• 17900 Citations
  • 47 Scopus h-Index
1979 …2021

Research output per year

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Research Output

  • 17900 Citations
  • 47 Scopus h-Index
  • 214 Article
2019

Breaking tolerance with engineered class I antigen-presenting molecules

Parks, C. A., Henning, K. R., Pavelko, K. D., Hansen, M. J., Van Keulen, V. P., Reed, B. K., Stone, J. D., Schrum, A. G., Gil, D., Kranz, D. M., Bordner, A. J., Barry, M. A. & Pease, L. R., Feb 19 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 8, p. 3136-3145 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Sterner, R. M., Sakemura, R., Cox, M. J., Yang, N., Khadka, R. H., Forsman, C. L., Hansen, M. J., Jin, F., Ayasoufi, K., Hefazi, M., Schick, K. J., Walters, D. K., Ahmed, O., Chappell, D., Sahmoud, T., Durrant, C., Nevala, W. K., Patnaik, M. M., Pease, L. R., Hedin, K. E. & 3 others, Kay, N. E., Johnson, A. J. & Kenderian, S., Feb 14 2019, In : Blood. 133, 7, p. 697-709 13 p.

Research output: Contribution to journalArticle

22 Scopus citations

Stochastic changes in gene expression promote chaotic dysregulation of homeostasis in clonal breast tumors

Felts, S. J., Tang, X., Willett, B., Van Keulen, V. P., Hansen, M. J., Kalari, K. R. & Pease, L. R., Dec 1 2019, In : Communications Biology. 2, 1, 206.

Research output: Contribution to journalArticle

Open Access

The early proximal αβ TCR signalosome specifies thymic selection outcome through a quantitative protein interaction network

Neier, S. C., Ferrer, A., Wilton, K. M., Smith, S. E. P., Kelcher, A. M. H., Pavelko, K. D., Canfield, J. M., Davis, T. R., Stiles, R. J., Chen, Z., McCluskey, J., Burrows, S. R., Rossjohn, J., Hebrink, D. M., Carmona Porquera, E. M., Limper, A. H., Kappes, D. J., Wettstein, P. J., Johnson, A. J., Pease, L. R. & 4 others, Daniels, M. A., Neuhauser, C., Gil, D. & Schrum, A. G., Feb 15 2019, In : Science immunology. 4, 32

Research output: Contribution to journalArticle

2 Scopus citations
2018

Exploring the effect of library preparation on RNA sequencing experiments

Wang, L., Felts, S. J., Van Keulen, V. P., Pease, L. R. & Zhang, Y., Jan 1 2018, (Accepted/In press) In : Genomics.

Research output: Contribution to journalArticle

Gene expression signatures characterized by longitudinal stability and interindividual variability delineate baseline phenotypic groups with distinct responses to immune stimulation

Scheid, A. D., Van Keulen, V. P., Felts, S. J., Neier, S. C., Middha, S., Nair, A. A., Techentin, R. W., Gilbert, B. K., Jen, J., Neuhauser, C., Zhang, Y. & Pease, L. R., Mar 1 2018, In : Journal of Immunology. 200, 5, p. 1917-1928 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Human perforin gene variation is geographically distributed

Willenbring, R. C., Ikeda, Y. H., Pease, L. R. & Johnson, A. J., Jan 1 2018, In : Molecular Genetics and Genomic Medicine. 6, 1, p. 44-55 12 p.

Research output: Contribution to journalArticle

1 Scopus citations

Integrative genome-wide analysis of long noncoding RNAs in diverse immune cell types of melanoma patients

Wang, L., Felts, S. J., Van Keulen, V. P., Scheid, A. D., Block, M. S., Markovic, S. N., Pease, L. R. & Zhang, Y., Aug 1 2018, In : Cancer Research. 78, 15, p. 4411-4423 13 p.

Research output: Contribution to journalArticle

4 Scopus citations

Non-equivalent antigen presenting capabilities of dendritic cells and macrophages in generating brain-infiltrating CD8 + T cell responses

Malo, C. S., Huggins, M. A., Goddery, E. N., Tolcher, H. M. A., Renner, D. N., Jin, F., Hansen, M. J., Pease, L. R., Pavelko, K. D. & Johnson, A. J., Dec 1 2018, In : Nature Communications. 9, 1, 633.

Research output: Contribution to journalArticle

4 Scopus citations
2017

Replicating single-cycle adenovirus vectors generate amplified influenza vaccine responses

Crosby, C. M., Matchett, W. E., Anguiano-Zarate, S. S., Parks, C. A., Weaver, E. A., Pease, L. R., Webby, R. J. & Barry, M. A., 2017, In : Journal of Virology. 91, 2, e00720-16.

Research output: Contribution to journalArticle

24 Scopus citations
2016

Definitive activation of endogenous antitumor immunity by repetitive cycles of cyclophosphamide with interspersed Tolllike receptor agonists

Manrique, S. Z., Dominguez, A. L., Mirza, N., Spencer, C. D., Bradley, J. M., Finke, J. H., Lee, J. J., Pease, L. R., Gendler, S. J. & Cohen, P. A., 2016, In : Oncotarget. 7, 28, p. 42919-42942 24 p.

Research output: Contribution to journalArticle

12 Scopus citations
2015

A natural human IgM that binds to gangliosides is therapeutic in murine models of amyotrophic lateral sclerosis

Xu, X., Denic, A., Jordan, L. R., Wittenberg, N. J., Warrington, A. E., Wootla, B., Papke, L. M., Zoecklein, L. J., Yoo, D., Shaver, J., Oh, S. H., Pease, L. R. & Rodriguez, M., Aug 1 2015, In : DMM Disease Models and Mechanisms. 8, 8, p. 831-842 12 p.

Research output: Contribution to journalArticle

19 Scopus citations

A versatile simple capture assay for assessing the structural integrity of MHC multimer reagents

Reed, B. K., Chopp, L. B., Malo, C. S., Renner, D. N., Van Keulen, V. S., Girtman, M. A., Nevala, W. N., Pavelko, K. D., Gil, D., Schrum, A. G., Johnson, A. J. & Pease, L. R., Sep 21 2015, In : PLoS One. 10, 9, e0137984.

Research output: Contribution to journalArticle

2 Scopus citations

Calcium-modulating cyclophilin ligand is essential for the survival of activated t cells and for adaptive immunity

Chan, S. L., Lindquist, L. D., Hansen, M. J., Girtman, M. A., Pease, L. R. & Bram, R. J., Dec 15 2015, In : Journal of Immunology. 195, 12, p. 5648-5656 9 p.

Research output: Contribution to journalArticle

6 Scopus citations

Combinatorial immunoprofiling in latent tuberculosis infection: Toward better risk stratification

Escalante, P., Peikert, T. D., Van Keulen, V. P., Erskine, C. L., Bornhorst, C. L., Andrist, B. R., McCoy, K., Pease, L. R., Abraham, R. S., Knutson, K. L., Kita, H., Schrum, A. G. & Limper, A. H., Sep 1 2015, In : American Journal of Respiratory and Critical Care Medicine. 192, 5, p. 605-617 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Co-potentiation of antigen recognition: A mechanism to boost weak T cell responses and provide immunotherapy in vivo

Hoffmann, M. M., Molina-Mendiola, C., Nelson, A. D., Parks, C. A., Reyes, E. E., Hansen, M. J., Rajagopalan, G., Pease, L. R., Schrum, A. G. & Gil, D., Jan 1 2015, In : Science advances. 1, 9, 1500415.

Research output: Contribution to journalArticle

4 Scopus citations

Gene expression patterns in CD4+ peripheral blood cells in healthy subjects and stage IV melanoma patients

Felts, S. J., Van Keulen, V. P., Scheid, A. D., Allen, K. S., Bradshaw, R. K., Jen, J., Peikert, T. D., Middha, S., Zhang, Y., Block, M. S., Markovic, S. N. & Pease, L. R., Aug 6 2015, In : Cancer Immunology, Immunotherapy. 64, 11, p. 1437-1447 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Widespread Non-Canonical Epigenetic Modifications in MMTV-NeuT Breast Cancer

Felts, S. J., Van Keulen, V. P., Hansen, M. J., Bell, M. P., Allen, K., Belachew, A. A., Vile, R. G., Cunningham, J. M., Hoskin, T. L., Pankratz, V. S. & Pease, L. R., Apr 1 2015, In : Neoplasia. 17, 4, p. 348-357 10 p.

Research output: Contribution to journalArticle

2 Scopus citations
2013

Gene splicing by overlap extension: tailor-made genes using the polymerase chain reaction. BioTechniques 8(5):528-535 (November 1990).

Horton, R. M., Cai, Z., Ho, S. M. & Pease, L. R., Mar 2013, In : BioTechniques. 54, 3, p. 129-133 5 p.

Research output: Contribution to journalArticle

7 Scopus citations

Gene splicing by overlap extension: Tailor-made genes using the polymerase chain reaction

Horton, R. M., Cai, Z., Ho, S. N. & Pease, L. R., Mar 2013, In : BioTechniques. 54, 3, p. 528-535 8 p.

Research output: Contribution to journalArticle

21 Scopus citations

The epitope integration site for vaccine antigens determines virus control while maintaining efficacy in an engineered cancer vaccine

Pavelko, K. D., Bell, M. P., Karyampudi, L., Hansen, M. J., Allen, K. S., Knutson, K. L. & Pease, L. R., May 2013, In : Molecular Therapy. 21, 5, p. 1087-1095 9 p.

Research output: Contribution to journalArticle

13 Scopus citations
2012

A factor found in the igg fraction of serum of patients with paraneoplastic bilateral diffuse uveal melanocytic proliferation causes proliferation of cultured human melanocytes

Miles, S. L., Niles, R. M., Pittock, S. J., Vile, R. G., Davies, J., Winters, J. L., Abu-Yaghi, N. E., Grothey, A. F., Siddiqui, M., Kaur, J. S., Hartmann, L., Kalli, K. R., Pease, L. R., Kravitz, D., Markovic, S. N. & Pulido, J. S., Oct 2012, In : Retina. 32, 9, p. 1959-1966 8 p.

Research output: Contribution to journalArticle

35 Scopus citations

Naturally occurring antibodies as therapeutics for neurologic disease: can human monoclonal IgMs replace the limited resource IVIG?

Warrington, A. E., Van Keulen, V., Pease, L. R. & Rodriguez, M., 2012, In : Advances in Experimental Medicine and Biology. 750, p. 44-55 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Nonequivalence of classical MHC class I loci in ability to direct effective antiviral immunity

Pavelko, K. D., Mendez-Fernandez, Y., Bell, M. P., Hansen, M. J., Johnson, A. J., David, C. S., Rodriguez, M. & Pease, L. R., Feb 2012, In : PLoS Pathogens. 8, 2, e1002541.

Research output: Contribution to journalArticle

5 Scopus citations

Two discreet subsets of CD8 T cells modulate PLP 91-110 induced experimental autoimmune encephalomyelitis in HLA-DR3 transgenic mice

Mangalam, A. K., Luckey, D., Giri, S., Smart, M., Pease, L. R., Rodriguez, M. & David, C. S., Jun 2012, In : Journal of Autoimmunity. 38, 4, p. 344-353 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Using virally expressed melanoma cDNA libraries to identify tumor-associated antigens that cure melanoma

Pulido, J. S., Kottke, T., Thompson, J., Galivo, F., Wongthida, P., Diaz, R. M., Rommelfanger, D., Ilett, E., Pease, L. R., Pandha, H., Harrington, K., Selby, P., Melcher, A. & Vile, R. G., Apr 2012, In : Nature Biotechnology. 30, 4, p. 337-343 7 p.

Research output: Contribution to journalArticle

67 Scopus citations
2011

A human IgM signals axon outgrowth: Coupling lipid raft to microtubules

Xu, X., Warrington, A. E., Wright, B. R., Bieber, A. J., Van Keulen, V., Pease, L. R. & Rodriguez, M., Oct 2011, In : Journal of Neurochemistry. 119, 1, p. 100-112 13 p.

Research output: Contribution to journalArticle

24 Scopus citations

A single dose of neuron-binding human monoclonal antibody improves spontaneous activity in a murine model of demyelination

Denic, A., Macura, S. I., Warrington, A. E., Pirko, I., Grossardt, B. R., Pease, L. R. & Rodriguez, M., Oct 12 2011, In : PLoS One. 6, 10, e26001.

Research output: Contribution to journalArticle

18 Scopus citations

Lineage -Sca1 +c-Kit -CD25 + cells are IL-33-responsive type 2 innate cells in the mouse bone marrow

Brickshawana, A., Shapiro, V. M., Kita, H. & Pease, L. R., Dec 1 2011, In : Journal of Immunology. 187, 11, p. 5795-5804 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Theiler's murine encephalomyelitis virus as a vaccine candidate for immunotherapy

Pavelko, K. D., Girtman, M. A., Mitsunaga, Y., Mendez-Fernandez, Y. V., Bell, M. P., Hansen, M. J., Allen, K. S., Rodriguez, M. & Pease, L. R., 2011, In : PLoS One. 6, 5, e20217.

Research output: Contribution to journalArticle

13 Scopus citations

Transgenic expression of viral capsid proteins predisposes to axonal injury in a murine model of multiple sclerosis

Denic, A., Zoecklein, L., Kerkvliet, J., Papke, L., Edukulla, R., Warrington, A., Bieber, A., Pease, L. R., David, C. S. & Rodriguez, M., Sep 2011, In : Brain Pathology. 21, 5, p. 501-515 15 p.

Research output: Contribution to journalArticle

8 Scopus citations
2010

Allelic variation in the Tyk2 and EGF genes as potential genetic determinants of CNS repair

Bieber, A. J., Suwansrinon, K., Kerkvliet, J., Zhang, W., Pease, L. R. & Rodriguez, M., 2010, In : Proceedings of the National Academy of Sciences of the United States of America. 107, 2, p. 792-797 6 p.

Research output: Contribution to journalArticle

12 Scopus citations

B7-DC/PD-L2 cross-linking induces NF-κB-dependent protection of dendritic cells from cell death (The Journal of Immunology (2007) 178, (1426-1432))

Radhakrishnan, S., Nguyen, L. T., Ciric, B., Van Keulen, V. P. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6554 1 p.

Research output: Contribution to journalArticle

2 Scopus citations

Blockade of allergic airway inflammation following systemic treatment with a B7-dendritic cell (PD-L2) cross-linking human antibody (The Journal of Immunology (2004) 173, (1360-1365))

Radhakrishnan, S., Iijima, K., Kobayashi, T., Rodriguez, M., Kita, H. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6553 1 p.

Research output: Contribution to journalArticle

Cross-linking the B7 family molecule B7-DC directly activates immune functions of dendritic cells (The Journal of Experimental Medicine (November 18, 2002) 196, 10 (1393-1398))

Nguyen, L. T., Radhakrishnan, S., Ciric, B., Tamada, K., Shin, T., Pardoll, D. M., Chen, L., Rodriguez, M. & Pease, L. R., Apr 12 2010, In : Journal of Experimental Medicine. 207, 4, p. 901 1 p.

Research output: Contribution to journalArticle

Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (The FASEB Journal (2006) 20, 13 (2408-2410) DOI: 10.1096/fj.06-6171fje)

Blocki, F. A., Radhakrishnan, S., Van Keulen, V. P., Heckman, K. L., Ciric, B., Howe, C. L., Rodriguez, M., Kwon, E. D. & Pease, L. R., Jun 2010, In : FASEB Journal. 24, 6, p. 2135-2136 2 p.

Research output: Contribution to journalArticle

Naturally occurring human IgM antibody that binds B7-DC and potentiates T cell stimulation by dendritic cells (The Journal of Immunology (2003) 170, (1830-1838))

Radhakrishnan, S., Nguyen, L. T., Ciric, B., Ure, D. R., Zhou, B., Tamada, K., Tseng, S. Y., Shin, T., Chen, L., Dong, H. M., Kyle, R. A., Rodriguez, M. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6552 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

Reprogrammed FoxP3+ T regulatory cells become IL-17+ antigen-specific autoimmune effectors in vitro and in vivo (The Journal of Immunology (2008) 181, (3137-3147))

Radhakrishnan, S., Cabrera, R., Schenk, E. L., Nava-Parada, P., Bell, M. P., Van Keulen, V. P., Marler, R. J., Felts, S. J. & Pease, L. R., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6556 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

Retraction: Immunotherapeutic potential of B7-DC (PD-L2) cross-linking antibody in conferring antitumor immunity (Cancer Research (2004) 1)

Nguyen, L. T., Ciric, B., Van Keulen, V. P., Rodriguez, M., Pease, L. R., Tamada, K., Flies, D. B. & Chen, L., Nov 15 2010, In : Cancer Research. 70, 22, p. 9528 1 p.

Research output: Contribution to journalArticle

Retraction: An effective vaccine strategy protective against antigenically distinct tumor variants (Cancer Research (2008) 1)

Pavelko, K. D., Hansen, M. J., Pease, L. R. & Heckman, K. L., Nov 15 2010, In : Cancer Research. 70, 22, p. 9528 1 p.

Research output: Contribution to journalArticle

Retraction: CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection (Cancer Research (2009) 1)

Pavelko, K. D., Hansen, M. J. & Pease, L. R., Nov 15 2010, In : Cancer Research. 70, 22, p. 9529 1 p.

Research output: Contribution to journalArticle

1 Scopus citations

TREM-2 mediated signaling induces antigen uptake and retention in mature myeloid dendritic cells (The Journal of Immunology (2008) 181, (7863-7872))

Radhakrishnan, S., Arneson, L. N., Upshaw, J. L., Howe, C. L., Felts, S. J., Rodriguez, M., Pease, L. R. & Colonna, M., Jun 1 2010, In : Journal of Immunology. 184, 11, p. 6557 1 p.

Research output: Contribution to journalArticle

Type III IFN interleukin-28 mediates the antitumor efficacy of oncolytic virus VSV in immune-competent mouse models of cancer

Wongthida, P., Diaz, R. M., Galivo, F., Kottke, T., Thompson, J., Pulido, J. S., Pavelko, K., Pease, L. R., Melcher, A. & Vile, R. G., Jun 1 2010, In : Cancer Research. 70, 11, p. 4539-4549 11 p.

Research output: Contribution to journalArticle

69 Scopus citations
2009

Asthma-related environmental fungus, Alternaria, activates dendritic cells and produces potent TH2 adjuvant activity

Kobayashi, T., Iijima, K., Radhakrishnan, S., Mehta, V., Vassallo, R., Lawrence, C. B., Cyong, J. C., Pease, L. R., Oguchi, K. & Kita, H., Feb 15 2009, In : Journal of Immunology. 182, 4, p. 2502-2510 9 p.

Research output: Contribution to journalArticle

74 Scopus citations

CTL activation using the natural low-affinity epitope 222-229 from tyrosinase-related protein 1 leads to tumor rejection

Pavelko, K. D., Hansen, M. J. & Pease, L. R., Apr 1 2009, In : Cancer Research. 69, 7, p. 3114-3120 7 p.

Research output: Contribution to journalArticle

4 Scopus citations

Indirect recruitment of a CD40 signaling pathway in dendritic cells by B7-DC cross-linking antibody modulates T cell functions

Radhakrishnan, S., Cabrera, R., Bruns, K. M., Van Keulen, V. P., Hansen, M. J., Felts, S. J. & Pease, L. R., Apr 28 2009, In : PLoS One. 4, 4, e5373.

Research output: Contribution to journalArticle

2 Scopus citations

Invited Article: Human natural autoantibodies in the treatment of neurologic disease

Rodriguez, M., Warrington, A. E. & Pease, L. R., Apr 7 2009, In : Neurology. 72, 14, p. 1269-1276 8 p.

Research output: Contribution to journalArticle

35 Scopus citations