensory Deprivation
Imaging techniques
Carisoprodol
Photons
1 Citation (Scopus)

Pain and the immune system: Emerging concepts of IgG-mediated autoimmune pain and immunotherapies

Xu, M., Bennett, D. L. H., Querol, L. A., Wu, L., Irani, S. R., Watson, J., Pittock, S. J. & Klein, C. J., Jan 1 2018, (Accepted/In press) In : Journal of Neurology, Neurosurgery and Psychiatry.

Research output: Contribution to journalArticle

Immune System Phenomena
Immunotherapy
Immunoglobulin G
Pain
Somatoform Disorders
6 Citations (Scopus)

RNAseq analysis of hippocampal microglia after kainic acid-induced seizures

Bosco, D. B., Zheng, J., Xu, Z., Peng, J., Eyo, U. B., Tang, K., Yan, C., Huang, J., Feng, L., Wu, G., Richardson, J. R., Wang, H. & Wu, L., Jun 20 2018, In : Molecular Brain. 11, 1, 34.

Research output: Contribution to journalArticle

Kainic Acid
Microglia
Seizures
Temporal Lobe Epilepsy
Interferon-beta
7 Citations (Scopus)

The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6

Hossain, M. M., Weig, B., Reuhl, K., Gearing, M., Wu, L. & Richardson, J. R., Oct 1 2018, In : Experimental Neurology. 308, p. 111-119 9 p.

Research output: Contribution to journalArticle

zonisamide
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Parkinson Disease
Pharmaceutical Preparations
Monoamine Oxidase
4 Citations (Scopus)

The GluN2A Subunit Regulates Neuronal NMDA receptor-Induced Microglia-Neuron Physical Interactions

Eyo, U. B., Bispo, A., Liu, J., Sabu, S., Wu, R., Dibona, V. L., Zheng, J., Murugan, M., Zhang, H., Tang, Y. & Wu, L., Dec 1 2018, In : Scientific Reports. 8, 1, 828.

Research output: Contribution to journalArticle

Microglia
N-Methyl-D-Aspartate Receptors
Neurons
Physical Phenomena
Photons
2017
11 Citations (Scopus)

Alternative microglial activation is associated with cessation of progressive dopamine neuron loss in mice systemically administered lipopolysaccharide

Beier, E. E., Neal, M., Alam, G., Edler, M., Wu, L. & Richardson, J. R., Dec 1 2017, In : Neurobiology of Disease. 108, p. 115-127 13 p.

Research output: Contribution to journalArticle

Dopaminergic Neurons
Lipopolysaccharides
Neuroglia
Parkinson Disease
Microglia
27 Citations (Scopus)

Chemokine CCL2-CCR2 signaling induces neuronal cell death via STAT3 activation and IL-1β production after status epilepticus

Tian, D. S., Peng, J., Murugan, M., Feng, L. J., Liu, J. L., Eyo, U. B., Zhou, L. J., Mogilevsky, R., Wang, W. & Wu, L., Aug 16 2017, In : Journal of Neuroscience. 37, 33, p. 7878-7892 15 p.

Research output: Contribution to journalArticle

Status Epilepticus
Chemokine CCL2
Interleukin-1
Transcriptional Activation
Seizures
35 Citations (Scopus)

Fingolimod protects against ischemic white matter damage by modulating microglia toward M2 polarization via STAT3 pathway

Qin, C., Fan, W. H., Liu, Q., Shang, K., Murugan, M., Wu, L., Wang, W. & Tian, D. S., Jan 1 2017, In : Stroke. 48, 12, p. 3336-3346 11 p.

Research output: Contribution to journalArticle

STAT3 Transcription Factor
Microglia
Carotid Stenosis
Demyelinating Diseases
Wounds and Injuries
51 Citations (Scopus)

Microglia–Neuron Communication in Epilepsy

Eyo, U. B., Murugan, M. & Wu, L., Jan 1 2017, In : GLIA. 65, 1, p. 5-18 14 p.

Research output: Contribution to journalReview article

Epilepsy
Communication
Microglia
Seizures
Neurogenesis
46 Citations (Scopus)

TNF-α differentially regulates synaptic plasticity in the hippocampus and spinal cord by microglia-dependent mechanisms after peripheral nerve injury

Liu, Y., Zhou, L. J., Wang, J., Li, D., Ren, W. J., Peng, J., Wei, X., Xu, T., Xin, W. J., Pang, R. P., Li, Y. Y., Qin, Z. H., Murugan, M., Mattson, M. P., Wu, L. & Liu, X. G., Jan 25 2017, In : Journal of Neuroscience. 37, 4, p. 871-881 11 p.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Neuronal Plasticity
Microglia
Hippocampus
Spinal Cord
20 Citations (Scopus)

TREM2 protects against cerebral ischemia/reperfusion injury

Wu, R., Li, X., Xu, P., Huang, L., Cheng, J., Huang, X., Jiang, J., Wu, L. & Tang, Y., Jun 7 2017, In : Molecular Brain. 10, 1, 20.

Research output: Contribution to journalArticle

Myeloid Cells
Reperfusion Injury
Brain Ischemia
Middle Cerebral Artery Infarction
Stroke
2016
17 Citations (Scopus)

Activation of microglial P2Y12 receptor is required for outward potassium currents in response to neuronal injury

Swiatkowski, P., Murugan, M., Eyo, U. B., Wang, Y., Rangaraju, S., Oh, S. B. & Wu, L., Mar 24 2016, In : Neuroscience. 318, p. 22-33 12 p.

Research output: Contribution to journalArticle

Microglia
Potassium
Chemotaxis
Wounds and Injuries
Quinine
14 Citations (Scopus)

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke

Tian, D. S., Li, C. Y., Qin, C., Murugan, M., Wu, L. & Liu, J. L., Oct 1 2016, In : Journal of Neurochemistry. 139, 1, p. 96-105 10 p.

Research output: Contribution to journalArticle

Microglia
Protons
Reactive Oxygen Species
Brain
Stroke
14 Citations (Scopus)

High-resolution transcriptome analysis reveals neuropathic pain gene-expression signatures in spinal microglia after nerve injury

Jeong, H., Na, Y. J., Lee, K., Kim, Y. H., Lee, Y., Kang, M., Jiang, B. C., Yeom, Y. I., Wu, L., Gao, Y. J., Kim, J. & Oh, S. B., Apr 1 2016, In : Pain. 157, 4, p. 964-976 13 p.

Research output: Contribution to journalArticle

Microglia
Neuralgia
Gene Expression Profiling
Transcriptome
Wounds and Injuries
48 Citations (Scopus)

Interleukin-1β overproduction is a common cause for neuropathic pain, memory deficit, and depression following peripheral nerve injury in rodents

Gui, W. S., Wei, X., Mai, C. L., Murugan, M., Wu, L., Xin, W. J., Zhou, L. J. & Liu, X. G., May 3 2016, In : Molecular Pain. 12

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Memory Disorders
Neuralgia
Interleukin-1
Interleukin-1beta
68 Citations (Scopus)

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

Peng, J., Gu, N., Zhou, L., B Eyo, U., Murugan, M., Gan, W. B. & Wu, L., Jun 28 2016, In : Nature Communications. 7, 12029.

Research output: Contribution to journalArticle

monocytes
pain
nerves
Microglia
Chronic Pain
34 Citations (Scopus)

Microglial P2Y12 receptors regulate microglial activation and surveillance during neuropathic pain

Gu, N., Eyo, U. B., Murugan, M., Peng, J., Matta, S., Dong, H. & Wu, L., Jul 1 2016, In : Brain, Behavior, and Immunity. 55, p. 82-92 11 p.

Research output: Contribution to journalArticle

Neuralgia
Spinal Nerves
Microglia
Wounds and Injuries
Purinergic Receptors
22 Citations (Scopus)

Regulation of physical microglia–neuron interactions by fractalkine signaling after status epilepticus

Eyo, U. B., Peng, J., Murugan, M., Mo, M., Lalani, A., Xie, P., Xu, P., Margolis, D. J. & Wu, L., Dec 29 2016, In : eNeuro. 3, 6, e0209.

Research output: Contribution to journalArticle

Chemokine CX3CL1
Status Epilepticus
Microglia
Seizures
Pilocarpine
48 Citations (Scopus)

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

Gu, N., Peng, J., Murugan, M., Wang, X., Eyo, U. B., Sun, D., Ren, Y., DiCicco-Bloom, E., Young, W., Dong, H. & Wu, L., Jul 19 2016, In : Cell Reports. 16, 3, p. 605-614 10 p.

Research output: Contribution to journalArticle

Peripheral Nerve Injuries
Neuralgia
Hypersensitivity
Chemokine CX3CL1
Pain
2015
11 Citations (Scopus)

Activation of acid-sensing ion channels by localized proton transient reveals their role in proton signaling

Zeng, W. Z., Liu, D. S., Liu, L., She, L., Wu, L. & Xu, T. L., Sep 15 2015, In : Scientific Reports. 5, 14125.

Research output: Contribution to journalArticle

Acid Sensing Ion Channels
Protons
Nervous System
Proton Pumps
Glycine
30 Citations (Scopus)

Extracellular ATP enhances radiation-induced brain injury through microglial activation and paracrine signaling via P2X7 receptor

Xu, P., Xu, Y., Hu, B., Wang, J., Pan, R., Murugan, M., Wu, L. & Tang, Y., Nov 1 2015, In : Brain, Behavior, and Immunity. 50, p. 87-100 14 p.

Research output: Contribution to journalArticle

Paracrine Communication
Purinergic P2X7 Receptors
Purinergic P2 Receptors
Brain Injuries
Adenosine Triphosphate
21 Citations (Scopus)

Microglial Hv1 proton channel promotes cuprizone-induced demyelination through oxidative damage

Liu, J., Tian, D., Murugan, M., Eyo, U. B., Dreyfus, C. F., Wang, W. & Wu, L., Oct 1 2015, In : Journal of Neurochemistry. 135, 2, p. 347-356 10 p.

Research output: Contribution to journalArticle

Cuprizone
Demyelinating Diseases
Protons
Reactive Oxygen Species
NADPH Oxidase
47 Citations (Scopus)

Modulation of microglial process convergence toward neuronal dendrites by extracellular calcium

Eyo, U. B., Gu, N., De, S., Dong, H., Richardson, J. R. & Wu, L., Jan 1 2015, In : Journal of Neuroscience. 35, 6, p. 2417-2422 6 p.

Research output: Contribution to journalArticle

Dendrites
Calcium
Brain
Microglia
Brain Diseases
2014
15 Citations (Scopus)

Microglial Voltage-Gated Proton Channel Hv1 in Ischemic Stroke

Wu, L., Feb 1 2014, In : Translational Stroke Research. 5, 1, p. 99-108 10 p.

Research output: Contribution to journalArticle

Microglia
NADPH Oxidase
Protons
Stroke
Reactive Oxygen Species
118 Citations (Scopus)

Neuronal hyperactivity recruits microglial processes via neuronal NMDA receptors and microglial P2Y12 receptors after status epilepticus

Eyo, U. B., Peng, J., Swiatkowski, P., Mukherjee, A., Bispo, A. & Wu, L., Aug 6 2014, In : Journal of Neuroscience. 34, 32, p. 10528-10540 13 p.

Research output: Contribution to journalArticle

Status Epilepticus
N-Methyl-D-Aspartate Receptors
Seizures
Microglia
Glutamic Acid
16 Citations (Scopus)

Voltage-gated proton channel HV1 in microglia

Wu, L., Jan 1 2014, In : Neuroscientist. 20, 6, p. 599-609 11 p.

Research output: Contribution to journalReview article

Microglia
Protons
Ion Channels
Brain
NADPH Oxidase
2013
22 Citations (Scopus)

A selective sweep across species boundaries in Drosophila

Brand, C. L., Kingan, S. B., Wu, L. & Garrigan, D., Sep 1 2013, In : Molecular Biology and Evolution. 30, 9, p. 2177-2186 10 p.

Research output: Contribution to journalArticle

Drosophila simulans
Drosophila sechellia
Drosophila
mutation
Haplotypes
91 Citations (Scopus)

Bidirectional microglia-neuron communication in the healthy brain

Eyo, U. B. & Wu, L., Jan 1 2013, In : Neural Plasticity. 2013, 456857.

Research output: Contribution to journalReview article

Microglia
Neurons
Brain
Chemokine CX3CL1
Brain Diseases
9 Citations (Scopus)

Microglia in neuronal circuits

Wu, L., Stevens, B., Duan, S. & MacVicar, B. A., Jan 1 2013, In : Neural Plasticity. 2013, 586426.

Research output: Contribution to journalEditorial

Nerve Net
Microglia
Brain Diseases
Health
Brain
29 Citations (Scopus)

P2X7 receptor activation regulates microglial cell death during oxygen-glucose deprivation

Eyo, U. B., Miner, S. A., Ahlers, K. E., Wu, L. & Dailey, M. E., Jan 1 2013, In : Neuropharmacology. 73, p. 311-319 9 p.

Research output: Contribution to journalArticle

Purinergic P2X7 Receptors
Microglia
Cell Death
Oxygen
Glucose
2012
19 Citations (Scopus)

Kainate receptor-mediated synaptic transmissions in the adult rodent insular cortex

Koga, K., Sim, S. E., Chen, T., Wu, L., Kaang, B. K. & Zhuo, M., Oct 1 2012, In : Journal of Neurophysiology. 108, 7, p. 1988-1998 11 p.

Research output: Contribution to journalArticle

Kainic Acid Receptors
Kainic Acid
Synaptic Transmission
Cerebral Cortex
Rodentia
97 Citations (Scopus)

The channel kinase, TRPM7, is required for early embryonic development

Jin, J., Wu, L., Jun, J., Cheng, X., Xu, H., Andrews, N. C. & Clapham, D. E., Jan 31 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 5

Research output: Contribution to journalArticle

Neural Stem Cells
Embryonic Development
Phosphotransferases
Induced Pluripotent Stem Cells
Neurons
117 Citations (Scopus)

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

Wu, L., Wu, G., Sharif, M. R. A., Baker, A., Jia, Y., Fahey, F. H., Luo, H. R., Feener, E. P. & Clapham, D. E., Apr 1 2012, In : Nature Neuroscience. 15, 4, p. 565-573 9 p.

Research output: Contribution to journalArticle

NADPH Oxidase
Protons
Stroke
Brain
Reactive Oxygen Species
2011
82 Citations (Scopus)

Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain

Wang, H., Xu, H., Wu, L., Kim, S. S., Chen, T., Koga, K., Descalzi, G., Gong, B., Vadakkan, K. I., Zhang, X., Kaang, B. K. & Zhuo, M., Jan 12 2011, In : Science Translational Medicine. 3, 65, 65ra3.

Research output: Contribution to journalArticle

Neuralgia
Wounds and Injuries
Posterior Horn Cells
Drug Design
Gyrus Cinguli
25 Citations (Scopus)

Interplay of amygdala and cingulate plasticity in emotional fear

Toyoda, H., Li, X. Y., Wu, L., Zhao, M. G., Descalzi, G., Chen, T., Koga, K. & Zhuo, M., Jan 1 2011, In : Neural Plasticity. 2011, 813749.

Research output: Contribution to journalReview article

Amygdala
Fear
Neuronal Plasticity
Hippocampus
Neurons