• 2166 Citations
  • 25 Scopus h-Index
19972019
If you made any changes in Pure, your changes will be visible here soon.

Research Output 1997 2019

  • 2166 Citations
  • 25 Scopus h-Index
  • 47 Article
  • 2 Chapter
  • 1 Comment/debate
2019

Corrigendum to “Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy” [Heliyon 4 (12) (December 2018) e01039] (Heliyon (2018) 4(12), (S2405844018323442), (10.1016/j.heliyon.2018.e01039))

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Mar 1 2019, In : Heliyon. 5, 3, e01309.

Research output: Contribution to journalComment/debate

Open Access
Drug Therapy
Neoplasms
corrigendum
2018
2 Citations (Scopus)

A tropomyosin-receptor kinase-fused gene mutation associates with vacuolar myopathy

Madigan, N. N., Tracy, J. A., Litchy, W. J., Niu, Z., Chen, C., Ling, K. & Milone, M., Dec 1 2018, In : Neurology: Genetics. 4, 6, e287.

Research output: Contribution to journalArticle

Mutation
Genes
tropomyosin kinase
Vacuolar myopathy
6 Citations (Scopus)

Axoneme polyglutamylation regulated by Joubert syndrome protein ARL13B controls ciliary targeting of signaling molecules

He, K., Ma, X., Xu, T., Li, Y., Hodge, A., Zhang, Q., Torline, J., Huang, Y., Zhao, J., Ling, K. & Hu, J., Dec 1 2018, In : Nature Communications. 9, 1, 3310.

Research output: Contribution to journalArticle

Axoneme
Cilia
proteins
effectors
disrupting
3 Citations (Scopus)

Targeting B7-H1 (PD-L1) sensitizes cancer cells to chemotherapy

Wu, X., Li, Y., Liu, X., Chen, C., Harrington, S. M., Cao, S., Xie, T., Orzechowski, A., Pham, T., Mansfield, A., Yan, Y., Kwon, E. D., Wang, L. M., Ling, K. & Dong, H. M., Dec 1 2018, In : Heliyon. 4, 12, e01039.

Research output: Contribution to journalArticle

Drug Therapy
Neoplasms
p38 Mitogen-Activated Protein Kinases
Clustered Regularly Interspaced Short Palindromic Repeats
B7 Antigens
2017
3 Citations (Scopus)

EGFR-induced phosphorylation of type Iγ phosphatidylinositol phosphate kinase promotes pancreatic cancer progression

Chen, C., Wang, X., Fang, J., Xue, J., Xiong, X., Huang, Y., Hu, J. & Ling, K., 2017, In : Oncotarget. 8, 26, p. 42621-42637 17 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Pancreatic Neoplasms
Adenocarcinoma
Phosphotransferases
Phosphorylation
6 Citations (Scopus)
Triple Negative Breast Neoplasms
Histone Deacetylase Inhibitors
Acetylation
Histone Deacetylases
Apoptosis
1 Citation (Scopus)

Silencing of type I-phosphatidylinositol phosphate kinase suppresses ovarian cancer cell proliferation, migration and invasion

Cao, S., Chen, C., Xue, J., Huang, Y., Yang, X. & Ling, K., 2017, In : Oncology Reports. 38, 1, p. 253-262 10 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Ovarian Neoplasms
Cell Movement
Phosphotransferases
Cell Proliferation
9 Citations (Scopus)

Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB

Xue, J., Chen, C., Qi, M., Huang, Y., Wang, L., Gao, Y., Dong, H. M. & Ling, K., 2017, In : Oncotarget. 8, 26, p. 42414-42427 14 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Phosphotransferases
Ligands
Triple Negative Breast Neoplasms
Neoplasms
2016
12 Citations (Scopus)

GTP-binding of ARL-3 is activated by ARL-13 as a GEF and stabilized by UNC-119

Zhang, Q., Li, Y., Zhang, Y., Torres, V., Harris, P. C., Ling, K. & Hu, J., Apr 22 2016, In : Scientific Reports. 6, 24534.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Guanosine Triphosphate
GTP Phosphohydrolases
Organogenesis
30 Citations (Scopus)

Phosphatidylinositol phosphate kinase PIPKIγ and phosphatase INPP5E coordinate initiation of ciliogenesis

Xu, Q., Zhang, Y., Wei, Q., Huang, Y., Hu, J. & Ling, K., Feb 26 2016, In : Nature Communications. 7, 10777.

Research output: Contribution to journalArticle

inositols
Phosphatidylinositol Phosphates
Polyphosphates
phosphatases
Phosphoric Monoester Hydrolases
6 Citations (Scopus)

Protein Kinase D1 regulates focal adhesion dynamics and cell adhesion through Phosphatidylinositol-4-phosphate 5-kinase type-l 3

Durand, N., Bastea, L. I., Long, J., Döppler, H., Ling, K. & Storz, P., Oct 24 2016, In : Scientific Reports. 6, 35963.

Research output: Contribution to journalArticle

Focal Adhesions
Cell Adhesion
Protein Kinases
Phosphorylation
Talin
9 Citations (Scopus)

The hydrolethalus syndrome protein HYLS-1 regulates formation of the ciliary gate

Wei, Q., Zhang, Y., Schouteden, C., Zhang, Y., Zhang, Q., Dong, J., Wonesch, V., Ling, K., Dammermann, A. & Hu, J., Aug 18 2016, In : Nature Communications. 7, 12437.

Research output: Contribution to journalArticle

Cilia
proteins
Fibers
Basal Bodies
Axoneme
2015
28 Citations (Scopus)

BBS4 and BBS5 show functional redundancy in the BBSome to regulate the degradative sorting of ciliary sensory receptors

Xu, Q., Zhang, Y., Wei, Q., Huang, Y., Li, Y., Ling, K. & Hu, J., Jul 7 2015, In : Scientific Reports. 5, 11855.

Research output: Contribution to journalArticle

Sensory Receptor Cells
Cilia
Lysosomes
Vertebrates
Homeostasis
28 Citations (Scopus)

The essential roles of transition fibers in the context of cilia

Wei, Q., Ling, K. & Hu, J., Aug 1 2015, In : Current Opinion in Cell Biology. 35, p. 98-105 8 p.

Research output: Contribution to journalArticle

Cilia
Organelles
Vertebrates
Proteins
2014
11 Citations (Scopus)

PIPKIγ targets to the centrosome and restrains centriole duplication

Xu, Q., Zhang, Y., Xiong, X., Huang, Y., Salisbury, J. L., Hu, J. & Ling, K., Mar 2014, In : Journal of Cell Science. 127, 6, p. 1293-1305 13 p.

Research output: Contribution to journalArticle

Centrioles
Centrosome
S Phase
Cell Division
Proteins
18 Citations (Scopus)

Targeting type Iγ phosphatidylinositol phosphate kinase inhibits breast cancer metastasis

Chen, C., Wang, X., Xiong, X., Liu, Q., Huang, Y., Xu, Q., Hu, J., Ge, G. & Ling, K., Dec 8 2014, In : Oncogene. 34, 35, p. 4635-4646 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Phosphotransferases
Breast Neoplasms
Neoplasm Metastasis
Cell Movement
2013
25 Citations (Scopus)

Molecular views of Arf-like small GTPases in cilia and ciliopathies

Zhang, Q., Hu, J. & Ling, K., Sep 10 2013, In : Experimental Cell Research. 319, 15, p. 2316-2322 7 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Inborn Genetic Diseases
Medical Genetics
Eukaryotic Cells
2 Citations (Scopus)

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

Li, Y., Zhang, Q., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Feb 2013, In : Journal of Cell Biology. 200, 3, p. 357 1 p.

Research output: Contribution to journalArticle

Sumoylation
Monomeric GTP-Binding Proteins
Sensory Receptor Cells
45 Citations (Scopus)

Transition fibre protein FBF1 is required for the ciliary entry of assembled intraflagellar transport complexes

Wei, Q., Xu, Q., Zhang, Y., Li, Y., Zhang, Q., Hu, Z., Harris, P. C., Torres, V., Ling, K. & Hu, J., Nov 15 2013, In : Nature Communications. 4, 3750.

Research output: Contribution to journalArticle

Cilia
entry
proteins
fibers
Fibers
2012
31 Citations (Scopus)

An association between type Iγ PI4P 5-kinase and Exo70 directs E-cadherin clustering and epithelial polarization

Xiong, X., Xu, Q., Huang, Y., Singh, R. D., Anderson, R., Leof, E. B., Hu, J. & Ling, K., Jan 1 2012, In : Molecular Biology of the Cell. 23, 1, p. 87-98 12 p.

Research output: Contribution to journalArticle

Cadherins
Cluster Analysis
Phosphotransferases
Adherens Junctions
Cell Membrane
70 Citations (Scopus)

Phosphoinositide Signaling Regulates the Exocyst Complex and Polarized Integrin Trafficking in Directionally Migrating Cells

Thapa, N., Sun, Y., Schramp, M., Choi, S., Ling, K. & Anderson, R. A., Jan 17 2012, In : Developmental Cell. 22, 1, p. 116-130 15 p.

Research output: Contribution to journalArticle

Phosphatidylinositols
Integrins
Talin
Cell Polarity
Cells
25 Citations (Scopus)

SUMOylation of the small GTPase ARL-13 promotes ciliary targeting of sensory receptors

Li, Y., Zhang, Q., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Nov 2012, In : Journal of Cell Biology. 199, 4, p. 589-598 10 p.

Research output: Contribution to journalArticle

Sumoylation
Monomeric GTP-Binding Proteins
Sensory Receptor Cells
Autosomal Dominant Polycystic Kidney
Cilia
117 Citations (Scopus)

The BBSome controls IFT assembly and turnaround in cilia

Wei, Q., Zhang, Y., Li, Y., Zhang, Q., Ling, K. & Hu, J., Sep 2012, In : Nature Cell Biology. 14, 9, p. 950-957 8 p.

Research output: Contribution to journalArticle

Cilia
Bardet-Biedl Syndrome
Caenorhabditis elegans
Recycling
Mutagenesis
22 Citations (Scopus)

The emerging role of Arf/Arl small GTPases in cilia and ciliopathies

Li, Y., Ling, K. & Hu, J., Jul 2012, In : Journal of Cellular Biochemistry. 113, 7, p. 2201-2207 7 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Mountings
Body Patterning
Organelles
2010
162 Citations (Scopus)

E-cadherin-mediated cell-cell contact is critical for induced pluripotent stem cell generation

Chen, T., Yuan, D., Wei, B., Jiang, J., Kang, J., Ling, K., Gu, Y., Li, J., Xiao, L. & Pei, G., Aug 2010, In : Stem Cells. 28, 8, p. 1315-1325 11 p.

Research output: Contribution to journalArticle

Induced Pluripotent Stem Cells
Cadherins
Small Molecule Libraries
Virus Integration
Embryonic Stem Cells
36 Citations (Scopus)

Gangliosides and β1-integrin are required for caveolae and membrane domains

Singh, R. D., Marks, D. L., Holicky, E. L., Wheatley, C. L., Kaptzan, T., Sato, S. B., Kobayashi, T., Ling, K. & Pagano, R. E., Mar 2010, In : Traffic. 11, 3, p. 348-360 13 p.

Research output: Contribution to journalArticle

endoglycoceramidase
Caveolae
Gangliosides
Integrins
Cell membranes
93 Citations (Scopus)

The small GTPases ARL-13 and ARL-3 coordinate intraflagellar transport and ciliogenesis

Li, Y., Wei, Q., Zhang, Y., Ling, K. & Hu, J., Jun 14 2010, In : Journal of Cell Biology. 189, 6, p. 1039-1051 13 p.

Research output: Contribution to journalArticle

Monomeric GTP-Binding Proteins
Cilia
Guanosine
Caenorhabditis elegans
Adenosine Diphosphate
42 Citations (Scopus)

Type I gamma phosphatidylinositol phosphate kinase modulates invasion and proliferation and its expression correlates with poor prognosis in breast cancer

Sun, Y., Turbin, D. A., Ling, K., Thapa, N., Leung, S., Huntsman, D. G. & Anderson, R. A., Jan 14 2010, In : Breast Cancer Research. 12, 1, R6.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Phosphotransferases
Breast Neoplasms
Cell Movement
Kaplan-Meier Estimate
2009
38 Citations (Scopus)

Clathrin regulates the association of PIPKIγ661 with the AP-2 adaptor β2 Appendage

Thieman, J. R., Mishra, S. K., Ling, K., Doray, B., Anderson, R. A. & Traub, L. M., May 15 2009, In : Journal of Biological Chemistry. 284, 20, p. 13924-13939 16 p.

Research output: Contribution to journalArticle

Clathrin
Phosphatidylinositol 4,5-Diphosphate
Clathrin Heavy Chains
Vesicular Transport Adaptor Proteins
Clathrin-Coated Vesicles
2008

Tracking the transport of E-cadherin to and from the plasma membrane

Wagoner, M. P., Ling, K. & Anderson, R. A., 2008, Methods in Molecular Biology. Humana Press Inc., Vol. 457. p. 267-278 12 p. (Methods in Molecular Biology; vol. 457).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cadherins
Cell Membrane
Epithelial-Mesenchymal Transition
Epithelial Cells
Adherens Junctions

Tracking the transport of E-cadherin to and from the plasma membrane

Wagoner, M. P., Ling, K. & Anderson, R. A., 2008, Methods in Molecular Biology. Vol. 457. p. 267-278 12 p. (Methods in Molecular Biology; vol. 457).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cadherins
Cell Membrane
Epithelial-Mesenchymal Transition
Epithelial Cells
Adherens Junctions
2007
73 Citations (Scopus)

A conspicuous connection: Structure defines function for the phosphatidylinositol-phosphate kinase family

Heck, J. N., Mellman, D. L., Ling, K., Sun, Y., Wagoner, M. P., Schill, N. J. & Anderson, R. A., Jan 2007, In : Critical Reviews in Biochemistry and Molecular Biology. 42, 1, p. 15-39 25 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Phosphotransferases
Second Messenger Systems
Phosphorylation
Phosphatidylinositols

Erratum: A conspicuous connection: Structure defines function for the phosphatidylinositol-phosphate kinase family (Critical Reviews in Biochemistry and Molecular Biology 42, (13-19))

Heck, J. N., Mellman, D. L., Ling, K., Sun, Y., Wagoner, M. P., Schill, N. J. & Anderson, R. A., May 2007, In : Critical Reviews in Biochemistry and Molecular Biology. 42, 3, p. 243 1 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Biochemistry
Molecular Biology
Phosphotransferases
44 Citations (Scopus)

Phosphatidylinositol-4,5 bisphosphate produced by PIP5KIγ regulates gelsolin, actin assembly, and adhesion strength of N-cadherin junctions

El Sayegh, T. Y., Arora, P. D., Ling, K., Laschinger, C., Janmey, P. A., Anderson, R. A. & McCulloch, C. A., Aug 2007, In : Molecular Biology of the Cell. 18, 8, p. 3026-3038 13 p.

Research output: Contribution to journalArticle

Gelsolin
Cadherins
Phosphatidylinositols
Actins
Microfilament Proteins
57 Citations (Scopus)

Type Iγ phosphatidylinositol phosphate kinase is required for EGF-stimulated directional cell migration

Sun, Y., Ling, K., Wagoner, M. P. & Anderson, R. A., Jul 16 2007, In : Journal of Cell Biology. 178, 2, p. 297-308 12 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Epidermal Growth Factor
Cell Movement
Phosphotransferases
Intercellular Signaling Peptides and Proteins
116 Citations (Scopus)

Type Iγ phosphatidylinositol phosphate kinase modulates adherens junction and E-cadherin trafficking via a direct interaction with μ 1B adaptin

Ling, K., Bairstow, S. F., Carbonara, C., Turbin, D. A., Huntsman, D. G. & Anderson, R. A., Jan 29 2007, In : Journal of Cell Biology. 176, 3, p. 343-353 11 p.

Research output: Contribution to journalArticle

Adherens Junctions
Phosphatidylinositol Phosphates
Cadherins
Phosphotransferases
Vesicular Transport Adaptor Proteins
2006
112 Citations (Scopus)

Movin' on up: the role of PtdIns(4,5)P2 in cell migration

Ling, K., Schill, N. J., Wagoner, M. P., Sun, Y. & Anderson, R. A., Jun 2006, In : Trends in Cell Biology. 16, 6, p. 276-284 9 p.

Research output: Contribution to journalArticle

Phosphatidylinositol 4,5-Diphosphate
Cell Movement
Phosphatidylinositol Phosphates
Focal Adhesions
Phosphatidylinositols
74 Citations (Scopus)

Type Iγ661 phosphatidylinositol phosphate kinase directly interacts with AP2 and regulates endocytosis

Bairstow, S. F., Ling, K., Su, X., Firestone, A. J., Carbonara, C. & Anderson, R. A., Jul 21 2006, In : Journal of Biological Chemistry. 281, 29, p. 20632-20642 11 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Transferrin
Endocytosis
Phosphotransferases
Sorting
2005
23 Citations (Scopus)

Phosphatidylinositol phosphate kinase type Iγ directly associates with and regulates Shp-1 tyrosine phosphatase

Bairstow, S. F., Ling, K. & Anderson, R. A., Jun 24 2005, In : Journal of Biological Chemistry. 280, 25, p. 23884-23891 8 p.

Research output: Contribution to journalArticle

Phosphatidylinositol Phosphates
Talin
Phosphoric Monoester Hydrolases
Focal Adhesions
Tyrosine
2003
58 Citations (Scopus)

Molecular dynamics simulations on SDF-1α: Binding with CXCR4 receptor

Huang, X., Shen, J., Cui, M., Shen, L., Luo, X., Ling, K., Pei, G., Jiang, H. & Chen, K., Jan 1 2003, In : Biophysical Journal. 84, 1, p. 171-184 14 p.

Research output: Contribution to journalArticle

CXCR4 Receptors
Molecular Dynamics Simulation
Signal Transduction
Static Electricity
Salts
120 Citations (Scopus)

Tyrosine phosphorylation of type Iγ phosphatidylinositol phosphate kinase by Src regulates an integrin-talin switch

Ling, K., Doughman, R. L., Iyer, V. V., Firestone, A. J., Bairstow, S. F., Mosher, D. F., Schaller, M. D. & Anderson, R. A., Dec 22 2003, In : Journal of Cell Biology. 163, 6, p. 1339-1349 11 p.

Research output: Contribution to journalArticle

Talin
Phosphatidylinositol Phosphates
Focal Adhesions
src-Family Kinases
Integrins
2002
347 Citations (Scopus)

Type Iγ phosphatidylinositol phosphate kinase targets and regulates focal adhesions

Ling, K., Doughman, R. L., Firestone, A. J., Bunce, M. W. & Anderson, R. A., Nov 7 2002, In : Nature. 420, 6911, p. 89-93 5 p.

Research output: Contribution to journalArticle

Talin
Phosphatidylinositol Phosphates
Focal Adhesions
Phosphotransferases
Extracellular Matrix
2001
35 Citations (Scopus)

Direct binding of β-arrestins to two distinct intracellular domains of the δ opioid receptor

Cen, B., Yu, Q., Guo, J., Wu, Y., Ling, K., Cheng, Z., Ma, L. & Pei, G., 2001, In : Journal of Neurochemistry. 76, 6, p. 1887-1894 8 p.

Research output: Contribution to journalArticle

Arrestins
delta Opioid Receptor
Opioid Receptors
Arrestin
Opiate Alkaloids
2000
34 Citations (Scopus)

Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase

Zhou, T. H., Ling, K., Guo, J., Zhou, H., Wu, Y. L., Jing, Q., Ma, L. & Pei, G., Jan 28 2000, In : Journal of Biological Chemistry. 275, 4, p. 2513-2519 7 p.

Research output: Contribution to journalArticle

Forensic Anthropology
Cyclic AMP-Dependent Protein Kinases
Brain
Protein Isoforms
Phosphotransferases
1999
72 Citations (Scopus)

Anti-HIV agent trichosanthin enhances the capabilities of chemokines to stimulate chemotaxis and G protein activation, and this is mediated through interaction of trichosanthin and chemokine receptors

Zhao, J., Ben, L. H., Wu, Y. L., Hu, W., Ling, K., Xin, S. M., Nie, H. L., Ma, L. & Pei, G., Jul 5 1999, In : Journal of Experimental Medicine. 190, 1, p. 101-111 11 p.

Research output: Contribution to journalArticle

Trichosanthin
Anti-HIV Agents
Chemokine Receptors
Chemotaxis
Chemokines
68 Citations (Scopus)

Five-transmembrane domains appear sufficient for a G protein-coupled receptor: Functional five-transmembrane domain chemokine receptors

Ling, K., Wang, P., Zhao, J., Wu, Y. L., Cheng, Z. J., Wu, G. X., Hu, W., Ma, L. & Pei, G., Jul 6 1999, In : Proceedings of the National Academy of Sciences of the United States of America. 96, 14, p. 7922-7927 6 p.

Research output: Contribution to journalArticle

Chemokine Receptors
G-Protein-Coupled Receptors
Confocal Microscopy
Arrestins
G-Protein-Coupled Receptor Kinases
1998
9 Citations (Scopus)

Differential efficacies of κ agonists to induce homologous desensitization of human κ opioid receptor

Ling, K., Ma, L. & Pei, G., Jan 2 1998, In : Neuroscience Letters. 240, 1, p. 25-28 4 p.

Research output: Contribution to journalArticle

Opioid Receptors
Dynorphins
Cricetulus
Ovary
Etorphine
6 Citations (Scopus)

Differential neurotoxicity of etorphine-like opiates: Lack of correlation with their ability to activate opiate receptors

Ren, X. H., Zhao, J., Pu, L., Ling, K., Yin, D. L. & Pei, G., May 15 1998, In : Toxicon. 36, 5, p. 735-743 9 p.

Research output: Contribution to journalArticle

Opiate Alkaloids
Etorphine
Opioid Receptors
Heroin
Cells
1997
19 Citations (Scopus)

Molecular characterization and functional expression of opioid receptor-likei receptor

Wu, Y. L., Pu, L., Ling, K., Zhao, J., Cheng, Z. J., Ma, L. & Pei, G., 1997, In : Cell Research. 7, 1, p. 69-77 9 p.

Research output: Contribution to journalArticle

Opioid Receptors
Cell Line
Radioligand Assay
CHO Cells
Colforsin
19 Citations (Scopus)

Nociceptin/orphanin FQ stimulates extracellular acidification and desensitization of the response involves protein kinase C

Pei, G., Ling, K., Pu, L., Cunningham, M. D. & Ma, L., Jul 21 1997, In : FEBS Letters. 412, 1, p. 253-256 4 p.

Research output: Contribution to journalArticle

Acidification
Opioid Receptors
Protein Kinase C
Cricetulus
Ovary