• 20885 Citations
  • 67 Scopus h-Index
1979 …2019
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Research Output 1990 2019

2019

Alterations in genetic and protein content of swine adipose tissue-derived mesenchymal stem cells in the metabolic syndrome

Pawar, A. S., Eirin, A., Krier, J. D., Woollard, J. R., Zhu, X. Y., Lerman, A., van Wijnen, A. J. & Lerman, L. O., May 1 2019, In : Stem Cell Research. 37, 101423.

Research output: Contribution to journalArticle

Open Access
Mesenchymal Stromal Cells
Adipose Tissue
Swine
MicroRNAs
Messenger RNA

A modified two-compartment model for measurement of renal function using dynamic contrast-enhanced computed tomography

Jiang, K., Ferguson, C. M., Abumoawad, A., Saad, A., Textor, S. C. & Lerman, L. O., Jan 1 2019, In : PloS one. 14, 7, e0219605.

Research output: Contribution to journalArticle

Open Access
renal function
computed tomography
Glomerular Filtration Rate
glomerular filtration rate
Tomography
3 Citations (Scopus)

Animal Models of Hypertension: A Scientific Statement From the American Heart Association

Lerman, L. O., Kurtz, T. W., Touyz, R. M., Ellison, D. H., Chade, A. R., Crowley, S. D., Mattson, D. L., Mullins, J. J., Osborn, J., Eirin, A., Reckelhoff, J. F., Iadecola, C. & Coffman, T. M., Jun 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 6, p. e87-e120

Research output: Contribution to journalArticle

Open Access
Animal Models
Hypertension
Comorbidity
Chronic Disease
Research Design
1 Citation (Scopus)

Assessment of peripheral endothelial function predicts future risk of solid-tumor cancer

Toya, T., Sara, J. D., Corban, M. T., Taher, R., Godo, S., Herrmann, J., Lerman, L. O. & Lerman, A., Jan 1 2019, (Accepted/In press) In : European Journal of Preventive Cardiology.

Research output: Contribution to journalArticle

Open Access
Hyperemia
Manometry
Neoplasms
Confidence Intervals
Body Mass Index
2 Citations (Scopus)

Circulating Osteogenic Progenitor Cells in Mild, Moderate, and Severe Aortic Valve Stenosis

Al-Hijji, M., Narula, N., Go, J. L., Khosla, S., Sarano, M. E., Loeffler, D., Lennon, R., Lerman, L. O. & Lerman, A., Apr 1 2019, In : Mayo Clinic proceedings. 94, 4, p. 652-659 8 p.

Research output: Contribution to journalArticle

Aortic Valve Stenosis
Stem Cells
Phenotype
Vascular Endothelial Growth Factor Receptor-2
Aortic Valve

Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs

Nargesi, A. A., Zhang, L., Tang, H., Jordan, K. L., Saadiq, I. M., Textor, S. C., Lerman, L. O. & Eirin, A., Oct 1 2019, In : Journal of hypertension. 37, 10, p. 2061-2073 13 p.

Research output: Contribution to journalArticle

Renal Artery Obstruction
Swine
Kidney
Wounds and Injuries
Renal Circulation
1 Citation (Scopus)

Coronary endothelial function testing may improve long-term quality of life in subjects with microvascular coronary endothelial dysfunction

Reriani, M., Flammer, A. J., Duhé, J., Li, J., Gulati, R., Rihal, C., Lennon, R., Tilford, J. M., Prasad, A., Lerman, L. O. & Lerman, A., Feb 1 2019, In : Open Heart. 6, 1, e000870.

Research output: Contribution to journalArticle

Open Access
Quality of Life
Coronary Artery Disease
Angina Pectoris
Chest Pain
Acetylcholine

Early podocyte injury and elevated levels of urinary podocyte-derived extracellular vesicles in swine with metabolic syndrome: role of podocyte mitochondria

Zhang, L. H., Zhu, X. Y., Eirin, A., Nargesi, A. A., Woollard, J. R., Santelli, A., Sun, I. O., Textor, S. C. & Lerman, L. O., Jul 1 2019, In : American journal of physiology. Renal physiology. 317, 7, p. F12-F22

Research output: Contribution to journalArticle

Podocytes
Mitochondria
Swine
Wounds and Injuries
Renal Circulation

Effect of Metformin on Microvascular Endothelial Function in Polycystic Ovary Syndrome

Heidari, B., Lerman, A., Lalia, A. Z., Lerman, L. O. & Chang, A. Y., Dec 2019, In : Mayo Clinic proceedings. 94, 12, p. 2455-2466 12 p.

Research output: Contribution to journalArticle

Open Access
Polycystic Ovary Syndrome
Metformin
Therapeutics
Prediabetic State
Manometry

Elevated serum uric acid is associated with peripheral endothelial dysfunction in women

Taher, R., Sara, J. D., Prasad, M., Kolluri, N., Toya, T., Lerman, L. O. & Lerman, A., Nov 1 2019, In : Atherosclerosis. 290, p. 37-43 7 p.

Research output: Contribution to journalArticle

Uric Acid
Serum
Cardiovascular Diseases
Odds Ratio
Confidence Intervals

Endothelial Dysfunction

Corban, M. T., Lerman, L. O. & Lerman, A., Jul 1 2019, In : Arteriosclerosis, thrombosis, and vascular biology. 39, 7, p. 1272-1274 3 p.

Research output: Contribution to journalEditorial

Coronary Circulation
Endothelium
Coronary Artery Disease
Atherosclerosis
1 Citation (Scopus)

Glomerular Volume and Glomerulosclerosis at Different Depths within the Human Kidney

Denic, A., Ricaurte, L., Lopez, C. L., Narasimhan, R., Lerman, L. O., Lieske, J. C., Thompson, R. H., Kremers, W. K. & Rule, A. D., Aug 1 2019, In : Journal of the American Society of Nephrology : JASN. 30, 8, p. 1471-1480 10 p.

Research output: Contribution to journalArticle

Kidney
Obesity
Arteriosclerosis
Nephrectomy
Proteinuria
Open Access
Haptoglobins
HDL Lipoproteins
Coronary Artery Disease
Hemoglobins
Phenotype
1 Citation (Scopus)
Open Access
Renal Artery
Uric Acid
Kidney
Blood Pressure
Serum
3 Citations (Scopus)

Improved renal outcomes after revascularization of the stenotic renal artery in pigs by prior treatment with low-energy extracorporeal shockwave therapy

Chen, X. J., Zhang, X., Jiang, K., Krier, J. D., Zhu, X., Lerman, A. & Lerman, L. O., Oct 1 2019, In : Journal of hypertension. 37, 10, p. 2074-2082 9 p.

Research output: Contribution to journalArticle

Renal Artery
Swine
Kidney
Renal Artery Obstruction
Angioplasty
3 Citations (Scopus)

Increased renal cellular senescence in murine high-fat diet: effect of the senolytic drug quercetin

Kim, S. R., Jiang, K., Ogrodnik, M., Chen, X., Zhu, X. Y., Lohmeier, H., Ahmed, L., Tang, H., Tchkonia, T., Hickson, L., Kirkland, J. L. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Translational Research.

Research output: Contribution to journalArticle

Cell Aging
Quercetin
High Fat Diet
Nutrition
Fats

Long-term outcomes after fractional flow reserve-guided percutaneous coronary intervention in patients with severe coronary stenosis

Zhang, Y. H., Li, J., Flammer, A. J., Matsuo, Y., Lee, M. S., Lennon, R. J., Bell, M. R., Holmes, D. R., Bresnahan, J. F., Rihal, C. S., Lerman, L. O. & Lerman, A., Jan 1 2019, In : Journal of Geriatric Cardiology. 16, 4, p. 329-337 9 p.

Research output: Contribution to journalArticle

Coronary Stenosis
Percutaneous Coronary Intervention
Pathologic Constriction
Stents
Angiography
1 Citation (Scopus)

Magnetization Transfer Imaging Is Unaffected by Decreases in Renal Perfusion in Swine

Jiang, K., Ferguson, C. M., Woollard, J. R., Landes, V. L., Krier, J. D., Zhu, X., Nayak, K. S. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Investigative radiology.

Research output: Contribution to journalArticle

Swine
Perfusion
Kidney
Fibrosis
Elasticity Imaging Techniques

Measurement of murine kidney functional biomarkers using DCE-MRI: A multi-slice TRICKS technique and semi-automated image processing algorithm

Jiang, K., Tang, H., Mishra, P. K., Macura, S. I. & Lerman, L. O., Nov 1 2019, In : Magnetic Resonance Imaging. 63, p. 226-234 9 p.

Research output: Contribution to journalArticle

Biomarkers
Magnetic resonance imaging
Image processing
Kidney
Imaging techniques

Metabolic Syndrome Induces Release of Smaller Extracellular Vesicles from Porcine Mesenchymal Stem Cells

Conley, S. M., Shook, J. E., Zhu, X. Y., Eirin, A., Jordan, K. L., Woollard, J. R., Isik, B., Hickson, L. T. J., Puranik, A. S. & Lerman, L. O., Sep 1 2019, In : Cell Transplantation. 28, 9-10, p. 1271-1278 8 p.

Research output: Contribution to journalArticle

Open Access
Stem cells
Mesenchymal Stromal Cells
Swine
RNA
Exosomes
2 Citations (Scopus)
Product Packaging
Mesenchymal Stromal Cells
Swine
Proteins
Extracellular Vesicles

Metabolic syndrome is associated with peripheral endothelial dysfunction amongst men

Taher, R., Sara, J. D., Heidari, B., Toya, T., Lerman, L. O. & Lerman, A., Jan 1 2019, In : Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 12, p. 1035-1045 11 p.

Research output: Contribution to journalArticle

Open Access
Cardiovascular Diseases
Chest Pain
Odds Ratio
Hypertension
Hypertriglyceridemia
1 Citation (Scopus)
Open Access
Renal Artery Obstruction
Cell Aging
Swine
Kidney
Mitochondrial Degradation

Non-infarct related artery microvascular obstruction is associated with worse persistent diastolic dysfunction in patients with revascularized ST elevation myocardial infarction

Corban, M. T., Khorramirouz, R., Yang, S. W., Lewis, B. R., Bois, J., Foley, T., Lerman, L. O., Oh, J. K. & Lerman, A., Jan 1 2019, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journalArticle

Coronary Vessels
Arteries
ST Elevation Myocardial Infarction
2 Citations (Scopus)

Noninvasive assessment of renal fibrosis by magnetic resonance imaging and ultrasound techniques

Jiang, K., Ferguson, C. M. & Lerman, L. O., Jul 1 2019, In : Translational Research. 209, p. 105-120 16 p.

Research output: Contribution to journalReview article

Magnetic resonance
Fibrosis
Ultrasonics
Magnetic Resonance Imaging
Kidney

Novel therapeutic strategies for renovascular disease

Eirin, A., Textor, S. C. & Lerman, L. O., Jul 1 2019, In : Current opinion in nephrology and hypertension. 28, 4, p. 383-389 7 p.

Research output: Contribution to journalArticle

Kidney
Therapeutics
Renal Artery
Inflammation
Protective Agents

Pain-induced peripheral artery tonometry scores in the control arm are impaired in patients with apical ballooning syndrome

Sun, T., Widmer, R. J., Matsuzawa, Y., Lennon, R. J., Park, K. H., Lerman, L. O. & Lerman, A., Jan 1 2019, In : Medicine. 98, 1, p. e13841

Research output: Contribution to journalArticle

Takotsubo Cardiomyopathy
Manometry
Arteries
Pain
Stroop Test
1 Citation (Scopus)

Renal Adiposity Does not Preclude Quantitative Assessment of Renal Function Using Dual-Energy Multidetector CT in Mildly Obese Human Subjects

Ferguson, C. M., Eirin, A., Michalak, G. J., Hedayat, F., Abumoawad, A. M., Hedayat, A. F., Zhu, X., Textor, S. C., McCollough, C. H. & Lerman, L. O., Jan 1 2019, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

Adiposity
Kidney
Multidetector Computed Tomography
Iodine
Aorta

Renal artery stenosis alters gene expression in swine scattered tubular-like cells

Nargesi, A. A., Zhu, X. Y., Liu, Y., Tang, H., Jordan, K. L., Lerman, L. O. & Eirin, A., Oct 2 2019, In : International journal of molecular sciences. 20, 20, 5069.

Research output: Contribution to journalArticle

Open Access
Renal Artery Obstruction
swine
gene expression
arteries
Gene expression
1 Citation (Scopus)

Renovascular disease induces mitochondrial damage in swine scattered tubular cells

Nargesi, A. A., Zhu, X. Y., Conley, S. M., Woollard, J. R., Saadiq, I. M., Lerman, L. O. & Eirin, A., Nov 1 2019, In : American journal of physiology. Renal physiology. 317, 5, p. F1142-F1153

Research output: Contribution to journalArticle

Mitochondrial Diseases
Swine
Renal Artery Obstruction
Kidney
Mitochondria

Reply

Chen, X. J., Zhang, X., Jiang, K., Krier, J. D., Zhu, X., Lerman, A. & Lerman, L. O., Nov 1 2019, In : Journal of hypertension. 37, 11, p. 2302-2303 2 p.

Research output: Contribution to journalLetter

Senescent Kidney Cells in Hypertensive Patients Release Urinary Extracellular Vesicles

Santelli, A., Sun, I. O., Eirin, A., Abumoawad, A. M., Woollard, J. R., Lerman, A., Textor, S. C., Puranik, A. S. & Lerman, L. O., Jun 4 2019, In : Journal of the American Heart Association. 8, 11, e012584.

Research output: Contribution to journalArticle

Open Access
Renovascular Hypertension
Kidney
Cell Aging
Healthy Volunteers
Uromodulin
4 Citations (Scopus)

Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease

Hickson, L. T. J., Langhi Prata, L. G. P., Bobart, S. A., Evans, T. K., Giorgadze, N., Hashmi, S. K., Herrmann, S. M., Jensen, M. D., Jia, Q., Jordan, K. L., Kellogg, T. A., Khosla, S., Koerber, D. M., Lagnado, A. B., Lawson, D. K., LeBrasseur, N. K., Lerman, L. O., McDonald, K. M., McKenzie, T. J., Passos, J. F. & 13 others, Pignolo, R. J., Pirtskhalava, T., Saadiq, I. M., Schaefer, K. K., Textor, S. C., Victorelli, S. G., Volkman, T. L., Xue, A., Wentworth, M. A., Wissler Gerdes, E. O., Zhu, Y., Tchkonia, T. & Kirkland, J. L., Sep 2019, In : EBioMedicine. 47, p. 446-456 11 p.

Research output: Contribution to journalArticle

Open Access
Quercetin
Diabetic Nephropathies
Clinical Trials
Macrophages
Tissue
Mesenchymal Stromal Cells
Chronic Renal Insufficiency
Comorbidity
Stem Cells
Kidney

Targeting senescence improves angiogenic potential of adipose-derived mesenchymal stem cells in patients with preeclampsia

Suvakov, S., Cubro, H., White, W. M., Butler Tobah, Y. S., Weissgerber, T. L., Jordan, K. L., Zhu, X. Y., Woollard, J. R., Chebib, F., Milic, N. M., Grande, J. P., Xu, M., Tchkonia, T., Kirkland, J. L., Lerman, L. O. & Garovic, V. D., Sep 14 2019, In : Biology of Sex Differences. 10, 1, 49.

Research output: Contribution to journalArticle

Open Access
Pre-Eclampsia
Mesenchymal Stromal Cells
pregnancy
proliferation
migration

The Role of Hypoxia in Ischemic Chronic Kidney Disease

Textor, S. C. & Lerman, L. O., Nov 2019, In : Seminars in Nephrology. 39, 6, p. 589-598 10 p.

Research output: Contribution to journalReview article

Chronic Renal Insufficiency
Kidney
Cytokines
Renal Circulation
Glomerular Filtration Rate
2 Citations (Scopus)

Tissue hypoxia, inflammation, and loss of glomerular filtration rate in human atherosclerotic renovascular disease

Abumoawad, A., Saad, A., Ferguson, C. M., Eirin, A., Woollard, J. R., Herrmann, S., Hickson, L., Bendel, E. C., Misra, S., Glockner, J., Lerman, L. O. & Textor, S. C., Apr 1 2019, In : Kidney international. 95, 4, p. 948-957 10 p.

Research output: Contribution to journalArticle

Renal Circulation
Glomerular Filtration Rate
Inflammation
Renal Veins
Chemokine CCL2
Open Access
Hydroxymethylglutaryl-CoA Reductase Inhibitors
HDL Lipoproteins
Triglycerides
Coronary Artery Disease
Cardiac Catheterization

Urinary microRNA in kidney disease: utility and roles

Sun, I. O. & Lerman, L. O., May 1 2019, In : American journal of physiology. Renal physiology. 316, 5, p. F785-F793

Research output: Contribution to journalArticle

Kidney Diseases
MicroRNAs
Kidney
Biomarkers
Urine
1 Citation (Scopus)
Mitochondrial DNA
Kidney
Wounds and Injuries
Renovascular Hypertension
Angioplasty
2018
2 Citations (Scopus)

Association of Search Engine Queries for Chest Pain with Coronary Heart Disease Epidemiology

Senecal, C., Widmer, R. J., Lerman, L. O. & Lerman, A., Jan 1 2018, (Accepted/In press) In : JAMA Cardiology.

Research output: Contribution to journalArticle

Search Engine
Chest Pain
Coronary Disease
Epidemiology
Hospitalization
7 Citations (Scopus)

Ccl2 deficiency protects against chronic renal injury in murine renovascular hypertension

Kashyap, S., Osman, M., Ferguson, C. M., Nath, M. C., Roy, B., Lien, K. R., Nath, K. A., Garovic, V. D., Lerman, L. O. & Grande, J. P., Dec 1 2018, In : Scientific Reports. 8, 1, 8598.

Research output: Contribution to journalArticle

Renovascular Hypertension
Knockout Mice
Kidney
Wounds and Injuries
Renal Artery Obstruction
3 Citations (Scopus)

Chronic inhibition of lipoprotein-associated phospholipase A2 does not improve coronary endothelial function: A prospective, randomized-controlled trial

Prasad, M., Lennon, R., Barsness, G. W., Prasad, A., Gulati, R., Lerman, L. O. & Lerman, A., Feb 15 2018, In : International Journal of Cardiology. 253, p. 7-13 7 p.

Research output: Contribution to journalArticle

1-Alkyl-2-acetylglycerophosphocholine Esterase
Randomized Controlled Trials
Placebos
Acetylcholine
Coronary Vessels
3 Citations (Scopus)

Clinical and Pathology Findings Associate Consistently with Larger Glomerular Volume

Denic, A., Mathew, J., Nagineni, V. V., Thompson, R. H., Leibovich, B. C., Lerman, L. O., Lieske, J. C., Alexander, M. P., Augustine, J. J., Kremers, W. K. & Rule, A. D., Jul 1 2018, In : Journal of the American Society of Nephrology. 29, 7, p. 1960-1969 10 p.

Research output: Contribution to journalArticle

Clinical Pathology
Kidney
Biopsy
Proteinuria
Comorbidity
1 Citation (Scopus)

Coronary Microvasculature: Are the Small and the Mighty Cross-Talking With the Epicardial Vessels?

Corban, M. T., Lerman, L. O. & Lerman, A., Oct 22 2018, In : JACC: Cardiovascular Interventions. 11, 20, p. 2069-2071 3 p.

Research output: Contribution to journalEditorial

Microvessels
1 Citation (Scopus)

Digital health intervention as an adjunct to a workplace health program in hypertension

Senecal, C., Widmer, R. J., Johnson, M. P., Lerman, L. O. & Lerman, A., Jan 1 2018, (Accepted/In press) In : Journal of the American Society of Hypertension.

Research output: Contribution to journalArticle

Workplace
Blood Pressure
Hypertension
Health
Body Mass Index
4 Citations (Scopus)

Emerging Paradigms in Chronic Kidney Ischemia

Eirin, A., Textor, S. C. & Lerman, L. O., Nov 1 2018, In : Hypertension (Dallas, Tex. : 1979). 72, 5, p. 1023-1030 8 p.

Research output: Contribution to journalArticle

Ischemia
Kidney

Enhancing Mitochondrial Health to Treat Hypertension

Eirin, A., Lerman, A. & Lerman, L. O., Oct 1 2018, In : Current Hypertension Reports. 20, 10, 89.

Research output: Contribution to journalReview article

Hypertension
Health
Mitochondria
Clinical Trials
Renal Hypertension
1 Citation (Scopus)

Experimental Metabolic Syndrome Model Associated with Mechanical and Structural Degenerative Changes of the Aortic Valve

Go, J. L., Prem, K., Al-Hijji, M. A., Qin, Q., Noble, C., Young, M. D., Lerman, L. O. & Lerman, A., Dec 1 2018, In : Scientific Reports. 8, 1, 17835.

Research output: Contribution to journalArticle

High Fat Diet
Aortic Valve
Collagen
1-Alkyl-2-acetylglycerophosphocholine Esterase
Blood Pressure