• 20102 Citations
  • 66 Scopus h-Index
1979 …2019
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Research Output 1990 2019

2019

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome

Pawar, A. S., Eirin, A., Krier, J. D., Woollard, J. R., Zhu, X. Y., Lerman, A., van Wijnen, A. J. & Lerman, L. O., May 1 2019, In : Stem Cell Research. 37, 101423.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Adipose Tissue
Swine
MicroRNAs
Messenger RNA

A modified two-compartment model for measurement of renal function using dynamic contrast-enhanced computed tomography

Jiang, K., Ferguson, C. M., Abumoawad, A., Saad, A., Textor, S. C. & Lerman, L. O., Jan 1 2019, In : PloS one. 14, 7, e0219605.

Research output: Contribution to journalArticle

Open Access
renal function
computed tomography
Glomerular Filtration Rate
glomerular filtration rate
Tomography

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120

Research output: Contribution to journalArticle

Open Access
Animal Models
Hypertension
Comorbidity
Chronic Disease
Research Design
2 Citations (Scopus)

Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis

Al-Hijji, M., Narula, N., Go, J. L., Khosla, S., Sarano, M. E., Loeffler, D., Lennon, R., Lerman, L. O. & Lerman, A., Apr 1 2019, In : Mayo Clinic proceedings. 94, 4, p. 652-659 8 p.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Stem Cells
Phenotype
Vascular Endothelial Growth Factor Receptor-2
Aortic Valve

Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs

Nargesi, A. A., Zhang, L., Tang, H., Jordan, K. L., Saadiq, I. M., Textor, S. C., Lerman, L. O. & Eirin, A., Oct 1 2019, In : Journal of hypertension. 37, 10, p. 2061-2073 13 p.

Research output: Contribution to journalArticle

Renal Artery Obstruction
Swine
Kidney
Wounds and Injuries
Renal Circulation
1 Citation (Scopus)

Coronary endothelial function testing may improve long-term quality of life in subjects with microvascular coronary endothelial dysfunction

Reriani, M., Flammer, A. J., Duhé, J., Li, J., Gulati, R., Rihal, C., Lennon, R., Tilford, J. M., Prasad, A., Lerman, L. O. & Lerman, A., Feb 1 2019, In : Open Heart. 6, 1, e000870.

Research output: Contribution to journalArticle

Open Access
Quality of Life
Coronary Artery Disease
Angina Pectoris
Chest Pain
Acetylcholine

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria

Zhang, L. H., Zhu, X. Y., Eirin, A., Nargesi, A. A., Woollard, J. R., Santelli, A., Sun, I. O., Textor, S. C. & Lerman, L. O., Jul 1 2019, In : American journal of physiology. Renal physiology. 317, 7, p. F12-F22

Research output: Contribution to journalArticle

Podocytes
Mitochondria
Swine
Wounds and Injuries
Renal Circulation

Elevated serum uric acid is associated with peripheral endothelial dysfunction in women

Taher, R., Sara, J. D., Prasad, M., Kolluri, N., Toya, T., Lerman, L. O. & Lerman, A., Nov 1 2019, In : Atherosclerosis. 290, p. 37-43 7 p.

Research output: Contribution to journalArticle

Uric Acid
Serum
Cardiovascular Diseases
Odds Ratio
Confidence Intervals

Endothelial Dysfunction

Corban, M. T., Lerman, L. O. & Lerman, A., Jul 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 7, p. 1272-1274 3 p.

Research output: Contribution to journalEditorial

Coronary Circulation
Endothelium
Coronary Artery Disease
Atherosclerosis

Glomerular Volume and Glomerulosclerosis at Different Depths within the Human Kidney

Denic, A., Ricaurte, L., Lopez, C. L., Narasimhan, R., Lerman, L. O., Lieske, J. C., Thompson, R. H., Kremers, W. K. & Rule, A. D., Aug 1 2019, In : Journal of the American Society of Nephrology : JASN. 30, 8, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Kidney
Obesity
Arteriosclerosis
Nephrectomy
Proteinuria
Open Access
Haptoglobins
HDL Lipoproteins
Coronary Artery Disease
Hemoglobins
Phenotype
Open Access
Renal Artery
Uric Acid
Kidney
Blood Pressure
Serum
3 Citations (Scopus)

Improved renal outcomes after revascularization of the stenotic renal artery in pigs by prior treatment with low-energy extracorporeal shockwave therapy

Chen, X. J., Zhang, X., Jiang, K., Krier, J. D., Zhu, X., Lerman, A. & Lerman, L. O., Oct 1 2019, In : Journal of hypertension. 37, 10, p. 2074-2082 9 p.

Research output: Contribution to journalArticle

Renal Artery
Swine
Kidney
Renal Artery Obstruction
Angioplasty
2 Citations (Scopus)

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X. Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L., Kirkland, J. L. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cell Aging
Quercetin
High Fat Diet
Nutrition
Fats

Long-term outcomes after fractional flow reserve-guided percutaneous coronary intervention in patients with severe coronary stenosis

Zhang, Y. H., Li, J., Flammer, A. J., Matsuo, Y., Lee, M. S., Lennon, R. J., Bell, M. R., Holmes, D. R., Bresnahan, J. F., Rihal, C., Lerman, L. O. & Lerman, A., Jan 1 2019, In : Journal of Geriatric Cardiology. 16, 4, p. 329-337 9 p.

Research output: Contribution to journalArticle

Coronary Stenosis
Percutaneous Coronary Intervention
Pathologic Constriction
Stents
Angiography

Magnetization Transfer Imaging Is Unaffected by Decreases in Renal Perfusion in Swine

Jiang, K., Ferguson, C. M., Woollard, J. R., Landes, V. L., Krier, J. D., Zhu, X., Nayak, K. S. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Investigative radiology.

Research output: Contribution to journalArticle

Swine
Perfusion
Kidney
Fibrosis
Elasticity Imaging Techniques

Measurement of murine kidney functional biomarkers using DCE-MRI: A multi-slice TRICKS technique and semi-automated image processing algorithm

Jiang, K., Tang, H., Mishra, P. K., Macura, S. I. & Lerman, L. O., Nov 1 2019, In : Magnetic Resonance Imaging. 63, p. 226-234 9 p.

Research output: Contribution to journalArticle

Biomarkers
Magnetic resonance imaging
Image processing
Kidney
Imaging techniques
Product Packaging
Mesenchymal Stromal Cells
Swine
Proteins
Extracellular Vesicles

Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men

Taher, R., Sara, J. D., Heidari, B., Toya, T., Lerman, L. O. & Lerman, A., Jan 1 2019, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 1035-1045 11 p.

Research output: Contribution to journalArticle

Open Access
Cardiovascular Diseases
Chest Pain
Odds Ratio
Hypertension
Hypertriglyceridemia
Open Access
Renal Artery Obstruction
Cell Aging
Swine
Kidney
Mitochondrial Degradation

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Jiang, K., Ferguson, C. M. & Lerman, L. O., Jul 1 2019, In : Translational Research. 209, p. 105-120 16 p.

Research output: Contribution to journalReview article

Magnetic resonance
Fibrosis
Ultrasonics
Magnetic Resonance Imaging
Kidney

Novel therapeutic strategies for renovascular disease

Eirin, A., Textor, S. C. & Lerman, L. O., Jul 1 2019, In : Current opinion in nephrology and hypertension. 28, 4, p. 383-389 7 p.

Research output: Contribution to journalArticle

Kidney
Therapeutics
Renal Artery
Inflammation
Protective Agents

Pain-induced peripheral artery tonometry scores in the control arm are impaired in patients with apical ballooning syndrome

Sun, T., Widmer, R. J., Matsuzawa, Y., Lennon, R. J., Park, K. H., Lerman, L. O. & Lerman, A., Jan 1 2019, In : Medicine. 98, 1, p. e13841

Research output: Contribution to journalArticle

Takotsubo Cardiomyopathy
Manometry
Arteries
Pain
Stroop Test

Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, F., Abumoawad, A. M., Hedayat, A. F., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

Adiposity
Kidney
Multidetector Computed Tomography
Iodine
Aorta

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Santelli, A., Sun, I. O., Eirin, A., Abumoawad, A. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e012584.

Research output: Contribution to journalArticle

Open Access
Renovascular Hypertension
Kidney
Cell Aging
Healthy Volunteers
Uromodulin

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Mesenchymal Stromal Cells
pregnancy
proliferation
migration
1 Citation (Scopus)

Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease

Abumoawad, A., Saad, A., Ferguson, C. M., Eirin, A., Woollard, J. R., Herrmann, S., Hickson, L., Bendel, E. C., Misra, S., Glockner, J., Lerman, L. O. & Textor, S. C., Apr 1 2019, In : Kidney international. 95, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

Renal Circulation
Glomerular Filtration Rate
Inflammation
Renal Veins
Chemokine CCL2
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HDL Lipoproteins
Triglycerides
Coronary Artery Disease
Cardiac Catheterization

Urinary microRNA in kidney disease: utility and roles

Sun, I. O. & Lerman, L. O., May 1 2019, In : American journal of physiology. Renal physiology. 316, 5, p. F785-F793

Research output: Contribution to journalArticle

Kidney Diseases
MicroRNAs
Kidney
Biomarkers
Urine
Mitochondrial DNA
Kidney
Wounds and Injuries
Renovascular Hypertension
Angioplasty
2018
2 Citations (Scopus)

Association of Search Engine Queries for Chest Pain with Coronary Heart Disease Epidemiology

Senecal, C., Widmer, R. J., Lerman, L. O. & Lerman, A., Jan 1 2018, (Accepted/In press) In : JAMA Cardiology.

Research output: Contribution to journalArticle

Search Engine
Chest Pain
Coronary Disease
Epidemiology
Hospitalization
5 Citations (Scopus)

Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension

Kashyap, S., Osman, M., Ferguson, C. M., Nath, M. C., Roy, B., Lien, K. R., Nath, K. A., Garovic, V. D., Lerman, L. O. & Grande, J. P., Dec 1 2018, In : Scientific Reports. 8, 1, 8598.

Research output: Contribution to journalArticle

Renovascular Hypertension
Knockout Mice
Kidney
Wounds and Injuries
Renal Artery Obstruction
2 Citations (Scopus)

Chronic inhibition of lipoprotein-associated phospholipase A2 does not improve coronary endothelial function: A prospective, randomized-controlled trial

Prasad, M., Lennon, R., Barsness, G. W., Prasad, A., Gulati, R., Lerman, L. O. & Lerman, A., Feb 15 2018, In : International Journal of Cardiology. 253, p. 7-13 7 p.

Research output: Contribution to journalArticle

1-Alkyl-2-acetylglycerophosphocholine Esterase
Randomized Controlled Trials
Placebos
Acetylcholine
Coronary Vessels
3 Citations (Scopus)

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume

Denic, A., Mathew, J., Nagineni, V. V., Thompson, R. H., Leibovich, B. C., Lerman, L. O., Lieske, J. C., Alexander, M. P., Augustine, J. J., Kremers, W. K. & Rule, A. D., Jul 1 2018, In : Journal of the American Society of Nephrology. 29, 7, p. 1960-1969 10 p.

Research output: Contribution to journalArticle

Clinical Pathology
Kidney
Biopsy
Proteinuria
Comorbidity

Coronary Microvasculature: Are the Small and the Mighty Cross-Talking With the Epicardial Vessels?

Corban, M. T., Lerman, L. O. & Lerman, A., Oct 22 2018, In : JACC: Cardiovascular Interventions. 11, 20, p. 2069-2071 3 p.

Research output: Contribution to journalEditorial

Microvessels
1 Citation (Scopus)

Digital health intervention as an adjunct to a workplace health program in hypertension

Senecal, C., Widmer, R. J., Johnson, M. P., Lerman, L. O. & Lerman, A., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Hypertension.

Research output: Contribution to journalArticle

Workplace
Blood Pressure
Hypertension
Health
Body Mass Index
3 Citations (Scopus)

Emerging Paradigms in Chronic Kidney Ischemia

Eirin, A., Textor, S. C. & Lerman, L. O., Nov 1 2018, In : Hypertension (Dallas, Tex. : 1979). 72, 5, p. 1023-1030 8 p.

Research output: Contribution to journalArticle

Ischemia
Kidney

Enhancing Mitochondrial Health to Treat Hypertension

Eirin, A., Lerman, A. & Lerman, L. O., Oct 1 2018, In : Current Hypertension Reports. 20, 10, 89.

Research output: Contribution to journalReview article

Hypertension
Health
Mitochondria
Clinical Trials
Renal Hypertension
1 Citation (Scopus)

Experimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve

Go, J. L., Prem, K., Al-Hijji, M. A., Qin, Q., Noble, C., Young, M. D., Lerman, L. O. & Lerman, A., Dec 1 2018, In : Scientific Reports. 8, 1, 17835.

Research output: Contribution to journalArticle

High Fat Diet
Aortic Valve
Collagen
1-Alkyl-2-acetylglycerophosphocholine Esterase
Blood Pressure
8 Citations (Scopus)

Extracellular matrix in cardiovascular pathophysiology: Chronic treatment with the mitochondrial peptide humanin prevents age-related myocardial fibrosis in mice

Qin, Q., Mehta, H., Yen, K., Navarrete, G., Brandhorst, S., Wan, J., Delrio, S., Zhang, X., Lerman, L. O., Cohen, P. & Lerman, A., Oct 1 2018, In : American Journal of Physiology - Heart and Circulatory Physiology. 315, 5, p. H1127-H1136

Research output: Contribution to journalArticle

Extracellular Matrix
Fibrosis
Peptides
Apoptosis
Staining and Labeling

Insights into coronary collateral formation from a novel porcine semiacute infarction model

Krackhardt, F., Harnoss, J. M., Waliszewski, M. W., Ritter, Z., Granzow, S., Felsenberg, D., Neumann, K., Lerman, L. O., Hillmeister, P., Gebker, R., Paetsch, I., Riediger, F., Bramlage, P. & Buschmann, I. R., Jan 1 2018, In : Coronary Artery Disease. 29, 2, p. 127-137 11 p.

Research output: Contribution to journalArticle

Infarction
Coronary Vessels
Myocardium
Swine
Coronary Occlusion
3 Citations (Scopus)

Intrarenal fat deposition does not interfere with the measurement of single-kidney perfusion in obese swine using multi-detector computed tomography

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, A. F., Abumoawad, A., Saad, A., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Jan 1 2018, (Accepted/In press) In : Journal of Cardiovascular Computed Tomography.

Research output: Contribution to journalArticle

Swine
Perfusion
Fats
Tomography
Kidney
4 Citations (Scopus)

Kidney-resident macrophages promote a proangiogenic environment in the normal and chronically ischemic mouse kidney

Puranik, A. S., Leaf, I. A., Jensen, M. A., Hedayat, A. F., Saad, A., Kim, K. W., Saadalla, A. M., Woollard, J. R., Kashyap, S., Textor, S. C., Grande, J. P., Lerman, A., Simari, R. D., Randolph, G. J., Duffield, J. S. & Lerman, L. O., Dec 1 2018, In : Scientific Reports. 8, 1, 13948.

Research output: Contribution to journalArticle

Renal Artery Obstruction
Macrophages
Kidney
Parabiosis
Endothelial Cells
13 Citations (Scopus)

Local Low Shear Stress and Endothelial Dysfunction in Patients With Nonobstructive Coronary Atherosclerosis

Siasos, G., Sara, J. D., Zaromytidou, M., Park, K. H., Coskun, A. U., Lerman, L. O., Oikonomou, E., Maynard, C. C., Fotiadis, D., Stefanou, K., Papafaklis, M., Michalis, L., Feldman, C., Lerman, A. & Stone, P. H., May 15 2018, In : Journal of the American College of Cardiology. 71, 19, p. 2092-2102 11 p.

Research output: Contribution to journalArticle

Coronary Artery Disease
Arteries
Atherosclerotic Plaques
Hydrodynamics
Coronary Angiography
1 Citation (Scopus)
Urokinase Plasminogen Activator Receptors
Coronary Circulation
Plasminogen Activator Inhibitor 1
Acetylcholine
Hemodynamics
1 Citation (Scopus)

Long-term darapladib use does not affect coronary plaque composition assessed using multimodality intravascular imaging modalities: A randomized-controlled study

Choi, W. G., Prasad, M., Lennon, R., Gulati, R., Prasad, A., Lerman, L. O. & Lerman, A., Jan 1 2018, In : Coronary Artery Disease. 29, 2, p. 104-113 10 p.

Research output: Contribution to journalArticle

1-Alkyl-2-acetylglycerophosphocholine Esterase
Macrophages
Lipids
Near-Infrared Spectroscopy
Optical Coherence Tomography
2 Citations (Scopus)

Loss of Renal Peritubular Capillaries in Hypertensive Patients Is Detectable by Urinary Endothelial Microparticle Levels

Sun, I. O., Santelli, A., Abumoawad, A., Eirin, A., Ferguson, C. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Nov 1 2018, In : Hypertension (Dallas, Tex. : 1979). 72, 5, p. 1180-1188 9 p.

Research output: Contribution to journalArticle

Kidney
Renal Veins
Healthy Volunteers
Wounds and Injuries
Fibrosis
10 Citations (Scopus)

Measurement of Murine Single-Kidney Glomerular Filtration Rate Using Dynamic Contrast-Enhanced MRI

Jiang, K., Tang, H., Mishra, P. K., Macura, S. I. & Lerman, L. O., Jun 1 2018, In : Magnetic Resonance in Medicine. 79, 6, p. 2935-2943 9 p.

Research output: Contribution to journalArticle

Glomerular Filtration Rate
Kidney
Perfusion
Inulin
Gadolinium
10 Citations (Scopus)

Mesenchymal Stem Cell-Derived Extracellular Vesicles Improve the Renal Microvasculature in Metabolic Renovascular Disease in Swine

Eirin, A., Zhu, X. Y., Jonnada, S., Lerman, A., van Wijnen, A. J. & Lerman, L. O., Jul 1 2018, In : Cell Transplantation. 27, 7, p. 1080-1095 16 p.

Research output: Contribution to journalArticle

Metabolic Diseases
Microvessels
Stem cells
Mesenchymal Stromal Cells
Swine