• 11142 Citations
  • 51 Scopus h-Index
1993 …2020

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Article
2020

The role of survivin in the progression of pancreatic ductal adenocarcinoma (PDAC) and a novel survivin-targeted therapeutic for PDAC

Brown, M., Zhang, W., Yan, D., Kenath, R., Le, L., Wang, H., Delitto, D., Ostrov, D., Robertson, K., Liu, C. & Pham, K., Jan 2020, In : PloS one. 15, 1, e0226917.

Research output: Contribution to journalArticle

Open Access
2019

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity

Wang, L., Marek, G. W., Hlady, R. A., Wagner, R. T., Zhao, X., Clark, V. C., Fan, A. X., Liu, C., Brantly, M. & Robertson, K. D., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

1 Scopus citations

Clinical, molecular, and prognostic correlates of number, type, and functional localization of TET2 mutations in chronic myelomonocytic leukemia (CMML)—a study of 1084 patients

Coltro, G., Mangaonkar, A. A., Lasho, T. L., Finke, C. M., Pophali, P., Carr, R., Gangat, N., Binder, M., Pardanani, A., Fernandez-Zapico, M., Robertson, K. D., Bosi, A., Droin, N., Vannucchi, A. M., Tefferi, A., Hunter, A., Padron, E., Solary, E. & Patnaik, M. M., Jan 1 2019, (Accepted/In press) In : Leukemia.

Research output: Contribution to journalArticle

1 Scopus citations

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma

Zheng, Y., Hlady, R. A., Joyce, B. T., Robertson, K. D., He, C., Nannini, D. R., Kibbe, W. A., Achenbach, C. J., Murphy, R. L., Roberts, L. R. & Hou, L., Oct 21 2019, In : Clinical Epigenetics. 11, 1, 145.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

Zhong, J., Ye, Z., Clark, C. R., Lenz, S. W., Nguyen, J. H., Yan, H. D., Robertson, K. D., Farrugia, G., Zhang, Z., Ordog, T. & Lee, J. H., Mar 29 2019, In : BMC genomics. 20, 1, 249.

Research output: Contribution to journalArticle

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

Hlady, R. A., Zhao, X., Pan, X., Dong Yang, J., Ahmed, F., Antwi, S. O., Giama, N. H., Patel, T., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 1 2019, In : Theranostics. 9, 24, p. 7239-7250 12 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations

Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder

Ho, A. M. C., Winham, S. J., Armasu, S. M., Blacker, C. J., Millischer, V., Lavebratt, C., Overholser, J. C., Jurjus, G. J., Dieter, L., Mahajan, G., Rajkowska, G., Vallender, E. J., Stockmeier, C. A., Robertson, K. D., Frye, M. A., Choi, D. S. & Veldic, M., Oct 1 2019, In : Journal of Psychiatric Research. 117, p. 45-54 10 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma

Yang, M., Hlady, R. A., Zhou, D., Ho, T. H. & Robertson, K. D., Sep 1 2019, In : Cancer medicine. 8, 12, p. 5760-5768 9 p.

Research output: Contribution to journalArticle

Open Access

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Hlady, R. A., Sathyanarayan, A., Thompson, J. J., Zhou, D., Wu, Q., Pham, K., Lee, J. H., Liu, C. & Robertson, K. D., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

9 Scopus citations

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Liu, J., Hanavan, P. D., Kras, K., Ruiz, Y. W., Castle, E. P., Lake, D. F., Chen, X., O'Brien, D., Luo, H., Robertson, K. D., Gu, H. & Ho, T. H., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 331-340 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2018

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome Biology. 19, 1, 43.

Research output: Contribution to journalArticle

13 Scopus citations

DNA methylation age is accelerated in alcohol dependence

Rosen, A. D., Robertson, K. D., Hlady, R. A., Muench, C., Lee, J., Philibert, R., Horvath, S., Kaminsky, Z. A. & Lohoff, F. W., Dec 1 2018, In : Translational Psychiatry. 8, 1, 182.

Research output: Contribution to journalArticle

14 Scopus citations

Epigenetics of gastrointestinal diseases: notes from a workshop

Marks, D. L., Olson, R. L., Urrutia, R., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R. C., Sarmento, O., Bamidele, A. O., Faubion, W. A., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., Robertson, K. D. & 3 others, Kisiel, J. B., Pin, C. L. & Fernandez-Zapico, M. E., Apr 3 2018, In : Epigenetics. 13, 4, p. 449-457 9 p.

Research output: Contribution to journalArticle

9 Scopus citations
1 Scopus citations

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

Thompson, J. J., Kaur, R., Sosa, C. P., Lee, J. H., Kashiwagi, K., Zhou, D. & Robertson, K. D., Nov 2 2018, In : Nucleic Acids Research. 46, 19, p. 10034-10051 18 p.

Research output: Contribution to journalArticle

12 Scopus citations
2017

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma

Wu, Q., Pi, L., Le Trinh, T., Zuo, C., Xia, M., Jiao, Y., Hou, Z., Jo, S., Puszyk, W., Pham, K., Nelson, D. R., Robertson, K. D., Ostrov, D., Rameshwar, P., Xia, C. Q. & Liu, C., 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

9 Scopus citations

CAME: Identification of chromatin accessibility from nucleosome occupancy and methylome sequencing

Piao, Y., Lee, S. K., Lee, E. J., Robertson, K. D., Shi, H., Ryu, K. H. & Choi, J. H., Apr 15 2017, In : Bioinformatics. 33, 8, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

1 Scopus citations

Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma

Zhao, X., Sun, W., Puszyk, W. M., Wallet, S., Hochwald, S., Robertson, K. D. & Liu, C., 2017, In : Tumor Biology. 39, 5

Research output: Contribution to journalArticle

1 Scopus citations

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

Hlady, R. A., Zhou, D., Puszyk, W., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 27 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

11 Scopus citations

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

Zhong, J., Ye, Z., Lenz, S. W., Clark, C. R., Bharucha, A. E., Farrugia, G., Robertson, K. D., Zhang, Z., Ordog, T. & Lee, J. H., Dec 21 2017, In : BMC Genomics. 18, 1, 985.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J. H., Choi, J. H., Ho, T. H. & Robertson, K. D., 2016, In : Oncotarget. 7, 2, p. 1927-1946 20 p.

Research output: Contribution to journalArticle

24 Scopus citations

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Zhou, D., Hlady, R. A., Schafer, M. J., White, T. A., Liu, C., Choi, J. H., Miller, J. D., Roberts, L. R., LeBrasseur, N. K. & Robertson, K. D., Dec 22 2016, (Accepted/In press) In : Epigenetics. p. 1-15 15 p.

Research output: Contribution to journalArticle

15 Scopus citations

Nucleosome positioning changes during human embryonic stem cell differentiation

Zhang, W., Li, Y., Kulik, M., Tiedemann, R. L., Robertson, K. D., Dalton, S. & Zhao, S., Jun 2 2016, In : Epigenetics. 11, 6, p. 426-437 12 p.

Research output: Contribution to journalArticle

2 Scopus citations
2015

ITagPlot: An accurate computation and interactive drawing tool for tag density plot

Kim, S. H., Ezenwoye, O., Cho, H. G., Robertson, K. D. & Choi, J. H., 2015, In : Bioinformatics. 31, 14, p. 2384-2387 4 p.

Research output: Contribution to journalArticle

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma

Zhao, X., Puszyk, W. M., Lu, Z., Ostrov, D. A., George, T. J., Robertson, K. D. & Liu, C., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

10 Scopus citations
2014

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

Tiedemann, R. L., Putiri, E. L., Lee, J. H., Hlady, R. A., Kashiwagi, K., Ordog, T., Zhang, Z., Liu, C., Choi, J. H. & Robertson, K. D., Nov 20 2014, In : Cell Reports. 9, 4, p. 1554-1566 13 p.

Research output: Contribution to journalArticle

26 Scopus citations

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Putiri, E. L., Tiedemann, R. L., Thompson, J. J., Liu, C., Ho, T. H., Choi, J. H. & Robertson, K. D., Jun 23 2014, In : Genome Biology. 15, 6, R81.

Research output: Contribution to journalArticle

51 Scopus citations

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis

Hlady, R. A., Tiedemann, R. L., Puszyk, W., Zendejas, I., Roberts, L. R., Choi, J. H., Liu, C. & Robertson, K. D., 2014, In : Oncotarget. 5, 19, p. 9425-9443 19 p.

Research output: Contribution to journalArticle

37 Scopus citations

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

Putiri, E. L., Tiedemann, R. L., Liu, C., Choi, J. H. & Robertson, K. D., 2014, In : Oncotarget. 5, 15, p. 6338-6352 15 p.

Research output: Contribution to journalArticle

7 Scopus citations
2013

DNA methyltransferases, DNA damage repair, and cancer

Jin, B. & Robertson, K. D., 2013, In : Advances in Experimental Medicine and Biology. 754, p. 3-29 27 p.

Research output: Contribution to journalArticle

208 Scopus citations
2012

Butyrate suppresses colonic inflammation through HDAC1-dependent fas upregulation and fas-mediated apoptosis of T cells

Zimmerman, M. A., Singh, N., Martin, P. M., Thangaraju, M., Ganapathy, V., Waller, J. L., Shi, H., Robertson, K. D., Munn, D. H. & Liu, K., Jun 15 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 12

Research output: Contribution to journalArticle

131 Scopus citations

Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus

Liu, H., Trinh, T. L., Dong, H., Robertson, K. D., Nelson, D. & Liu, C., Oct 22 2012, In : PLoS One. 7, 10, e46631.

Research output: Contribution to journalArticle

33 Scopus citations

Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

Jin, B., Ernst, J., Tiedemann, R. L., Xu, H., Sureshchandra, S., Kellis, M., Dalton, S., Liu, C., Choi, J. H. & Robertson, K. D., Nov 29 2012, In : Cell Reports. 2, 5, p. 1411-1424 14 p.

Research output: Contribution to journalArticle

77 Scopus citations

Molecular modeling of inhibitors of human DNa methyltransferase with a crystal structure: Discovery of a novel dnmt1 inhibitor

Yoo, J., Kim, J. H., Robertson, K. D. & Medina-Franco, J. L., 2012, In : Advances in Protein Chemistry and Structural Biology. 87, p. 219-247 29 p.

Research output: Contribution to journalArticle

43 Scopus citations
2011

DNA methylation: Superior or subordinate in the epigenetic hierarchy?

Jin, B., Li, Y. & Robertson, K. D., Jun 2011, In : Genes and Cancer. 2, 6, p. 607-617 11 p.

Research output: Contribution to journalArticle

240 Scopus citations

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma

Liu, H., Dong, H., Robertson, K. D. & Liu, C., Feb 2011, In : American Journal of Pathology. 178, 2, p. 652-661 10 p.

Research output: Contribution to journalArticle

48 Scopus citations

Epigenetic mechanisms and genome stability

Putiri, E. L. & Robertson, K. D., Aug 2011, In : Clinical Epigenetics. 2, 2, p. 299-314 16 p.

Research output: Contribution to journalArticle

47 Scopus citations

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

Van Emburgh, B. O. & Robertson, K. D., Jul 2011, In : Nucleic Acids Research. 39, 12, p. 4984-5002 19 p.

Research output: Contribution to journalArticle

46 Scopus citations

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery

Ha, K., Lee, G. E., Palii, S. S., Brown, K. D., Takeda, Y., Liu, K., Bhalla, K. N. & Robertson, K. D., Jan 2011, In : Human Molecular Genetics. 20, 1, p. 126-140 15 p.

Research output: Contribution to journalArticle

65 Scopus citations

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

Peng, L., Yuan, Z., Ling, H., Fukasawa, K., Robertson, K. D., Olashaw, N., Koomen, J., Chen, J., Lane, W. S. & Seto, E., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4720-4734 15 p.

Research output: Contribution to journalArticle

106 Scopus citations

Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing

Lee, E. J., Pei, L., Srivastava, G., Joshi, T., Kushwaha, G., Choi, J. H., Robertson, K. D., Wang, X., Colbourne, J. K., Zhang, L., Schroth, G. P., Xu, D., Zhang, K. & Shi, H., Oct 2011, In : Nucleic Acids Research. 39, 19

Research output: Contribution to journalArticle

42 Scopus citations

The transglutaminase 2 gene is aberrantly hypermethylated in glioma

Dyer, L. M., Schooler, K. P., Ai, L., Klop, C., Qiu, J., Robertson, K. D. & Brown, K. D., Feb 2011, In : Journal of Neuro-Oncology. 101, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

20 Scopus citations

Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3

Liu, F., Liu, Q., Yang, D., Bollag, W. B., Robertson, K. D., Wu, P. & Liu, K., Nov 1 2011, In : Cancer Research. 71, 21, p. 6807-6816 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2009

A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding

Gopalakrishnan, S., Van Emburgh, B. O., Shan, J., Su, Z., Fields, C. R., Vieweg, J., Hamazaki, T., Schwartz, P. H., Terada, N. & Robertson, K. D., Oct 2009, In : Molecular Cancer Research. 7, 10, p. 1622-1634 13 p.

Research output: Contribution to journalArticle

57 Scopus citations

Comparative epigenomics of human and mouse mammary tumors

Demircan, B., Dyer, L. M., Gerace, M., Lobenhofer, E. K., Robertson, K. D. & Brown, K. D., Jan 2009, In : Genes Chromosomes and Cancer. 48, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

43 Scopus citations

DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer

Jin, B., Yao, B., Li, J. L., Fields, C. R., Delmas, A. L., Liu, C. & Robertson, K. D., 2009, In : Cancer Research. 69, 18, p. 7412-7421 10 p.

Research output: Contribution to journalArticle

77 Scopus citations

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

Gopalakrishnan, S., Sullivan, B. A., Trazzi, S., Della Valle, G. & Robertson, K. D., 2009, In : Human Molecular Genetics. 18, 17, p. 3178-3193 16 p.

Research output: Contribution to journalArticle

87 Scopus citations

Missteps in "tango" for epigenome targeting

Robertson, K. D. & Bhalla, K. N., 2009, In : Blood. 114, 13, p. 2569-2570 2 p.

Research output: Contribution to journalArticle

1 Scopus citations

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

Takeda, M., Briggs, L. E., Wakimoto, H., Marks, M. H., Warren, S. A., Lu, J. T., Weinberg, E. O., Robertson, K. D., Chien, K. R. & Kasahara, H., Sep 2009, In : Laboratory Investigation. 89, 9, p. 983-993 11 p.

Research output: Contribution to journalArticle

36 Scopus citations