• 21202 Citations
  • 68 Scopus h-Index
1979 …2020
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Research Output 1990 2020

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Article
2019

Senescence marker activin A is increased in human diabetic kidney disease: Association with kidney function and potential implications for therapy

Bian, X., Griffin, T. P., Zhu, X., Islam, M. N., Conley, S. M., Eirin, A., Tang, H., O'Shea, P. M., Palmer, A. K., McCoy, R. G., Herrmann, S. M., Mehta, R. A., Woollard, J. R., Rule, A. D., Kirkland, J. L., Tchkonia, T., Textor, S. C., Griffin, M. D., Lerman, L. O. & Hickson, L. T. J., Dec 15 2019, In : BMJ Open Diabetes Research and Care. 7, 1, e000720.

Research output: Contribution to journalArticle

Open Access
Diabetic Nephropathies
Kidney
Activins
Wounds and Injuries
Glomerular Filtration Rate

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Santelli, A., Sun, I. O., Eirin, A., Abumoawad, A. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e012584.

Research output: Contribution to journalArticle

Open Access
Renovascular Hypertension
Kidney
Cell Aging
Healthy Volunteers
Uromodulin
8 Citations (Scopus)

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Diabetic Nephropathies
Clinical Trials
Macrophages
Tissue
Mesenchymal Stromal Cells
Chronic Renal Insufficiency
Comorbidity
Stem Cells
Kidney

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Mesenchymal Stromal Cells
pregnancy
proliferation
migration
2 Citations (Scopus)

Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease

Abumoawad, A., Saad, A., Ferguson, C. M., Eirin, A., Woollard, J. R., Herrmann, S., Hickson, L., Bendel, E. C., Misra, S., Glockner, J., Lerman, L. O. & Textor, S. C., Apr 1 2019, In : Kidney international. 95, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

Renal Circulation
Glomerular Filtration Rate
Inflammation
Renal Veins
Chemokine CCL2
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HDL Lipoproteins
Triglycerides
Coronary Artery Disease
Cardiac Catheterization

Urinary microRNA in kidney disease: utility and roles

Sun, I. O. & Lerman, L. O., May 1 2019, In : American journal of physiology. Renal physiology. 316, 5, p. F785-F793

Research output: Contribution to journalArticle

Kidney Diseases
MicroRNAs
Kidney
Biomarkers
Urine
1 Citation (Scopus)
Mitochondrial DNA
Kidney
Wounds and Injuries
Renovascular Hypertension
Angioplasty
2020

Selective intrarenal delivery of mesenchymal stem cell-derived extracellular vesicles attenuates myocardial injury in experimental metabolic renovascular disease

Zhang, L., Zhu, X. Y., Zhao, Y., Eirin, A., Liu, L., Ferguson, C. M., Tang, H., Lerman, A. & Lerman, L. O., Mar 1 2020, In : Basic Research in Cardiology. 115, 2, 16.

Research output: Contribution to journalArticle

Metabolic Diseases
Mesenchymal Stromal Cells
Renal Artery Obstruction
Wounds and Injuries
Kidney