• 17993 Citations
  • 47 Scopus h-Index
1979 …2021

Research output per year

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Research Output

  • 17993 Citations
  • 47 Scopus h-Index
  • 194 Article
  • 13 Comment/debate
  • 6 Review article
  • 1 Chapter
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Article
2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Exploring the effect of library preparation on RNA sequencing experiments

Wang, L., Felts, S. J., Van Keulen, V. P., Pease, L. R. & Zhang, Y., Dec 2019, In : Genomics. 111, 6, p. 1752-1759 8 p.

Research output: Contribution to journalArticle

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Sterner, R. M., Sakemura, R., Cox, M. J., Yang, N., Khadka, R. H., Forsman, C. L., Hansen, M. J., Jin, F., Ayasoufi, K., Hefazi, M., Schick, K. J., Walters, D. K., Ahmed, O., Chappell, D., Sahmoud, T., Durrant, C., Nevala, W. K., Patnaik, M. M., Pease, L. R., Hedin, K. E. & 3 others, Kay, N. E., Johnson, A. J. & Kenderian, S., Feb 14 2019, In : Blood. 133, 7, p. 697-709 13 p.

Research output: Contribution to journalArticle

32 Scopus citations

Stochastic changes in gene expression promote chaotic dysregulation of homeostasis in clonal breast tumors

Felts, S. J., Tang, X., Willett, B., Van Keulen, V. P., Hansen, M. J., Kalari, K. R. & Pease, L. R., Dec 1 2019, In : Communications Biology. 2, 1, 206.

Research output: Contribution to journalArticle

Open Access

The early proximal TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Neier, S. C., Ferrer, A., Wilton, K. M., Smith, S. E. P., Kelcher, A. M. H., Pavelko, K. D., Canfield, J. M., Davis, T. R., Stiles, R. J., Chen, Z., McCluskey, J., Burrows, S. R., Rossjohn, J., Hebrink, D. M., Carmona, E. M., Limper, A. H., Kappes, D. J., Wettstein, P. J., Johnson, A. J., Pease, L. R. & 4 others, Daniels, M. A., Neuhauser, C., Gil, D. & Schrum, A. G., Jan 1 2019, In : Science Immunology. 4, 32, eaal2201.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Gene expression signatures characterized by longitudinal stability and interindividual variability delineate baseline phenotypic groups with distinct responses to immune stimulation

Scheid, A. D., Van Keulen, V. P., Felts, S. J., Neier, S. C., Middha, S., Nair, A. A., Techentin, R. W., Gilbert, B. K., Jen, J., Neuhauser, C., Zhang, Y. & Pease, L. R., Mar 1 2018, In : Journal of Immunology. 200, 5, p. 1917-1928 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human perforin gene variation is geographically distributed

Willenbring, R. C., Ikeda, Y. H., Pease, L. R. & Johnson, A. J., Jan 1 2018, In : Molecular Genetics and Genomic Medicine. 6, 1, p. 44-55 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Integrative genome-wide analysis of long noncoding RNAs in diverse immune cell types of melanoma patients

Wang, L., Felts, S. J., Van Keulen, V. P., Scheid, A. D., Block, M. S., Markovic, S. N., Pease, L. R. & Zhang, Y., Aug 1 2018, In : Cancer Research. 78, 15, p. 4411-4423 13 p.

Research output: Contribution to journalArticle

5 Scopus citations

Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Malo, C. S., Huggins, M. A., Goddery, E. N., Tolcher, H. M. A., Renner, D. N., Jin, F., Hansen, M. J., Pease, L. R., Pavelko, K. D. & Johnson, A. J., Dec 1 2018, In : Nature Communications. 9, 1, 633.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Replicating single-cycle adenovirus vectors generate amplified influenza vaccine responses

Crosby, C. M., Matchett, W. E., Anguiano-Zarate, S. S., Parks, C. A., Weaver, E. A., Pease, L. R., Webby, R. J. & Barry, M. A., 2017, In : Journal of Virology. 91, 2, e00720-16.

Research output: Contribution to journalArticle

25 Scopus citations
2016

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

13 Scopus citations
2015

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

Xu, X., Denic, A., Jordan, L. R., Wittenberg, N. J., Warrington, A. E., Wootla, B., Papke, L. M., Zoecklein, L. J., Yoo, D., Shaver, J., Oh, S. H., Pease, L. R. & Rodriguez, M., Aug 1 2015, In : DMM Disease Models and Mechanisms. 8, 8, p. 831-842 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

A versatile simple capture assay for assessing the structural integrity of MHC multimer reagents

Reed, B. K., Chopp, L. B., Malo, C. S., Renner, D. N., Van Keulen, V. S., Girtman, M. A., Nevala, W. N., Pavelko, K. D., Gil, D., Schrum, A. G., Johnson, A. J. & Pease, L. R., Sep 21 2015, In : PLoS One. 10, 9, e0137984.

Research output: Contribution to journalArticle

2 Scopus citations

Calcium-modulating cyclophilin ligand is essential for the survival of activated t cells and for adaptive immunity

Chan, S. L., Lindquist, L. D., Hansen, M. J., Girtman, M. A., Pease, L. R. & Bram, R. J., Dec 15 2015, In : Journal of Immunology. 195, 12, p. 5648-5656 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Combinatorial immunoprofiling in latent tuberculosis infection: Toward better risk stratification

Escalante, P., Peikert, T. D., Van Keulen, V. P., Erskine, C. L., Bornhorst, C. L., Andrist, B. R., McCoy, K., Pease, L. R., Abraham, R. S., Knutson, K. L., Kita, H., Schrum, A. G. & Limper, A. H., Sep 1 2015, In : American Journal of Respiratory and Critical Care Medicine. 192, 5, p. 605-617 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo

Hoffmann, M. M., Molina-Mendiola, C., Nelson, A. D., Parks, C. A., Reyes, E. E., Hansen, M. J., Rajagopalan, G., Pease, L. R., Schrum, A. G. & Gil, D., Jan 1 2015, In : Science advances. 1, 9, 1500415.

Research output: Contribution to journalArticle

5 Scopus citations

Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients

Felts, S. J., Van Keulen, V. P., Scheid, A. D., Allen, K. S., Bradshaw, R. K., Jen, J., Peikert, T., Middha, S., Zhang, Y., Block, M. S., Markovic, S. N. & Pease, L. R., Nov 1 2015, In : Cancer Immunology, Immunotherapy. 64, 11, p. 1437-1447 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer

Felts, S. J., Van Keulen, V. P., Hansen, M. J., Bell, M. P., Allen, K., Belachew, A. A., Vile, R. G., Cunningham, J. M., Hoskin, T. L., Pankratz, V. S. & Pease, L. R., Apr 1 2015, In : Neoplasia. 17, 4, p. 348-357 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. BioTechniques 8(5):528-535 (November 1990).

Horton, R. M., Cai, Z., Ho, S. M. & Pease, L. R., Mar 1 2013, In : BioTechniques. 54, 3, p. 129-133 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gene splicing by overlap extension: Tailor-made genes using the polymerase chain reaction

Horton, R. M., Cai, Z., Ho, S. N. & Pease, L. R., Jan 1 2013, In : BioTechniques. 54, 3, p. 528-535 8 p.

Research output: Contribution to journalArticle

Open Access
23 Scopus citations

The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine

Pavelko, K. D., Bell, M. P., Karyampudi, L., Hansen, M. J., Allen, K. S., Knutson, K. L. & Pease, L. R., May 2013, In : Molecular Therapy. 21, 5, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

A factor found in the igg fraction of serum of patients with paraneoplastic bilateral diffuse uveal melanocytic proliferation causes proliferation of cultured human melanocytes

Miles, S. L., Niles, R. M., Pittock, S., Vile, R., Davies, J., Winters, J. L., Abu-Yaghi, N. E., Grothey, A., Siddiqui, M., Kaur, J., Hartmann, L., Kalli, K. R., Pease, L., Kravitz, D., Markovic, S. & Pulido, J. S., Oct 1 2012, In : Retina. 32, 9, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity

Pavelko, K. D., Mendez-Fernandez, Y., Bell, M. P., Hansen, M. J., Johnson, A. J., David, C. S., Rodriguez, M. & Pease, L. R., Feb 1 2012, In : PLoS pathogens. 8, 2, e1002541.

Research output: Contribution to journalArticle

5 Scopus citations

Two discreet subsets of CD8 T cells modulate PLP 91-110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

Mangalam, A. K., Luckey, D., Giri, S., Smart, M., Pease, L. R., Rodriguez, M. & David, C. S., Jun 1 2012, In : Journal of Autoimmunity. 38, 4, p. 344-353 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

Pulido, J., Kottke, T., Thompson, J., Galivo, F., Wongthida, P., Diaz, R. M., Rommelfanger, D., Ilett, E., Pease, L., Pandha, H., Harrington, K., Selby, P., Melcher, A. & Vile, R., Apr 1 2012, In : Nature biotechnology. 30, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

67 Scopus citations
2011

A human IgM signals axon outgrowth: Coupling lipid raft to microtubules

Xu, X., Warrington, A. E., Wright, B. R., Bieber, A. J., Van Keulen, V., Pease, L. R. & Rodriguez, M., Oct 1 2011, In : Journal of neurochemistry. 119, 1, p. 100-112 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination

Denic, A., Macura, S. I., Warrington, A. E., Pirko, I., Grossardt, B. R., Pease, L. R. & Rodriguez, M., Oct 12 2011, In : PloS one. 6, 10, e26001.

Research output: Contribution to journalArticle

18 Scopus citations

Lineage -Sca1 +c-Kit -CD25 + cells are IL-33-responsive type 2 innate cells in the mouse bone marrow

Brickshawana, A., Shapiro, V. S., Kita, H. & Pease, L. R., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 5795-5804 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy

Pavelko, K. D., Girtman, M. A., Mitsunaga, Y., Mendez-Fernandez, Y. V., Bell, M. P., Hansen, M. J., Allen, K. S., Rodriguez, M. & Pease, L. R., May 26 2011, In : PloS one. 6, 5, e20217.

Research output: Contribution to journalArticle

13 Scopus citations

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis

Denic, A., Zoecklein, L., Kerkvliet, J., Papke, L., Edukulla, R., Warrington, A., Bieber, A., Pease, L. R., David, C. S. & Rodriguez, M., Sep 1 2011, In : Brain Pathology. 21, 5, p. 501-515 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair

Bieber, A. J., Suwansrinon, K., Kerkvliet, J., Zhang, W., Pease, L. R. & Rodriguez, M., Feb 15 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 2, p. 792-797 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer

Wongthida, P., Diaz, R. M., Galivo, F., Kottke, T., Thompson, J., Pulido, J., Pavelko, K., Pease, L., Melcher, A. & Vile, R., Jun 1 2010, In : Cancer research. 70, 11, p. 4539-4549 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
2009

Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent TH2 adjuvant activity

Kobayashi, T., Iijima, K., Radhakrishnan, S., Mehta, V., Vassallo, R., Lawrence, C. B., Cyong, J. C., Pease, L. R., Oguchi, K. & Kita, H., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 2502-2510 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection

Pavelko, K. D., Hansen, M. J. & Pease, L. R., Apr 1 2009, In : Cancer research. 69, 7, p. 3114-3120 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions

Radhakrishnan, S., Cabrera, R., Bruns, K. M., Van Keulen, V. P., Hansen, M. J., Felts, S. J. & Pease, L. R., Apr 28 2009, In : PloS one. 4, 4, e5373.

Research output: Contribution to journalArticle

2 Scopus citations

Invited Article: Human natural autoantibodies in the treatment of neurologic disease

Rodriguez, M., Warrington, A. E. & Pease, L. R., Apr 7 2009, In : Neurology. 72, 14, p. 1269-1276 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Transgenic expression of the 3D polymerase inhibits Theiler's virus infection and demyelination

Kerkvliet, J., Zoecklein, L., Papke, L., Denic, A., Bieber, A. J., Pease, L. R., David, C. S. & Rodriguez, M., Dec 1 2009, In : Journal of virology. 83, 23, p. 12279-12289 11 p.

Research output: Contribution to journalArticle

14 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2009, In : Journal of Immunology. 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

12 Scopus citations
2008

An effective vaccine strategy protective against antigenically distinct tumor variants

Pavelko, K. D., Heckman, K. L., Hansen, M. J. & Pease, L. R., Apr 1 2008, In : Cancer research. 68, 7, p. 2471-2478 8 p.

Research output: Contribution to journalArticle

10 Scopus citations

Cigarette smoke-induced oxidative stress suppresses generation of dendritic cell IL-12 and IL-23 through ERK-dependent pathways

Kroening, P. R., Barnes, T. W., Pease, L., Limper, A., Kita, H. & Vassallo, R., Jul 15 2008, In : Journal of Immunology. 181, 2, p. 1536-1547 12 p.

Research output: Contribution to journalArticle

Open Access
67 Scopus citations

Human HLA-DR transgenes protect mice from fatal virus-induced encephalomyelitis and chronic demyelination

Rodriguez, M., Zoecklein, L., Kerkvliet, J. G., Pavelko, K. D., Papke, L., Howe, C. L., Pease, L. R. & David, C., Apr 1 2008, In : Journal of virology. 82, 7, p. 3369-3380 12 p.

Research output: Contribution to journalArticle

3 Scopus citations

PCR mutagenesis by overlap extension and gene SOE

Vallejo, A. N., Pogulis, R. J. & Pease, L. R., Feb 1 2008, In : Cold Spring Harbor Protocols. 3, 2

Research output: Contribution to journalArticle

28 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Sep 1 2008, In : Journal of Immunology. 181, 5, p. 3137-3147 11 p.

Research output: Contribution to journalArticle

Open Access
98 Scopus citations

T-bet expression by dendritic cells is required for the repolarization of allergic airway inflammation

Heckman, K. L., Radhakrishnan, S., Peikert, T., Iijima, K., McGregor, H. C., Bell, M. P., Kita, H. & Pease, L. R., Sep 1 2008, In : European Journal of Immunology. 38, 9, p. 2464-2474 11 p.

Research output: Contribution to journalArticle

10 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells.

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Colonna, M., Leibson, P. J., Rodriguez, M. & Pease, L. R., Dec 1 2008, In : Journal of immunology (Baltimore, Md. : 1950). 181, 11, p. 7863-7872 10 p.

Research output: Contribution to journalArticle

2007

A recombinant human IgM promotes myelin repair after a single, very low dose

Warrington, A. E., Bieber, A. J., Ciric, B., Pease, L. R., Van Keulen, V. & Rodriguez, M., Apr 1 2007, In : Journal of Neuroscience Research. 85, 5, p. 967-976 10 p.

Research output: Contribution to journalArticle

81 Scopus citations

B7-DC/PD-L2 cross-linking induces NF-κB-dependent protection of dendritic cells from cell death

Radhakrishnan, S., Nguyen, L. T., Ciric, B., Van Keulen, V. P. & Pease, L. R., Feb 1 2007, In : Journal of Immunology. 178, 3, p. 1426-1432 7 p.

Research output: Contribution to journalArticle

23 Scopus citations

Fast-tracked CTL: Rapid induction of potent anti-tumor killer T cells in situ

Heckman, K. L., Schenk, E. L., Radhakrishnan, S., Pavelko, K. D., Hansen, M. J. & Pease, L. R., Jul 1 2007, In : European Journal of Immunology. 37, 7, p. 1827-1835 9 p.

Research output: Contribution to journalArticle

11 Scopus citations

Gene splicing and mutagenesis by PCR-driven overlap extension

Heckman, K. L. & Pease, L. R., Apr 1 2007, In : Nature Protocols. 2, 4, p. 924-932 9 p.

Research output: Contribution to journalArticle

703 Scopus citations