Lifeng Yu, PhD

  • 5547 Citations
  • 40 Scopus h-Index
20022019
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Research Output 2002 2019

  • 5547 Citations
  • 40 Scopus h-Index
  • 151 Article
  • 58 Conference contribution
  • 1 Letter
2019
2 Citations (Scopus)

A deep learning- and partial least square regression-based model observer for a low-contrast lesion detection task in CT

Gong, H., Yu, L., Leng, S., Dilger, S. K., Ren, L., Zhou, W., Fletcher, J. G. & McCollough, C. H., Jan 1 2019, In : Medical physics.

Research output: Contribution to journalArticle

Least-Squares Analysis
Learning
Noise
Liver
Radiation

Clinical assessment of metal artifact reduction methods in dual-energy CT examinations of instrumented spines

Long, Z., De Lone, D. R., Kotsenas, A. L., Lehman, V. T., Nagelschneider, A. A., Michalak, G. J., Fletcher, J. G., McCollough, C. H. & Yu, L., Feb 1 2019, In : American Journal of Roentgenology. 212, 2, p. 395-401 7 p.

Research output: Contribution to journalArticle

Artifacts
Spine
Metals
Bone and Bones

Computed Tomography Cholangiography Using the Magnetic Resonance Contrast Agent Gadoxetate Disodium: A Phantom Study

Dilger, S. K. N., Nelson, N., Venkatesh, S. K., Ehman, E., Fidler, J. L., Fletcher, J. G., McCollough, C. H. & Yu, L., Sep 1 2019, In : Investigative radiology. 54, 9, p. 572-579 8 p.

Research output: Contribution to journalArticle

Cholangiography
Contrast Media
Noise
Magnetic Resonance Spectroscopy
Tomography

Correlation between a deep-learning-based model observer and human observer for a realistic lung nodule localization task in chest CT

Gong, H., Walther, A., Hu, Q., Koo, C. W., Takahashi, E. A., Levin, D. L., Johnson, T. F., Hora, M. J., Leng, S., Fletcher, J. G., McCollough, C. H. & Yu, L., Jan 1 2019, Medical Imaging 2019: Image Perception, Observer Performance, and Technology Assessment. Nishikawa, R. M. & Samuelson, F. W. (eds.). SPIE, 109520K. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10952).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

chest
nodules
lungs
learning
Thorax

Impact of prior information on material decomposition in dual- and multienergy computed tomography

Ren, L., Tao, S., Rajendran, K., McCollough, C. H. & Yu, L., Jan 1 2019, In : Journal of Medical Imaging. 6, 1, 013503.

Research output: Contribution to journalArticle

Tomography
Iodine
Noise
Water
Gadolinium
1 Citation (Scopus)

Lead shielding in pediatric chest CT: Effect of apron placement outside the scan volume on radiation dose reduction

Yu, L., Bruesewitz, M. R., Vrieze, T. J. & McCollough, C. H., Jan 1 2019, In : American Journal of Roentgenology. 212, 1, p. 151-156 6 p.

Research output: Contribution to journalArticle

Thorax
Radiation
Pediatrics
Pelvis
Abdomen
1 Citation (Scopus)
Liver
Water
Noise
Computer-Assisted Image Processing
ROC Curve
Theoretical Models
Liver
Water
Task Performance and Analysis
ROC Curve

Material decomposition in photon-counting-detector CT: Threshold or bin images?

Ren, L., Tao, S., McCollough, C. H. & Yu, L., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109482S. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Bins
Least-Squares Analysis
Photons
counting
Detectors

Multi-energy CT with triple x-ray beams and photon-counting-detector CT for simultaneous imaging of two contrast agents: An experimental comparison

Ren, L., McCollough, C. H. & Yu, L., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109481B. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
Iodine
Contrast Media
counting
Bismuth
1 Citation (Scopus)

Simulation of CT images reconstructed with different kernels using a convolutional neural network and its implications for efficient CT workflow

Missert, A. D., Leng, S., McCollough, C. H., Fletcher, J. G. & Yu, L., Jan 1 2019, Medical Imaging 2019: Physics of Medical Imaging. Bosmans, H., Chen, G-H. & Schmidt, T. G. (eds.). SPIE, 109482Y. (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; vol. 10948).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Workflow
Tomography
tomography
X-Ray Computed Tomography Scanners
Neural networks

Technical Note: Increased photon starvation artifacts at low helical pitch in ultra-low-dose CT

Browne, J. E., Bruesewitz, M. R., Vrieze, T. J., McCollough, C. H. & Yu, L., Jan 1 2019, (Accepted/In press) In : Medical physics.

Research output: Contribution to journalArticle

Starvation
Photons
Artifacts
Delivery of Health Care
Noise
2018
1 Citation (Scopus)

Breathe New Life Into Your Chest CT Exams: Using Advanced Acquisition and Postprocessing Techniques

Weber, N. M., Koo, C. W., Yu, L., Bartholmai, B. J., Halaweish, A. F., McCollough, C. H. & Fletcher, J. G., Jan 1 2018, (Accepted/In press) In : Current Problems in Diagnostic Radiology.

Research output: Contribution to journalArticle

Thorax
Tomography
Artifacts
Lung Diseases
X-Rays

Correction to: Chest computed tomography angiography in children on extracorporeal membrane oxygenation (ECMO)

Hull, N. C., Schooler, G. R., Binkovitz, L. A., Williamson, E. E., Araoz, P. A., Yu, L. & Young, P. M., Jan 3 2018, (Accepted/In press) In : Pediatric Radiology. 1 p.

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
Emotions
Thorax
Computed Tomography Angiography
1 Citation (Scopus)

Correlation between model observers in uniform background and human observers in patient liver background for a low-contrast detection task in CT

Gong, H., Yu, L., Leng, S., DIlger, S., Zhou, W., Ren, L. & McCollough, C. H., Jan 1 2018, Medical Imaging 2018: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 10577. 105770M

Research output: Chapter in Book/Report/Conference proceedingConference contribution

liver
Liver
lesions
Computerized tomography
Image quality
6 Citations (Scopus)

Dual-source multienergy CT with triple or quadruple x-ray beams

Yu, L., Ren, L., Li, Z., Leng, S. & McCollough, C. H., Jul 1 2018, In : Journal of Medical Imaging. 5, 3, 033502.

Research output: Contribution to journalArticle

Photons
X-Rays
Contrast Media
Computer Simulation
Noise
5 Citations (Scopus)

Evaluation of cross-sectional and longitudinal changes in volumetric bone mineral density in postmenopausal women using single- versus dual-energy quantitative computed tomography

Sfeir, J. G., Drake, M. M., Atkinson, E. J., Achenbach, S. J., Camp, J. J., Tweed, A. J., McCready, L. K., Yu, L., Adkins, M. C., Amin, S. & Khosla, S., Jul 1 2018, In : Bone. 112, p. 145-152 8 p.

Research output: Contribution to journalArticle

Bone Density
Bone Marrow
Tomography
Fats
Bone and Bones
2 Citations (Scopus)

Evaluation of projection- and dual-energy-based methods for metal artifact reduction in CT using a phantom study

Long, Z., Bruesewitz, M. R., Delone, D. R., Morris, J. M., Amrami, K. K., Adkins, M. C., Glazebrook, K. N., Kofler, J. M., Leng, S., McCollough, C. H., Fletcher, J. G., Halaweish, A. F. & Yu, L., Jan 1 2018, (Accepted/In press) In : Journal of Applied Clinical Medical Physics.

Research output: Contribution to journalArticle

Artifacts
artifacts
projection
Metals
evaluation
3 Citations (Scopus)

Inter-laboratory comparison of channelized hotelling observer computation

Ba, A., Abbey, C. K., Baek, J., Han, M., Bouwman, R. W., Balta, C., Brankov, J., Massanes, F., Gifford, H. C., Hernandez-Giron, I., Veldkamp, W. J. H., Petrov, D., Marshall, N., Samuelson, F. W., Zeng, R., Solomon, J. B., Samei, E., Timberg, P., Förnvik, H., Reiser, I. & 3 others, Yu, L., Gong, H. & Bochud, F. O., Jul 1 2018, In : Medical Physics. 45, 7, p. 3019-3030 12 p.

Research output: Contribution to journalArticle

Uncertainty
Task Performance and Analysis
Diagnostic Imaging
Water

Motion-compensated reconstruction for limited-angle multiphase cardiac CT

Jin, M., Zhao, C., Jia, X. & Yu, L., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. Schmidt, T. G., Chen, G-H. & Lo, J. Y. (eds.). SPIE, Vol. 10573. 1057333

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Dosimetry
Motion estimation
Electrocardiography
Mean square error
Image quality
5 Citations (Scopus)

Observer performance with varying radiation dose and reconstruction methods for detection of hepatic metastases

Fletcher, J. G., Fidler, J. L., Venkatesh, S. K., Hough, D. M., Takahashi, N. M., Yu, L., Johnson, M., Leng, S., Holmes III, D. R., Carter, R. E. & McCollough, C. H., Nov 1 2018, In : Radiology. 289, 2, p. 455-464 10 p.

Research output: Contribution to journalArticle

Radiation
Neoplasm Metastasis
Liver
ROC Curve
Cone-Beam Computed Tomography
1 Citation (Scopus)

Simulating low-dose cone-beam CT: A phantom study

Ferrero, A., Fetterly, K., Yu, L. & Schueler, B. A., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. SPIE, Vol. 10573. 1057347

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Cone-Beam Computed Tomography
Cones
cones
dosage
Iodine
1 Citation (Scopus)

Three-material decomposition in multi-energy CT: Impact of prior information on noise and bias

Ren, L., McCollough, C. H. & Yu, L., Jan 1 2018, Medical Imaging 2018: Physics of Medical Imaging. SPIE, Vol. 10573. 105731G

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Noise
Decomposition
decomposition
Gadolinium
Photons
2017
10 Citations (Scopus)

An effective noise reduction method for multi-energy CT images that exploit spatio-spectral features

Li, Z., Leng, S., Yu, L., Manduca, A. & McCollough, C. H., May 1 2017, In : Medical Physics. 44, 5, p. 1610-1623 14 p.

Research output: Contribution to journalArticle

Noise
Cadaver
Radiology
Swine
Head
3 Citations (Scopus)

A virtual clinical trial using projection-based nodule insertion to determine radiologist reader performance in lung cancer screening CT

Yu, L., Hu, Q., Koo, C. W., Takahashi, E. A., Levin, D. L., Johnson, T., Hora, M. J., Dirks, S., Chen, B., McMillan, K., Leng, S., Fletcher, J. G. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101321R

Research output: Chapter in Book/Report/Conference proceedingConference contribution

nodules
readers
Early Detection of Cancer
lungs
insertion

Chest computed tomography angiography in children on extracorporeal membrane oxygenation (ECMO)

Hull, N. C., Schooler, G. R., Binkovitz, L. A., Williamson, E. E., Araoz, P. A., Yu, L. & Young, P. M., Dec 7 2017, (Accepted/In press) In : Pediatric Radiology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Extracorporeal Membrane Oxygenation
Thorax
Pediatrics
Anatomy
Communication
13 Citations (Scopus)

Correlation between a 2D channelized Hotelling observer and human observers in a low-contrast detection task with multislice reading in CT

Yu, L., Chen, B., Kofler, J. M., Favazza, C. P., Leng, S., Kupinski, M. A. & McCollough, C. H., Aug 1 2017, In : Medical Physics. 44, 8, p. 3990-3999 10 p.

Research output: Contribution to journalArticle

Reading
Confidence Intervals
Radiation
10 Citations (Scopus)

Estimating patient dose from CT exams that use automatic exposure control: Development and validation of methods to accurately estimate tube current values

Mcmillan, K., Bostani, M., Cagnon, C. H., Yu, L., Leng, S., McCollough, C. H. & Mcnitt-Gray, M. F., 2017, (Accepted/In press) In : Medical Physics.

Research output: Contribution to journalArticle

Pelvis
Abdomen
Thorax
Breast
Spleen

Evaluation of a projection-domain lung nodule insertion technique in thoracic computed tomography

Ma, C., Yu, L., Chen, B., Koo, C. W., Takahashi, E. A., Fletcher, J. G., Levin, D. L., Kuzo, R. S., Viers, L. D., Vincent-Sheldon, S. A., Leng, S. & McCollough, C. H., Jan 1 2017, In : Journal of Medical Imaging. 4, 1, 013510.

Research output: Contribution to journalArticle

Tomography
Thorax
Confidence Intervals
Lung
Image quality

Learning-based stochastic object models for use in optimizing imaging systems

Dolly, S. R., Anastasio, M. A., Yu, L. & Li, H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101321T

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Imaging systems
learning
Anatomy
Learning
Anatomic Models
6 Citations (Scopus)

Low-dose CT for craniosynostosis: Preserving diagnostic benefit with substantial radiation dose reduction

Montoya, J. C., Eckel, L. J., DeLone, D. R., Kotsenas, A. L., Diehn, F. E., Yu, L., Bartley, A. C., Carter, R. E., McCollough, C. H. & Fletcher, J. G., Apr 1 2017, In : American Journal of Neuroradiology. 38, 4, p. 672-677 6 p.

Research output: Contribution to journalArticle

Craniosynostoses
Radiation
Pediatrics
Sutures
Head
18 Citations (Scopus)

Low-dose CT for the detection and classification of metastatic liver lesions: Results of the 2016 Low Dose CT Grand Challenge

McCollough, C. H., Bartley, A. C., Carter, R. E., Chen, B., Drees, T. A., Edwards, P., Holmes III, D. R., Huang, A. E., Khan, F., Leng, S., McMillan, K. L., Michalak, G. J., Nunez, K. M., Yu, L. & Fletcher, J. G., Oct 1 2017, In : Medical Physics. 44, 10, p. e339-e352

Research output: Contribution to journalArticle

Liver
Neoplasm Metastasis
Noise
ROC Curve
Information Dissemination
5 Citations (Scopus)

Low kV versus dual-energy virtual monoenergetic CT imaging for proven liver lesions: what are the advantages and trade-offs in conspicuity and image quality? A pilot study

Hanson, G. J., Michalak, G. J., Childs, R., McCollough, B., Kurup, A. N., Hough, D. M., Frye, J. M., Fidler, J. L., Venkatesh, S. K., Leng, S., Yu, L., Halaweish, A. F., Harmsen, W. S., McCollough, C. H. & Fletcher, J. G., Oct 5 2017, (Accepted/In press) In : Abdominal Radiology. p. 1-9 9 p.

Research output: Contribution to journalArticle

Noise
Artifacts
Liver
Iodine
Radiologists
2 Citations (Scopus)

Practical implementation of channelized hotelling observers: Effect of ROI size

Ferrero, A., Favazza, C. P., Yu, L., Leng, S. & McCollough, C. H., 2017, Medical Imaging 2017: Physics of Medical Imaging. SPIE, Vol. 10132. 101320G

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Gabor filters
Diagnostic Imaging
Anatomy
Research Personnel
Image acquisition
3 Citations (Scopus)

Selection of optimal tube potential settings for dual-energy CT virtual mono-energetic imaging of iodine in the abdomen

Michalak, G., Grimes, J., Fletcher, J. G., Halaweish, A., Yu, L., Leng, S. & McCollough, C. H., Apr 1 2017, (Accepted/In press) In : Abdominal Radiology. p. 1-8 8 p.

Research output: Contribution to journalArticle

Photons
Iodine
Abdomen
Water
Information Systems
20 Citations (Scopus)

Spectral performance of a whole-body research photon counting detector CT: Quantitative accuracy in derived image sets

Leng, S., Zhou, W., Yu, Z., Halaweish, A., Krauss, B., Schmidt, B., Yu, L., Kappler, S. & McCollough, C. H., Aug 21 2017, In : Physics in Medicine and Biology. 62, 17, p. 7216-7232 17 p.

Research output: Contribution to journalArticle

Photons
Iodine
X-Ray Computed Tomography Scanners
Research
Tomography
1 Citation (Scopus)

Task-based image quality assessment in radiation therapy: Initial characterization and demonstration with CT simulation images

Dolly, S. R., Anastasio, M. A., Yu, L. & Li, H., 2017, Medical Imaging 2017: Image Perception, Observer Performance, and Technology Assessment. SPIE, Vol. 10136. 101360Y

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Radiotherapy
Image quality
radiation therapy
Demonstrations
simulation
1 Citation (Scopus)

Technical Note: Insertion of digital lesions in the projection domain for dual-source, dual-energy CT

Ferrero, A., Chen, B., Li, Z., Yu, L. & McCollough, C. H., May 1 2017, In : Medical Physics. 44, 5, p. 1655-1660 6 p.

Research output: Contribution to journalArticle

Kidney Calculi
X-Rays
Minerals
Calcium
Iodine
3 Citations (Scopus)
Pelvis
Abdomen
CT protocol
2016
4 Citations (Scopus)

An open library of CT patient projection data

Chen, B., Leng, S., Yu, L., Holmes III, D. R., Fletcher, J. G. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97831B

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Digital Imaging and Communications in Medicine (DICOM)
abdomen
chest
files
Abdomen
6 Citations (Scopus)

A robust noise reduction technique for time resolved CT

Li, Z., Yu, L., Leng, S., Williamson, E. E., Kotsenas, A. L., DeLone, D. R., Manduca, A. & McCollough, C. H., Jan 1 2016, In : Medical Physics. 43, 1, p. 347-359 13 p.

Research output: Contribution to journalArticle

Noise
Perfusion
Brain
Four-Dimensional Computed Tomography
16 Citations (Scopus)

Construction of realistic phantoms from patient images and a commercial three-dimensional printer

Leng, S., Chen, B., Vrieze, T., Kuhlmann, J., Yu, L., Alexander, A., Matsumoto, J., Morris, J. & McCollough, C. H., Jul 1 2016, In : Journal of Medical Imaging. 3, 3, 033501.

Research output: Contribution to journalArticle

Tomography
Liver
Printing
Cerebrospinal fluid
Cerebrospinal Fluid
9 Citations (Scopus)

Dealing with uncertainty in CT images

Fletcher, J. G., Leng, S., Yu, L. & McCollough, C. H., Apr 1 2016, In : Radiology. 279, 1, p. 5-10 6 p.

Research output: Contribution to journalArticle

X Ray Computed Tomography
Uncertainty
7 Citations (Scopus)

Dual-source multi-energy CT with triple or quadruple x-ray beams

Yu, L., Li, Z., Leng, S. & McCollough, C. H., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 978312

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Photons
X-Rays
Decomposition
X rays
Contrast Media
8 Citations (Scopus)

Estimation of Observer Performance for Reduced Radiation Dose Levels in CT. Eliminating Reduced Dose Levels That Are Too Low Is the First Step

Fletcher, J. G., Yu, L., Fidler, J. L., Levin, D. L., DeLone, D. R., Hough, D. M., Takahashi, N., Venkatesh, S. K., Sykes, A-M. G., White, D., Lindell, R. M., Kotsenas, A. L., Campeau, N. G., Lehman, V. T., Bartley, A. C., Leng, S., Holmes III, D. R., Toledano, A. Y., Carter, R. E. & McCollough, C. H., Aug 30 2016, (Accepted/In press) In : Academic Radiology.

Research output: Contribution to journalArticle

Tomography
Radiation
Head
ROC Curve
Thorax
3 Citations (Scopus)

Evaluation of a projection-domain lung nodule insertion technique in thoracic CT

Ma, C., Chen, B., Koo, C. W., Takahashi, E. A., Fletcher, J. G., McCollough, C. H., Levin, D. L., Kuzo, R. S., Viers, L. D., Vincent Sheldon, S. A., Leng, S. & Yu, L., 2016, Medical Imaging 2016: Physics of Medical Imaging. SPIE, Vol. 9783. 97835Y

Research output: Chapter in Book/Report/Conference proceedingConference contribution

nodules
lungs
lesions
Tomography
insertion
90 Citations (Scopus)

Evaluation of conventional imaging performance in a research whole-body CT system with a photon-counting detector array

Yu, Z., Leng, S., Jorgensen, S. M., Li, Z., Gutjahr, R., Chen, B., Halaweish, A. F., Kappler, S., Yu, L., Ritman, E. L. & McCollough, C. H., Feb 2 2016, In : Physics in Medicine and Biology. 61, 4, p. 1572-1595 24 p., 1572.

Research output: Contribution to journalArticle

Photons
Research
Noise
Whole-Body Counting
X-Rays
69 Citations (Scopus)

Human Imaging With Photon Counting–Based Computed Tomography at Clinical Dose Levels: Contrast-to-Noise Ratio and Cadaver Studies

Gutjahr, R., Halaweish, A. F., Yu, Z., Leng, S., Yu, L., Li, Z., Jorgensen, S. M., Ritman, E. L., Kappler, S. & McCollough, C. H., Jan 25 2016, (Accepted/In press) In : Investigative Radiology.

Research output: Contribution to journalArticle

Photons
Cadaver
Noise
Tomography
X-Ray Computed Tomography Scanners
8 Citations (Scopus)

Impact of number of repeated scans on model observer performance for a low-contrast detection task in computed tomography

Ma, C., Yu, L., Chen, B., Favazza, C., Leng, S. & McCollough, C. H., Apr 1 2016, In : Journal of Medical Imaging. 3, 2, 023504.

Research output: Contribution to journalArticle

Tomography
X-Ray Computed Tomography Scanners
ROC Curve
Research Design
Radiation