• 10917 Citations
  • 50 Scopus h-Index
1993 …2019
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Research Output 1993 2019

Article
8 Citations (Scopus)
Genetic Heterogeneity
Liver Neoplasms
Epigenomics
Liver Diseases
Homeostasis

Genome-wide discovery and validation of diagnostic DNA methylation-based biomarkers for hepatocellular cancer detection in circulating cell free DNA

Hlady, R. A., Zhao, X., Pan, X., Dong Yang, J., Ahmed, F., Antwi, S. O., Giama, N. H., Patel, T., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 1 2019, In : Theranostics. 9, 24, p. 7239-7250 12 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Liver Neoplasms
Hepatocellular Carcinoma
Biomarkers
Genome

Genome-wide DNA methylomic differences between dorsolateral prefrontal and temporal pole cortices of bipolar disorder

Ho, A. M. C., Winham, S. J., Armasu, S. M., Blacker, C. J., Millischer, V., Lavebratt, C., Overholser, J. C., Jurjus, G. J., Dieter, L., Mahajan, G., Rajkowska, G., Vallender, E. J., Stockmeier, C. A., Robertson, K. D., Frye, M. A., Choi, D. S. & Veldic, M., Oct 1 2019, In : Journal of Psychiatric Research. 117, p. 45-54 10 p.

Research output: Contribution to journalArticle

Open Access
Temporal Lobe
Bipolar Disorder
Genome
DNA
Brain
12 Citations (Scopus)

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Zhou, D., Hlady, R. A., Schafer, M. J., White, T. A., Liu, C., Choi, J. H., Miller, J. D., Roberts, L. R., LeBrasseur, N. K. & Robertson, K. D., Dec 22 2016, (Accepted/In press) In : Epigenetics. p. 1-15 15 p.

Research output: Contribution to journalArticle

High Fat Diet
Diet
Liver
DNA
DNA Methylation
65 Citations (Scopus)

Histone deacetylase inhibitors for cancer therapy

Kim, T. Y., Bang, Y. J. & Robertson, K. D., 2006, In : Epigenetics. 1, 1, p. 14-23 10 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Neoplasms
Therapeutics
Epigenomics
DNA Methylation
147 Citations (Scopus)

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

Espada, J., Ballestar, E., Fraga, M. F., Villar-Garea, A., Juarranz, A., Stockert, J. C., Robertson, K. D., Fuks, F. & Esteller, M., Aug 27 2004, In : Journal of Biological Chemistry. 279, 35, p. 37175-37184 10 p.

Research output: Contribution to journalArticle

Histone Code
Methyltransferases
Histones
Maintenance
DNA
7 Citations (Scopus)

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

Putiri, E. L., Tiedemann, R. L., Liu, C., Choi, J. H. & Robertson, K. D., 2014, In : Oncotarget. 5, 15, p. 6338-6352 15 p.

Research output: Contribution to journalArticle

Histone Code
DNA Methylation
DNA
Post Translational Protein Processing
Polycomb Repressive Complex 2
142 Citations (Scopus)

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer

Ai, L., Tao, Q., Zhong, S., Fields, C. R., Kim, W. J., Lee, M. W., Cui, Y., Brown, K. D. & Robertson, K. D., Jul 2006, In : Carcinogenesis. 27, 7, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

Wnt Proteins
Epigenomics
Breast Neoplasms
decitabine
Neoplasms
11 Citations (Scopus)

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

Hlady, R. A., Zhou, D., Puszyk, W., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 27 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Liver Neoplasms
Epigenomics
Disease Progression
Hepatocellular Carcinoma

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma

Yang, M., Hlady, R. A., Zhou, D., Ho, T. H. & Robertson, K. D., Sep 1 2019, In : Cancer medicine. 8, 12, p. 5760-5768 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Renal Cell Carcinoma
Computer Simulation
Biomarkers
Methylation
8 Citations (Scopus)

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Hlady, R. A., Sathyanarayan, A., Thompson, J. J., Zhou, D., Wu, Q., Pham, K., Lee, J. H., Liu, C. & Robertson, K. D., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Epigenomics
Hepatocellular Carcinoma
Histone Code
dimethylaniline monooxygenase (N-oxide forming)
Liver
47 Citations (Scopus)

Invasion suppressor cystatin E/M (CST6): High-level cell type-specific expression in normal brain and epigenetic silencing in gliomas

Qiu, J., Ai, L., Ramachandran, C., Yao, B., Gopalakrishnan, S., Fields, C. R., Delmas, A. L., Dyer, L. M., Melnick, S. J., Yachnis, A. T., Schwartz, P. H., Fine, H. A., Brown, K. D. & Robertson, K. D., Sep 2008, In : Laboratory Investigation. 88, 9, p. 910-925 16 p.

Research output: Contribution to journalArticle

Cystatin M
Epigenomics
Glioma
Brain
Brain Neoplasms
33 Citations (Scopus)

Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus

Liu, H., Trinh, T. L., Dong, H., Robertson, K. D., Nelson, D. & Liu, C., Oct 22 2012, In : PLoS One. 7, 10, e46631.

Research output: Contribution to journalArticle

Hepcidins
Hepatitis C virus
Viruses
Hepacivirus
Antiviral Agents
92 Citations (Scopus)

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Chen, Y., Mazumdar, M., Heale, J. T., Schmiesing, J. A., Kim, W., Yokomori, K., Zhao, Y. & Robertson, K. D., 2004, In : Nucleic Acids Research. 32, 9, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

Methyltransferases
Chromosomes
Genomic Instability
DNA Methylation
Mitosis

ITagPlot: An accurate computation and interactive drawing tool for tag density plot

Kim, S. H., Ezenwoye, O., Cho, H. G., Robertson, K. D. & Choi, J. H., 2015, In : Bioinformatics. 31, 14, p. 2384-2387 4 p.

Research output: Contribution to journalArticle

Biological Phenomena
Graphical user interfaces
Cluster Analysis
Statistics
Engines
45 Citations (Scopus)

Kinetic analysis of the reaction of melphalan with water, phosphate, and glutathione

Bolton, M. G., Hilton, J., Robertson, K. D., Streeper, R. T., Colvin, O. M. & Noe, D. A., 1993, In : Drug Metabolism and Disposition. 21, 6, p. 986-996 11 p.

Research output: Contribution to journalArticle

Melphalan
Glutathione
Phosphates
Rate constants
Glutathione Transferase
76 Citations (Scopus)

Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

Jin, B., Ernst, J., Tiedemann, R. L., Xu, H., Sureshchandra, S., Kellis, M., Dalton, S., Liu, C., Choi, J. H. & Robertson, K. D., Nov 29 2012, In : Cell Reports. 2, 5, p. 1411-1424 14 p.

Research output: Contribution to journalArticle

Nucleosomes
Methyltransferases
DNA Methylation
Epigenomics
Tumors
2 Citations (Scopus)

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Liu, J., Hanavan, P. D., Kras, K., Ruiz, Y. W., Castle, E. P., Lake, D. F., Chen, X., O'Brien, D., Luo, H., Robertson, K. D., Gu, H. & Ho, T. H., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 331-340 10 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Renal Cell Carcinoma
Cells
Switches
Cell Line
42 Citations (Scopus)
Virus Latency
Human herpesvirus 4
Human Herpesvirus 4
Genetic Promoter Regions
methylation
58 Citations (Scopus)

Methylation of the Epstein-Barr virus genome in normal lymphocytes

Robertson, K. D. & Ambinder, R. F., Dec 1 1997, In : Blood. 90, 11, p. 4480-4484 5 p.

Research output: Contribution to journalArticle

Methylation
Lymphocytes
Human Herpesvirus 4
Viruses
Genes
88 Citations (Scopus)

Methylation status of the Epstein-Barr virus major latent promoter C in latrogenic B cell lymphoproliferative disease: Application of PCR-based analysis

Qian, T., Swinnen, L. J., Yang, J., Srivastava, G., Robertson, K. D. & Ambinder, R. F., Aug 1999, In : American Journal of Pathology. 155, 2, p. 619-625 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Methylation
B-Lymphocytes
Polymerase Chain Reaction
Lymphoma
1 Citation (Scopus)

Missteps in "tango" for epigenome targeting

Robertson, K. D. & Bhalla, K. N., 2009, In : Blood. 114, 13, p. 2569-2570 2 p.

Research output: Contribution to journalArticle

Azacitidine
Histone Deacetylase Inhibitors
Leukemia
Blood
Therapeutics
98 Citations (Scopus)

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Y., Sankpal, U. T., Robertson, A. K., McNally, J. G., Karpova, T. & Robertson, K. D., 2004, In : Nucleic Acids Research. 32, 2, p. 598-610 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Sumoylation
Methyltransferases
Genomic Imprinting
Ubiquitin-Protein Ligases
45 Citations (Scopus)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

Van Emburgh, B. O. & Robertson, K. D., Jul 2011, In : Nucleic Acids Research. 39, 12, p. 4984-5002 19 p.

Research output: Contribution to journalArticle

Alternative Splicing
DNA
Protein Isoforms
Inborn Genetic Diseases
Aptitude
43 Citations (Scopus)

Molecular modeling of inhibitors of human DNa methyltransferase with a crystal structure: Discovery of a novel dnmt1 inhibitor

Yoo, J., Kim, J. H., Robertson, K. D. & Medina-Franco, J. L., 2012, In : Advances in Protein Chemistry and Structural Biology. 87, p. 219-247 29 p.

Research output: Contribution to journalArticle

Molecular modeling
Aurintricarboxylic Acid
Methyltransferases
Crystal structure
DNA
2 Citations (Scopus)

Nucleosome positioning changes during human embryonic stem cell differentiation

Zhang, W., Li, Y., Kulik, M., Tiedemann, R. L., Robertson, K. D., Dalton, S. & Zhao, S., Jun 2 2016, In : Epigenetics. 11, 6, p. 426-437 12 p.

Research output: Contribution to journalArticle

Nucleosomes
Cell Differentiation
Base Composition
Chromatin
Smooth Muscle Myocytes
11 Citations (Scopus)
Neoplasm DNA
Viral Gene Expression Regulation
Molecular Sequence Data
Tumor Virus Infections
Viral Matrix Proteins
96 Citations (Scopus)

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D., Apr 19 2007, In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Histones
58 Citations (Scopus)

Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy

Jung, Y., Park, J., Kim, T. Y., Park, J. H., Jong, H. S., Im, S. A., Robertson, K. D., Bang, Y. J. & Kim, T. Y., Oct 2007, In : Journal of Molecular Medicine. 85, 10, p. 1137-1148 12 p.

Research output: Contribution to journalArticle

Methyltransferases
decitabine
DNA
Neoplasms
Therapeutics
117 Citations (Scopus)

Preferential methylation of unmethylated DNA by mammalian de novo DNA methyltransferase Dnmt3a

Yokochi, T. & Robertson, K. D., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11735-11745 11 p.

Research output: Contribution to journalArticle

Methylation
Methyltransferases
DNA Methylation
DNA
Substrates
5 Citations (Scopus)

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

Zhong, J., Ye, Z., Lenz, S. W., Clark, C. R., Bharucha, A. E., Farrugia, G., Robertson, K. D., Zhang, Z., Ordog, T. & Lee, J. H., Dec 21 2017, In : BMC Genomics. 18, 1, 985.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
DNA
Gene Library
Libraries
Buffers
63 Citations (Scopus)

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery

Ha, K., Lee, G. E., Palii, S. S., Brown, K. D., Takeda, Y., Liu, K., Bhalla, K. N. & Robertson, K. D., Jan 2011, In : Human Molecular Genetics. 20, 1, p. 126-140 15 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Methyltransferases
DNA Damage
DNA
Genomic Instability
109 Citations (Scopus)

Roles of cell division and gene transcription in the methylation of CpG islands

Bender, C. M., Gonzalgo, M. L., Gonzales, F. A., Nguyen, C. T., Robertson, K. D. & Jones, P. A., Oct 1999, In : Molecular and Cellular Biology. 19, 10, p. 6690-6698 9 p.

Research output: Contribution to journalArticle

CpG Islands
Cell Division
Methylation
Exons
Genes
102 Citations (Scopus)

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

Peng, L., Yuan, Z., Ling, H., Fukasawa, K., Robertson, K. D., Olashaw, N., Koomen, J., Chen, J., Lane, W. S. & Seto, E., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4720-4734 15 p.

Research output: Contribution to journalArticle

Protein Methyltransferases
Methyltransferases
DNA
DNA Methylation
Lysine
35 Citations (Scopus)

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

Takeda, M., Briggs, L. E., Wakimoto, H., Marks, M. H., Warren, S. A., Lu, J. T., Weinberg, E. O., Robertson, K. D., Chien, K. R. & Kasahara, H., Sep 2009, In : Laboratory Investigation. 89, 9, p. 983-993 11 p.

Research output: Contribution to journalArticle

Tamoxifen
Cardiac Myocytes
Cell Cycle
Alleles
Homeodomain Proteins
9 Citations (Scopus)

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma

Zhao, X., Puszyk, W. M., Lu, Z., Ostrov, D. A., George, T. J., Robertson, K. D. & Liu, C., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Pancreatic Neoplasms
Apoptosis
Drug Therapy
gemcitabine
168 Citations (Scopus)

Specific loss of histone H3 lysine 9 trimethylation and HP1γ/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD)

Zeng, W., De Greef, J. C., Chen, Y. Y., Chien, R., Kong, X., Gregson, H. C., Winokur, S. T., Pyle, A., Robertson, K. D., Schmiesing, J. A., Kimonis, V. E., Balog, J., Frants, R. R., Ball, A. R., Lock, L. F., Donovan, P. J., Van Der Maarel, S. M. & Yokomori, K., Jul 2009, In : PLoS Genetics. 5, 7, e1000559.

Research output: Contribution to journalArticle

histones
Histones
contraction
Lysine
lysine
70 Citations (Scopus)

Stealth technology: How Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection

Tao, Q. & Robertson, K. D., Oct 2003, In : Clinical Immunology. 109, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Human Herpesvirus 4
Technology
Immune System
Genome
40 Citations (Scopus)

Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing

Lee, E. J., Pei, L., Srivastava, G., Joshi, T., Kushwaha, G., Choi, J. H., Robertson, K. D., Wang, X., Colbourne, J. K., Zhang, L., Schroth, G. P., Xu, D., Zhang, K. & Shi, H., Oct 2011, In : Nucleic Acids Research. 39, 19

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
CpG Islands
Cell Line
Nucleic Acid Regulatory Sequences
Methylation
58 Citations (Scopus)

The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive

Tao, Q., Robertson, K. D., Manns, A., Hildesheim, A. & Ambinder, R. F., Sep 1998, In : Journal of Virology. 72, 9, p. 7075-7083 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 4
Human Herpesvirus 4
methylation
Methylation
promoter regions
60 Citations (Scopus)

The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells

Liang, G., Robertson, K. D., Talmadge, C., Sumegi, J. & Jones, P. A., Sep 1 2000, In : Cancer Research. 60, 17, p. 4907-4912 6 p.

Research output: Contribution to journalArticle

Follistatin
Epidermal Growth Factor
Colon
CpG Islands
Tumor Cell Line
322 Citations (Scopus)
cdc Genes
decitabine
DNA Methylation
Regulator Genes
Islands
645 Citations (Scopus)

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors

Robertson, K. D., Uzvolgyi, E., Liang, G., Talmadge, C., Sumegi, J., Gonzales, F. A. & Jones, P. A., Jun 1 1999, In : Nucleic Acids Research. 27, 11, p. 2291-2298 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Messenger RNA
Methylation
Chromosomes
X Chromosome Inactivation
25 Citations (Scopus)
Viral Gene Expression Regulation
Molecular Sequence Data
Virus Latency
CpG Islands
Epstein-Barr Virus Infections
20 Citations (Scopus)

The transglutaminase 2 gene is aberrantly hypermethylated in glioma

Dyer, L. M., Schooler, K. P., Ai, L., Klop, C., Qiu, J., Robertson, K. D. & Brown, K. D., Feb 2011, In : Journal of Neuro-Oncology. 101, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

Glioma
Genes
Brain Neoplasms
Doxorubicin
decitabine
80 Citations (Scopus)

The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas

Chan, S. L., Cui, Y., Van Hasselt, A., Li, H., Srivastava, G., Jin, H., Ng, K. M., Wang, Y., Lee, K. Y., Tsao, G. S. W., Zhong, S., Robertson, K. D., Rha, S. Y., Chan, A. T. C. & Tao, Q., Jul 5 2007, In : Laboratory Investigation. 87, 7, p. 644-650 7 p.

Research output: Contribution to journalArticle

Wnt Proteins
Methylation
Epigenomics
Neoplasms
decitabine
80 Citations (Scopus)

Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus

Robertson, K. D. & Jones, P. A., Jul 1 1999, In : Oncogene. 18, 26, p. 3810-3820 11 p.

Research output: Contribution to journalArticle

Alternative Splicing
Cell Cycle
RNA Splice Sites
Introns
Pancreas
99 Citations (Scopus)

Transcriptional activation of the Epstein-Barr Virus latency C promoter after 5-azacytidine treatment: Evidence that demethylation at a single CpG site is crucial

Robertson, K. D., Hayward, S. D., Ling, P. D., Samid, D. & Ambinder, R. F., 1995, In : Molecular and Cellular Biology. 15, 11, p. 6150-6159 10 p.

Research output: Contribution to journalArticle

Virus Latency
Azacitidine
Human Herpesvirus 4
Methylation
Transcriptional Activation
1 Citation (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Epigenomics
Transcriptional Activation
Therapeutics
30 Citations (Scopus)

Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3

Liu, F., Liu, Q., Yang, D., Bollag, W. B., Robertson, K. D., Wu, P. & Liu, K., Nov 1 2011, In : Cancer Research. 71, 21, p. 6807-6816 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Colon
Up-Regulation
Apoptosis
Carcinoma