Liewei M Wang, MD, PhD

  • 6278 Citations
  • 40 Scopus h-Index
19982021

Research output per year

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Research Output

2019
1 Scopus citations

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

Dudenkov, T. M., Liu, D., Cairns, J., Devarajan, S., Zhuang, Y., Ingle, J. N., Buzdar, A. U., Robson, M. E., Kubo, M., Batzler, A., Barman, P., Jenkins, G. D., Carlson, E. E., Goetz, M. P., Northfelt, D. W., Moreno-Aspitia, A., Desta, Z., Reid, J. M., Kalari, K. R., Wang, L. & 1 others, Weinshilboum, R. M., Jul 2019, In : Clinical pharmacology and therapeutics. 106, 1, p. 219-227 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Cell-level somatic mutation detection from single-cell RNA sequencing

Vu, T. N., Nguyen, H. N., Calza, S., Kalari, K. R., Wang, L., Pawitan, Y. & Berger, B., Nov 1 2019, In : Bioinformatics. 35, 22, p. 4679-4687 9 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Clopidogrel pharmacogenetics state-of-the-art review and the TAILOR-PCI study

Pereira, N. L., Rihal, C. S., So, D. Y. F., Rosenberg, Y., Lennon, R. J., Mathew, V., Goodman, S. G., Weinshilboum, R. M., Wang, L., Baudhuin, L. M., Lerman, A., Hasan, A., Iturriaga, E., Fu, Y. P., Geller, N., Bailey, K. & Farkouh, M. E., Apr 1 2019, In : Circulation: Cardiovascular Interventions. 12, 4

Research output: Contribution to journalArticle

8 Scopus citations
2 Scopus citations

Corrigendum to “Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy” [Heliyon 4 (12) (December 2018) e01039] (Heliyon (2018) 4(12), (S2405844018323442), (10.1016/j.heliyon.2018.e01039))

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Mar 1 2019, In : Heliyon. 5, 3, e01309.

Research output: Contribution to journalComment/debate

Open Access

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer

Ingle, J. N., Kalari, K. R., Momozawa, Y., Kubo, M., Furukawa, Y., Shepherd, L. E., Ellis, M. J., Goss, P. E., Barman, P., Carlson, E. E., Sinnwell, J. P., Tang, X., Goetz, M. P., Chen, B. E., Cairns, J., Weinshilboum, R. M. & Wang, L., Oct 1 2019, In : Pharmacogenetics and genomics. 29, 8, p. 183-191 9 p.

Research output: Contribution to journalArticle

Genetic predictors of chemotherapy-related amenorrhea in women with breast cancer

Ruddy, K. J., Schaid, D. J., Partridge, A. H., Larson, N. B., Batzler, A., Häberle, L., Dittrich, R., Widschwendter, P., Fink, V., Bauer, E., Schwitulla, J., Rübner, M., Ekici, A. B., Aivazova-Fuchs, V., Stewart, E. A., Beckmann, M. W., Ginsburg, E., Wang, L., Weinshilboum, R. M., Couch, F. J. & 4 others, Janni, W., Rack, B., Vachon, C. & Fasching, P. A., Jan 1 2019, (Accepted/In press) In : Fertility and Sterility.

Research output: Contribution to journalArticle

Identification of pathways associated with chemosensitivity through network embedding

Wang, S., Huang, E., Cairns, J., Peng, J., Wang, L. M. & Sinha, S., Mar 1 2019, In : PLoS computational biology. 15, 3, p. e1006864

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Metabolomic signature of exposure and response to citalopram/escitalopram in depressed outpatients

Bhattacharyya, S., Ahmed, A. T., Arnold, M., Liu, D., Luo, C., Zhu, H., Mahmoudiandehkordi, S., Neavin, D., Louie, G., Dunlop, B. W., Frye, M. A., Wang, L., Weinshilboum, R. M., Krishnan, R. R., Rush, A. J. & Kaddurah-Daouk, R., Dec 1 2019, In : Translational psychiatry. 9, 1, 173.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
3 Scopus citations

Pharmacogenomics-Driven Prediction of Antidepressant Treatment Outcomes: A Machine-Learning Approach With Multi-trial Replication

Athreya, A. P., Neavin, D., Carrillo-Roa, T., Skime, M., Biernacka, J., Frye, M. A., Rush, A. J., Wang, L., Binder, E. B., Iyer, R. K., Weinshilboum, R. M. & Bobo, W. V., Oct 1 2019, In : Clinical pharmacology and therapeutics. 106, 4, p. 855-865 11 p.

Research output: Contribution to journalArticle

9 Scopus citations

Pharmacogenomics in Practice

Wang, L. & Weinshilboum, R., Nov 1 2019, In : Clinical pharmacology and therapeutics. 106, 5, p. 936-938 3 p.

Research output: Contribution to journalComment/debate

Open Access
1 Scopus citations
4 Scopus citations
Open Access

The association of obesity and coronary artery disease genes with response to SSRIs treatment in major depression

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Jan 1 2019, (Accepted/In press) In : Journal of Neural Transmission.

Research output: Contribution to journalArticle

3 Scopus citations

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Cairns, J., Ingle, J. N., Kalari, K. R., Shepherd, L. E., Kubo, M., Goetz, M. P., Weinshilboum, R. M. & Wang, L. M., Apr 3 2019, In : Breast Cancer Research. 21, 1, 47.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

UFL1 promotes histone H4 ufmylation and ATM activation

Qin, B., Yu, J., Nowsheen, S., Wang, M., Tu, X., Liu, T., Li, H., Wang, L. M. & Lou, Z., Dec 1 2019, In : Nature communications. 10, 1, 1242.

Research output: Contribution to journalArticle

Open Access
13 Scopus citations
2018

Androgen receptor splice variants bind to constitutively open chromatin and promote abiraterone-resistant growth of prostate cancer

He, Y., Lu, J., Ye, Z., Hao, S., Wang, L. M., Kohli, M., Tindall, D. J., Li, B., Zhu, R., Wang, L. & Huang, H., Feb 28 2018, In : Nucleic Acids Research. 46, 4, p. 1895-1911 17 p.

Research output: Contribution to journalArticle

18 Scopus citations

Association of the polygenic scores for personality traits and response to selective serotonin reuptake inhibitors in patients with major depressive disorder

Amare, A. T., Schubert, K. O., Tekola-Ayele, F., Hsu, Y. H., Sangkuhl, K., Jenkins, G., Whaley, R. M., Barman, P., Batzler, A., Altman, R. B., Arolt, V., Brockmöller, J., Chen, C. H., Domschke, K., Hall-Flavin, D. K., Hong, C. J., Illi, A., Ji, Y., Kampman, O., Kinoshita, T. & 17 others, Leinonen, E., Liou, Y. J., Mushiroda, T., Nonen, S., Skime, M. K., Wang, L. M., Kato, M., Liu, Y. L., Praphanphoj, V., Stingl, J. C., Bobo, W. V., Tsai, S. J., Kubo, M., Klein, T. E., Weinshilboum, R. M., Biernacka, J. M. & Baune, B. T., Mar 6 2018, In : Frontiers in Psychiatry. 9, MAR, 65.

Research output: Contribution to journalArticle

8 Scopus citations

ATR Inhibition Is a Promising Radiosensitizing Strategy for Triple-Negative Breast Cancer

Tu, X., Kahila, M. M., Zhou, Q., Yu, J., Kalari, K. R., Wang, L. M., Harmsen, W. S., Yuan, J., Boughey, J. C., Goetz, M. P., Sarkaria, J. N., Lou, Z. & Mutter, R., Nov 1 2018, In : Molecular Cancer Therapeutics. 17, 11, p. 2462-2472 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Augmentation of physician assessments with multi-omics enhances predictability of drug response: A case study of major depressive disorder

Athreya, A., Iyer, R., Neavin, D., Wang, L. M., Weinshilboum, R. M., Kaddurah-Daouk, R., Rush, J., Frye, M. A. & Bobo, W. V., Aug 1 2018, In : IEEE Computational Intelligence Magazine. 13, 3, p. 20-31 12 p., 8416980.

Research output: Contribution to journalArticle

6 Scopus citations

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: Metabolomics-informed genomics

Liu, D., Ray, B., Neavin, D. R., Zhang, J., Athreya, A. P., Biernacka, J. M., Bobo, W. V., Hall-Flavin, D. K., Skime, M. K., Zhu, H., Jenkins, G. D., Batzler, A., Kalari, K. R., Boakye-Agyeman, F., Matson, W. R., Bhasin, S. S., Mushiroda, T., Nakamura, Y., Kubo, M., Iyer, R. K. & 4 others, Wang, L. M., Frye, M. A., Kaddurah-Daouk, R. & Weinshilboum, R. M., Dec 1 2018, In : Translational Psychiatry. 8, 1, 56.

Research output: Contribution to journalArticle

12 Scopus citations

BRCA1/2 Mutations and bevacizumab in the neoadjuvant treatment of breast cancer: Response and prognosis results in patients with triple-negative breast cancer From the geparquinto study

Fasching, P. A., Loibl, S., Hu, C., Hart, S. N., Shimelis, H., Moore, R., Schem, C., Tesch, H., Untch, M., Hilfrich, J., Rezai, M., Gerber, B., Costa, S. D., Blohmer, J. U., Fehm, T., Huober, J., Liedtke, C., Weinshilboum, R. M., Wang, L., Ingle, J. N. & 7 others, Müller, V., Nekljudova, V., Weber, K. E., Rack, B., Rübner, M., Von Minckwitz, G. & Couch, F. J., Aug 1 2018, In : Journal of Clinical Oncology. 36, 22, p. 2281-2287 7 p.

Research output: Contribution to journalArticle

27 Scopus citations

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure

Orlenko, A., Moore, J. H., Orzechowski, P., Olson, R. S., Cairns, J., Caraballo, P., Weinshilboum, R. M., Wang, L. M. & Breitenstein, M. K., Jan 1 2018, PACIFIC SYMPOSIUM ON BIOCOMPUTING 2018. 212669 ed. World Scientific Publishing Co. Pte Ltd, p. 460-471 12 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Differential roles of ERRFI1 in EGFR and AKT pathway regulation affect cancer proliferation

Cairns, J., Fridley, B. L., Jenkins, G. D., Zhuang, Y., Yu, J. & Wang, L. M., Jan 1 2018, (Accepted/In press) In : EMBO Reports.

Research output: Contribution to journalArticle

4 Scopus citations

Discovery of a glucocorticoid receptor (gr) activity signature using selective gr antagonis in er-negative breast cancer

West, D. C., Kocherginsky, M., Tonsing-Carter, E. Y., Dolcen, D. N., Hosfield, D. J., Lastra, R. R., Sinnwell, J. P., Thompson, K. J., Bowie, K. R., Harkless, R. V., Skor, M. N., Pierce, C. F., Styke, S. C., Kim, C. R., De Wet, L., Greene, G. L., Boughey, J. C., Goetz, M. P., Kalari, K. R., Wang, L. & 3 others, Fleming, G. F., Gyorffy, B. & Conzen, S. D., Jul 15 2018, In : Clinical Cancer Research. 24, 14, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

9 Scopus citations

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

21 Scopus citations

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

Ingle, J. N., Kalari, K. R., Wickerham, D. L., Von Minckwitz, G., Fasching, P. A., Furukawa, Y., Mushiroda, T., Goetz, M. P., Barman, P., Carlson, E. E., Rastogi, P., Costantino, J. P., Cairns, J., Paik, S., Bear, H. D., Kubo, M., Wang, L. M., Wolmark, N. & Weinshilboum, R. M., Jan 1 2018, In : Pharmacogenetics and Genomics. 28, 6, p. 147-152 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Isoform-level gene expression patterns in single-cell RNA-sequencing data

Vu, T. N., Wills, Q. F., Kalari, K. R., Niu, N., Wang, L. M., Pawitan, Y. & Rantalainen, M., Jan 1 2018, In : Bioinformatics. 34, 14, p. 2392-2400 9 p.

Research output: Contribution to journalArticle

3 Scopus citations

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

Ho, M. F., Correia, C., Ingle, J. N., Kaddurah-Daouk, R., Wang, L. M., Kaufmann, S. H. & Weinshilboum, R. M., Jun 1 2018, In : Biochemical Pharmacology. 152, p. 279-292 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Machine Learning helps Identify New Drug Mechanisms in Triple-Negative Breast Cancer

Athreya, A. P., Gaglio, A. J., Cairns, J., Kalari, K. R., Weinshilboum, R. M., Wang, L. M., Kalbarczyk, Z. T. & Iyer, R. K., Jun 29 2018, (Accepted/In press) In : IEEE Transactions on Nanobioscience.

Research output: Contribution to journalArticle

3 Scopus citations

Mapping depression rating scale phenotypes onto research domain criteria (RDoC) to inform biological research in mood disorders

The Mood Disorders Precision Medicine Consortium (MDPMC), Oct 1 2018, In : Journal of Affective Disorders. 238, p. 1-7 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

NOTCH3 expression is linked to breast cancer seeding and distant metastasis

Leontovich, A. A., Jalalirad, M., Salisbury, J. L., Mills, L., Haddox, C., Schroeder, M., Tuma, A., Guicciardi, M. E., Zammataro, L., Gambino, M. W., Amato, A., Di Leonardo, A., McCubrey, J., Lange, C. A., Liu, M. C., Haddad, T. C., Goetz, M. P., Boughey, J. C., Sarkaria, J. N., Wang, L. M. & 3 others, Ingle, J. N., Galanis, E. & D'Assoro, A., Sep 4 2018, In : Breast Cancer Research. 20, 1, 105.

Research output: Contribution to journalArticle

12 Scopus citations

Pathway-based analysis of genome-wide association data identified SNPs in HMMR as biomarker for chemotherapy- induced neutropenia in breast cancer patients

Bidadi, B., Liu, D., Kalari, K. R., Rubner, M., Hein, A., Beckmann, M. W., Rack, B., Janni, W., Fasching, P. A., Weinshilboum, R. M. & Wang, L., Mar 13 2018, In : Frontiers in Pharmacology. 9, MAR, 158.

Research output: Contribution to journalArticle

5 Scopus citations

Principled multi-omic analysis reveals gene regulatory mechanisms of phenotype variation

Hanson, C., Cairns, J., Wang, L. M. & Sinha, S., Aug 1 2018, In : Genome Research. 28, 8, p. 1207-1216 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

Prognostic association of plasma cell-free DNA-based androgen receptor amplification and circulating tumor cells in pre-chemotherapy metastatic castration-resistant prostate cancer patients

Kohli, M., Li, J., Du, M., Hillman, D. W., Dehm, S. M., Tan, W., Carlson, R., Campion, M. B., Wang, L., Wang, L. M., Zhang, H., Zhang, P., Kilari, D., Huang, C. C. & Wang, L., Jun 1 2018, (Accepted/In press) In : Prostate Cancer and Prostatic Diseases. p. 1-8 8 p.

Research output: Contribution to journalArticle

6 Scopus citations
2 Scopus citations

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Orzechowski, A., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Dec 1 2018, In : Heliyon. 4, 12, e01039.

Research output: Contribution to journalArticle

3 Scopus citations

TCL1A, a novel transcription factor and a coregulator of nuclear factor kB p65: Single nucleotide polymorphism and estrogen dependences

Ho, M. F., Lummertz da Rocha, E., Zhang, C., Ingle, J. N., Goss, P. E., Shepherd, L. E., Kubo, M., Wang, L., Li, H. & Weinshilboum, R. M., Jun 2018, In : Journal of Pharmacology and Experimental Therapeutics. 365, 3, p. 700-710 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Tyrosine Phosphorylation of Mitochondrial Creatine Kinase 1 Enhances a Druggable Tumor Energy Shuttle Pathway

Kurmi, K., Hitosugi, S., Yu, J., Boakye-Agyeman, F., Wiese, E. K., Larson, T. R., Dai, Q., Machida, Y., Lou, Z., Wang, L. M., Boughey, J. C., Kaufmann, S. H., Goetz, M. P., Karnitz, L. M. & Hitosugi, T. D., Dec 4 2018, In : Cell Metabolism. 28, 6, p. 833-847.e8

Research output: Contribution to journalArticle

6 Scopus citations
2017

A comprehensive analysis of breast cancer microbiota and host gene expression

Thompson, K. J., Ingle, J. N., Tang, X., Chia, N. D., Jeraldo, P. R., Walther-Antonio, M., Kandimalla, K. K., Johnson, S., Yao, J. Z., Harrington, S. C., Suman, V. J., Wang, L. M., Weinshilboum, R. M., Boughey, J. C., Kocher, J-P., Nelson, H., Goetz, M. P. & Kalari, K. R., Nov 1 2017, In : PLoS One. 12, 11, e0188873.

Research output: Contribution to journalArticle

15 Scopus citations

Androgen receptor variant AR-V9 is coexpressed with AR-V7 in prostate cancer metastases and predicts abiraterone resistance

Kohli, M., Ho, Y., Hillman, D. W., Van Etten, J. L., Henzler, C., Yang, R., Sperger, J. M., Li, Y., Tseng, E., Hon, T., Clark, T., Tan, W., Carlson, R. E., Wang, L., Sicotte, H., Thai, H., Jimenez, R., Huang, H., Vedell, P. T., Eckloff, B. W. & 9 others, Quevedo, J. F., Pitot, H. C., Costello, B. A., Jen, J., Wieben, E. D., Silverstein, K. A. T., Lang, J. M., Wang, L. & Dehm, S. M., Aug 15 2017, In : Clinical Cancer Research. 23, 16, p. 4704-4715 12 p.

Research output: Contribution to journalArticle

49 Scopus citations

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

Qin, S., Ingle, J. N., Liu, M., Yu, J., Wickerham, D. L., Kubo, M., Weinshilboum, R. M. & Wang, L., Aug 18 2017, In : Breast Cancer Research. 19, 1, 95.

Research output: Contribution to journalArticle

10 Scopus citations

CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1

Liu, T., Yu, J., Deng, M., Yin, Y., Zhang, H., Luo, K., Qin, B., Li, Y., Wu, C., Ren, T., Han, Y., Yin, P., Kim, J. J., Lee, S. B., Lin, J., Zhang, L., Zhang, J., Nowsheen, S., Wang, L., Boughey, J. & 3 others, Goetz, M. P., Yuan, J. & Lou, Z., Jan 9 2017, In : Nature communications. 8, 13923.

Research output: Contribution to journalArticle

46 Scopus citations

Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity

Fasching, P. A., Häberle, L., Rack, B., Li, L., Hein, A., Ekici, A. B., Reis, A., Lux, M. P., Cunningham, J. M., Ruebner, M., Jenkins, G., Fridley, B., Schneeweiss, A., Tesch, H., Lichtenegger, W., Fehm, T., Heinrich, G., Rezai, M., Beckmann, M. W., Janni, W. & 2 others, Weinshilboum, R. M. & Wang, L., Jan 1 2017, In : Oncotarget. 8, 44, p. 78133-78143 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Data-driven longitudinal modeling and prediction of symptom dynamics in major depressive disorder: Integrating factor graphs and learning methods

Athreya, A. P., Banerjee, S. S., Neavin, D., Kaddurah-Daouk, R., Rush, A. J., Frye, M. A., Wang, L. M., Weinshilboum, R. M., Bobo, W. V. & Iyer, R. K., Oct 4 2017, 2017 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology, CIBCB 2017. Institute of Electrical and Electronics Engineers Inc., 8058559

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Differential gene expression profiling of matched primary renal cell carcinoma and metastases reveals upregulation of extracellular matrix genes

Ho, T. H., Serie, D. J., Parasramka, M., Cheville, J. C., Bot, B. M., Tan, W., Wang, L. M., Joseph, R. W., Hilton, T., Leibovich, B. C., Parker, A. & Eckel-Passow, J. E., 2017, In : Annals of Oncology. 28, 3, p. 604-610 7 p.

Research output: Contribution to journalArticle

23 Scopus citations