Lewis Rowland Roberts, MB, ChB, PhD

  • 17074 Citations
  • 71 Scopus h-Index
1991 …2020
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Research Output 1991 2019

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1991
7 Citations (Scopus)

Molecular cloning of cDNA for the Bβ subunit of Xenopus fibrinogen, the product of a coordinately-regulated gene family

Bhattacharya, A., Shepard, A. R., Moser, D. R., Roberts, L. R. & Holland, L., 1991, In : Molecular and Cellular Endocrinology. 75, 2, p. 111-121 11 p.

Research output: Contribution to journalArticle

Cloning
Molecular Cloning
Xenopus
Fibrinogen
Complementary DNA
1992
19 Citations (Scopus)

A major estrogen-regulated protein secreted from the liver of xenopus Laevis is a member of the serpin superfamily: Nucleotide sequence of cDNA and hormonal Induction of mRNA

Holland, L. J., Suksang, C., Wall, A. A., Roberts, L. R., Moser, D. R. & Bhattacharya, A., Apr 5 1992, In : Journal of Biological Chemistry. 267, 10, p. 7053-7059 7 p.

Research output: Contribution to journalArticle

Serpins
Xenopus laevis
Liver
Nucleotides
Complementary DNA
1993
12 Citations (Scopus)
Xenopus laevis
Fibrinogen
Glucocorticoids
Liver
Genes
12 Citations (Scopus)
Hepatocyte Nuclear Factor 1
Xenopus laevis
Liver
Fibrinogen
Glucocorticoids
1995
3 Citations (Scopus)

cDNA and amino-acid sequences and organization of the gene encoding the Bβ subunit of fibrinogen from Xenopus laevis

Roberts, L. R., Nichols, L. A. & Holland, L., 1995, In : Gene. 160, 2, p. 223-228 6 p.

Research output: Contribution to journalArticle

Xenopus laevis
Fibrinogen
Amino Acid Sequence
Complementary DNA
Genes
1996
32 Citations (Scopus)

Ascites and hepatorenal syndrome: Pathophysiology and management

Roberts, L. R. & Kamath, P. S., 1996, In : Mayo Clinic Proceedings. 71, 9, p. 874-881 8 p.

Research output: Contribution to journalArticle

Hepatorenal Syndrome
Ascites
Diuretics
Liver Transplantation
Fibrosis
43 Citations (Scopus)

MELAS- and Kearns-Sayre-type commutation with myopathy and autoimmune polyendocrinopathy

Ohno, K., Yamamoto, M., Engel, A. G., Harper, C. M., Roberts, L. R., Tan, G. H. & Fatourechi, V., Jun 1996, In : Annals of Neurology. 39, 6, p. 761-766 6 p.

Research output: Contribution to journalArticle

Autoimmune Polyendocrinopathies
Lactic Acidosis
Brain Diseases
Muscular Diseases
Mitochondrial DNA
38 Citations (Scopus)

Pathophysiology and treatment of variceal hemorrhage

Roberts, L. R. & Kamath, P. S., 1996, In : Mayo Clinic Proceedings. 71, 10, p. 973-983 11 p.

Research output: Contribution to journalArticle

Varicose Veins
Hemorrhage
Transjugular Intrahepatic Portasystemic Shunt
Portal Pressure
Octreotide
1997
153 Citations (Scopus)

Cathepsin B contributes to bile salt-induced apoptosis of rat hepatocytes

Roberts, L. R., Kurosawa, H., Bronk, S. F., Fesmier, P. J., Agellon, L. B., Leung W.-, Y., Mao, F. & Gores, G. J., 1997, In : Gastroenterology. 113, 5, p. 1714-1726 13 p.

Research output: Contribution to journalArticle

Cathepsin B
Bile Acids and Salts
Hepatocytes
Apoptosis
Glycochenodeoxycholic Acid
84 Citations (Scopus)

Hepatocytes in the bile duct-ligated rat express Bcl-2

Kurosawa, H., Que, F., Roberts, L. R., Fesmier, P. J. & Gores, G. J., Jun 1997, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 272, 6 35-6

Research output: Contribution to journalArticle

Bile Ducts
Hepatocytes
Cholestasis
Apoptosis
Bile
2 Citations (Scopus)

Serum-ascitic fluid albumin gradient, portal hypertension, and ascites

Rubin, E., Roberts, L. R. & Kamath, P. S., 1997, In : Mayo Clinic Proceedings. 72, 5, p. 487 1 p.

Research output: Contribution to journalArticle

Ascitic Fluid
Portal Hypertension
Ascites
Serum Albumin
Albumins
3 Citations (Scopus)

The role of hepatocyte apoptosis in liver diseases and growth regulation

Roberts, L. R. & Gores, G. J., 1997, In : Progress in Liver Diseases. 15, p. 57-83 27 p.

Research output: Contribution to journalArticle

Liver Diseases
Hepatocytes
Apoptosis
Growth
1998
141 Citations (Scopus)

Dysregulation of apoptosis as a mechanism of liver disease: An overview

Patel, T. C., Roberts, L. R., Jones, B. A. & Gores, G. J., 1998, In : Seminars in Liver Disease. 18, 2, p. 105-114 10 p.

Research output: Contribution to journalArticle

Liver Diseases
Apoptosis
Cell Death
Ligands
Liver
1 Citation (Scopus)

Image of the month

Roberts, L. R., Burgart, L. J. & Patel, T. C., 1998, In : Gastroenterology. 114, 3, p. 432 1 p.

Research output: Contribution to journalArticle

Image of the month. Solitary rectal ulcer.

Roberts, L. R., Burgart, L. J. & Patel, T., Mar 1998, In : Gastroenterology. 114, 3

Research output: Contribution to journalArticle

Rectal Diseases
Rectal Prolapse
Ulcer

Prophylaxis and pharmacotherapy of variceal hemorrhage

Roberts, L. R. & Kamath, P. S., Dec 1998, In : Problems in General Surgery. 15, 4, p. 52-62 11 p.

Research output: Contribution to journalArticle

Hemorrhage
Drug Therapy
Pharmacology
1999
91 Citations (Scopus)

Cathepsins as effector proteases in hepatocyte apoptosis

Roberts, L. R., Adjei, P. N. & Gores, G. J., 1999, In : Cell Biochemistry and Biophysics. 30, 1, p. 71-88 18 p.

Research output: Contribution to journalArticle

Pepstatins
Antisense DNA
Topoisomerase Inhibitors
Cathepsins
Camptothecin
11 Citations (Scopus)

Pathophysiology of variceal bleeding

Roberts, L. R. & Kamath, P. S., 1999, In : Gastrointestinal Endoscopy Clinics of North America. 9, 2, p. 167-174 8 p.

Research output: Contribution to journalArticle

Portal Pressure
Varicose Veins
Portal Hypertension
Hemorrhage
Vascular Resistance
2000
12 Citations (Scopus)
Microsatellite Instability
Tumor Suppressor Genes
Carcinogenesis
81 Citations (Scopus)

The characterization of the common fragile site FRA16D and its involvement in multiple myeloma translocations

Krummel, K. A., Roberts, L. R., Kawakami, M., Glover, T. W. & Smith, D. I., Oct 1 2000, In : Genomics. 69, 1, p. 37-46 10 p.

Research output: Contribution to journalArticle

Metaphase
Multiple Myeloma
Aphidicolin
Microsatellite Repeats
Names
2001
37 Citations (Scopus)

hMLH1 and hMSH2 expression in human hepatocellular carcinoma.

Wang, L., Bani-Hani, A., Montoya, D. P., Roche, P. C., Thibodeau, S. N., Burgart, L. J. & Roberts, L. R., Sep 2001, In : International Journal of Oncology. 19, 3, p. 567-570 4 p.

Research output: Contribution to journalArticle

Microsatellite Instability
Hepatocellular Carcinoma
DNA Mismatch Repair
Colorectal Neoplasms
Carcinogenesis
2002
372 Citations (Scopus)

Mutational spectrum of β-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas

Taniguchi, K., Roberts, L. R., Aderca, I. N., Dong, X., Qian, C., Murphy, L. M., Nagorney, D. M., Burgart, L. J., Roche, P. C., Smith, D. I., Ross, J. A. & Liu, W., Jul 18 2002, In : Oncogene. 21, 31, p. 4863-4871 9 p.

Research output: Contribution to journalArticle

Hepatoblastoma
Catenins
Hepatocellular Carcinoma
Mutation
Missense Mutation
2003

67-Year-old man with hepatitis C infection and abdominal distention

Choong, N. W. W., Asfandiyar, S. & Roberts, L. R., Feb 1 2003, In : Mayo Clinic Proceedings. 78, 2, p. 217-220 4 p.

Research output: Contribution to journalArticle

Hepatitis C
Infection
152 Citations (Scopus)

Integrations of the hepatitis B virus (HBV) and human papillomavirus (HPV) into the human telomerase reverse transcriptase (hTERT) gene in liver and cervical cancers

Ferber, M. J., Montoya, D. P., Yu, C., Aderca, I., McGee, A., Thorland, E. C., Nagorney, D. M., Gostout, B. S., Burgart, L. J., Boix, L., Bruix, J., McMahon, B. J., Cheung, T. H., Chung, T. K. H., Wong, Y. F., Smith, D. I. & Roberts, L. R., Jun 12 2003, In : Oncogene. 22, 24, p. 3813-3820 8 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Hepatitis B virus
Uterine Cervical Neoplasms
Virus Integration
Genes
188 Citations (Scopus)

Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer

Lai, J., Chien, J., Staub, J., Avula, R., Greene, E. L., Matthews, T. A., Smith, D. I., Kaufmann, S. H., Roberts, L. R. & Shridhar, V., Jun 20 2003, In : Journal of Biological Chemistry. 278, 25, p. 23107-23117 11 p.

Research output: Contribution to journalArticle

Heparan Sulfate Proteoglycans
Heparin
Intercellular Signaling Peptides and Proteins
Up-Regulation
Cells
16 Citations (Scopus)

Primer on medical genomics part VI: Genomics and molecular genetics in clinical practice

Ansell, S. M., Ackerman, M. J., Black, J. L., Roberts, L. R. & Tefferi, A., Mar 1 2003, In : Mayo Clinic Proceedings. 78, 3, p. 307-317 11 p.

Research output: Contribution to journalArticle

Genomics
Molecular Biology
Genes
Forensic Anthropology
Modern 1601-history
6 Citations (Scopus)

Tumor seeding complicating radiofrequency ablation of hepatocellular carcinoma

Decker, G. A., Gores, G. J. & Roberts, L. R., May 1 2003, In : Journal of Hepatology. 38, 5, p. 692 1 p.

Research output: Contribution to journalArticle

2004
259 Citations (Scopus)

A comparison of routine cytology and fluorescence in situ hybridization for the detection of malignant bile duct strictures

Kipp, B. R., Stadheim, L. M., Halling, S. A., Pochron, N. L., Harmsen, S., Nagorney, D. M., Sebo, T. J., Therneau, T. M., Gores, G. J., De Groen, P. C., Baron, T. H., Levy, M. J., Halling, K. C. & Roberts, L. R., Sep 2004, In : American Journal of Gastroenterology. 99, 9, p. 1675-1681 7 p.

Research output: Contribution to journalArticle

Bile Ducts
Fluorescence In Situ Hybridization
Cell Biology
Pathologic Constriction
Neoplasms

Erratum: Loss of HSulf-1 up-regulates heparin-binding growth factor signaling in cancer (Journal of Biological Chemistry (2003) 278 (23107-23117))

Lai, J., Chien, J., Staub, J., Avula, R., Greene, L. E., Matthews, T. A., Smith, D. I., Kaufmann, S. H., Roberts, L. R. & Shridhar, V., Mar 26 2004, In : Journal of Biological Chemistry. 279, 13, p. 13284 1 p.

Research output: Contribution to journalArticle

Heparin
Intercellular Signaling Peptides and Proteins
103 Citations (Scopus)

HSulf-1 modulates HGF-mediated tumor cell invasion and signaling in head and neck squamous carcinoma

Lai, J. P., Chien, J., Strome, S. E., Staub, J., Montoya, D. P., Greene, E. L., Smith, D. I., Roberts, L. R. & Shridhar, V., Feb 19 2004, In : Oncogene. 23, 7, p. 1439-1447 9 p.

Research output: Contribution to journalArticle

Hepatocyte Growth Factor
Squamous Cell Carcinoma
Neck
Head
Fibroblast Growth Factor 2
117 Citations (Scopus)

hSulf1 Sulfatase Promotes Apoptosis of Hepatocellular Cancer Cells by Decreasing Heparin-Binding Growth Factor Signaling

Lai, J. P., Chien, J. R., Moser, D. R., Staub, J. K., Aderca, I., Montoya, D. P., Matthews, T. A., Nagorney, D. M., Cunningham, J. M., Smith, D. I., Greene, E. L., Shridhar, V. & Roberts, L. R., Jan 2004, In : Gastroenterology. 126, 1 SUPPL. 1, p. 231-248 18 p.

Research output: Contribution to journalArticle

Sulfatases
Liver Neoplasms
Heparin
Intercellular Signaling Peptides and Proteins
Apoptosis
86 Citations (Scopus)

Parkin Gene Alterations in Hepatocellular Carcinoma

Wang, F., Denison, S., Lai, J. P., Philips, L. A., Montoya, D., Kock, N., Schüle, B., Klein, C., Shridhar, V., Roberts, L. R. & Smith, D. I., Jun 2004, In : Genes Chromosomes and Cancer. 40, 2, p. 85-96 12 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Cell Line
Exons
Genes
Neoplasms
2005
7 Citations (Scopus)

Chemokines as attractive targets in liver carcinogenesis [4]

Roberts, L. R., Feb 2005, In : American Journal of Gastroenterology. 100, 2, p. 499-501 3 p.

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Chemokine Receptors
Liver Neoplasms
Chemokines
Hepatocellular Carcinoma
234 Citations (Scopus)

Hepatocellular carcinoma: Molecular pathways and new therapeutic targets

Roberts, L. R. & Gores, G. J., May 2005, In : Seminars in Liver Disease. 25, 2, p. 212-225 14 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Catenins
Wnt Signaling Pathway
Critical Pathways
Telomerase
131 Citations (Scopus)

The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma

Guerrero, R. B. & Roberts, L. R., May 2005, In : Journal of Hepatology. 42, 5, p. 760-777 18 p.

Research output: Contribution to journalArticle

Virus Integration
Hepatitis B virus
Hepatocellular Carcinoma
2006
216 Citations (Scopus)

Advanced Cytologic Techniques for the Detection of Malignant Pancreatobiliary Strictures

Moreno Luna, L. E., Kipp, B., Halling, K. C., Sebo, T. J., Kremers, W. K., Roberts, L. R., Barr Fritcher, E. G., Levy, M. J. & Gores, G. J., Oct 2006, In : Gastroenterology. 131, 4, p. 1064-1072 9 p.

Research output: Contribution to journalArticle

Cell Biology
Fluorescence In Situ Hybridization
Pathologic Constriction
Cystic Duct
Sclerosing Cholangitis
674 Citations (Scopus)

A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells

Lee, J. S., Heo, J., Libbrecht, L., Chu, I. S., Kaposi-Novak, P., Calvisi, D. F., Mikaelyan, A., Roberts, L. R., Demetris, A. J., Sun, Z., Nevens, F., Roskams, T. & Thorgeirsson, S. S., Apr 2006, In : Nature Medicine. 12, 4, p. 410-416 7 p.

Research output: Contribution to journalArticle

Gene expression
Hepatocytes
Hepatocellular Carcinoma
Stem Cells
Tumors
89 Citations (Scopus)
Proteasome Inhibitors
JNK Mitogen-Activated Protein Kinases
Apoptosis
Tumor Cell Line
Glioma
39 Citations (Scopus)

Emerging drugs for hepatocellular carcinoma

Roberts, L. R. & Gores, G. J., Sep 2006, In : Expert Opinion on Emerging Drugs. 11, 3, p. 469-487 19 p.

Research output: Contribution to journalArticle

Hepatocellular Carcinoma
Pharmaceutical Preparations
Catenins
Wnt Signaling Pathway
Critical Pathways
14 Citations (Scopus)

Fiducial markers for MR histological correlation in ex vivo or short-term in vivo animal experiments: A screening study

Rouvière, O., Reynolds, C., Le, Y., Lai, J., Roberts, L. R., Felmlee, J. P. & Ehman, R. L., Jan 2006, In : Journal of Magnetic Resonance Imaging. 23, 1, p. 50-59 10 p.

Research output: Contribution to journalArticle

Fiducial Markers
Magnetic Resonance Spectroscopy
Paint
Microscopy
Iron
1 Citation (Scopus)

Molecular targets for therapy of hepatitis B virus-induced hepatocellular carcinoma

Tharayil, V. S. & Roberts, L. R., Dec 2006, In : Minerva Gastroenterologica e Dietologica. 52, 4, p. 387-406 20 p.

Research output: Contribution to journalArticle

Hepatitis B virus
Hepatocellular Carcinoma
Therapeutics
Carcinogenesis
Allelic Imbalance
9 Citations (Scopus)

MYH Y165C and G382D mutations in hepatocellular carcinoma and cholangiocarcinoma patients

Baudhuin, L. M., Roberts, L. R., Enders, F. T., Swanson, R. L., Mettler, T. A., Aderca, I., Stadheim, L. M. & Highsmith, W. E. J., Mar 2006, In : Journal of Cancer Research and Clinical Oncology. 132, 3, p. 159-162 4 p.

Research output: Contribution to journalArticle

Cholangiocarcinoma
Hepatocellular Carcinoma
Mutation
Liver Diseases
Reactive Oxygen Species
49 Citations (Scopus)

SULF1 Inhibits Tumor Growth and Potentiates the Effects of Histone Deacetylase Inhibitors in Hepatocellular Carcinoma

Lai, J. P., Yu, C., Moser, C. D., Aderca, I., Han, T., Garvey, T. D., Murphy, L. M., Garrity-Park, M. M., Shridhar, V., Adjei, A. & Roberts, L. R., Jul 2006, In : Gastroenterology. 130, 7, p. 2130-2144 15 p.

Research output: Contribution to journalArticle

Sulfatases
Histone Deacetylase Inhibitors
Hepatocellular Carcinoma
Enzymes
Growth
2007
72 Citations (Scopus)

{A figure is presented}The Utility of Lens Culinaris Agglutinin-Reactive α-Fetoprotein in the Diagnosis of Hepatocellular Carcinoma: Evaluation in a United States Referral Population

Leerapun, A., Suravarapu, S. V., Bida, J. P., Clark, R. J., Sanders, E. L., Mettler, T. A., Stadheim, L. M., Aderca, I., Moser, C. D., Nagorney, D. M., La Russo, N. F., de Groen, P. C., Menon, K. V. N., Lazaridis, K. N., Gores, G. J., Charlton, M. R., Roberts, R. O., Therneau, T. M., Katzmann, J. A. & Roberts, L. R., Mar 2007, In : Clinical Gastroenterology and Hepatology. 5, 3, p. 394-402 9 p.

Research output: Contribution to journalArticle

Fetal Proteins
Hepatocellular Carcinoma
Referral and Consultation
Population
lentil lectin
61 Citations (Scopus)

Abrogation of MAPK and Akt signaling by AEE788 synergistically potentiates histone deacetylase inhibitor-induced apoptosis through reactive oxygen species generation

Yu, C., Friday, B. B., Lai, J. P., McCollum, A., Atadja, P., Roberts, L. R. & Adjei, A., Feb 15 2007, In : Clinical Cancer Research. 13, 4, p. 1140-1148 9 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Mitogen-Activated Protein Kinases
Reactive Oxygen Species
Apoptosis
trichostatin A
1 Citation (Scopus)

A Moveable Feast

Camilleri, M., Sandborn, W. J., Kolars, J. C., Murray, J. A., Poterucha, J. J., Roberts, L. R., Sinicrope, F. A. & Wang, K. K. N., Jun 2007, In : Clinical Gastroenterology and Hepatology. 5, 6, p. 646-647 2 p.

Research output: Contribution to journalArticle

Gastroenterology
38 Citations (Scopus)

An assessment of chromosomal alterations detected by fluorescence in situ hybridization and p16 expression in sporadic and primary sclerosing cholangitis-associated cholangiocarcinomas

DeHaan, R. D., Kipp, B. R., Smyrk, T. C., Abraham, S. C., Roberts, L. R. & Halling, K. C., Mar 2007, In : Human Pathology. 38, 3, p. 491-499 9 p.

Research output: Contribution to journalArticle

Sclerosing Cholangitis
Cholangiocarcinoma
Fluorescence In Situ Hybridization
Chromosome Aberrations
Neoplasms
1 Citation (Scopus)

Casting a wider net: Improving access to medical literature in developing countries

Roberts, L. R., Missen, C. & Grimes, G. C., 2007, In : Mayo Clinic Proceedings. 82, 7, p. 846-848 3 p.

Research output: Contribution to journalArticle

Digital Libraries
Developing Countries
Delivery of Health Care
Quality of Health Care
Evidence-Based Medicine
46 Citations (Scopus)

Correlating routine cytology, quantitative nuclear morphometry by digital image analysis, and genetic alterations by fluorescence in situ hybridization to assess the sensitivity of cytology for detecting pancreatobiliary tract malignancy

Barr Fritcher, E. G., Kipp, B. R., Slezak, J. M., Moreno-Luna, L. E., Gores, G. J., Levy, M. J., Roberts, L. R., Halling, K. C. & Sebo, T. J., Aug 2007, In : American Journal of Clinical Pathology. 128, 2, p. 272-279 8 p.

Research output: Contribution to journalArticle

Fluorescence In Situ Hybridization
Cell Biology
Neoplasms
Trisomy
Pathologic Constriction
75 Citations (Scopus)

Epigenetic silencing of HSulf-1 in ovarian cancer: Implications in chemoresistance

Staub, J., Chien, J., Pan, Y., Qian, X., Narita, K., Aletti, G., Scheerer, M., Roberts, L. R., Molina, J. R. & Shridhar, V., Jul 26 2007, In : Oncogene. 26, 34, p. 4969-4978 10 p.

Research output: Contribution to journalArticle

Epigenomics
Ovarian Neoplasms
Down-Regulation
decitabine
Tumor Cell Line