• 652 Citations
  • 11 Scopus h-Index
19972019
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Research Output 1997 2019

  • 652 Citations
  • 11 Scopus h-Index
  • 34 Article
  • 6 Letter
  • 1 Comment/debate
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Article
2019
1 Citation (Scopus)

Acute leukemias harboring KMT2A/MLLT10 fusion: a 10-year experience from a single genomics laboratory

Peterson, J. F., Sukov, W. R., Pitel, B. A., Smoley, S. A., Pearce, K. E., Meyer, R. G., Williamson, C. M., Smadbeck, J., Vasmatzis, G., Hoppman, N. L., Greipp, P. T., Baughn, L. & Ketterling, R. P., Jan 1 2019, In : Genes Chromosomes and Cancer.

Research output: Contribution to journalArticle

Genomics
Leukemia
Fluorescence In Situ Hybridization
Acute Myeloid Leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma

A near-haploid clone harboring a BCR/ABL1 gene fusion in an adult patient with newly diagnosed B-lymphoblastic leukemia

Peterson, J. F., Ketterling, R. P., Huang, L., Finn, L. E., Shi, M., Hoppman, N. L., Greipp, P. T. & Baughn, L., Sep 1 2019, In : Genes Chromosomes and Cancer. 58, 9, p. 665-668 4 p.

Research output: Contribution to journalArticle

Gene Fusion
Haploidy
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Clone Cells
Chromosomes

Characterization of a cryptic IGH/CCND1 rearrangement in a case of mantle cell lymphoma with negative CCND1 FISH studies

Peterson, J. F., Baughn, L., Ketterling, R. P., Pitel, B. A., Smoley, S. A., Vasmatzis, G., Smadbeck, J., Greipp, P. T., Mangaonkar, A. A., Thompson, C. A., Parikh, S. A., Chen, D. & Viswanatha, D. S., Jan 1 2019, In : Blood Advances. 3, 8, p. 1298-1302 5 p.

Research output: Contribution to journalArticle

Open Access
Mantle-Cell Lymphoma
Cyclin D1
Fluorescence In Situ Hybridization
B-Cell Lymphoma
Cyclin D

Characterization of a rarely reported STAT5B/RARA gene fusion in a young adult with newly diagnosed acute promyelocytic leukemia with resistance to ATRA therapy

Peterson, J. F., He, R. R., Nayer, H., Cuevo, R. S., Smadbeck, J., Vasmatzis, G., Greipp, P. T., Ketterling, R. P., Hoppman, N. L. & Baughn, L., Sep 1 2019, In : Cancer Genetics. 237, p. 51-54 4 p.

Research output: Contribution to journalArticle

Acute Promyelocytic Leukemia
Gene Fusion
Tretinoin
Young Adult
Fluorescence In Situ Hybridization

Detection of a cryptic NUP214/ABL1 gene fusion by mate-pair sequencing (MPseq) in a newly diagnosed case of pediatric T-lymphoblastic leukemia

Peterson, J. F., Pitel, B. A., Smoley, S. A., Smadbeck, J., Johnson, S. H., Vasmatzis, G., Koon, S. J., Webley, M. R., McGrath, M., Bayerl, M. G., Baughn, L., Rowsey, R. A., Ketterling, R. P., Greipp, P. T. & Hoppman, N. L., Apr 1 2019, In : Cold Spring Harbor molecular case studies. 5, 2

Research output: Contribution to journalArticle

Open Access
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Pediatrics
T-cells
Gene Fusion
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Open Access
B-Cell Lymphoma
Fluorescence In Situ Hybridization
Non-Hodgkin's Lymphoma
Fluorescence
Cells
6 Citations (Scopus)

Mate pair sequencing improves detection of genomic abnormalities in acute myeloid leukemia

Aypar, U., Smoley, S. A., Pitel, B. A., Pearce, K. E., Zenka, R. M., Vasmatzis, G., Johnson, S. H., Smadbeck, J., Peterson, J. F., Geiersbach, K. B., Van Dyke, D. L., Thorland, E. C., Jenkins, R. B., Ketterling, R. P., Greipp, P. T., Kearney, H. M., Hoppman, N. L. & Baughn, L., Jan 1 2019, In : European Journal of Haematology. 102, 1, p. 87-96 10 p.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Cytogenetics
Hematologic Neoplasms
Fluorescence In Situ Hybridization
Molecular Biology

Molecular signatures of multiple myeloma progression through single cell RNA-Seq

Jang, J. S., Li, Y., Mitra, A. K., Bi, L., Abyzov, A., van Wijnen, A. J., Baughn, L., Van Ness, B., Rajkumar, S. V., Kumar, S. K. & Jen, J., Jan 1 2019, In : Blood Cancer Journal. 9, 1, 2.

Research output: Contribution to journalArticle

Multiple Myeloma
RNA
Genes
Oxidative Phosphorylation
Plasma Cells
2 Citations (Scopus)

Rapid assessment of hyperdiploidy in plasma cell disorders using a novel multi-parametric flow cytometry method

Sidana, S., Jevremovic, D., Ketterling, R. P., Tandon, N., Dispenzieri, A., Gertz, M., Greipp, P. T., Baughn, L., Buadi, F. K., Lacy, M., Morice, W., Hanson, C., Timm, M., Dingli, D. M., Hayman, S. R., Gonsalves, W., Kapoor, P., Kyle, R. A., Leung, N., Go, R. S. & 3 others, Lust, J. A., Rajkumar, S. V. & Kumar, S. K., Jan 1 2019, (Accepted/In press) In : American Journal of Hematology.

Research output: Contribution to journalArticle

Polyploidy
Plasma Cells
Flow Cytometry
Trisomy
Fluorescence In Situ Hybridization
3 Citations (Scopus)

The future of myeloma precision medicine: integrating the compendium of known drug resistance mechanisms with emerging tumor profiling technologies

Harding, T., Baughn, L., Kumar, S. K. & Van Ness, B., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Precision Medicine
Multiple Myeloma
Drug Resistance
Technology
Biomarkers
1 Citation (Scopus)

Use of mate-pair sequencing to characterize a complex cryptic BCR/ABL1 rearrangement observed in a newly diagnosed case of chronic myeloid leukemia

Peterson, J. F., Pitel, B. A., Smoley, S. A., Smadbeck, J., Johnson, S. H., Vasmatzis, G., Kearney, H. M., Greipp, P. T., Hoppman, N. L., Baughn, L. & Ketterling, R. P., Jan 1 2019, In : Human Pathology.

Research output: Contribution to journalArticle

Chromosomes, Human, Pair 22
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Fluorescence In Situ Hybridization
Cytogenetics
Chromosomes

Whole Genome Mate-pair Sequencing of Plasma Cell Neoplasm as a Novel Diagnostic Strategy: A Case of Unrecognized t(2;11) Structural Variation

Peterson, J. F., Meyer, R. G., Smoley, S. A., Webley, M., Smadbeck, J., Vasmatzis, G., Pearce, K., Greipp, P. T., Ketterling, R. P., Craig, F. E., Stewart, A. K. & Baughn, L., Jan 1 2019, In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Open Access
Plasma Cell Neoplasms
Multiple Myeloma
Fluorescence In Situ Hybridization
Genome
2018

Constitutional chromosome rearrangements that mimic the 2017 world health organization “acute myeloid leukemia with recurrent genetic abnormalities”: A study of three cases and review of the literature

Peterson, J. F., Pitel, B. A., Smoley, S. A., Smadbeck, J., Johnson, S. H., Vasmatzis, G., Pearce, K. E., He, R., Kelemen, K., Al-Mondhiry, H. A. B., Lamparella, N. E., Hoppman, N. L., Kearney, H. M., Baughn, L., Ketterling, R. P. & Greipp, P. T., Jan 1 2018, (Accepted/In press) In : Cancer genetics.

Research output: Contribution to journalArticle

Acute Myeloid Leukemia
Chromosomes
Bone Marrow
Primary Ovarian Insufficiency
Hematologic Neoplasms
1 Citation (Scopus)

Core-binding factor acute myeloid leukemia with t(8;21): Risk factors and a novel scoring system (I-CBFit)

Ustun, C., Morgan, E., Moodie, E. E. M., Pullarkat, S., Yeung, C., Broesby-Olsen, S., Ohgami, R., Kim, Y., Sperr, W., Vestergaard, H., Chen, D., Kluin, P. M., Dolan, M., Mrózek, K., Czuchlewski, D., Horny, H. P., George, T. I., Kristensen, T. K., Ku, N. K., Yi, C. A. & 26 others, Møller, M. B., Marcucci, G., Baughn, L., Schiefer, A. I., Hilberink, J. R., Pullarkat, V., Shanley, R., Kohlschmidt, J., Coulombe, J., Salhotra, A., Soma, L., Cho, C., Linden, M. A., Akin, C., Gotlib, J., Hoermann, G., Hornick, J., Nakamura, R., Deeg, J., Bloomfield, C. D., Weisdorf, D., Litzow, M. R., Valent, P., Huls, G., Perales, M. A. & Borthakur, G., Sep 1 2018, In : Cancer Medicine. 7, 9, p. 4447-4455 9 p.

Research output: Contribution to journalArticle

Core Binding Factors
Acute Myeloid Leukemia
Cell Transplantation
Recurrence
Polyploidy
7 Citations (Scopus)
Paraproteinemias
Multiple Myeloma
Precision Medicine
Genetic Predisposition to Disease
Cytogenetics
5 Citations (Scopus)

KMT2A (MLL) rearrangements observed in pediatric/young adult T-lymphoblastic leukemia/lymphoma: A 10-year review from a single cytogenetic laboratory

Peterson, J. F., Baughn, L., Pearce, K. E., Williamson, C. M., Benevides Demasi, J. C., Olson, R. M., Goble, T. A., Meyer, R. G., Greipp, P. T. & Ketterling, R. P., Jan 1 2018, (Accepted/In press) In : Genes Chromosomes and Cancer.

Research output: Contribution to journalArticle

Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
antineoplaston A10
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Cytogenetics
Young Adult

Necrotizing enterocolitis in two siblings and an unrelated infant with overlapping chromosome 6q25 deletions

Esdal, H. C. D., Ghbeis, M. B., Saltzman, D. A., Hess, D., Hume, J. R., Reed, R. C., Berry, S. A., Hoggard, E., Hirsch, B., Baughn, L. & Schimmenti, L. A., May 1 2018, In : Molecular Syndromology. 9, 3, p. 141-148 8 p.

Research output: Contribution to journalArticle

Chromosome Deletion
Necrotizing Enterocolitis
Chromosomes, Human, Pair 6
Siblings
Necrosis
1 Citation (Scopus)

SH2B3 aberrations enriched in iAMP21 B lymphoblastic leukemia

Baughn, L., Meredith, M. M., Oseth, L., Smolarek, T. A. & Hirsch, B., Oct 1 2018, In : Cancer genetics. 226-227, p. 30-35 6 p.

Research output: Contribution to journalArticle

Chromosomes, Human, 4-5
Chromosomes, Human, Pair 21
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Fluorescence In Situ Hybridization
Protein-Tyrosine Kinases
2 Citations (Scopus)

The utilization of chromosomal microarray technologies for hematologic neoplasms: An ACLPS critical review

Peterson, J. F., Van Dyke, D. L., Hoppman, N. L., Kearney, H. M., Sukov, W. R., Greipp, P. T., Ketterling, R. P. & Baughn, L., Oct 1 2018, In : American Journal of Clinical Pathology. 150, 5, p. 375-384 10 p.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Loss of Heterozygosity
Technology
Fluorescence In Situ Hybridization
Clone Cells
2017
20 Citations (Scopus)

Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder

Koemans, T. S., Kleefstra, T., Chubak, M. C., Stone, M. H., Reijnders, M. R. F., de Munnik, S., Willemsen, M. H., Fenckova, M., Stumpel, C. T. R. M., Bok, L. A., Sifuentes Saenz, M., Byerly, K. A., Baughn, L., Stegmann, A. P. A., Pfundt, R., Zhou, H., van Bokhoven, H., Schenck, A. & Kramer, J. M., Oct 1 2017, In : PLoS Genetics. 13, 10, e1006864.

Research output: Contribution to journalArticle

Euchromatin
disability
methyltransferases
histones
Intellectual Disability
5 Citations (Scopus)

Phenotypic and functional characterization of a bortezomib-resistant multiple myeloma cell line by flow and mass cytometry

Baughn, L., Sachs, Z., Noble-Orcutt, K. E., Mitra, A., Van Ness, B. G. & Linden, M. A., Aug 3 2017, In : Leukemia and Lymphoma. 58, 8, p. 1931-1940 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Flow Cytometry
Cell Line
Fluorescence
Plasma Cell Neoplasms
2016
8 Citations (Scopus)

CNV-RF Is a Random Forest–Based Copy Number Variation Detection Method Using Next-Generation Sequencing

Onsongo, G., Baughn, L., Bower, M., Henzler, C., Schomaker, M., Silverstein, K. A. T. & Thyagarajan, B., Nov 1 2016, In : Journal of Molecular Diagnostics. 18, 6, p. 872-881 10 p.

Research output: Contribution to journalArticle

Computational Biology
Nucleotides
Genes
Polymerase Chain Reaction
Molecular Pathology
2015
8 Citations (Scopus)

Bosutinib, a Lyn/Btk inhibiting tyrosine kinase inhibitor, is ineffective in advanced systemic mastocytosis

Randall, N., Courville, E. L., Baughn, L., Afrin, L. & Ustun, C., Jan 1 2015, In : American Journal of Hematology. 90, 4, p. E74-E74

Research output: Contribution to journalArticle

Aniline Compounds
Piperazines
Benzamides
Multiple Hamartoma Syndrome
PTEN Phosphohydrolase
18 Citations (Scopus)

Integration of cytogenomic data for furthering the characterization of pediatric B-cell acute lymphoblastic leukemia: A multi-institution, multi-platform microarray study

Baughn, L., Biegel, J. A., South, S. T., Smolarek, T. A., Volkert, S., Carroll, A. J., Heerema, N. A., Rabin, K. R., Zweidler-McKay, P. A., Loh, M. & Hirsch, B., Jan 1 2015, In : Cancer genetics. 208, 1-2, p. 1-18 18 p.

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
Precursor Cell Lymphoblastic Leukemia-Lymphoma
B-Lymphocytes
Pediatrics
Cytogenetics
2014
16 Citations (Scopus)

Utilization of translational bioinformatics to identify novel biomarkers of bortezomib resistance in multiple myeloma

Fall, D. J., Stessman, H., Patel, S. S., Sachs, Z., Van Ness, B. G., Baughn, L. & Linden, M. A., Jan 1 2014, In : Journal of Cancer. 5, 9, p. 720-727 8 p.

Research output: Contribution to journalArticle

Computational Biology
Multiple Myeloma
Biomarkers
Proteasome Inhibitors
Gene Expression Profiling
2013
11 Citations (Scopus)

Bortezomib resistance can be reversed by induced expression of plasma cell maturation markers in a mouse in vitro model of multiple myeloma.

Stessman, H. A. F., Mansoor, A., Zhan, F., Linden, M. A., Van Ness, B. & Baughn, L., Jan 1 2013, In : PLoS One. 8, 10

Research output: Contribution to journalArticle

myeloma
plasma cells
Plasma Cells
Multiple Myeloma
Plasmas
38 Citations (Scopus)

Profiling bortezomib resistance identifies secondary therapies in a mouse myeloma model

Stessman, H. A. F., Baughn, L., Sarver, A., Xia, T., Deshpande, R., Mansoor, A., Walsh, S. A., Sunderland, J. J., Dolloff, N. G., Linden, M. A., Zhan, F., Janz, S., Myers, C. L. & Van Ness, B. G., Jun 1 2013, In : Molecular Cancer Therapeutics. 12, 6, p. 1140-1150 11 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Histone Deacetylase Inhibitors
Proteasome Inhibitors
Therapeutics
Gene Expression Profiling
2011
6 Citations (Scopus)

Recombinase-mediated cassette exchange as a novel method to study somatic hypermutation in ramos cells

Baughn, L., Kalis, S. L., MacCarthy, T., Wei, L., Fan, M., Bergman, A. & Scharff, M. D., Sep 1 2011, In : mBio. 2, 5

Research output: Contribution to journalArticle

Recombinases
Immunoglobulin Genes
Antibody Affinity
Antibody Diversity
Immunoglobulin Variable Region
2009
27 Citations (Scopus)

CDK2 phosphorylation of Smad2 disrupts TGF-β transcriptional regulation in resistant primary bone marrow myeloma cells

Baughn, L., Di Liberto, M., Niesvizky, R., Cho, H. J., Jayabalan, D., Lane, J., Liu, F. & Chen-Kiang, S., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 1810-1817 8 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Bone Marrow Cells
Phosphorylation
Cell Cycle Checkpoints
Multiple Myeloma
2006
159 Citations (Scopus)

A novel orally active small molecule potently induces G1 arrest in primary myeloma cells and prevents tumor growth by specific inhibition of cyclin-dependent kinase 4/6

Baughn, L., Di Liberto, M., Wu, K., Toogood, P. L., Louie, T., Gottschalk, R., Niesvizky, R., Cho, H., Ely, S., Moore, M. A. S. & Chen-Kiang, S., Aug 1 2006, In : Cancer Research. 66, 15, p. 7661-7667 7 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin-Dependent Kinase 4
Bone Marrow Cells
Growth
Neoplasms
2005
8 Citations (Scopus)

Disruption of the Shc/Grb2 complex during Abelson virus transformation affects proliferation, but not apoptosis

Baughn, L. & Rosenberg, N., Feb 1 2005, In : Journal of Virology. 79, 4, p. 2325-2334 10 p.

Research output: Contribution to journalArticle

Abelson murine leukemia virus
Murine leukemia virus
apoptosis
B-Lymphoid Precursor Cells
Apoptosis
85 Citations (Scopus)

Mutually exclusive cyclin-dependent kinase 4/cyclin D1 and cyclin-dependent kinase 6/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma

Ely, S., Di Liberto, M., Niesvizky, R., Baughn, L., Cho, H. J., Hatada, E. N., Knowles, D. M., Lane, J. & Chen-Kiang, S., Dec 15 2005, In : Cancer Research. 65, 24, p. 11345-11353 9 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinase 6
Cyclin D2
Cyclin-Dependent Kinase 4
Retinoblastoma Protein
Cyclin D1
1998
135 Citations (Scopus)

Overexpression, purification, and characterization of the cloned metallo-β-lactamase L1 from Stenotrophomonas maltophilia

Crowder, M. W., Walsh, T. R., Baughn, L., Pettit, M. & Spencer, J., Apr 1 1998, In : Antimicrobial Agents and Chemotherapy. 42, 4, p. 921-926 6 p.

Research output: Contribution to journalArticle

Stenotrophomonas maltophilia
Enzymes
Cephalosporins
Penicillins
Gel Chromatography
1997
48 Citations (Scopus)

Glyoxalase II from A. thialana requires Zn(II) for catalytic activity

Crowder, M. W., Maiti, M. K., Baughn, L. & Makaroff, C. A., Dec 1 1997, In : FEBS Letters. 418, 3, p. 351-354 4 p.

Research output: Contribution to journalArticle

hydroxyacylglutathione hydrolase
Catalyst activity
Enzymes
Arabidopsis
Metals