Liewei M Wang, MD, PhD

  • 6520 Citations
  • 41 Scopus h-Index
19992020

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2020

Acylcarnitine metabolomic profiles inform clinically-defined major depressive phenotypes

The Mood Disorders Precision Medicine Consortium (MDPMC), Mar 1 2020, In : Journal of Affective Disorders. 264, p. 90-97 8 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Alternating em algorithm for a bilinear model in isoform quantification from RNA-seq data

Deng, W., Mou, T., Kalari, K. R., Niu, N., Wang, L., Pawitan, Y. & Vu, T. N., Feb 1 2020, In : Bioinformatics. 36, 3, p. 805-812 8 p.

Research output: Contribution to journalArticle

Open Access

Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor

Ingle, J. N., Cairns, J., Suman, V. J., Shepherd, L. E., Fasching, P. A., Hoskin, T. L., Singh, R. J., Desta, Z., Kalari, K. R., Ellis, M. J., Goss, P. E., Chen, B. E., Volz, B., Barman, P., Carlson, E. E., Haddad, T., Goetz, M. P., Goodnature, B., Cuellar, M. E., Walters, M. A. & 4 others, Correia, C., Kaufmann, S. H., Weinshilboum, R. M. & Wang, L., Jun 15 2020, In : Clinical Cancer Research. 26, 12, p. 2986-2996 11 p.

Research output: Contribution to journalArticle

Open Access

A transcriptionally definable subgroup of triple-negative breast and ovarian cancer samples shows sensitivity to Hsp90 inhibition

Shee, K., Wells, J. D., Ung, M., Hampsch, R. A., Traphagen, N. A., Yang, W., Liu, S. C., Zeldenrust, M. A., Wang, L., Kalari, K. R., Yu, J., Boughey, J. C., Demidenko, E., Kettenbach, A. N., Cheng, C., Goetz, M. P. & Miller, T. W., Jan 1 2020, In : Clinical Cancer Research. 26, 1, p. 159-170 12 p.

Research output: Contribution to journalArticle

Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol)

Bielinski, S. J., St Sauver, J. L., Olson, J. E., Larson, N. B., Black, J. L., Scherer, S. E., Bernard, M. E., Boerwinkle, E., Borah, B. J., Caraballo, P. J., Curry, T. B., Doddapaneni, H. V., Formea, C. M., Freimuth, R. R., Gibbs, R. A., Giri, J., Hathcock, M. A., Hu, J., Jacobson, D. J., Jones, L. A. & 28 others, Kalla, S., Koep, T. H., Korchina, V., Kovar, C. L., Lee, S., Liu, H., Matey, E. T., McGree, M. E., McAllister, T. M., Moyer, A. M., Muzny, D. M., Nicholson, W. T., Oyen, L. J., Qin, X., Raj, R., Roger, V. L., Rohrer Vitek, C. R., Ross, J. L., Sharp, R. R., Takahashi, P. Y., Venner, E., Walker, K., Wang, L., Wang, Q., Wright, J. A., Wu, T. J., Wang, L. & Weinshilboum, R. M., Feb 1 2020, In : International journal of epidemiology. 49, 1, p. 23-24K

Research output: Contribution to journalArticle

5 Scopus citations
Open Access

CYP2C9 and CYP2C19: Deep Mutational Scanning and Functional Characterization of Genomic Missense Variants

Zhang, L., Sarangi, V., Moon, I., Yu, J., Liu, D., Devarajan, S., Reid, J. M., Kalari, K. R., Wang, L. & Weinshilboum, R., Jul 1 2020, In : Clinical and translational science. 13, 4, p. 727-742 16 p.

Research output: Contribution to journalArticle

Open Access

Different transcriptome profiles between human retinoblastoma Y79 cells and an etoposide-resistant subline reveal a chemoresistance mechanism

Song, W. P., Zheng, S., Yao, H. J., Zhou, X. F., Li, R., Zhang, C. Y., Zhao, J. Y., Wang, L. W., Shao, R. G. & Li, L., Mar 6 2020, In : BMC Ophthalmology. 20, 1, 92.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Knowledge-guided analysis of "omics" data using the KnowEnG cloud platform

Blatti, C., Emad, A., Berry, M. J., Gatzke, L., Epstein, M., Lanier, D., Rizal, P., Ge, J., Liao, X., Sobh, O., Lambert, M., Post, C. S., Xiao, J., Groves, P., Epstein, A. T., Chen, X., Srinivasan, S., Lehnert, E., Kalari, K. R., Wang, L. & 8 others, Weinshilboum, R. M., Song, J. S., Jongeneel, C. V., Han, J., Ravaioli, U., Sobh, N., Bushell, C. B. & Sinha, S., 2020, In : PLoS biology. 18, 1, e3000583.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Plasma cell-free DNA-based predictors of response to abiraterone acetate/prednisone and prognostic factors in metastatic castration-resistant prostate cancer

Du, M., Tian, Y., Tan, W., Wang, L., Wang, L., Kilari, D., Huang, C. C., Wang, L. & Kohli, M., Jan 1 2020, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases.

Research output: Contribution to journalArticle

1 Scopus citations

Regulation of sister chromatid cohesion by nuclear PD-L1

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Tu, X., Dong, H., Boughey, J. C., Goetz, M. P., Weinshilboum, R., Lou, Z. & Wang, L., 2020, (Accepted/In press) In : Cell Research.

Research output: Contribution to journalArticle

Open Access

STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation

Qin, B., Qin, B., Yu, J., Nowsheen, S., Nowsheen, S., Zhao, F., Wang, L. & Lou, Z., Jun 2020, In : Science Advances. 6, 23, EAAX8214.

Research output: Contribution to journalArticle

Open Access
2019
2 Scopus citations

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno-Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. & 1 others, Weinshilboum, R. M., Jul 2019, In : Clinical pharmacology and therapeutics. 106, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cell-level somatic mutation detection from single-cell RNA sequencing

Vu, T. N., Nguyen, H. N., Calza, S., Kalari, K. R., Wang, L., Pawitan, Y. & Berger, B., Nov 1 2019, In : Bioinformatics. 35, 22, p. 4679-4687 9 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Clopidogrel pharmacogenetics state-of-the-art review and the TAILOR-PCI study

Pereira, N. L., Rihal, C. S., So, D. Y. F., Rosenberg, Y., Lennon, R. J., Mathew, V., Goodman, S. G., Weinshilboum, R. M., Wang, L., Baudhuin, L. M., Lerman, A., Hasan, A., Iturriaga, E., Fu, Y. P., Geller, N., Bailey, K. & Farkouh, M. E., Apr 1 2019, In : Circulation: Cardiovascular Interventions. 12, 4

Research output: Contribution to journalArticle

11 Scopus citations

Comparison of 99mTc-sestamibi molecular breast imaging and breast MRI in patients with invasive breast cancer receiving neoadjuvant chemotherapy

Hunt, K. N., Conners, A. L., Goetz, M. P., O’Connor, M. K., Suman, V., Kalari, K., Weinshilboum, R., Wang, L., Carter, J., McLaughlin, S. A., Aspitia, A. M., Gray, R. J., Northfelt, D. & Boughey, J. C., Jan 1 2019, In : American Journal of Roentgenology. 213, 4, p. 932-943 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer

Ingle, J. N., Kalari, K. R., Momozawa, Y., Kubo, M., Furukawa, Y., Shepherd, L. E., Ellis, M. J., Goss, P. E., Barman, P., Carlson, E. E., Sinnwell, J. P., Tang, X., Goetz, M. P., Chen, B. E., Cairns, J., Weinshilboum, R. M. & Wang, L., Oct 1 2019, In : Pharmacogenetics and genomics. 29, 8, p. 183-191 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N. B., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Identification of pathways associated with chemosensitivity through network embedding

Wang, S., Huang, E., Cairns, J., Peng, J., Wang, L. & Sinha, S., Mar 2019, In : PLoS computational biology. 15, 3, e1006864.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients

Bhattacharyya, S., Ahmed, A. T., Arnold, M., Liu, D., Luo, C., Zhu, H., Mahmoudiandehkordi, S., Neavin, D., Louie, G., Dunlop, B. W., Frye, M. A., Wang, L., Weinshilboum, R. M., Krishnan, R. R., Rush, A. J. & Kaddurah-Daouk, R., Dec 1 2019, In : Translational psychiatry. 9, 1, 173.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations
4 Scopus citations

Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication

Athreya, A. P., Neavin, D., Carrillo-Roa, T., Skime, M., Biernacka, J., Frye, M. A., Rush, A. J., Wang, L., Binder, E. B., Iyer, R. K., Weinshilboum, R. M. & Bobo, W. V., Oct 1 2019, In : Clinical pharmacology and therapeutics. 106, 4, p. 855-865 11 p.

Research output: Contribution to journalArticle

14 Scopus citations
4 Scopus citations
Open Access
1 Scopus citations

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Jan 1 2019, (Accepted/In press) In : Journal of Neural Transmission.

Research output: Contribution to journalArticle

3 Scopus citations

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., Weinshilboum, R. M. & Wang, L. M., Apr 3 2019, In : Breast Cancer Research. 21, 1, 47.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
15 Scopus citations
2018

Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer

He, Y., Lu, J., Ye, Z., Hao, S., Wang, L., Kohli, M., Tindall, D. J., Li, B., Zhu, R., Wang, L. & Huang, H., Feb 28 2018, In : Nucleic acids research. 46, 4, p. 1895-1911 17 p.

Research output: Contribution to journalArticle

21 Scopus citations

Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Mar 6 2018, In : Frontiers in Psychiatry. 9, MAR, 65.

Research output: Contribution to journalArticle

8 Scopus citations

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

Athreya, A., Iyer, R., Neavin, D., Wang, L. M., Weinshilboum, R. M., Kaddurah-Daouk, R., Rush, J., Frye, M. A. & Bobo, W. V., Aug 1 2018, In : IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

Research output: Contribution to journalArticle

10 Scopus citations

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K. & 4 others, Wang, L. M., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 56.

Research output: Contribution to journalArticle

15 Scopus citations

BRCA1/2 Mutations and bevacizumab in the neoadjuvant treatment of breast cancer: Response and prognosis results in patients with triple-negative breast cancer From the geparquinto study

Fasching, P. A., Loibl, S., Hu, C., Hart, S. N., Shimelis, H., Moore, R., Schem, C., Tesch, H., Untch, M., Hilfrich, J., Rezai, M., Gerber, B., Costa, S. D., Blohmer, J. U., Fehm, T., Huober, J., Liedtke, C., Weinshilboum, R. M., Wang, L., Ingle, J. N. & 7 others, Müller, V., Nekljudova, V., Weber, K. E., Rack, B., Rübner, M., Von Minckwitz, G. & Couch, F. J., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2281-2287 7 p.

Research output: Contribution to journalArticle

30 Scopus citations

Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation

Cairns, J., Fridley, B. L., Jenkins, G. D., Zhuang, Y., Yu, J. & Wang, L., Mar 2018, In : EMBO Reports. 19, 3, e44767.

Research output: Contribution to journalArticle

6 Scopus citations

Discovery of a glucocorticoid receptor (gr) activity signature using selective gr antagonis in er-negative breast cancer

West, D. C., Kocherginsky, M., Tonsing-Carter, E. Y., Dolcen, D. N., Hosfield, D. J., Lastra, R. R., Sinnwell, J. P., Thompson, K. J., Bowie, K. R., Harkless, R. V., Skor, M. N., Pierce, C. F., Styke, S. C., Kim, C. R., De Wet, L., Greene, G. L., Boughey, J. C., Goetz, M. P., Kalari, K. R., Wang, L. & 3 others, Fleming, G. F., Gyorffy, B. & Conzen, S. D., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

10 Scopus citations

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A., McLaughlin, S. A., Moreno-Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

28 Scopus citations

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L. M., Wolmark, N. & Weinshilboum, R. M., Jan 1 2018, In : Pharmacogenetics and Genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isoform-level gene expression patterns in single-cell RNA-sequencing data

Vu, T. N., Wills, Q. F., Kalari, K. R., Niu, N., Wang, L. M., Pawitan, Y. & Rantalainen, M., Jan 1 2018, In : Bioinformatics. 34, 14, p. 2392-2400 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Ho, M. F., Correia, C., Ingle, J. N., Kaddurah-Daouk, R., Wang, L. M., Kaufmann, S. H. & Weinshilboum, R. M., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 279-292 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Machine learning helps identify new drug mechanisms in triple-negative breast cancer

Athreya, A. P., Gaglio, A. J., Cairns, J., Kalari, K. R., Weinshilboum, R. M., Wang, L., Kalbarczyk, Z. T. & Iyer, R. K., Jul 2018, In : IEEE Transactions on Nanobioscience. 17, 3, p. 251-259 9 p., 8401331.

Research output: Contribution to journalArticle

3 Scopus citations

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

The Mood Disorders Precision Medicine Consortium (MDPMC), Oct 1 2018, In : Journal of Affective Disorders. 238, p. 1-7 7 p.

Research output: Contribution to journalArticle

6 Scopus citations

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C., Schroeder, M., Tuma, A., Guicciardi, M. E., Zammataro, L., Gambino, M. W., Amato, A., Di Leonardo, A., McCubrey, J., Lange, C. A., Liu, M., Haddad, T., Goetz, M., Boughey, J., Sarkaria, J., Wang, L. & 3 others, Ingle, J. N., Galanis, E. & D'Assoro, A. B., Sep 4 2018, In : Breast Cancer Research. 20, 1, 105.

Research output: Contribution to journalArticle

12 Scopus citations

PANOPLY: Omics-guided drug prioritization method tailored to an individual patient

Kalari, K. R., Sinnwell, J. P., Thompson, K. J., Tang, X., Carlson, E. E., Yu, J., Vedell, P. T., Ingle, J. N., Weinshilboum, R. M., Boughey, J. C., Wang, L., Goetz, M. P. & Suman, V., Jan 1 2018, In : JCO Clinical Cancer Informatics. 2018, 2, p. 1-12 12 p.

Research output: Contribution to journalArticle

Pathway-based analysis of genome-wide association data identified SNPs in HMMR as biomarker for chemotherapy- induced neutropenia in breast cancer patients

Bidadi, B., Liu, D., Kalari, K. R., Rubner, M., Hein, A., Beckmann, M. W., Rack, B., Janni, W., Fasching, P. A., Weinshilboum, R. M. & Wang, L., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 158.

Research output: Contribution to journalArticle

5 Scopus citations

Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation

Hanson, C., Cairns, J., Wang, L. & Sinha, S., Aug 2018, In : Genome Research. 28, 8, p. 1207-1216 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Prognostic association of plasma cell-free DNA-based androgen receptor amplification and circulating tumor cells in pre-chemotherapy metastatic castration-resistant prostate cancer patients

Kohli, M., Li, J., Du, M., Hillman, D. W., Dehm, S. M., Tan, W., Carlson, R., Campion, M. B., Wang, L., Wang, L. M., Zhang, H., Zhang, P., Kilari, D., Huang, C. C. & Wang, L., Jun 1 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-8 8 p.

Research output: Contribution to journalArticle

8 Scopus citations
3 Scopus citations