Leif Bergsagel, MD

Professor

Accepting PhD Students

  • 22317 Citations
  • 80 h-Index
1984 …2020
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Multiple Myeloma Medicine & Life Sciences
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Survival Medicine & Life Sciences

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Projects 1997 2020

Monoclonal Gammopathy of Undetermined Significance
Plasma Cells
Multiple Myeloma
Mutation
Bone Neoplasms
Multiple Myeloma
Oncolytic Virotherapy
Clonal Evolution
Vesicular Stomatitis
Research
Multiple Myeloma
Therapeutics
Cell Line
Clustered Regularly Interspaced Short Palindromic Repeats
Polyploidy
Multiple Myeloma
Disease Progression
Polyploidy
Mutation
Drug Resistance

Research Output 1984 2019

Identification of lenalidomide resistance pathways in myeloma and targeted resensitization using cereblon replacement, inhibition of STAT3 or targeting of IRF4

Zhu, Y. X., Shi, C. X., Bruins, L. A., Wang, X., Riggs, D. L., Porter, B., Ahmann, J. M., de Campos, C. B., Braggio, E. D., Bergsagel, P. L. & Stewart, A. K., Feb 1 2019, In : Blood cancer journal. 9, 2, 19.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Cell Line
Down-Regulation
lenalidomide
Sequence Deletion

Oncolytic immunotherapy and bortezomib synergy improves survival of refractory multiple myeloma in a preclinical model

Thirukkumaran, C. M., Shi, Z. Q., Nuovo, G. J., Luider, J., Kopciuk, K. A., Dong, Y., Mostafa, A. A., Thakur, S., Gratton, K., Yang, A., Chin, A. C., Coffey, M. C., Jimenez-Zepeda, V. H., Stewart, D., Chesi, M., Bergsagel, P. L. & Morris, D., Mar 12 2019, In : Blood advances. 3, 5, p. 797-812 16 p.

Research output: Contribution to journalArticle

Open Access
Multiple Myeloma
Immunotherapy
Survival
Neoplasms
Therapeutics

Antigen-mediated regulation in monoclonal gammopathies and myeloma

Nair, S., Sng, J., Boddupalli, C. S., Seckinger, A., Chesi, M., Fulciniti, M., Zhang, L., Rauniyar, N., Lopez, M., Neparidze, N., Parker, T., Munshi, N. C., Sexton, R., Barlogie, B., Orlowski, R., Bergsagel, P. L., Hose, D., Flavell, R. A., Mistry, P. K., Meffre, E. & 1 othersDhodapkar, M. V., Apr 19 2018, In : JCI insight. 3, 8

Research output: Contribution to journalArticle

Open Access
Paraproteinemias
Antigens
Gaucher Disease
Plasma Cells
Multiple Myeloma

A phase 2 study of rituximab, cyclophosphamide, bortezomib and dexamethasone (R-CyBorD) in relapsed low grade and mantle cell lymphoma

Sonbol, M. B., Hilal, T., Dueck, A., Rosenthal, A. C., Conley, C. R., Kosiorek, H. E., Ginos, B. F., Gano, K. M., Nichols, C. S., Leis, J. F., Johnston, P. B., Habermann, T. M., Northfelt, D. W., Bergsagel, P. L., Inwards, D. J., Witzig, T. E., Ansell, S. M. & Reeder, C. B., Jan 11 2018, (Accepted/In press) In : Leukemia and Lymphoma. p. 1-7 7 p.

Research output: Contribution to journalArticle

Mantle-Cell Lymphoma
Cyclophosphamide
Dexamethasone
Safety
Peripheral Nervous System Diseases
4 Citations (Scopus)

Blocking IFNAR1 inhibits multiple myeloma-driven Treg expansion and immunosuppression

Kawano, Y., Zavidij, O., Park, J., Moschetta, M., Kokubun, K., Mouhieddine, T. H., Manier, S., Mishima, Y., Murakami, N., Bustoros, M., Pistofidis, R. S., Reidy, M., Shen, Y. J., Rahmat, M., Lukyanchykov, P., Karreci, E. S., Tsukamoto, S., Shi, J., Takagi, S., Huynh, D. & 7 othersSacco, A., Tai, Y. T., Chesi, M., Bergsagel, P. L., Roccaro, A. M., Azzi, J. & Ghobrial, I. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2487-2499 13 p.

Research output: Contribution to journalArticle

Interferon Type I
Immunosuppressive Agents
Multiple Myeloma
Immunosuppression
Regulatory T-Lymphocytes