Kenchappa Rajappa

2022

Activation of STAT3 through combined SRC and EGFR signaling drives resistance to a mitotic kinesin inhibitor in glioblastoma

Kenchappa, R. S., Dovas, A., Argenziano, M. G., Meyer, C. T., Stopfer, L. E., Banu, M. A., Pereira, B., Griffith, J., Mohammad, A., Talele, S., Haddock, A., Zarco, N., Elmquist, W., White, F., Quaranta, V., Sims, P., Canoll, P. & Rosenfeld, S. S., Jun 21 2022, In: Cell reports. 39, 12, 110991.

Research output: Contribution to journal › Article › peer-review

Open Access

2021

Protein kinase C_ι and SRC signaling define reciprocally related subgroups of glioblastoma with distinct therapeutic vulnerabilities

Kenchappa, R. S., Liu, Y., Argenziano, M. G., Banu, M. A., Mladek, A. C., West, R., Luu, A., Quiñones-Hinojosa, A., Hambardzumyan, D., Justilien, V., Leitges, M., Sarkaria, J. N., Sims, P. A., Canoll, P., Murray, N. R., Fields, A. P. & Rosenfeld, S. S., Nov 23 2021, In: Cell reports. 37, 8, 110054.

Research output: Contribution to journal › Article › peer-review

Open Access

2020

Enhancing Brain Retention of a KIF11 Inhibitor Significantly Improves its Efficacy in a Mouse Model of Glioblastoma

Gampa, G., Kenchappa, R. S., Mohammad, A. S., Parrish, K. E., Kim, M., Crish, J. F., Luu, A., West, R., Hinojosa, A. Q., Sarkaria, J. N., Rosenfeld, S. S. & Elmquist, W. F., Dec 1 2020, In: Scientific reports. 10, 1, 6524.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Myosin 10 Regulates Invasion, Mitosis, and Metabolic Signaling in Glioblastoma

Kenchappa, R. S., Mistriotis, P., Wisniewski, E., Bhattacharya, S., Kulkarni, T., West, R., Luu, A., Conlon, M., Heimsath, E., Crish, J. F., Picariello, H. S., Dovas, A., Zarco, N., Lara-Velazquez, M., Quiñones-Hinojosa, A., Hammer, J. A., Mukhopadhyay, D., Cheney, R. E., Konstantopoulos, K., Canoll, P., & 1 othersRosenfeld, S. S., Dec 18 2020, In: iScience. 23, 12, 101802.

Research output: Contribution to journal › Article › peer-review

Open Access

2019

Myosin IIA suppresses glioblastoma development in a mechanically sensitive manner

Picariello, H. S., Kenchappa, R. S., Rai, V., Crish, J. F., Dovas, A., Pogoda, K., McMahon, M., Bell, E. S., Chandrasekharan, U., Luu, A., West, R., Lammerding, J., Canoll, P., Odde, D. J., Janmey, P. A., Egelhoff, T. & Rosenfeld, S. S., Jul 30 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 31, p. 15550-15559 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

14 Scopus citations

2017

BIRC3 is a biomarker of mesenchymal habitat of glioblastoma, and a mediator of survival adaptation in hypoxia-driven glioblastoma habitats

Wang, D., Berglund, A. E., Kenchappa, R. S., MacAulay, R. J., Mulé, J. J. & Etame, A. B., Dec 1 2017, In: Scientific reports. 7, 1, 9350.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA

Fell, S. M., Li, S., Wallis, K., Kock, A., Surova, O., Rraklli, V., Höfig, C. S., Li, W., Mittag, J., Henriksson, M. A., Kenchappa, R. S., Holmberg, J., Kogner, P. & Schlisio, S., May 15 2017, In: Genes and Development. 31, 10, p. 1036-1053 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

2016

A rare case of leptomeningeal carcinomatosis in a patient with uveal melanoma: Case report and review of literature

Fedorenko, I. V., Evernden, B., Kenchappa, R. S., Sahebjam, S., Ryzhova, E., Puskas, J., McIntosh, L., Caceres, G., Magliocco, A., Etame, A., Harbour, J. W., Smalley, K. S. M. & Forsyth, P. A., 2016, In: Melanoma research. 26, 5, p. 481-486 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

2 Scopus citations

BIRC3 is a novel driver of therapeutic resistance in Glioblastoma

Wang, D., Berglund, A., Kenchappa, R. S., Forsyth, P. A., Mule, J. J. & Etame, A. B., Feb 18 2016, In: Scientific reports. 6, 21710.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

M011L-deficient oncolytic myxoma virus induces apoptosis in brain tumor-initiating cells and enhances survival in a novel immunocompetent mouse model of glioblastoma

Pisklakova, A., McKenzie, B., Zemp, F., Lun, X., Kenchappa, R. S., Etame, A. B., Rahman, M. M., Reilly, K., Pilon-Thomas, S., McFadden, G., Kurz, E. & Forsyth, P. A., Aug 1 2016, In: Neuro-oncology. 18, 8, p. 1088-1098 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

20 Scopus citations

Managing leptomeningeal melanoma metastases in the era of immune and targeted therapy

Smalley, K. S. M., Fedorenko, I. V., Kenchappa, R. S., Sahebjam, S. & Forsyth, P. A., Sep 15 2016, In: International Journal of Cancer. 139, 6, p. 1195-1201 7 p.

Research output: Contribution to journal › Review article › peer-review

Open Access

14 Scopus citations

The 1p36 Tumor Suppressor KIF 1Bβ Is Required for Calcineurin Activation, Controlling Mitochondrial Fission and Apoptosis

Li, S., Fell, S. M., Surova, O., Smedler, E., Wallis, K., Chen, Z. X., Hellman, U., Johnsen, J. I., Martinsson, T., Kenchappa, R. S., Uhlén, P., Kogner, P. & Schlisio, S., Jan 25 2016, In: Developmental Cell. 36, 2, p. 164-178 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

21 Scopus citations

XAF1 promotes neuroblastoma tumor suppression and is required for KIF1Bβ-mediated apoptosis

Choo, Z., Koh, R. Y. L., Wallis, K., Koh, T. J. W., Kuick, C. H., Sobrado, V., Kenchappa, R. S., Loh, A. H. P., Soh, S. Y., Schlisio, S., Chang, K. T. E. & Chen, Z. X., Jun 7 2016, In: Oncotarget. 7, 23, p. 34229-34239 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2015

In vitro screen of a small molecule inhibitor drug library identifies multiple compounds that synergize with oncolytic myxoma virus against human brain tumor-initiating cells

McKenzie, B. A., Zemp, F. J., Pisklakova, A., Narendran, A., McFadden, G., Lun, X., Kenchappa, R. S., Kurz, E. U. & Forsyth, P. A., Aug 2015, In: Neuro-oncology. 17, 8, p. 1086-1094 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

22 Scopus citations

Neurotrophin Signaling via TrkB and TrkC Receptors Promotes the Growth of Brain Tumor-initiating Cells

Lawn, S., Krishna, N., Pisklakova, A., Qu, X., Fenstermacher, D. A., Fournier, M., Vrionis, F. D., Tran, N., Chan, J. A., Kenchappa, R. S. & Forsyth, P. A., Feb 6 2015, In: Journal of Biological Chemistry. 290, 6, p. 3814-3824 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

85 Scopus citations

2014

p75 neurotrophin receptor cleavage by α- and γ-secretases is required for neurotrophin-mediated proliferation of brain tumor-initiating cells

Forsyth, P. A., Krishna, N., Lawn, S., Valadez, J. G., Qu, X., Fenstermacher, D. A., Fournier, M., Potthast, L., Chinnaiyan, P., Gibney, G. T., Zeinieh, M., Barker, P. A., Carter, B. D., Cooper, M. K. & Kenchappa, R. S., Mar 21 2014, In: Journal of Biological Chemistry. 289, 12, p. 8067-8085 19 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

RNA helicase a is a downstream mediator of KIF1Bβ tumor-suppressor function in neuroblastoma

Chen, Z. X., Wallis, K., Fell, S. M., Sobrado, V. R., Hemmer, M. C., Ramsköld, D., Hellman, U., Sandberg, R., Kenchappa, R. S., Martinson, T., Johnsen, J. I., Kogner, P. & Schlisio, S., Apr 2014, In: Cancer discovery. 4, 4, p. 434-451 18 p.

Research output: Contribution to journal › Article › peer-review

Open Access

34 Scopus citations

2013

Neurotrophin Receptor Signaling

Kenchappa, R. S. & Carter, B. D., Feb 15 2013, Encyclopedia of Biological Chemistry: Second Edition. Elsevier Inc., p. 241-246 6 p.

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Novel treatments for melanoma brain metastases

Kenchappa, R. S., Tran, N., Rao, N. G., Smalley, K. S., Gibney, G. T., Sondak, V. K. & Forsyth, P. A., Oct 2013, In: Cancer Control. 20, 4, p. 298-306 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

11 Scopus citations

2011

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility

Astuti, D., Ricketts, C. J., Chowdhury, R., McDonough, M. A., Gentle, D., Kirby, G., Schlisio, S., Kenchappa, R. S., Carter, B. D., Kaelin, W. G., Ratcliffe, P. J., Schofield, C. J., Latif, F. & Maher, E. R., Feb 2011, In: Endocrine-Related Cancer. 18, 1, p. 73-83 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

45 Scopus citations

2010

P75 Neurotrophin receptor-mediated apoptosis in sympathetic neurons involves a biphasic activation of JNK and up-regulation of tumor necrosis factor-α-converting enzyme/ADAM17

Kenchappa, R. S., Tep, C., Korade, Z., Urra, S., Bronfman, F. C., Yoon, S. O. & Carter, B. D., Jun 25 2010, In: Journal of Biological Chemistry. 285, 26, p. 20358-20368 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

93 Scopus citations

2009

Activation of the p75 Neurotrophin Receptor through Conformational Rearrangement of Disulphide-Linked Receptor Dimers

Vilar, M., Charalampopoulos, I., Kenchappa, R. S., Simi, A., Karaca, E., Reversi, A., Choi, S., Bothwell, M., Mingarro, I., Friedman, W. J., Schiavo, G., Bastiaens, P. I. H., Verveer, P. J., Carter, B. D. & Ibáñez, C. F., Apr 16 2009, In: Neuron. 62, 1, p. 72-83 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

107 Scopus citations

Ligand-independent signaling by disulfide-crosslinked dimers of the p75 neurotrophin receptor

Vilar, M., Charalampopoulos, I., Kenchappa, R. S., Reversi, A., Klos-Applequist, J. M., Karaca, E., Simi, A., Spuch, C., Choi, S., Friedman, W. J., Ericson, J., Schiavo, G., Carter, B. D. & Ibáñez, C. F., Sep 15 2009, In: Journal of cell science. 122, 18, p. 3351-3357 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

44 Scopus citations

NRIF is a regulator of neuronal cholesterol biosynthesis genes

Korade, Z., Kenchappa, R. S., Mirnics, K. & Carter, B. D., Jun 2009, In: Journal of Molecular Neuroscience. 38, 2, p. 152-158 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

5 Scopus citations

2008

Induction of proneurotrophins and activation of p75^NTR-mediated apoptosis via neurotrophin receptor-interacting factor in hippocampal neurons after seizures

Volosin, M., Trotter, C., Cragnolini, A., Kenchappa, R. S., Light, M., Hempstead, B. L., Carter, B. D. & Friedman, W. J., Sep 24 2008, In: Journal of Neuroscience. 28, 39, p. 9870-9879 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

114 Scopus citations

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo

Bertrand, M. J. M., Kenchappa, R. S., Andrieu, D., Leclercq-Smekens, M., Nguyen, H. N. T., Carter, B. D., Muscatelli, F., Barker, P. A. & De Backer, O., 2008, In: Cell Death and Differentiation. 15, 12, p. 1921-1929 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

52 Scopus citations

The kinesin KIF1Bβ acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor

Schlisio, S., Kenchappa, R. S., Vredeveld, L. C. W., George, R. E., Stewart, R., Greulich, H., Shahriari, K., Nguyen, N. V., Pigny, P., Dahia, P. L., Pomeroy, S. L., Maris, J. M., Look, A. T., Meyerson, M., Peeper, D. S., Carter, B. D. & Kaelin, W. G., Apr 1 2008, In: Genes and Development. 22, 7, p. 884-893 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

254 Scopus citations

2007

Downregulation of glutaredoxin but not glutathione loss leads to mitochondrial dysfunction in female mice CNS: Implications in excitotoxicity

Diwakar, L., Kenchappa, R. S., Annepu, J. & Ravindranath, V., Jul 2007, In: Neurochemistry International. 51, 1, p. 37-46 10 p.

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

2006

Down-regulation of glutaredoxin by estrogen receptor antagonist renders female mice susceptible to excitatory amino acid mediated complex I inhibition in CNS

Diwakar, L., Kenchappa, R. S., Annepu, J., Saeed, U., Sujanitha, R. & Ravindranath, V., Dec 13 2006, In: Brain Research. 1125, 1, p. 176-184 9 p.

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Ligand-Dependent Cleavage of the P75 Neurotrophin Receptor Is Necessary for NRIF Nuclear Translocation and Apoptosis in Sympathetic Neurons

Kenchappa, R. S., Zampieri, N., Chao, M. V., Barker, P. A., Teng, H. K., Hempstead, B. L. & Carter, B. D., Apr 20 2006, In: Neuron. 50, 2, p. 219-232 14 p.

Research output: Contribution to journal › Article › peer-review

Open Access