• 11392 Citations
  • 51 Scopus h-Index
1993 …2020

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Article
2020

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients

Coltro, G., Mangaonkar, A. A., Lasho, T. L., Finke, C. M., Pophali, P., Carr, R., Gangat, N., Binder, M., Pardanani, A., Fernandez-Zapico, M., Robertson, K. D., Bosi, A., Droin, N., Vannucchi, A. M., Tefferi, A., Hunter, A., Padron, E., Solary, E. & Patnaik, M. M., May 1 2020, In : Leukemia. 34, 5, p. 1407-1421 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC

Brown, M., Zhang, W., Yan, D., Kenath, R., Le, L., Wang, H., Delitto, D., Ostrov, D., Robertson, K., Liu, C. & Pham, K., Jan 2020, In : PloS one. 15, 1, e0226917.

Research output: Contribution to journalArticle

Open Access
2019

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity

Wang, L., Marek, G. W., Hlady, R. A., Wagner, R. T., Zhao, X., Clark, V. C., Fan, A. X., Liu, C., Brantly, M. & Robertson, K. D., Jul 2019, In : Hepatology. 70, 1, p. 51-66 16 p.

Research output: Contribution to journalArticle

2 Scopus citations

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma

Zheng, Y., Hlady, R. A., Joyce, B. T., Robertson, K. D., He, C., Nannini, D. R., Kibbe, W. A., Achenbach, C. J., Murphy, R. L., Roberts, L. R. & Hou, L., Oct 21 2019, In : Clinical Epigenetics. 11, 1, 145.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

Zhong, J., Ye, Z., Clark, C. R., Lenz, S. W., Nguyen, J. H., Yan, H., Robertson, K. D., Farrugia, G., Zhang, Z. H., Ordog, T. & Lee, J. H., Mar 29 2019, In : BMC genomics. 20, 1, 249.

Research output: Contribution to journalArticle

2 Scopus citations

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

Hlady, R. A., Zhao, X., Pan, X., Dong Yang, J., Ahmed, F., Antwi, S. O., Giama, N. H., Patel, T., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 1 2019, In : Theranostics. 9, 24, p. 7239-7250 12 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder

Ho, A. M. C., Winham, S. J., Armasu, S. M., Blacker, C. J., Millischer, V., Lavebratt, C., Overholser, J. C., Jurjus, G. J., Dieter, L., Mahajan, G., Rajkowska, G., Vallender, E. J., Stockmeier, C. A., Robertson, K. D., Frye, M. A., Choi, D. S. & Veldic, M., Oct 1 2019, In : Journal of Psychiatric Research. 117, p. 45-54 10 p.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma

Yang, M., Hlady, R. A., Zhou, D., Ho, T. H. & Robertson, K. D., Sep 1 2019, In : Cancer medicine. 8, 12, p. 5760-5768 9 p.

Research output: Contribution to journalArticle

Open Access

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Hlady, R. A., Sathyanarayan, A., Thompson, J. J., Zhou, D., Wu, Q., Pham, K., Lee, J. H., Liu, C. & Robertson, K. D., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

13 Scopus citations

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Liu, J., Hanavan, P. D., Kras, K., Ruiz, Y. W., Castle, E. P., Lake, D. F., Chen, X., O'Brien, D., Luo, H., Robertson, K. D., Gu, H. & Ho, T. H., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 331-340 10 p.

Research output: Contribution to journalArticle

5 Scopus citations
2018

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome biology. 19, 1, 43.

Research output: Contribution to journalArticle

16 Scopus citations

DNA methylation age is accelerated in alcohol dependence

Rosen, A. D., Robertson, K. D., Hlady, R. A., Muench, C., Lee, J., Philibert, R., Horvath, S., Kaminsky, Z. A. & Lohoff, F. W., Dec 1 2018, In : Translational psychiatry. 8, 1, 182.

Research output: Contribution to journalArticle

17 Scopus citations

Epigenetics of gastrointestinal diseases: notes from a workshop

Marks, D. L., Olson, R. L., Urrutia, R. A., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R., Sarmento, O., Bamidele, A. O., Faubion, W., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., Robertson, K. & 3 others, Kisiel, J., Pin, C. L. & Fernandez-Zapico, M. E., Apr 3 2018, In : Epigenetics. 13, 4, p. 449-457 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
1 Scopus citations

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

Thompson, J. J., Kaur, R., Sosa, C. P., Lee, J. H., Kashiwagi, K., Zhou, D. & Robertson, K. D., 2018, In : Nucleic acids research. 46, 19, p. 10034-10051 18 p.

Research output: Contribution to journalArticle

14 Scopus citations
2017

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma

Wu, Q., Pi, L., Le Trinh, T., Zuo, C., Xia, M., Jiao, Y., Hou, Z., Jo, S., Puszyk, W., Pham, K., Nelson, D. R., Robertson, K. D., Ostrov, D., Rameshwar, P., Xia, C. Q. & Liu, C., 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

11 Scopus citations

CAME: Identification of chromatin accessibility from nucleosome occupancy and methylome sequencing

Piao, Y., Lee, S. K., Lee, E. J., Robertson, K. D., Shi, H., Ryu, K. H. & Choi, J. H., Apr 15 2017, In : Bioinformatics. 33, 8, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

2 Scopus citations

Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma

Zhao, X., Sun, W., Puszyk, W. M., Wallet, S., Hochwald, S., Robertson, K. D. & Liu, C., 2017, In : Tumor Biology. 39, 5

Research output: Contribution to journalArticle

2 Scopus citations

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

Hlady, R. A., Zhou, D., Puszyk, W., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 27 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

13 Scopus citations

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

Zhong, J., Ye, Z., Lenz, S. W., Clark, C. R., Bharucha, A., Farrugia, G., Robertson, K. D., Zhang, Z., Ordog, T. & Lee, J. H., Dec 21 2017, In : BMC genomics. 18, 1, 985.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J. H., Choi, J. H., Ho, T. H. & Robertson, K. D., 2016, In : Oncotarget. 7, 2, p. 1927-1946 20 p.

Research output: Contribution to journalArticle

27 Scopus citations

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Zhou, D., Hlady, R. A., Schafer, M. J., White, T. A., Liu, C., Choi, J. H., Miller, J. D., Roberts, L. R., LeBrasseur, N. K. & Robertson, K. D., Dec 22 2016, (Accepted/In press) In : Epigenetics. p. 1-15 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nucleosome positioning changes during human embryonic stem cell differentiation

Zhang, W., Li, Y., Kulik, M., Tiedemann, R. L., Robertson, K. D., Dalton, S. & Zhao, S., Jun 2 2016, In : Epigenetics. 11, 6, p. 426-437 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

ITagPlot: An accurate computation and interactive drawing tool for tag density plot

Kim, S. H., Ezenwoye, O., Cho, H. G., Robertson, K. D. & Choi, J. H., 2015, In : Bioinformatics. 31, 14, p. 2384-2387 4 p.

Research output: Contribution to journalArticle

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma

Zhao, X., Puszyk, W. M., Lu, Z., Ostrov, D. A., George, T. J., Robertson, K. D. & Liu, C., Jan 1 2015, In : Molecular cancer therapeutics. 14, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

11 Scopus citations
2014

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

Tiedemann, R. L., Putiri, E. L., Lee, J. H., Hlady, R. A., Kashiwagi, K., Ordog, T., Zhang, Z., Liu, C., Choi, J. H. & Robertson, K. D., Nov 20 2014, In : Cell Reports. 9, 4, p. 1554-1566 13 p.

Research output: Contribution to journalArticle

27 Scopus citations

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Putiri, E. L., Tiedemann, R. L., Thompson, J. J., Liu, C., Ho, T., Choi, J. H. & Robertson, K. D., Jun 23 2014, In : Genome biology. 15, 6, R81.

Research output: Contribution to journalArticle

54 Scopus citations

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis

Hlady, R. A., Tiedemann, R. L., Puszyk, W., Zendejas, I., Roberts, L. R., Choi, J. H., Liu, C. & Robertson, K. D., 2014, In : Oncotarget. 5, 19, p. 9425-9443 19 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

Putiri, E. L., Tiedemann, R. L., Liu, C., Choi, J. H. & Robertson, K. D., 2014, In : Oncotarget. 5, 15, p. 6338-6352 15 p.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations
2012

Butyrate suppresses colonic inflammation through HDAC1-dependent fas upregulation and fas-mediated apoptosis of T cells

Zimmerman, M. A., Singh, N., Martin, P. M., Thangaraju, M., Ganapathy, V., Waller, J. L., Shi, H., Robertson, K. D., Munn, D. H. & Liu, K., Jun 15 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 12, p. G1405-G1415

Research output: Contribution to journalArticle

139 Scopus citations

Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus

Liu, H., Trinh, T. L., Dong, H., Keith, R., Nelson, D. & Liu, C., Oct 22 2012, In : PloS one. 7, 10, e46631.

Research output: Contribution to journalArticle

35 Scopus citations

Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

Jin, B., Ernst, J., Tiedemann, R. L., Xu, H., Sureshchandra, S., Kellis, M., Dalton, S., Liu, C., Choi, J. H. & Robertson, K. D., Nov 29 2012, In : Cell reports. 2, 5, p. 1411-1424 14 p.

Research output: Contribution to journalArticle

82 Scopus citations
2011

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma

Liu, H., Dong, H., Robertson, K. & Liu, C., Feb 2011, In : American Journal of Pathology. 178, 2, p. 652-661 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

Van Emburgh, B. O. & Robertson, K. D., Jul 2011, In : Nucleic acids research. 39, 12, p. 4984-5002 19 p.

Research output: Contribution to journalArticle

48 Scopus citations

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery

Ha, K., Lee, G. E., Palii, S. S., Brown, K. D., Takeda, Y., Liu, K., Bhalla, K. N. & Robertson, K. D., Jan 1 2011, In : Human molecular genetics. 20, 1, p. 126-140 15 p.

Research output: Contribution to journalArticle

69 Scopus citations

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

Peng, L., Yuan, Z., Ling, H., Fukasawa, K., Robertson, K., Olashaw, N., Koomen, J., Chen, J., Lane, W. S. & Seto, E., Dec 1 2011, In : Molecular and cellular biology. 31, 23, p. 4720-4734 15 p.

Research output: Contribution to journalArticle

110 Scopus citations

Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing

Lee, E. J., Pei, L., Srivastava, G., Joshi, T., Kushwaha, G., Choi, J. H., Robertson, K. D., Wang, X., Colbourne, J. K., Zhang, L., Schroth, G. P., Xu, D., Zhang, K. & Shi, H., Oct 2011, In : Nucleic acids research. 39, 19

Research output: Contribution to journalArticle

44 Scopus citations

The transglutaminase 2 gene is aberrantly hypermethylated in glioma

Dyer, L. M., Schooler, K. P., Ai, L., Klop, C., Qiu, J., Robertson, K. D. & Brown, K. D., Feb 1 2011, In : Journal of neuro-oncology. 101, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3

Liu, F., Liu, Q., Yang, D., Bollag, W. B., Robertson, K., Wu, P. & Liu, K., Nov 1 2011, In : Cancer research. 71, 21, p. 6807-6816 10 p.

Research output: Contribution to journalArticle

35 Scopus citations
2009

A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding

Gopalakrishnan, S., Van Emburgh, B. O., Shan, J., Su, Z., Fields, C. R., Vieweg, J., Hamazaki, T., Schwartz, P. H., Terada, N. & Robertson, K. D., Oct 2009, In : Molecular Cancer Research. 7, 10, p. 1622-1634 13 p.

Research output: Contribution to journalArticle

58 Scopus citations

Comparative epigenomics of human and mouse mammary tumors

Demircan, B., Dyer, L. M., Gerace, M., Lobenhofer, E. K., Robertson, K. D. & Brown, K. D., Jan 1 2009, In : Genes Chromosomes and Cancer. 48, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

44 Scopus citations

DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer

Jin, B., Yao, B., Li, J. L., Fields, C. R., Delmas, A. L., Liu, C. & Robertson, K. D., 2009, In : Cancer research. 69, 18, p. 7412-7421 10 p.

Research output: Contribution to journalArticle

78 Scopus citations

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

Gopalakrishnan, S., Sullivan, B. A., Trazzi, S., Della Valle, G. & Robertson, K. D., 2009, In : Human molecular genetics. 18, 17, p. 3178-3193 16 p.

Research output: Contribution to journalArticle

89 Scopus citations

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

Takeda, M., Briggs, L. E., Wakimoto, H., Marks, M. H., Warren, S. A., Lu, J. T., Weinberg, E. O., Robertson, K. D., Chien, K. R. & Kasahara, H., Sep 1 2009, In : Laboratory Investigation. 89, 9, p. 983-993 11 p.

Research output: Contribution to journalArticle

36 Scopus citations

Specific loss of histone H3 lysine 9 trimethylation and HP1γ/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD)

Zeng, W., De Greef, J. C., Chen, Y. Y., Chien, R., Kong, X., Gregson, H. C., Winokur, S. T., Pyle, A., Robertson, K. D., Schmiesing, J. A., Kimonis, V. E., Balog, J., Frants, R. R., Ball, A. R., Lock, L. F., Donovan, P. J., Van Der Maarel, S. M. & Yokomori, K., Jul 2009, In : PLoS genetics. 5, 7, e1000559.

Research output: Contribution to journalArticle

173 Scopus citations
2008

DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B

Palii, S. S., Van Emburgh, B. O., Sankpal, U. T., Brown, K. D. & Robertson, K. D., Jan 1 2008, In : Molecular and cellular biology. 28, 2, p. 752-771 20 p.

Research output: Contribution to journalArticle

233 Scopus citations

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function

Jin, B., Tao, Q., Peng, J., Soo, H. M., Wu, W., Ying, J., Fields, C. R., Delmas, A. I., Liu, X., Qiu, J. & Robertson, K. D., Mar 1 2008, In : Human molecular genetics. 17, 5, p. 690-709 20 p.

Research output: Contribution to journalArticle

163 Scopus citations

Invasion suppressor cystatin E/M (CST6): High-level cell type-specific expression in normal brain and epigenetic silencing in gliomas

Qiu, J., Ai, L., Ramachandran, C., Yao, B., Gopalakrishnan, S., Fields, C. R., Delmas, A. L., Dyer, L. M., Melnick, S. J., Yachnis, A. T., Schwartz, P. H., Fine, H. A., Brown, K. D. & Robertson, K. D., Sep 1 2008, In : Laboratory Investigation. 88, 9, p. 910-925 16 p.

Research output: Contribution to journalArticle

48 Scopus citations
2007

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D., Apr 19 2007, In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

101 Scopus citations