Liewei M Wang, MD, PhD

  • 5624 Citations
  • 37 Scopus h-Index
19982021
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Research Output 1999 2019

2019
docetaxel
Estrogen Receptors
Single Nucleotide Polymorphism
Estrogens
Breast Neoplasms

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. M. & 1 others, Weinshilboum, R. M., Jan 1 2019, In : Clinical pharmacology and therapeutics.

Research output: Contribution to journalArticle

Open Access
Aromatase Inhibitors
Genome-Wide Association Study
Single Nucleotide Polymorphism
Pharmaceutical Preparations
Breast Neoplasms
2 Citations (Scopus)

Clopidogrel Pharmacogenetics

Pereira, N. L., Rihal, C., So, D. Y. F., Rosenberg, Y., Lennon, R. J., Mathew, V., Goodman, S. G., Weinshilboum, R. M., Wang, L. M., Baudhuin, L. M., Lerman, A., Hasan, A., Iturriaga, E., Fu, Y. P., Geller, N., Bailey, K. R. & Farkouh, M. E., Apr 1 2019, In : Circulation. Cardiovascular interventions. 12, 4, p. e007811

Research output: Contribution to journalArticle

clopidogrel
Pharmacogenetics
Percutaneous Coronary Intervention
Alleles
Drug Labeling

Corrigendum to “Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy” [Heliyon 4 (12) (December 2018) e01039] (Heliyon (2018) 4(12), (S2405844018323442), (10.1016/j.heliyon.2018.e01039))

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Mar 1 2019, In : Heliyon. 5, 3, e01309.

Research output: Contribution to journalComment/debate

Open Access
Drug Therapy
Neoplasms
corrigendum

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L. M., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. M. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Amenorrhea
Breast Neoplasms
Drug Therapy
Menstruation
Phosphopantothenoyl-cysteine decarboxylase

Identification of pathways associated with chemosensitivity through network embedding

Wang, S., Huang, E., Cairns, J., Peng, J., Wang, L. M. & Sinha, S., Mar 1 2019, In : PLoS computational biology. 15, 3, p. e1006864

Research output: Contribution to journalArticle

Open Access
Pathway
Genes
Gene
gene
genes

Pharmacogenomic next-generation DNA sequencing: Lessons from the identification and functional characterization of variants of unknown significance in CYP2C9 and CYP2C19

Devarajan, S., Moon, I., Ho, M. F., Larson, N., Neavin, D. R., Moyer, A. M., Black, J. L., Bielinski, S. J., Scherer, S. E., Wang, L. M., Weinshilboum, R. M. & Reid, J. M., Apr 1 2019, In : Drug Metabolism and Disposition. 47, 4, p. 425-435 11 p.

Research output: Contribution to journalArticle

Pharmacogenetics
DNA Sequence Analysis
Cytochrome P-450 Enzyme System
Oxidoreductases
Proteins
3 Citations (Scopus)
Citalopram
Major Depressive Disorder
Cytochrome P-450 CYP2D6
Treatment Failure
Pharmacokinetics
2 Citations (Scopus)

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Jan 1 2019, (Accepted/In press) In : Journal of Neural Transmission.

Research output: Contribution to journalArticle

Serotonin Uptake Inhibitors
Coronary Artery Disease
Obesity
Depression
Genes

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., Weinshilboum, R. M. & Wang, L. M., Apr 3 2019, In : Breast Cancer Research. 21, 1, 47.

Research output: Contribution to journalArticle

Open Access
Early Growth Response Protein 1
Lemur
Long Noncoding RNA
Aromatase Inhibitors
Protein-Tyrosine Kinases
2 Citations (Scopus)

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
ataxia
Ataxia Telangiectasia
Ligases
Histones
Chemical activation
2018
10 Citations (Scopus)

Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer

He, Y., Lu, J., Ye, Z., Hao, S., Wang, L. M., Kohli, M., Tindall, D. J., Li, B., Zhu, R., Wang, L. & Huang, H., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1895-1911 17 p.

Research output: Contribution to journalArticle

Androgen Receptors
Castration
Chromatin
Prostatic Neoplasms
Growth
2 Citations (Scopus)

Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Mar 6 2018, In : Frontiers in Psychiatry. 9, MAR, 65.

Research output: Contribution to journalArticle

Major Depressive Disorder
Serotonin Uptake Inhibitors
Personality
Genome-Wide Association Study
Meta-Analysis
2 Citations (Scopus)

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Radiotherapy
Exome
Homologous Recombination
Neoplasms
3 Citations (Scopus)

Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

Athreya, A., Iyer, R., Neavin, D., Wang, L. M., Weinshilboum, R. M., Kaddurah-Daouk, R., Rush, J., Frye, M. A. & Bobo, W. V., Aug 1 2018, In : IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

Research output: Contribution to journalArticle

Predictability
Augmentation
Disorder
Drugs
Metabolites
10 Citations (Scopus)

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K. & 4 others, Wang, L. M., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 56.

Research output: Contribution to journalArticle

beta-Defensins
Kynurenine
Aryl Hydrocarbon Receptors
Metabolomics
Major Depressive Disorder
19 Citations (Scopus)

BRCA1/2 Mutations and bevacizumab in the neoadjuvant treatment of breast cancer: Response and prognosis results in patients with triple-negative breast cancer From the geparquinto study

Fasching, P. A., Loibl, S., Hu, C., Hart, S., Shimelis, H., Moore, R., Schem, C., Tesch, H., Untch, M., Hilfrich, J., Rezai, M., Gerber, B., Costa, S. D., Blohmer, J. U., Fehm, T., Huober, J., Liedtke, C., Weinshilboum, R. M., Wang, L. M., Ingle, J. N. & 7 others, Müller, V., Nekljudova, V., Weber, K. E., Rack, B., Rübner, M., Von Minckwitz, G. & Couch, F. J., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2281-2287 7 p.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Neoadjuvant Therapy
Breast Neoplasms
Mutation
Disease-Free Survival
1 Citation (Scopus)

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure

Orlenko, A., Moore, J. H., Orzechowski, P., Olson, R. S., Cairns, J., Caraballo, P., Weinshilboum, R. M., Wang, L. M. & Breitenstein, M. K., Jan 1 2018, PACIFIC SYMPOSIUM ON BIOCOMPUTING 2018. 212669 ed. World Scientific Publishing Co. Pte Ltd, p. 460-471 12 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Learning systems
Plasmas
Metabolites
Feature extraction
Vitamins
1 Citation (Scopus)

Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation

Cairns, J., Fridley, B. L., Jenkins, G. D., Zhuang, Y., Yu, J. & Wang, L. M., Jan 1 2018, (Accepted/In press) In : EMBO Reports.

Research output: Contribution to journalArticle

Chemotherapy
Feedback
Drug Therapy
Neoplasms
Cells
5 Citations (Scopus)

Discovery of a glucocorticoid receptor (gr) activity signature using selective gr antagonis in er-negative breast cancer

West, D. C., Kocherginsky, M., Tonsing-Carter, E. Y., Dolcen, D. N., Hosfield, D. J., Lastra, R. R., Sinnwell, J. P., Thompson, K. J., Bowie, K. R., Harkless, R. V., Skor, M. N., Pierce, C. F., Styke, S. C., Kim, C. R., De Wet, L., Greene, G. L., Boughey, J. C., Goetz, M. P., Kalari, K. R., Wang, L. M. & 3 others, Fleming, G. F., Gyorffy, B. & Conzen, S. D., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

Glucocorticoid Receptors
Breast Neoplasms
Estrogen Receptors
Genes
Gene Expression
7 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L. M., Wolmark, N. & Weinshilboum, R. M., Jan 1 2018, In : Pharmacogenetics and Genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Single Nucleotide Polymorphism
Drug Therapy
Disease-Free Survival
Genome
Gene transfer
Horizontal Gene Transfer
Workflow
Sequencing
Work Flow
2 Citations (Scopus)

Isoform-level gene expression patterns in single-cell RNA-sequencing data

Vu, T. N., Wills, Q. F., Kalari, K. R., Niu, N., Wang, L. M., Pawitan, Y. & Rantalainen, M., Jan 1 2018, In : Bioinformatics. 34, 14, p. 2392-2400 9 p.

Research output: Contribution to journalArticle

RNA Sequence Analysis
RNA
Gene expression
Sequencing
Gene Expression
6 Citations (Scopus)

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Ho, M. F., Correia, C., Ingle, J. N., Kaddurah-Daouk, R., Wang, L. M., Kaufmann, S. H. & Weinshilboum, R. M., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 279-292 14 p.

Research output: Contribution to journalArticle

alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
AMPA Receptors
Glutamate Receptors
Ketamine
Metabolites
1 Citation (Scopus)

Machine Learning helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

Athreya, A. P., Gaglio, A. J., Cairns, J., Kalari, K. R., Weinshilboum, R. M., Wang, L. M., Kalbarczyk, Z. T. & Iyer, R. K., Jun 29 2018, (Accepted/In press) In : IEEE Transactions on Nanobioscience.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Learning systems
Genes
Metformin
Pharmaceutical Preparations
1 Citation (Scopus)

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

The Mood Disorders Precision Medicine Consortium (MDPMC), Oct 1 2018, In : Journal of Affective Disorders. 238, p. 1-7 7 p.

Research output: Contribution to journalArticle

Mood Disorders
Depression
Phenotype
Research
Anxiety
7 Citations (Scopus)

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C., Schroeder, M., Tuma, A., Guicciardi, M. E., Zammataro, L., Gambino, M. W., Amato, A., Di Leonardo, A., McCubrey, J., Lange, C. A., Liu, M. C., Haddad, T. C., Goetz, M. P., Boughey, J. C., Sarkaria, J. N., Wang, L. M. & 3 others, Ingle, J. N., Galanis, E. & D'Assoro, A., Sep 4 2018, In : Breast Cancer Research. 20, 1, 105.

Research output: Contribution to journalArticle

Triple Negative Breast Neoplasms
Breast Neoplasms
Neoplasm Metastasis
Neoplasms
Phenotype
2 Citations (Scopus)

Pathway-based analysis of genome-wide association data identified SNPs in HMMR as biomarker for chemotherapy- induced neutropenia in breast cancer patients

Bidadi, B., Liu, D., Kalari, K. R., Rubner, M., Hein, A., Beckmann, M. W., Rack, B., Janni, W., Fasching, P. A., Weinshilboum, R. M. & Wang, L. M., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 158.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Neutropenia
Single Nucleotide Polymorphism
Biomarkers
Breast Neoplasms
3 Citations (Scopus)

Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation

Hanson, C., Cairns, J., Wang, L. M. & Sinha, S., Aug 1 2018, In : Genome Research. 28, 8, p. 1207-1216 10 p.

Research output: Contribution to journalArticle

Regulator Genes
Transcription Factors
Quantitative Trait Loci
Phenotype
Gene Expression
3 Citations (Scopus)

Prognostic association of plasma cell-free DNA-based androgen receptor amplification and circulating tumor cells in pre-chemotherapy metastatic castration-resistant prostate cancer patients

Kohli, M., Li, J., Du, M., Hillman, D. W., Dehm, S. M., Tan, W., Carlson, R., Campion, M. B., Wang, L., Wang, L. M., Zhang, H., Zhang, P., Kilari, D., Huang, C. C. & Wang, L., Jun 1 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-8 8 p.

Research output: Contribution to journalArticle

Circulating Neoplastic Cells
Castration
Androgen Receptors
Plasma Cells
Prostatic Neoplasms
2 Citations (Scopus)
Aryl Hydrocarbon Receptors
Cytochrome P-450 CYP1A1
Response Elements
Xenobiotics
Single Nucleotide Polymorphism
2 Citations (Scopus)

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Orzechowski, A., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Dec 1 2018, In : Heliyon. 4, 12, e01039.

Research output: Contribution to journalArticle

Drug Therapy
Neoplasms
p38 Mitogen-Activated Protein Kinases
Clustered Regularly Interspaced Short Palindromic Repeats
B7 Antigens
1 Citation (Scopus)

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L. M., Li, H. & Weinshilboum, R. M., Jun 1 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journalArticle

T-Cell Leukemia
Single Nucleotide Polymorphism
Estrogens
Transcription Factors
RNA Sequence Analysis
4 Citations (Scopus)

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

Mitochondrial Form Creatine Kinase
Phosphocreatine
Tyrosine
Phosphorylation
Breast Neoplasms
2017
8 Citations (Scopus)

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N. D., Jeraldo, P. R., Walther-Antonio, M., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L. M., Weinshilboum, R. M., Boughey, J. C., Kocher, J-P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PLoS One. 12, 11, e0188873.

Research output: Contribution to journalArticle

Microbiota
Gene expression
breast neoplasms
Tumors
Breast Neoplasms
29 Citations (Scopus)

Androgen receptor variant AR-V9 is coexpressed with AR-V7 in prostate cancer metastases and predicts abiraterone resistance

Kohli, M., Ho, Y., Hillman, D. W., Van Etten, J. L., Henzler, C., Yang, R., Sperger, J. M., Li, Y., Tseng, E., Hon, T., Clark, T., Tan, W., Carlson, R. E., Wang, L., Sicotte, H., Ho, T. H., Jimenez, R. E., Huang, H., Vedell, P. T., Eckloff, B. W. & 9 others, Quevedo, J. F., Pitot, H. C., Costello, B., Jen, J., Wieben, E. D., Silverstein, K. A. T., Lang, J. M., Wang, L. M. & Dehm, S. M., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4704-4715 12 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Neoplasm Metastasis
Castration
abiraterone
8 Citations (Scopus)

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

Qin, S., Ingle, J. N., Liu, M., Yu, J., Wickerham, D. L., Kubo, M., Weinshilboum, R. M. & Wang, L. M., Aug 18 2017, In : Breast Cancer Research. 19, 1, 95.

Research output: Contribution to journalArticle

Selective Estrogen Receptor Modulators
Estrogen Receptor alpha
Calmodulin
Single Nucleotide Polymorphism
Estrogens
36 Citations (Scopus)

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L. M., Boughey, J. C. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature Communications. 8, 13923.

Research output: Contribution to journalArticle

metastasis
Tumors
breast
cancer
Chemical activation
2 Citations (Scopus)

Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity

Fasching, P. A., Häberle, L., Rack, B., Li, L., Hein, A., Ekici, A. B., Reis, A., Lux, M. P., Cunningham, J. M., Ruebner, M., Jenkins, G., Fridley, B., Schneeweiss, A., Tesch, H., Lichtenegger, W., Fehm, T., Heinrich, G., Rezai, M., Beckmann, M. W., Janni, W. & 2 others, Weinshilboum, R. M. & Wang, L. M., 2017, In : Oncotarget. 8, 44, p. 78133-78143 11 p.

Research output: Contribution to journalArticle

docetaxel
gemcitabine
Single Nucleotide Polymorphism
Drug Therapy
Epirubicin
1 Citation (Scopus)

Data-driven longitudinal modeling and prediction of symptom dynamics in major depressive disorder: Integrating factor graphs and learning methods

Athreya, A. P., Banerjee, S. S., Neavin, D., Kaddurah-Daouk, R., Rush, A. J., Frye, M. A., Wang, L. M., Weinshilboum, R. M., Bobo, W. V. & Iyer, R. K., Oct 4 2017, 2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2017. Institute of Electrical and Electronics Engineers Inc., 8058559

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Integrating Factor
Factor Graph
Major Depressive Disorder
Data-driven
Antidepressive Agents
15 Citations (Scopus)

Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes

Ho, T. H., Serie, D. J., Parasramka, M., Cheville, J. C., Bot, B. M., Tan, W., Wang, L. M., Joseph, R. W., Hilton, T., Leibovich, B. C., Parker, A. & Eckel-Passow, J. E., 2017, In : Annals of Oncology. 28, 3, p. 604-610 7 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
Renal Cell Carcinoma
Extracellular Matrix
Up-Regulation
Neoplasm Metastasis
10 Citations (Scopus)

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A. M., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

Heterografts
Breast Neoplasms
Biopsy
Drug Therapy
Neoplasms
4 Citations (Scopus)

Knowledge-guided gene prioritization reveals new insights into the mechanisms of chemoresistance

Emad, A., Cairns, J., Kalari, K. R., Wang, L. M. & Sinha, S., Aug 11 2017, In : Genome Biology. 18, 1, 153.

Research output: Contribution to journalArticle

prioritization
drug
gene
drugs
Genes

Methyltransferases

Lennard, L. & Wang, L. M., Dec 15 2017, Biotransformation. Elsevier Inc., Vol. 10-15. p. 497-516 20 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Methyltransferases
S-Adenosylmethionine
Enzymes
Methylation
Catalytic Domain
4 Citations (Scopus)

Model-based unsupervised learning informs metformininduced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

Athreya, A. P., Kalari, K. R., Cairns, J., Gaglio, A. J., Wills, Q. F., Niu, N., Weinshilboum, R. M., Iyer, R. K. & Wang, L. M., 2017, In : Oncotarget. 8, 16, p. 27199-27215 17 p.

Research output: Contribution to journalArticle

Cell Migration Inhibition
AMP-Activated Protein Kinases
Metformin
Learning
Breast Neoplasms
3 Citations (Scopus)

Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study

Wang, L. M., Ingle, J. & Weinshilboum, R. M., Jan 1 2017, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journalArticle

Genome-Wide Association Study
Pharmacogenetics
Breast Neoplasms
Clinical Pharmacology
Research
15 Citations (Scopus)

Pharmacogenomics: Precision Medicine and Drug Response

Weinshilboum, R. M. & Wang, L. M., Nov 1 2017, In : Mayo Clinic Proceedings. 92, 11, p. 1711-1722 12 p.

Research output: Contribution to journalReview article

Precision Medicine
Pharmacogenetics
Pharmaceutical Preparations
Electronic Health Records
Human Genome
50 Citations (Scopus)

Prostate cancer-Associated SPOP mutations confer resistance to BET inhibitors through stabilization of BRD4

Dai, X., Gan, W., Li, X., Wang, S., Zhang, W., Huang, L., Liu, S., Zhong, Q., Guo, J., Zhang, J., Chen, T., Shimizu, K., Beca, F., Blattner, M., Vasudevan, D., Buckley, D. L., Qi, J., Buser, L., Liu, P., Inuzuka, H. & 12 others, Beck, A. H., Wang, L. M., Wild, P. J., Garraway, L. A., Rubin, M. A., Barbieri, C. E., Wong, K. K., Muthuswamy, S. K., Huang, J., Chen, Y., Bradner, J. E. & Wei, W., Sep 1 2017, In : Nature Medicine. 23, 9, p. 1063-1071 9 p.

Research output: Contribution to journalArticle

Prostatic Neoplasms
Stabilization
Mutation
Proteins
Neoplasms
17 Citations (Scopus)

Regulation of Serine-Threonine Kinase Akt Activation by NAD+-Dependent Deacetylase SIRT7

Yu, J., Qin, B., Wu, F., Qin, S., Nowsheen, S., Shan, S., Zayas, J., Pei, H., Lou, Z. & Wang, L. M., Jan 31 2017, In : Cell Reports. 18, 5, p. 1229-1240 12 p.

Research output: Contribution to journalArticle

Protein-Serine-Threonine Kinases
NAD
Lysine
Cell Survival
Chemical activation