• 2198 Citations
  • 25 Scopus h-Index
19972019

Research output per year

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Research Output

  • 2198 Citations
  • 25 Scopus h-Index
  • 41 Article
  • 4 Review article
  • 3 Comment/debate
  • 2 Chapter
2019

Corrigendum to “Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy” [Heliyon 4 (12) (December 2018) e01039] (Heliyon (2018) 4(12), (S2405844018323442), (10.1016/j.heliyon.2018.e01039))

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Mar 1 2019, In : Heliyon. 5, 3, e01309.

Research output: Contribution to journalComment/debate

Open Access
2018

A tropomyosin-receptor kinase-fused gene mutation associates with vacuolar myopathy

Madigan, N. N., Tracy, J. A., Litchy, W. J., Niu, Z., Chen, C., Ling, K. & Milone, M., Dec 1 2018, In : Neurology: Genetics. 4, 6, e287.

Research output: Contribution to journalArticle

2 Scopus citations

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

He, K., Ma, X., Xu, T., Li, Y., Hodge, A., Zhang, Q., Torline, J., Huang, Y., Zhao, J., Ling, K. & Hu, J., Dec 1 2018, In : Nature communications. 9, 1, 3310.

Research output: Contribution to journalArticle

8 Scopus citations

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Orzechowski, A., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Dec 1 2018, In : Heliyon. 4, 12, e01039.

Research output: Contribution to journalArticle

3 Scopus citations
2017

EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression

Chen, C., Wang, X., Fang, J., Xue, J., Xiong, X., Huang, Y., Hu, J. & Ling, K., Jan 1 2017, In : Oncotarget. 8, 26, p. 42621-42637 17 p.

Research output: Contribution to journalArticle

3 Scopus citations
7 Scopus citations

Silencing of type I-phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion

Cao, S., Chen, C., Xue, J., Huang, Y., Yang, X. & Ling, K., 2017, In : Oncology Reports. 38, 1, p. 253-262 10 p.

Research output: Contribution to journalArticle

1 Scopus citations

Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB

Xue, J., Chen, C., Qi, M., Huang, Y., Wang, L., Gao, Y., Dong, H. & Ling, K., Jan 1 2017, In : Oncotarget. 8, 26, p. 42414-42427 14 p.

Research output: Contribution to journalArticle

10 Scopus citations
2016

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119

Zhang, Q., Li, Y., Zhang, Y., Torres, V., Harris, P. C., Ling, K. & Hu, J., Apr 22 2016, In : Scientific Reports. 6, 24534.

Research output: Contribution to journalArticle

14 Scopus citations

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

Xu, Q., Zhang, Y., Wei, Q., Huang, Y., Hu, J. & Ling, K., Feb 26 2016, In : Nature Communications. 7, 10777.

Research output: Contribution to journalArticle

31 Scopus citations

Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l 3

Durand, N., Bastea, L. I., Long, J., Döppler, H., Ling, K. & Storz, P., Oct 24 2016, In : Scientific Reports. 6, 35963.

Research output: Contribution to journalArticle

6 Scopus citations

The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate

Wei, Q., Zhang, Y., Schouteden, C., Zhang, Y., Zhang, Q., Dong, J., Wonesch, V., Ling, K., Dammermann, A. & Hu, J., Aug 18 2016, In : Nature Communications. 7, 12437.

Research output: Contribution to journalArticle

11 Scopus citations
2015

BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors

Xu, Q., Zhang, Y., Wei, Q., Huang, Y., Li, Y., Ling, K. & Hu, J., Jul 7 2015, In : Scientific Reports. 5, 11855.

Research output: Contribution to journalArticle

31 Scopus citations

The essential roles of transition fibers in the context of cilia

Wei, Q., Ling, K. & Hu, J., Aug 1 2015, In : Current Opinion in Cell Biology. 35, p. 98-105 8 p.

Research output: Contribution to journalArticle

30 Scopus citations
2014

PIPKIγ targets to the centrosome and restrains centriole duplication

Xu, Q., Zhang, Y., Xiong, X., Huang, Y., Salisbury, J. L., Hu, J. & Ling, K., Mar 1 2014, In : Journal of cell science. 127, 6, p. 1293-1305 13 p.

Research output: Contribution to journalArticle

11 Scopus citations

Targeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis

Chen, C., Wang, X., Xiong, X., Liu, Q., Huang, Y., Xu, Q., Hu, J., Ge, G. & Ling, K., Dec 8 2014, In : Oncogene. 34, 35, p. 4635-4646 12 p.

Research output: Contribution to journalArticle

18 Scopus citations
2013

Molecular views of Arf-like small GTPases in cilia and ciliopathies

Zhang, Q., Hu, J. & Ling, K., Sep 10 2013, In : Experimental Cell Research. 319, 15, p. 2316-2322 7 p.

Research output: Contribution to journalReview article

25 Scopus citations

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

Li, Y., Zhang, Q., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Feb 1 2013, In : Journal of Cell Biology. 200, 3, 1 p.

Research output: Contribution to journalComment/debate

2 Scopus citations

Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

Wei, Q., Xu, Q., Zhang, Y., Li, Y., Zhang, Q., Hu, Z., Harris, P. C., Torres, V. E., Ling, K. & Hu, J., Nov 15 2013, In : Nature communications. 4, 3750.

Research output: Contribution to journalArticle

47 Scopus citations
2012

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

Xiong, X., Xu, Q., Huang, Y., Singh, R. D., Anderson, R., Leof, E., Hu, J. & Ling, K., Jan 1 2012, In : Molecular biology of the cell. 23, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

31 Scopus citations

Phosphoinositide Signaling Regulates the Exocyst Complex and Polarized Integrin Trafficking in Directionally Migrating Cells

Thapa, N., Sun, Y., Schramp, M., Choi, S., Ling, K. & Anderson, R. A., Jan 17 2012, In : Developmental Cell. 22, 1, p. 116-130 15 p.

Research output: Contribution to journalArticle

72 Scopus citations

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

Li, Y., Zhang, Q., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Nov 1 2012, In : Journal of Cell Biology. 199, 4, p. 589-598 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

The BBSome controls IFT assembly and turnaround in cilia

Wei, Q., Zhang, Y., Li, Y., Zhang, Q., Ling, K. & Hu, J., Sep 1 2012, In : Nature Cell Biology. 14, 9, p. 950-957 8 p.

Research output: Contribution to journalArticle

119 Scopus citations

The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Li, Y., Ling, K. & Hu, J., Jul 1 2012, In : Journal of cellular biochemistry. 113, 7, p. 2201-2207 7 p.

Research output: Contribution to journalReview article

22 Scopus citations
2010

E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation

Chen, T., Yuan, D., Wei, B., Jiang, J., Kang, J., Ling, K., Gu, Y., Li, J., Xiao, L. & Pei, G., Aug 1 2010, In : Stem Cells. 28, 8, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

163 Scopus citations

Gangliosides and β1-integrin are required for caveolae and membrane domains

Singh, R. D., Marks, D. L., Holicky, E. L., Wheatley, C. L., Kaptzan, T., Sato, S. B., Kobayashi, T., Ling, K. & Pagano, R. E., Mar 1 2010, In : Traffic. 11, 3, p. 348-360 13 p.

Research output: Contribution to journalArticle

36 Scopus citations

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

Li, Y., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Jun 14 2010, In : Journal of Cell Biology. 189, 6, p. 1039-1051 13 p.

Research output: Contribution to journalArticle

95 Scopus citations

Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer

Sun, Y., Turbin, D. A., Ling, K., Thapa, N., Leung, S., Huntsman, D. G. & Anderson, R. A., Jan 14 2010, In : Breast Cancer Research. 12, 1, R6.

Research output: Contribution to journalArticle

42 Scopus citations
2009

Clathrin regulates the association of PIPKIγ661 with the AP-2 adaptor β2 Appendage

Thieman, J. R., Mishra, S. K., Ling, K., Doray, B., Anderson, R. A. & Traub, L. M., May 15 2009, In : Journal of Biological Chemistry. 284, 20, p. 13924-13939 16 p.

Research output: Contribution to journalArticle

38 Scopus citations
2008

Tracking the transport of E-cadherin to and from the plasma membrane

Wagoner, M. P., Ling, K. & Anderson, R. A., 2008, Methods in Molecular Biology. Humana Press Inc., Vol. 457. p. 267-278 12 p. (Methods in Molecular Biology; vol. 457).

Research output: Chapter in Book/Report/Conference proceedingChapter

Tracking the transport of E-cadherin to and from the plasma membrane

Wagoner, M. P., Ling, K. & Anderson, R. A., 2008, Methods in Molecular Biology. Vol. 457. p. 267-278 12 p. (Methods in Molecular Biology; vol. 457).

Research output: Chapter in Book/Report/Conference proceedingChapter

2007

A conspicuous connection: Structure defines function for the phosphatidylinositol-phosphate kinase family

Heck, J. N., Mellman, D. L., Ling, K., Sun, Y., Wagoner, M. P., Schill, N. J. & Anderson, R. A., Jan 1 2007, In : Critical Reviews in Biochemistry and Molecular Biology. 42, 1, p. 15-39 25 p.

Research output: Contribution to journalReview article

74 Scopus citations

Erratum: A conspicuous connection: Structure defines function for the phosphatidylinositol-phosphate kinase family (Critical Reviews in Biochemistry and Molecular Biology 42, (13-19))

Heck, J. N., Mellman, D. L., Ling, K., Sun, Y., Wagoner, M. P., Schill, N. J. & Anderson, R. A., May 1 2007, In : Critical Reviews in Biochemistry and Molecular Biology. 42, 3, 1 p.

Research output: Contribution to journalComment/debate

Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIγ regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions

El Sayegh, T. Y., Arora, P. D., Ling, K., Laschinger, C., Janmey, P. A., Anderson, R. A. & McCulloch, C. A., Aug 1 2007, In : Molecular biology of the cell. 18, 8, p. 3026-3038 13 p.

Research output: Contribution to journalArticle

44 Scopus citations

Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration

Sun, Y., Ling, K., Wagoner, M. P. & Anderson, R. A., Jul 16 2007, In : Journal of Cell Biology. 178, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

58 Scopus citations

Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ 1B adaptin

Ling, K., Bairstow, S. F., Carbonara, C., Turbin, D. A., Huntsman, D. G. & Anderson, R. A., Jan 29 2007, In : Journal of Cell Biology. 176, 3, p. 343-353 11 p.

Research output: Contribution to journalArticle

116 Scopus citations
2006

Movin' on up: the role of PtdIns(4,5)P2 in cell migration

Ling, K., Schill, N. J., Wagoner, M. P., Sun, Y. & Anderson, R. A., Jun 1 2006, In : Trends in Cell Biology. 16, 6, p. 276-284 9 p.

Research output: Contribution to journalReview article

112 Scopus citations

Type Iγ661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis

Bairstow, S. F., Ling, K., Su, X., Firestone, A. J., Carbonara, C. & Anderson, R. A., Jul 21 2006, In : Journal of Biological Chemistry. 281, 29, p. 20632-20642 11 p.

Research output: Contribution to journalArticle

74 Scopus citations
2005

Phosphatidylinositol phosphate kinase type Iγ directly associates with and regulates Shp-1 tyrosine phosphatase

Bairstow, S. F., Ling, K. & Anderson, R. A., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23884-23891 8 p.

Research output: Contribution to journalArticle

23 Scopus citations
2003

Molecular dynamics simulations on SDF-1α: Binding with CXCR4 receptor

Huang, X., Shen, J., Cui, M., Shen, L., Luo, X., Ling, K., Pei, G., Jiang, H. & Chen, K., Jan 1 2003, In : Biophysical Journal. 84, 1, p. 171-184 14 p.

Research output: Contribution to journalArticle

Open Access
58 Scopus citations

Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch

Ling, K., Doughman, R. L., Iyer, V. V., Firestone, A. J., Bairstow, S. F., Mosher, D. F., Schaller, M. D. & Anderson, R. A., Dec 22 2003, In : Journal of Cell Biology. 163, 6, p. 1339-1349 11 p.

Research output: Contribution to journalArticle

121 Scopus citations
2002

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

Ling, K., Doughman, R. L., Firestone, A. J., Bunce, M. W. & Anderson, R. A., Nov 7 2002, In : Nature. 420, 6911, p. 89-93 5 p.

Research output: Contribution to journalArticle

351 Scopus citations
2001

Direct binding of β-arrestins to two distinct intracellular domains of the δ opioid receptor

Cen, B., Yu, Q., Guo, J., Wu, Y., Ling, K., Cheng, Z., Ma, L. & Pei, G., Mar 28 2001, In : Journal of neurochemistry. 76, 6, p. 1887-1894 8 p.

Research output: Contribution to journalArticle

35 Scopus citations
2000

Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase

Zhou, T. H., Ling, K., Guo, J., Zhou, H., Wu, Y. L., Jing, Q., Ma, L. & Pei, G., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2513-2519 7 p.

Research output: Contribution to journalArticle

35 Scopus citations
1999

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors

Zhao, J., Ben, L. H., Wu, Y. L., Hu, W., Ling, K., Xin, S. M., Nie, H. L., Ma, L. & Pei, G., Jul 5 1999, In : Journal of Experimental Medicine. 190, 1, p. 101-111 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors

Ling, K., Wang, P., Zhao, J., Wu, Y. L., Cheng, Z. J., Wu, G. X., Hu, W., Ma, L. & Pei, G., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 7922-7927 6 p.

Research output: Contribution to journalArticle

68 Scopus citations
1998

Differential efficacies of κ agonists to induce homologous desensitization of human κ opioid receptor

Ling, K., Ma, L. & Pei, G., Jan 2 1998, In : Neuroscience Letters. 240, 1, p. 25-28 4 p.

Research output: Contribution to journalArticle

9 Scopus citations

Differential neurotoxicity of etorphine-like opiates: Lack of correlation with their ability to activate opiate receptors

Ren, X. H., Zhao, J., Pu, L., Ling, K., Yin, D. L. & Pei, G., May 15 1998, In : Toxicon. 36, 5, p. 735-743 9 p.

Research output: Contribution to journalArticle

6 Scopus citations
1997

Molecular characterization and functional expression of opioid receptor-likei receptor

Wu, Y. L., Pu, L., Ling, K., Zhao, J., Cheng, Z. J., Ma, L. & Pei, G., Jan 1 1997, In : Cell Research. 7, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C

Pei, G., Ling, K., Pu, L., Cunningham, M. D. & Ma, L., Jul 21 1997, In : FEBS Letters. 412, 1, p. 253-256 4 p.

Research output: Contribution to journalArticle

19 Scopus citations