Leif Bergsagel, MD

Professor

Accepting PhD Students

  • 21347 Citations
  • 80 h-Index
1984 …2020
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Multiple Myeloma Medicine & Life Sciences
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Projects 1997 2020

Monoclonal Gammopathy of Undetermined Significance
Plasma Cells
Multiple Myeloma
Mutation
Bone Neoplasms

Mayo Clinic Multiple Myeloma SPORE

Fonseca, R., Stewart, A. K., Dueck, A., Chesi, M., Bergsagel, P. L., Chesi, M. & Dueck, A.

National Institutes of Health

9/1/158/31/20

Project: Research projectSpecialized Center

Multiple Myeloma
Oncolytic Virotherapy
Clonal Evolution
Vesicular Stomatitis
Research
Multiple Myeloma
Therapeutics
Cell Line
Clustered Regularly Interspaced Short Palindromic Repeats
Polyploidy

Molecular Pathogenesis of Multiple Myeloma

Bergsagel, P. L.

National Institutes of Health

6/1/094/30/14

Project: Research projectResearch Project

Multiple Myeloma
Disease Progression
Polyploidy
Mutation
Drug Resistance

Research Output 1984 2018

A phase 2 study of rituximab, cyclophosphamide, bortezomib and dexamethasone (R-CyBorD) in relapsed low grade and mantle cell lymphoma

Sonbol, M. B., Hilal, T., Dueck, A., Rosenthal, A. C., Conley, C. R., Kosiorek, H. E., Ginos, B. F., Gano, K. M., Nichols, C. S., Leis, J. F., Johnston, P. B., Habermann, T. M., Northfelt, D. W., Bergsagel, P. L., Inwards, D. J., Witzig, T. E., Ansell, S. M. & Reeder, C. B., Jan 11 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-7 7 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Cyclophosphamide
Dexamethasone
Safety
Peripheral Nervous System Diseases

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression

Kawano, Y., Zavidij, O., Park, J., Moschetta, M., Kokubun, K., Mouhieddine, T. H., Manier, S., Mishima, Y., Murakami, N., Bustoros, M., Pistofidis, R. S., Reidy, M., Shen, Y. J., Rahmat, M., Lukyanchykov, P., Karreci, E. S., Tsukamoto, S., Shi, J., Takagi, S., Huynh, D. & 7 othersSacco, A., Tai, Y. T., Chesi, M., Bergsagel, P. L., Roccaro, A. M., Azzi, J. & Ghobrial, I. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2487-2499 13 p.

Research output: Contribution to journalArticle

Interferon Type I
Immunosuppressive Agents
Multiple Myeloma
Immunosuppression
Regulatory T-Lymphocytes

Detailing the genomic landscape of myeloma

Bergsagel, P. L. & Michael Kuehl, W., Aug 9 2018, In : Blood. 132, 6, p. 554-555 2 p.

Research output: Contribution to journalReview article

Multiple Myeloma
Blood
Paraproteinemias
Multiple Myeloma
Precision Medicine
Genetic Predisposition to Disease
Cytogenetics
1 Citations

Dysregulated IL-18 Is a Key Driver of Immunosuppression and a Possible Therapeutic Target in the Multiple Myeloma Microenvironment

Nakamura, K., Kassem, S., Cleynen, A., Chrétien, M. L., Guillerey, C., Putz, E. M., Bald, T., Förster, I., Vuckovic, S., Hill, G. R., Masters, S. L., Chesi, M., Bergsagel, P. L., Avet-Loiseau, H., Martinet, L. & Smyth, M. J., Jan 1 2018, (Accepted/In press) In : Cancer Cell.

Research output: Contribution to journalArticle

Interleukin-18
Multiple Myeloma
Immunosuppression
Therapeutics
T-Lymphocytes