• 7502 Citations
  • 52 Scopus h-Index
19962020
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1996 2019

  • 7502 Citations
  • 52 Scopus h-Index
  • 128 Article
  • 17 Conference contribution
  • 5 Chapter
2019

Composite Hydrogel Embedded with Porous Microspheres for Long-Term pH-Sensitive Drug Delivery

Liu, X., Fundora, K. A., Zhou, Z., Miller, A. L. & Lu, L., Feb 1 2019, In : Tissue Engineering - Part A. 25, 3-4, p. 172-182 11 p.

Research output: Contribution to journalArticle

Hydrogel
Microspheres
Drug delivery
Hydrogels
Doxorubicin

Effect of Biomaterial Electrical Charge on Bone Morphogenetic Protein-2-Induced In Vivo Bone Formation

Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M., Tryfonidou, M. A., Yaszemski, M. J., Dhert, W. J. A. & Lu, L., Jul 1 2019, In : Tissue Engineering - Part A. 25, 13-14, p. 1037-1052 16 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Biocompatible Materials
Osteogenesis
Biomaterials
Bone

Injectable Catalyst-Free Poly(Propylene Fumarate) System Cross-Linked by Strain Promoted Alkyne-Azide Cycloaddition Click Chemistry for Spine Defect Filling

Liu, X., Miller, A. L., Xu, H., Waletzki, B. E. & Lu, L., Sep 9 2019, In : Biomacromolecules. 20, 9, p. 3352-3365 14 p.

Research output: Contribution to journalArticle

Fumarates
Alkynes
Azides
Cycloaddition
Propylene

Mechanical testing setups affect spine segment fracture outcomes

Rezaei, A., Giambini, H., Carlson, K. D., Xu, H., Uthamaraj, S., Dragomir Daescu, M. D., Yaszemski, M. J. & Lu, L., Dec 1 2019, In : Journal of the Mechanical Behavior of Biomedical Materials. 100, 103399.

Research output: Contribution to journalArticle

Mechanical testing
Testing
Hydrogel
Tissue engineering
Hydrogels
Polyethylene glycols
Calcium
2 Citations (Scopus)

Rapid conjugation of nanoparticles, proteins and siRNAs to microbubbles by strain-promoted click chemistry for ultrasound imaging and drug delivery

Liu, X., Gong, P., Song, P., Xie, F., Miller, A. L., Chen, S. D. & Lu, L., Feb 14 2019, In : Polymer Chemistry. 10, 6, p. 705-717 13 p.

Research output: Contribution to journalArticle

Click Chemistry
Microbubbles
Alkynes
Azides
Cycloaddition
1 Citation (Scopus)

The Osteoinductive Effect of Controlled Bone Morphogenic Protein 2 Release Is Location Dependent

Olthof, M. G. L., Lu, L., Tryfonidou, M. A., Loozen, L. D., Pouran, B., Yaszemski, M. J., Meij, B. P., Dhert, W. J. A., Alblas, J. & Kempen, D. H. R., Feb 1 2019, In : Tissue Engineering - Part A. 25, 3-4, p. 193-202 10 p.

Research output: Contribution to journalArticle

Bone
Proteins
Bone and Bones
Osteogenesis
Porifera
5 Citations (Scopus)

Two-Dimensional Black Phosphorus and Graphene Oxide Nanosheets Synergistically Enhance Cell Proliferation and Osteogenesis on 3D Printed Scaffolds

Liu, X., Miller, A. L., Park, S., George, M. N., Waletzki, B. E., Xu, H., Terzic, A. & Lu, L., Jan 1 2019, In : ACS Applied Materials and Interfaces.

Research output: Contribution to journalArticle

Graphite
Nanosheets
Cell proliferation
Scaffolds (biology)
Phosphorus
2018

Bone biology and engineering

Westendorf, J. J., Lu, L. & Yaszemski, M. J., Jan 1 2018, Orthopaedic Basic Science: Foundations of Clinical Practice, Fourth Edition. Wolters Kluwer Health, p. 281-293 13 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone and Bones
6 Citations (Scopus)

Bone morphogenetic protein-2 release profile modulates bone formation in phosphorylated hydrogel

Olthof, M. G. L., Kempen, D. H. R., Liu, X., Dadsetan, M., Tryfonidou, M. A., Yaszemski, M. J., Dhert, W. J. A. & Lu, L., Jan 1 2018, (Accepted/In press) In : Journal of Tissue Engineering and Regenerative Medicine.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Hydrogel
Osteogenesis
Hydrogels
Bone
3 Citations (Scopus)

Cross-linkable graphene oxide embedded nanocomposite hydrogel with enhanced mechanics and cytocompatibility for tissue engineering

Liu, X., Miller, A. L., Waletzki, B. E. & Lu, L., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

Graphite
Hydrogel
Tissue engineering
Hydrogels
Oxides
9 Citations (Scopus)

Effective nerve cell modulation by electrical stimulation of carbon nanotube embedded conductive polymeric scaffolds

Zhou, Z., Liu, X., Wu, W., Park, S., Miller, A. L., Terzic, A. & Lu, L., Sep 1 2018, In : Biomaterials Science. 6, 9, p. 2375-2385 11 p.

Research output: Contribution to journalArticle

Polycaprolactone
Carbon Nanotubes
Scaffolds (biology)
Neurons
Carbon nanotubes
8 Citations (Scopus)

Electrically conductive nanocomposite hydrogels embedded with functionalized carbon nanotubes for spinal cord injury

Liu, X., Kim, J. C., Miller, A. L., Waletzki, B. E. & Lu, L., Jan 1 2018, In : New Journal of Chemistry. 42, 21, p. 17671-17681 11 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Hydrogels
Polyethylene glycols
Carbon nanotubes
Nanocomposites
1 Citation (Scopus)

Endoscopic magnet placement into subadventitial tunnels for augmenting the lower esophageal sphincter using submucosal endoscopy: ex vivo and in vivo study in a porcine model (with video)

Dobashi, A., Wu, S. W., Deters, J. L., Miller, C. A., Knipschield, M. A., Cameron, G. P., Lu, L., Rajan, E. & Gostout, C. J., Jan 1 2018, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journalArticle

Lower Esophageal Sphincter
Magnets
Endoscopy
Swine
Endoscopes
6 Citations (Scopus)

Fast functionalization of ultrasound microbubbles using strain promoted click chemistry

Liu, X., Gong, P., Song, P., Xie, F., Miller, A. L., Chen, S. D. & Lu, L., Mar 1 2018, In : Biomaterials Science. 6, 3, p. 623-632 10 p.

Research output: Contribution to journalArticle

Azides
Cycloaddition
Ultrasonics
Ligands
Imaging techniques
1 Citation (Scopus)

In Vitro and In Vivo Correlation of Bone Morphogenetic Protein-2 Release Profiles from Complex Delivery Vehicles

Olthof, M. G. L., Tryfonidou, M. A., Dadsetan, M., Dhert, W. J. A., Yaszemski, M. J., Kempen, D. H. R. & Lu, L., Jul 1 2018, In : Tissue Engineering - Part C: Methods. 24, 7, p. 379-390 12 p.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Bone
Proteins
Bone Regeneration
Buffers
6 Citations (Scopus)

Phosphate Functional Groups Improve Oligo[(Polyethylene Glycol) Fumarate] Osteoconduction and BMP-2 Osteoinductive Efficacy

Olthof, M. G. L., Tryfonidou, M. A., Liu, X., Pouran, B., Meij, B. P., Dhert, W. J. A., Yaszemski, M. J., Lu, L., Alblas, J. & Kempen, D. H. R., May 1 2018, In : Tissue Engineering - Part A. 24, 9-10, p. 819-829 11 p.

Research output: Contribution to journalArticle

Fumarates
Bone Regeneration
Functional groups
Polyethylene glycols
Bone
4 Citations (Scopus)

Poly(Propylene Fumarate)-Hydroxyapatite Nanocomposite Can Be a Suitable Candidate for Cervical Cages

Teng, Y., Giambini, H., Rezaei, A., Liu, X., Miller, A. L., Waletzki, B. E. & Lu, L., Oct 1 2018, In : Journal of Biomechanical Engineering. 140, 10, 101009.

Research output: Contribution to journalArticle

Nanocomposites
Fumarates
Durapatite
Hydroxyapatite
Polypropylenes
17 Citations (Scopus)

Strengthening injectable thermo-sensitive NIPAAm-g-chitosan hydrogels using chemical cross-linking of disulfide bonds as scaffolds for tissue engineering

Wu, S. W., Liu, X., Miller, A. L., Cheng, Y. S., Yeh, M. L. & Lu, L., Jul 15 2018, In : Carbohydrate Polymers. 192, p. 308-316 9 p.

Research output: Contribution to journalArticle

Hydrogels
Chitosan
Scaffolds (biology)
Tissue engineering
Sulfhydryl Compounds
3 Citations (Scopus)

Strontium-substituted hydroxyapatite stimulates osteogenesis on poly(propylene fumarate) nanocomposite scaffolds

Li, J., Liu, X., Park, S., Miller, A. L., Terzic, A. & Lu, L., Jan 1 2018, (Accepted/In press) In : Journal of Biomedical Materials Research - Part A.

Research output: Contribution to journalArticle

Strontium
Durapatite
Hydroxyapatite
Scaffolds
Polypropylenes
1 Citation (Scopus)

The trabecular effect: A population-based longitudinal study on age and sex differences in bone mineral density and vertebral load bearing capacity

Oppenheimer-Velez, M. L., Giambini, H., Rezaei, A., Camp, J. J., Khosla, S. & Lu, L., Jun 1 2018, In : Clinical Biomechanics. 55, p. 73-78 6 p.

Research output: Contribution to journalArticle

Weight-Bearing
Sex Characteristics
Bone Density
Longitudinal Studies
Population
2 Citations (Scopus)

Three-dimensional porous poly(propylene fumarate)-co-poly(lactic-co-glycolic acid) scaffolds for tissue engineering

Wu, W., Liu, X., Zhou, Z., Miller, A. L. & Lu, L., Sep 1 2018, In : Journal of Biomedical Materials Research - Part A. 106, 9, p. 2507-2517 11 p.

Research output: Contribution to journalArticle

Scaffolds (biology)
Tissue engineering
Scaffolds
Polypropylenes
Acids
2017
3 Citations (Scopus)

A method to estimate cadaveric femur cortical strains during fracture testing using digital image correlation

Rossman, T., Uthamaraj, S., Rezaei, A., McEligot, S., Giambini, H., Jasiuk, I., Yaszemski, M. J., Lu, L. & Dragomir Daescu, M. D., Sep 14 2017, In : Journal of Visualized Experiments. 2017, 127, e54942.

Research output: Contribution to journalArticle

Fracture testing
Femur
Finite Element Analysis
Paint
Thigh
4 Citations (Scopus)

A New Vertebral Body Replacement Strategy Using Expandable Polymeric Cages

Liu, X., Paulsen, A., Giambini, H., Guo, J., Miller, A. L., Lin, P. C., Yaszemski, M. J. & Lu, L., Mar 1 2017, In : Tissue Engineering - Part A. 23, 5-6, p. 223-232 10 p.

Research output: Contribution to journalArticle

Hydrogel
Nerve Tissue
Fumarates
Biocompatible Materials
Operative Time
4 Citations (Scopus)

Are DXA/aBMD and QCT/FEA Stiffness and Strength Estimates Sensitive to Sex and Age?

Rezaei, A., Giambini, H., Rossman, T., Carlson, K. D., Yaszemski, M. J., Lu, L. & Dragomir Daescu, M. D., Sep 22 2017, (Accepted/In press) In : Annals of Biomedical Engineering. p. 1-10 10 p.

Research output: Contribution to journalArticle

Tomography
Bone
Minerals
Stiffness
Finite element method
8 Citations (Scopus)

Effect of different sustained bone morphogenetic protein-2 release kinetics on bone formation in poly(propylene fumarate) scaffolds

Olthof, M. G. L., Kempen, D. H. R., Herrick, J. L., Yaszemski, M. J., Dhert, W. J. A. & Lu, L., 2017, (Accepted/In press) In : Journal of Biomedical Materials Research - Part B Applied Biomaterials.

Research output: Contribution to journalArticle

Bone Morphogenetic Protein 2
Scaffolds (biology)
Scaffolds
Polypropylenes
Bone
36 Citations (Scopus)

Functionalized Carbon Nanotube and Graphene Oxide Embedded Electrically Conductive Hydrogel Synergistically Stimulates Nerve Cell Differentiation

Liu, X., Miller, A. L., Park, S., Waletzki, B. E., Zhou, Z., Terzic, A. & Lu, L., May 3 2017, In : ACS Applied Materials and Interfaces. 9, 17, p. 14677-14690 14 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Graphite
Hydrogel
Hydrogels
Oxides
3 Citations (Scopus)

Method and Instrumented Fixture for Femoral Fracture Testing in a Sideways Fall-on-the-Hip Position

Dragomir Daescu, M. D., Rezaei, A., Rossman, T., Uthamaraj, S., Entwistle, R., McEligot, S., Lambert, V., Giambini, H., Jasiuk, I., Yaszemski, M. J. & Lu, L., Aug 17 2017, In : Journal of visualized experiments : JoVE. 126

Research output: Contribution to journalArticle

Fracture testing
Femoral Fractures
Femur
Hip
Bone
9 Citations (Scopus)

Novel porous poly(propylene fumarate-co-caprolactone) scaffolds fabricated by thermally induced phase separation

Guo, J., Liu, X., Lee Miller, A., Waletzki, B. E., Yaszemski, M. J. & Lu, L., Jan 1 2017, In : Journal of Biomedical Materials Research - Part A. 105, 1, p. 226-235 10 p.

Research output: Contribution to journalArticle

Scaffolds
Phase separation
Polypropylenes
Fumarates
Propylene
4 Citations (Scopus)

Proximal cadaveric femur preparation for fracture strength testing and quantitative CT-based finite element analysis

Dragomir Daescu, M. D., Rezaei, A., Uthamaraj, S., Rossman, T., Bronk, J. T., Bolander, M., Lambert, V., McEligot, S., Entwistle, R., Giambini, H., Jasiuk, I., Yaszemski, M. J. & Lu, L., Mar 11 2017, In : Journal of Visualized Experiments. 2017, 121, e54925.

Research output: Contribution to journalArticle

Finite Element Analysis
Femur
Fracture toughness
Bone
Finite element method
2016

Animal models for evaluation of tissue-engineered orthopedic implants

Lu, L., Jabbari, E., Moore, M. J. & Yaszemski, M. J., Apr 19 2016, Tissue Engineering and Artificial Organs. CRC Press, p. 689-698 10 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Orthopedics
Animals
Tissue

Bone Disorders

Zang, J., Lu, L. & Yaszemski, M. J., Nov 21 2016, Materials and Devices for Bone Disorders. Elsevier Inc., p. 83-118 36 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Bone
Calcium
Bearings (structural)
Tendons
Muscle
22 Citations (Scopus)

Covalent crosslinking of graphene oxide and carbon nanotube into hydrogels enhances nerve cell responses

Liu, X., Miller, A. L., Park, S., Waletzki, B. E., Terzic, A., Yaszemski, M. J. & Lu, L., 2016, In : Journal of Materials Chemistry B. 4, 43, p. 6930-6941 12 p.

Research output: Contribution to journalArticle

Carbon Nanotubes
Hydrogels
Graphite
Hydrogel
Crosslinking
15 Citations (Scopus)

Expansile crosslinked polymersomes for pH sensitive delivery of doxorubicin

Liu, X., Yaszemski, M. J. & Lu, L., Feb 1 2016, In : Biomaterials Science. 4, 2, p. 245-249 5 p.

Research output: Contribution to journalArticle

Doxorubicin
Swelling
Drug delivery
Hydrolysis
Polymers
6 Citations (Scopus)

Noninvasive Failure Load Prediction of Vertebrae with Simulated Lytic Defects and Biomaterial Augmentation

Giambini, H., Fang, Z., Zeng, H., Camp, J. J., Yaszemski, M. J. & Lu, L., Aug 1 2016, In : Tissue Engineering - Part C: Methods. 22, 8, p. 717-724 8 p.

Research output: Contribution to journalArticle

Biocompatible Materials
Biomaterials
Spine
Defects
Tomography
20 Citations (Scopus)

Poly(ϵ-caprolactone) Dendrimer Cross-Linked via Metal-Free Click Chemistry: Injectable Hydrophobic Platform for Tissue Engineering

Liu, X., Miller, A. L., Fundora, K. A., Yaszemski, M. J. & Lu, L., Nov 15 2016, In : ACS Macro Letters. 5, 11, p. 1261-1265 5 p.

Research output: Contribution to journalArticle

Dendrimers
Azides
Tissue engineering
Polymers
Metals
2015
19 Citations (Scopus)
rhodamine B
Fluorescent Dyes
Folic Acid
Polyethylene glycols
Polypropylenes
38 Citations (Scopus)

Effect of calcium phosphate coating and rhBMP-2 on bone regeneration in rabbit calvaria using poly(propylene fumarate) scaffolds

Dadsetan, M., Guda, T., Runge, M. B., Mijares, D., Legeros, R. Z., Legeros, J. P., Silliman, D. T., Lu, L., Wenke, J. C., Brown Baer, P. R. & Yaszemski, M. J., May 1 2015, In : Acta Biomaterialia. 18, p. 9-20 12 p.

Research output: Contribution to journalArticle

Phosphate coatings
Bone Regeneration
Calcium phosphate
Skull
Scaffolds
8 Citations (Scopus)

Hydrolysable core crosslinked particles for receptor-mediated pH-sensitive anticancer drug delivery

Liu, X., Lee Miller, A., Waletzki, B. E., Mamo, T. K., Yaszemski, M. J. & Lu, L., Sep 3 2015, In : New Journal of Chemistry. 39, 11, p. 8840-8847 8 p.

Research output: Contribution to journalArticle

Micelles
Drug delivery
Folic Acid
Polyethylene glycols
Ligands
27 Citations (Scopus)

Molecularly engineered biodegradable polymer networks with a wide range of stiffness for bone and peripheral nerve regeneration

Wang, S., Kempen, D. H. R., De Ruiter, G. C. W., Cai, L., Spinner, R. J., Windebank, A. J., Yaszemski, M. J. & Lu, L., May 13 2015, In : Advanced Functional Materials. 25, 18, p. 2715-2724 10 p.

Research output: Contribution to journalArticle

Polycaprolactone
Biodegradable polymers
nerves
regeneration
Fumarates
20 Citations (Scopus)

Nanocomposite bone scaffolds based on biodegradable polymers and hydroxyapatite

Becker, J., Lu, L., Runge, M. B., Zeng, H., Yaszemski, M. J. & Dadsetan, M., Aug 1 2015, In : Journal of Biomedical Materials Research - Part A. 103, 8, p. 2549-2557 9 p.

Research output: Contribution to journalArticle

Biodegradable polymers
Durapatite
Scaffolds (biology)
Hydroxyapatite
Nanocomposites
24 Citations (Scopus)

Novel biodegradable poly(propylene fumarate)-co-poly(l-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications

Liu, X., Miller, A. L., Waletzki, B. E., Yaszemski, M. J. & Lu, L., 2015, In : RSC Advances. 5, 27, p. 21301-21309 9 p.

Research output: Contribution to journalArticle

Lactic acid
Scaffolds (biology)
Tissue engineering
Scaffolds
Phase separation
13 Citations (Scopus)

Tissue Engineered Constructs: Perspectives on Clinical Translation

Lu, L., Arbit, H. M., Herrick, J. L., Segovis, S. G., Maran, A. & Yaszemski, M. J., Mar 1 2015, In : Annals of Biomedical Engineering. 43, 3, p. 796-804 9 p.

Research output: Contribution to journalArticle

Tissue
Animals
Industry
20 Citations (Scopus)

Tunable tissue scaffolds fabricated by in situ crosslink in phase separation system

Liu, X., Chen, W., Gustafson, C. T., Miller, A. L., Waletzki, B. E., Yaszemski, M. J. & Lu, L., 2015, In : RSC Advances. 5, 122, p. 100824-100833 10 p.

Research output: Contribution to journalArticle

Tissue Scaffolds
Scaffolds
Phase separation
Polymers
Tissue regeneration
2014
14 Citations (Scopus)

Biomechanical evaluation of an injectable and biodegradable copolymer P(PF-co-CL) in a cadaveric vertebral body defect model

Fang, Z., Giambini, H., Zeng, H., Camp, J. J., Dadsetan, M., Robb, R. A., An, K. N., Yaszemski, M. J. & Lu, L., Mar 1 2014, In : Tissue Engineering - Part A. 20, 5-6, p. 1096-1102 7 p.

Research output: Contribution to journalArticle

Fumarates
Polymethyl Methacrylate
Propylene
Spine
Copolymers
22 Citations (Scopus)

Specimen-specific nonlinear finite element modeling to predict vertebrae fracture loads after vertebroplasty

Matsuura, Y., Giambini, H., Ogawa, Y., Fang, Z., Thoreson, A. R., Yaszemski, M. J., Lu, L. & An, K. N., Oct 15 2014, In : Spine. 39, 22, p. E1291-E1296

Research output: Contribution to journalArticle

Vertebroplasty
Polymethyl Methacrylate
Spine
Tomography
Polymers
2013
52 Citations (Scopus)

Controlled release of doxorubicin from pH-responsive microgels

Dadsetan, M., Taylor, K. E., Yong, C., Bajzer, Ž., Lu, L. & Yaszemski, M. J., Mar 2013, In : Acta Biomaterialia. 9, 3, p. 5438-5446 9 p.

Research output: Contribution to journalArticle

Doxorubicin
Sodium
Ionic strength
Drug delivery
Tumors
2 Citations (Scopus)

Correction to Potential therapeutic application of gold nanoparticles in B-chronic lymphocytic leukemia (BCLL): Enhancing apoptosis [J Nanobiotechnol 5 (2007) 4]

Mukherjee, P., Bhattacharya, R., Bone, N., Lee, Y. K., Patra, C. R., Wang, S., Lu, L., Secreto, C., Banerjee, P. C., Yaszemski, M. J., Kay, N. E. & Mukhopadhyay, D., Jul 1 2013, In : Journal of Nanobiotechnology. 11, 1, 23.

Research output: Contribution to journalArticle

Gold
Apoptosis
Nanoparticles
8 Citations (Scopus)

Hydrogel-PLGA delivery system prolongs 2-methoxyestradiol-mediated anti-tumor effects in osteosarcoma cells

Maran, A., Dadsetan, M., Buenz, C. M., Shogren, K. L., Lu, L. & Yaszemski, M. J., Sep 2013, In : Journal of Biomedical Materials Research - Part A. 101 A, 9, p. 2491-2499 9 p.

Research output: Contribution to journalArticle

Hydrogel
Hydrogels
Tumors
Acids
Composite materials
2012

Fracture risk assessment: Improved evaluation of vertebral integrity among metastatic cancer patients to aid in surgical decision-making

Augustine, K. E., Camp, J. J., Holmes III, D. R., Huddleston, P. M., Lu, L., Yaszemski, M. J., Robb, R. A. & Clinic, M., 2012, Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 8317. 83171A

Research output: Chapter in Book/Report/Conference proceedingConference contribution

risk assessment
decision making
spine
Risk assessment
integrity