Leif Bergsagel, MD

Accepting PhD Students

  • 22936 Citations
  • 81 Scopus h-Index
1984 …2020
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Research Output 1984 2019

2019

Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model

Guillerey, C., Nakamura, K., Pichler, A. C., Barkauskas, D., Krumeich, S., Stannard, K., Miles, K., Harjunpää, H., Yu, Y., Casey, M., Doban, A. I., Lazar, M., Hartel, G., Smith, D., Vuckovic, S., Teng, M. W. L., Bergsagel, P. L., Chesi, M., Hill, G. R., Martinet, L. & 1 others, Smyth, M. J., Jul 25 2019, In : JCI Insight. 4, 14, :e125932.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Immunotherapy
Drug Therapy
T-Lymphocytes
Therapeutics

Dynamic CD138 surface expression regulates switch between myeloma growth and dissemination

Akhmetzyanova, I., McCarron, M. J., Parekh, S., Chesi, M., Bergsagel, P. L. & Fooksman, D. R., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Growth
Syndecan-1
Bone and Bones
Licensure
Plasma Cells
1 Citation (Scopus)

Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4

Zhu, Y. X., Shi, C. X., Bruins, L. A., Wang, X., Riggs, D. L., Porter, B., Ahmann, J. M., de Campos, C. B., Braggio, E. D., Bergsagel, P. L. & Stewart, A. K., Feb 1 2019, In : Blood cancer journal. 9, 2, 19.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Cell Line
Down-Regulation
lenalidomide
Sequence Deletion

MYC dysregulation in the progression of multiple myeloma

MMRF CoMMpass Network, Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalLetter

Multiple Myeloma

Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model

Thirukkumaran, C. M., Shi, Z. Q., Nuovo, G. J., Luider, J., Kopciuk, K. A., Dong, Y., Mostafa, A. A., Thakur, S., Gratton, K., Yang, A., Chin, A. C., Coffey, M. C., Jimenez-Zepeda, V. H., Stewart, D., Chesi, M., Bergsagel, P. L. & Morris, D., Mar 12 2019, In : Blood advances. 3, 5, p. 797-812 16 p.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Immunotherapy
Survival
Neoplasms
Therapeutics

Polyclonal serum free light chain elevation is associated with increased risk of monoclonal gammopathies

Kumar, S. K., Larson, D. R., Dispenzieri, A., Therneau, T. M., Murray, D. L., Bergsagel, P. L., Kyle, R. A. & Rajkumar, S. V., Jun 1 2019, In : Blood cancer journal. 9, 6, 49.

Research output: Contribution to journalArticle

Open Access
Paraproteinemias
Monoclonal Gammopathy of Undetermined Significance
Light
Serum
Plasma Cells
1 Citation (Scopus)

Reprogrammed marrow adipocytes contribute to myeloma-induced bone disease

Liu, H., He, J., Koh, S. P., Zhong, Y., Liu, Z., Wang, Z., Zhang, Y., Li, Z., Tam, B. T., Lin, P., Xiao, M., Young, K. H., Amini, B., Starbuck, M. W., Lee, H. C., Navone, N. M., Davis, R. E., Tong, Q., Bergsagel, P. L., Hou, J. & 4 others, Yi, Q., Orlowski, R. Z., Gagel, R. F. & Yang, J., Jan 1 2019, In : Science translational medicine. 11, 494, eaau9087.

Research output: Contribution to journalArticle

Bone Diseases
Adipocytes
Bone Marrow
Peroxisomes
Polycomb Repressive Complex 2
2018
2 Citations (Scopus)

Antigen-mediated regulation in monoclonal gammopathies and myeloma

Nair, S., Sng, J., Boddupalli, C. S., Seckinger, A., Chesi, M., Fulciniti, M., Zhang, L., Rauniyar, N., Lopez, M., Neparidze, N., Parker, T., Munshi, N. C., Sexton, R., Barlogie, B., Orlowski, R., Bergsagel, P. L., Hose, D., Flavell, R. A., Mistry, P. K., Meffre, E. & 1 others, Dhodapkar, M. V., Apr 19 2018, In : JCI insight. 3, 8

Research output: Contribution to journalArticle

Open Access
Paraproteinemias
Antigens
Gaucher Disease
Plasma Cells
Multiple Myeloma

A phase 2 study of rituximab, cyclophosphamide, bortezomib and dexamethasone (R-CyBorD) in relapsed low grade and mantle cell lymphoma

Sonbol, M. B., Hilal, T., Dueck, A., Rosenthal, A. C., Conley, C. R., Kosiorek, H. E., Ginos, B. F., Gano, K. M., Nichols, C. S., Leis, J. F., Johnston, P. B., Habermann, T. M., Northfelt, D. W., Bergsagel, P. L., Inwards, D. J., Witzig, T. E., Ansell, S. M. & Reeder, C. B., Jan 11 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-7 7 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Cyclophosphamide
Dexamethasone
Safety
Peripheral Nervous System Diseases
7 Citations (Scopus)

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression

Kawano, Y., Zavidij, O., Park, J., Moschetta, M., Kokubun, K., Mouhieddine, T. H., Manier, S., Mishima, Y., Murakami, N., Bustoros, M., Pistofidis, R. S., Reidy, M., Shen, Y. J., Rahmat, M., Lukyanchykov, P., Karreci, E. S., Tsukamoto, S., Shi, J., Takagi, S., Huynh, D. & 7 others, Sacco, A., Tai, Y. T., Chesi, M., Bergsagel, P. L., Roccaro, A. M., Azzi, J. & Ghobrial, I. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2487-2499 13 p.

Research output: Contribution to journalArticle

Interferon Type I
Immunosuppressive Agents
Multiple Myeloma
Immunosuppression
Regulatory T-Lymphocytes
1 Citation (Scopus)

Detailing the genomic landscape of myeloma

Bergsagel, P. L. & Michael Kuehl, W., Aug 9 2018, In : Blood. 132, 6, p. 554-555 2 p.

Research output: Contribution to journalReview article

Multiple Myeloma
Blood
7 Citations (Scopus)
Paraproteinemias
Multiple Myeloma
Precision Medicine
Genetic Predisposition to Disease
Cytogenetics
8 Citations (Scopus)

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

Nakamura, K., Kassem, S., Cleynen, A., Chrétien, M. L., Guillerey, C., Putz, E. M., Bald, T., Förster, I., Vuckovic, S., Hill, G. R., Masters, S. L., Chesi, M., Bergsagel, P. L., Avet-Loiseau, H., Martinet, L. & Smyth, M. J., Jan 1 2018, (Accepted/In press) In : Cancer Cell.

Research output: Contribution to journalArticle

Interleukin-18
Multiple Myeloma
Immunosuppression
Therapeutics
T-Lymphocytes
5 Citations (Scopus)

Evaluation of Revised International Staging System (R-ISS) for transplant-eligible multiple myeloma patients

González-Calle, V., Slack, A., Keane, N., Luft, S., Pearce, K. E., Ketterling, R. P., Jain, T., Chirackal, S., Reeder, C., Mikhael, J. R., Noel, P., Mayo, A., Adams, R. H., Ahmann, G., Braggio, E. D., Stewart, A. K., Bergsagel, P. L., van Wier, S. A. & Fonseca, R., Apr 6 2018, (Accepted/In press) In : Annals of Hematology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Transplants
Survival
Chromosome Aberrations
Stem Cells
1 Citation (Scopus)

Importin-β and exportin-5 are strong biomarkers of productive reoviral infection of cancer cells

Nuovo, G., Tran, H., Gutierrez, A., Fadda, P., Pichiorri, F., Caserta, E., Hofmeister, C. C., Chesi, M., Bergsagel, P. L., Morris, D., Shi, Q., Coffey, M. & Thirukkumaran, C., Feb 1 2018, In : Annals of Diagnostic Pathology. 32, p. 28-34 7 p.

Research output: Contribution to journalArticle

Karyopherins
Biomarkers
Capsid Proteins
Infection
Caspase 3
3 Citations (Scopus)

Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma

Bianchi-Smiraglia, A., Bagati, A., Fink, E. E., Affronti, H. C., Lipchick, B. C., Moparthy, S., Long, M. D., Rosario, S. R., Lightman, S. M., Moparthy, K., Wolff, D. W., Yun, D. H., Han, Z., Polechetti, A., Roll, M. V., Gitlin, I. I., Leonova, K. I., Rowsam, A. M., Kandel, E. S., Gudkov, A. V. & 4 others, Bergsagel, P. L., Lee, K. P., Smiraglia, D. J. & Nikiforov, M. A., Oct 1 2018, In : Journal of Clinical Investigation. 128, 10, p. 4682-4696 15 p.

Research output: Contribution to journalArticle

Aryl Hydrocarbon Receptors
Polyamines
Multiple Myeloma
Clofazimine
Proteasome Inhibitors
1 Citation (Scopus)

Inhibitors of the protein disulfide isomerase family for the treatment of multiple myeloma

Robinson, R. M., Reyes, L., Duncan, R. M., Bian, H., Reitz, A. B., Manevich, Y., McClure, J. J., Champion, M. M., Chou, C. J., Sharik, M. E., Chesi, M., Bergsagel, P. L. & Dolloff, N. G., Jan 1 2018, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Protein Disulfide-Isomerases
Multiple Myeloma
Proteasome Inhibitors
Click Chemistry
Small Molecule Libraries
7 Citations (Scopus)

Microbiota-driven interleukin-17-producing cells and eosinophils synergize to accelerate multiple myeloma progression

Calcinotto, A., Brevi, A., Chesi, M., Ferrarese, R., Garcia Perez, L., Grioni, M., Kumar, S. K., Garbitt, V. M., Sharik, M. E., Henderson, K. J., Tonon, G., Tomura, M., Miwa, Y., Esplugues, E., Flavell, R. A., Huber, S., Canducci, F., Rajkumar, S. V., Bergsagel, P. L. & Bellone, M., Dec 1 2018, In : Nature Communications. 9, 1, 4832.

Research output: Contribution to journalArticle

eosinophils
interleukins
Interleukin-17
Microbiota
Multiple Myeloma

Molecular genetic aspects of plasma cell disorders

Bergsagel, P. L., Stewart, A. K., Russell, S. J. & Fonseca, R., Nov 19 2018, Wintrobe's Clinical Hematology: Fourteenth Edition. Wolters Kluwer Health Pharma Solutions (Europe) Ltd, p. 6311-6327 17 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Plasma Cells
Molecular Biology
3 Citations (Scopus)

Phase 1/2 trial of ixazomib, cyclophosphamide and dexamethasone in patients with previously untreated symptomatic multiple myeloma

Kumar, S. K., Buadi, F. K., LaPlant, B., Halvorson, A., Leung, N., Kapoor, P., Dingli, D. M., Gertz, M., Go, R. S., Bergsagel, P. L., Lin, Y., Dispenzieri, A., Hwa, Y. L., Fonder, A., Hobbs, M., Fonseca, R., Hayman, S. R., Stewart, A. K., Lust, J. A., Mikhael, J. R. & 5 others, Gonsalves, W., Reeder, C., Skacel, T., Rajkumar, S. V. & Lacy, M., Aug 1 2018, In : Blood Cancer Journal. 8, 8, 70.

Research output: Contribution to journalArticle

Multiple Myeloma
Cyclophosphamide
Dexamethasone
Maximum Tolerated Dose
Proteasome Inhibitors
6 Citations (Scopus)

Pomalidomide-dexamethasone in refractory multiple myeloma: Long-term follow-up of a multi-cohort phase II clinical trial

Ailawadhi, S., Mikhael, J. R., Laplant, B. R., Laumann, K. M., Kumar, S. K., Roy, V., Dingli, D. M., Bergsagel, P. L., Buadi, F. K., Rajkumar, S. V., Fonseca, R., Gertz, M., Kapoor, P., Sher, T., Hayman, S. R., Stewart, A. K., Dispenzieri, A., Kyle, R. A., Gonsalves, W., Reeder, C. B. & 8 others, Lin, Y., Go, R. S., Leung, N., Kourelis, T., Lust, J. A., Russell, S. J., Chanan Khan, A. A. & Lacy, M., Mar 1 2018, In : Leukemia. 32, 3, p. 719-728 10 p.

Research output: Contribution to journalArticle

Phase II Clinical Trials
Multiple Myeloma
Dexamethasone
Appointments and Schedules
Therapeutics
2 Citations (Scopus)
Plasma Cell Leukemia
Multiple Myeloma
Plasma Cells
Survival

Treatment With Bortezomib-based Therapy, Followed by Autologous Stem Cell Transplantation, Improves Outcomes in Light Chain Amyloidosis: A Retrospective Study

Jain, T., Kosiorek, H. E., Kung, S. T., Shah, V. S., Dueck, A., Gonzalez-Calle, V., Luft, S., Reeder, C. B., Adams, R., Noel, P., Larsen, J. T., Mikhael, J. R., Bergsagel, P. L., Stewart, A. K. & Fonseca, R., Jan 1 2018, (Accepted/In press) In : Clinical Lymphoma, Myeloma and Leukemia.

Research output: Contribution to journalArticle

Stem Cell Transplantation
Amyloidosis
Retrospective Studies
Light
Therapeutics
11 Citations (Scopus)

Utilization of hematopoietic stem cell transplantation for the treatment of multiple myeloma: a Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus statement

Gonsalves, W., Buadi, F. K., Ailawadhi, S., Bergsagel, P. L., Chanan Khan, A. A., Dingli, D. M., Dispenzieri, A., Fonseca, R., Hayman, S. R., Kapoor, P., Kourelis, T. V., Lacy, M., Larsen, J. T., Muchtar, E., Reeder, C. B., Sher, T., Stewart, A. K., Warsame, R., Go, R. S., Kyle, R. A. & 14 others, Leung, N., Lin, Y., Lust, J. A., Russell, S. J., Zeldenrust, S. R., Fonder, A. L., Hwa, Y. L., Hobbs, M. A., Mayo, A. A., Hogan, W., Rajkumar, S. V., Kumar, S. K., Gertz, M. & Roy, V., Jul 9 2018, (Accepted/In press) In : Bone Marrow Transplantation. p. 1-15 15 p.

Research output: Contribution to journalArticle

Hematopoietic Stem Cell Transplantation
Multiple Myeloma
Stem Cells
Transplants
Therapeutics
2017
1 Citation (Scopus)

Changes in uninvolved immunoglobulins during induction therapy for newly diagnosed multiple myeloma

Ravi, P., Kumar, S. K., Gonsalves, W., Buadi, F., Lacy, M., Go, R. S., Dispenzieri, A., Kapoor, P., Lust, J. A., Dingli, D. M., Lin, Y., Russell, S. J., Leung, N., Gertz, M., Kyle, R. A., Bergsagel, P. L. & Rajkumar, S. V., Jun 16 2017, In : Blood Cancer Journal. 7, 6, p. e569

Research output: Contribution to journalArticle

Multiple Myeloma
Dexamethasone
Immunoglobulins
Cyclophosphamide
Lymphocyte Count
42 Citations (Scopus)

Diagnosis and management of Waldenström macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) guidelines 2016

Kapoor, P., Ansell, S. M., Fonseca, R., Chanan Khan, A. A., Kyle, R. A., Kumar, S. K., Mikhael, J. R., Witzig, T. E., Mauermann, M. M., Dispenzieri, A., Ailawadhi, S., Stewart, A. K., Lacy, M., Thompson, C. A., Buadi, F. K., Dingli, D. M., Morice, W. G., Go, R. S., Jevremovic, D., Sher, T. & 27 others, King, R. L., Braggio, E. D., Novak, A. J., Roy, V., Ketterling, R. P., Greipp, P. T., Grogan, M., Micallef, I., Bergsagel, P. L., Colgan, J. P., Leung, N., Gonsalves, W., Lin, Y., Inwards, D. J., Hayman, S. R., Nowakowski, G. S., Johnston, P. B., Russell, S. J., Markovic, S. N., Zeldenrust, S. R., Hwa, Y. L., Lust, J. A., Porrata, L. F., Habermann, T. M., Rajkumar, S. V., Gertz, M. & Reeder, C. B., Sep 1 2017, In : JAMA oncology. 3, 9, p. 1257-1265 9 p.

Research output: Contribution to journalArticle

Waldenstrom Macroglobulinemia
Guidelines
Stem Cell Transplantation
Therapeutics
Clinical Trials
5 Citations (Scopus)

Multiple myeloma cells' capacity to decompose H2O2 determines lenalidomide sensitivity

Sebastian, S., Zhu, Y. X., Braggio, E. D., Shi, C. X., Panchabhai, S. C., Van Wier, S. A., Ahmann, G. J., Chesi, M., Bergsagel, P. L., Stewart, A. K. & Fonseca, R., Feb 23 2017, In : Blood. 129, 8, p. 991-1007 17 p.

Research output: Contribution to journalArticle

Thioredoxin-Disulfide Reductase
Multiple Myeloma
Cytotoxicity
Thioredoxins
Cells
26 Citations (Scopus)

Overexpression of EZH2 in multiple myeloma is associated with poor prognosis and dysregulation of cell cycle control

Pawlyn, C., Bright, M. D., Buros, A. F., Stein, C. K., Walters, Z., Aronson, L. I., Mirabella, F., Jones, J. R., Kaiser, M. F., Walker, B. A., Jackson, G. H., Clarke, P. A., Bergsagel, P. L., Workman, P., Chesi, M., Morgan, G. J. & Davies, F. E., Jan 1 2017, In : Blood Cancer Journal. 7, 3, e549.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Multiple Myeloma
Epigenomics
Cyclin-Dependent Kinases
Therapeutics
22 Citations (Scopus)

Pomalidomide, bortezomib, and dexamethasone for patients with relapsed lenalidomide-refractory multiple myeloma

Paludo, J., Mikhael, J. R., Laplant, B. R., Halvorson, A. E., Kumar, S. K., Gertz, M., Hayman, S. R., Buadi, F. K., Dispenzieri, A., Lust, J. A., Kapoor, P., Leung, N., Russell, S. J., Dingli, D. M., Go, R. S., Lin, Y., Gonsalves, W., Fonseca, R., Bergsagel, P. L., Roy, V. & 8 others, Sher, T., Chanan Khan, A. A., Ailawadhi, S., Stewart, A. K., Reeder, C. B., Richardson, P. G., Rajkumar, S. V. & Lacy, M., Sep 7 2017, In : Blood. 130, 10, p. 1198-1204 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Refractory materials
Dexamethasone
Toxicity
Physical vapor deposition
10 Citations (Scopus)

Preclinical anti-myeloma activity of EDO-S101, a new bendamustine-derived molecule with added HDACi activity, through potent DNA damage induction and impairment of DNA repair

López-Iglesias, A. A., Herrero, A. B., Chesi, M., San-Segundo, L., González-Méndez, L., Hernández-García, S., Misiewicz-Krzeminska, I., Quwaider, D., Martín-Sánchez, M., Primo, D., Paíno, T., Bergsagel, P. L., Mehrling, T., González-Díaz, M., San-Miguel, J. F., Mateos, M. V., Gutiérrez, N. C., Garayoa, M. & Ocio, E. M., Jun 20 2017, In : Journal of Hematology and Oncology. 10, 1, 127.

Research output: Contribution to journalArticle

DNA Repair
DNA Damage
Multiple Myeloma
Cell Line
Pharmaceutical Preparations
1 Citation (Scopus)

Systolic dysfunction associated with carfilzomib use in patients with multiple myeloma

Jain, T., Narayanasamy, H., Mikhael, J. R., Reeder, C. B., Bergsagel, P. L., Mayo, A., Stewart, A. K., Mookadam, F. & Fonseca, R., Dec 1 2017, In : Blood Cancer Journal. 7, 12, 642.

Research output: Contribution to journalLetter

Multiple Myeloma
carfilzomib
19 Citations (Scopus)

The p97 inhibitor CB-5083 is a unique disrupter of protein homeostasis in models of multiple myeloma

Le Moigne, R., Aftab, B. T., Djakovic, S., Dhimolea, E., Valle, E., Murnane, M., King, E. M., Soriano, F., Menon, M. K., Wu, Z. Y., Wong, S. T., Lee, G. J., Yao, B., Wiita, A. P., Lam, C., Rice, J., Wang, J., Chesi, M., Bergsagel, P. L., Kraus, M. & 11 others, Driessen, C., Von Soly, S. K., Yakes, F. M., Wustrow, D., Shawver, L., Zhou, H. J., Martin, T. G., Wolf, J. L., Mitsiades, C. S., Anderson, D. J. & Rolfe, M., Nov 1 2017, In : Molecular Cancer Therapeutics. 16, 11, p. 2375-2386 12 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Homeostasis
Proteins
Proteasome Inhibitors
Proteasome Endopeptidase Complex
37 Citations (Scopus)

Therapy for Relapsed Multiple Myeloma: Guidelines From the Mayo Stratification for Myeloma and Risk-Adapted Therapy

Dingli, D. M., Ailawadhi, S., Bergsagel, P. L., Buadi, F. K., Dispenzieri, A., Fonseca, R., Gertz, M., Gonsalves, W., Hayman, S. R., Kapoor, P., Kourelis, T., Kumar, S. K., Kyle, R. A., Lacy, M., Leung, N., Lin, Y., Lust, J. A., Mikhael, J. R., Reeder, C. B., Roy, V. & 7 others, Russell, S. J., Sher, T., Stewart, A. K., Warsame, R., Zeldenrust, S. R., Rajkumar, S. V. & Chanan Khan, A. A., Apr 1 2017, In : Mayo Clinic Proceedings. 92, 4, p. 578-598 21 p.

Research output: Contribution to journalReview article

Multiple Myeloma
Guidelines
Recurrence
Patient Care
Therapeutics
8 Citations (Scopus)

The varied distribution and impact of RAS codon and other key DNA alterations across the translocation cyclin D subgroups in multiple myeloma

Stein, C. K., Pawlyn, C., Chavan, S., Rasche, L., Weinhold, N., Corken, A., Buros, A., Sonneveld, P., Jackson, G. H., Landgren, O., Mughal, T., He, J., Barlogie, B., Bergsagel, P. L., Davies, F. E., Walker, B. A. & Morgan, G. J., 2017, In : Oncotarget. 8, 17, p. 27854-27867 14 p.

Research output: Contribution to journalArticle

Cyclin D
Multiple Myeloma
Codon
Mutation
DNA
2016
33 Citations (Scopus)

Carfilzomib and the cardiorenal system in myeloma: An endothelial effect?

Rosenthal, A., Luthi, J., Belohlavek, M., Kortüm, K. M., Mookadam, F., Mayo, A., Fonseca, R., Bergsagel, P. L., Reeder, C. B., Mikhael, J. R. & Stewart, A. K., 2016, In : Blood Cancer Journal. 6, 1, e384.

Research output: Contribution to journalArticle

Creatinine
Clinical Trials
Blood Pressure
Therapeutics
Troponin
12 Citations (Scopus)

Chromogranin a is preferentially cleaved into proangiogenic peptides in the bone marrow of multiple myeloma patients

Bianco, M., Gasparri, A. M., Colombo, B., Curnis, F., Girlanda, S., Ponzoni, M., Bertilaccio, M. T. S., Calcinotto, A., Sacchi, A., Ferrero, E., Ferrarini, M., Chesi, M., Bergsagel, P. L., Bellone, M., Tonon, G., Ciceri, F., Marcatti, M., Caligaris-Cappio, F. & Corti, A., Apr 1 2016, In : Cancer Research. 76, 7, p. 1781-1791 11 p.

Research output: Contribution to journalArticle

Chromogranins
Multiple Myeloma
Bone Marrow
Peptides
Chromogranin A
16 Citations (Scopus)

Evolving changes in disease biomarkers and risk of early progression in smoldering multiple myeloma

Ravi, P., Kumar, S. K., Larsen, J. T., Gonsalves, W., Buadi, F., Lacy, M., Go, R., Dispenzieri, A., Kapoor, P., Lust, J. A., Dingli, D. M., Lin, Y., Russell, S. J., Leung, N., Gertz, M., Kyle, R. A., Bergsagel, P. L. & Rajkumar, S. V., Jul 29 2016, In : Blood Cancer Journal. 6, 7, p. e454

Research output: Contribution to journalArticle

Multiple Myeloma
Biomarkers
Odds Ratio
Immunoglobulin M
Proteins
3 Citations (Scopus)

Frequent occurrence of large duplications at reciprocal genomic rearrangement breakpoints in multiple myeloma and other tumors

Demchenko, Y., Roschke, A., Chen, W. D., Asmann, Y., Bergsagel, P. L. & Kuehl, W. M., Sep 30 2016, In : Nucleic Acids Research. 44, 17, p. 8189-8198 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Comparative Genomic Hybridization
Tumor Cell Line
Eukaryota
Oncogenes
49 Citations (Scopus)

IAP antagonists induce anti-tumor immunity in multiple myeloma

Chesi, M., Mirza, N. N., Garbitt, V. M., Sharik, M. E., Dueck, A., Asmann, Y., Akhmetzyanova, I., Kosiorek, H. E., Calcinotto, A., Riggs, D. L., Keane, N., Ahmann, G. J., Morrison, K. M., Fonseca, R., Lacy, M., Dingli, D. M., Kumar, S. K., Ailawadhi, S., Dispenzieri, A., Buadi, F. & 7 others, Gertz, M., Reeder, C. B., Lin, Y., Chanan Khan, A. A., Stewart, A. K., Fooksman, D. & Bergsagel, P. L., Dec 1 2016, In : Nature Medicine. 22, 12, p. 1411-1420 10 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Immunity
Apoptosis
Neoplasms

Induction of iron excess restricts malignant plasma cells expansion and potentiates bortezomib effect in models of multiple myeloma

Bordini, J., Galvan, S., Ponzoni, M., Bertilaccio, M. T. S., Chesi, M., Bergsagel, P. L., Camaschella, C. & Campanella, A., Dec 13 2016, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

Plasma Cells
Multiple Myeloma
Iron
Bortezomib
24 Citations (Scopus)

Panel sequencing for clinically oriented variant screening and copy number detection in 142 untreated multiple myeloma patients

Kortuem, K. M., Braggio, E. D., Bruins, L., Barrio, S., Shi, C. S., Zhu, Y. X., Tibes, R., Viswanatha, D., Votruba, P., Ahmann, G., Fonseca, R., Jedlowski, P., Schlam, I., Kumar, S. K., Bergsagel, P. L. & Stewart, A. K., 2016, In : Blood Cancer Journal. 6, 2, e397.

Research output: Contribution to journalArticle

Multiple Myeloma
Mutation
Genes
Costs and Cost Analysis
Pharmaceutical Preparations
2 Citations (Scopus)

Phase II trial of nab-paclitaxel in patients with relapsed or refractory multiple myeloma

Jain, T., Dueck, A., Kosiorek, H. E., Ginos, B. F., Mayo, A., Reeder, C. B., Chesi, M., Mikhael, J. R., Stewart, A. K., Bergsagel, P. L. & Fonseca, R., Dec 1 2016, In : American Journal of Hematology. 91, 12, p. E504-E505

Research output: Contribution to journalLetter

Multiple Myeloma
130-nm albumin-bound paclitaxel

Promiscuous mechanisms underlie the antitumor effects of thalidomide analogs

Bergsagel, P. L. & Chesi, M., Jul 7 2016, In : Nature Medicine. 22, 7, p. 706-707 2 p.

Research output: Contribution to journalShort survey

Thalidomide
28 Citations (Scopus)

Randomized phase 2 trial of ixazomib and dexamethasone in relapsed multiple myeloma not refractory to bortezomib

Kumar, S. K., LaPlant, B. R., Reeder, C. B., Roy, V., Halvorson, A. E., Buadi, F., Gertz, M., Bergsagel, P. L., Dispenzieri, A., Thompson, M. A., Crawley, J., Kapoor, P., Mikhael, J. R., Stewart, A. K., Hayman, S. R., Hwa, Y. L., Gonsalves, W., Witzig, T. E., Ailawadhi, S., Dingli, D. M. & 5 others, Go, R. S., Lin, Y., Rivera, C. E., Rajkumar, S. V. & Lacy, M., Nov 17 2016, In : Blood. 128, 20, p. 2415-2422 8 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Refractory materials
Dexamethasone
Toxicity
Proteasome Inhibitors
44 Citations (Scopus)

Targeted sequencing of refractory myeloma reveals a high incidence of mutations in CRBN and Ras pathway genes

Kortüm, K. M., Mai, E. K., Hanafiah, N. H., Shi, C. X., Zhu, Y. X., Bruins, L., Barrio, S., Jedlowski, P., Merz, M., Xu, J., Stewart, R. A., Andrulis, M., Jauch, A., Hillengass, J., Goldschmidt, H., Bergsagel, P. L., Braggio, E. D., Stewart, A. K. & Raab, M. S., Sep 1 2016, In : Blood. 128, 9, p. 1226-1233 8 p.

Research output: Contribution to journalArticle

ras Genes
Refractory materials
Genes
Proteasome Inhibitors
Mutation
19 Citations (Scopus)

Targeting vasculogenesis to prevent progression in multiple myeloma

Moschetta, M., Mishima, Y., Kawano, Y., Manier, S., Paiva, B., Palomera, L., Aljawai, Y., Calcinotto, A., Unitt, C., Sahin, I., Sacco, A., Glavey, S., Shi, J., Reagan, M. R., Prosper, F., Bellone, M., Chesi, M., Bergsagel, P. L., Vacca, A., Roccaro, A. M. & 1 others, Ghobrial, I. M., May 1 2016, In : Leukemia. 30, 5, p. 1103-1115 13 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Neoplasms
Hematologic Neoplasms
Endothelial Cells
RNA Sequence Analysis
3 Citations (Scopus)

The society for immunotherapy of cancer consensus statement on immunotherapy for the treatment of hematologic malignancies: Multiple myeloma, lymphoma, and acute leukemia

Boyiadzis, M., Bishop, M. R., Abonour, R., Anderson, K. C., Ansell, S. M., Avigan, D., Barbarotta, L., Barrett, A. J., Besien, K., Bergsagel, P. L., Borrello, I., Brody, J., Brufsky, J., Cairo, M., Chari, A., Cohen, A., Cortes, J., Forman, S. J., Friedberg, J. W., Fuchs, E. J. & 28 others, Gore, S. D., Jagannath, S., Kahl, B. S., Kline, J., Kochenderfer, J. N., Kwak, L. W., Levy, R., Lima, M., Litzow, M. R., Mahindra, A., Miller, J., Munshi, N. C., Orlowski, R. Z., Pagel, J. M., Porter, D. L., Russell, S. J., Schwartz, K., Shipp, M. A., Siegel, D., Stone, R. M., Tallman, M. S., Timmerman, J. M., Rhee, F., Waller, E. K., Welsh, A., Werner, M., Wiernik, P. H. & Dhodapkar, M. V., Dec 20 2016, In : Journal for ImmunoTherapy of Cancer. 4, 1, 90.

Research output: Contribution to journalArticle

Hematologic Neoplasms
Multiple Myeloma
Immunotherapy
Lymphoma
Leukemia
2015
21 Citations (Scopus)

Advances in the pathogenesis and diagnosis of multiple myeloma

Chesi, M. & Bergsagel, P. L., May 1 2015, In : International Journal of Laboratory Hematology. 37, S1, p. 108-114 7 p.

Research output: Contribution to journalArticle

Multiple Myeloma
Tumors
Neoplasms
Immunoglobulin Heavy Chain Genes
Immunoglobulin Heavy Chains
30 Citations (Scopus)

Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy

Desantis, A., Bruno, T., Catena, V., De Nicola, F., Goeman, F., Iezzi, S., Sorino, C., Ponzoni, M., Bossi, G., Federico, V., La Rosa, F., Ricciardi, M. R., Lesma, E., De Meo, P. D. O., Castrignanò, T., Petrucci, M. T., Pisani, F., Chesi, M., Bergsagel, P. L., Floridi, A. & 4 others, Tonon, G., Passananti, C., Blandino, G. & Fanciulli, M., May 5 2015, In : EMBO Journal. 34, 9, p. 1214-1230 17 p.

Research output: Contribution to journalArticle

Autophagy
Sirolimus
Cell growth
Multiple Myeloma
RNA-Binding Proteins
4 Citations (Scopus)

Erratum: Immunosurveillance and therapy of multiple myeloma are CD226 dependent (Journal of Clinical Investigation (2015) 125:5 (2077-2089) DOI:10.1172/JCI77181)

Guillerey, C., De Andrade, L. F., Vuckovic, S., Miles, K., Ngiow, S. F., Yong, M. C. R., Teng, M. W. L., Colonna, M., Ritchie, D. S., Chesi, M., Bergsagel, P. L., Hill, G. R., Smyth, M. J. & Martinet, L., Jul 1 2015, In : Journal of Clinical Investigation. 125, 7, p. 2904 1 p.

Research output: Contribution to journalArticle

Immunologic Monitoring
Multiple Myeloma
Therapeutics