• 10854 Citations
  • 50 Scopus h-Index
1993 …2019
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Research Output 1993 2019

2009
1 Citation (Scopus)

Missteps in "tango" for epigenome targeting

Robertson, K. D. & Bhalla, K. N., 2009, In : Blood. 114, 13, p. 2569-2570 2 p.

Research output: Contribution to journalArticle

Azacitidine
Histone Deacetylase Inhibitors
Leukemia
Blood
Therapeutics
35 Citations (Scopus)

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

Takeda, M., Briggs, L. E., Wakimoto, H., Marks, M. H., Warren, S. A., Lu, J. T., Weinberg, E. O., Robertson, K. D., Chien, K. R. & Kasahara, H., Sep 2009, In : Laboratory Investigation. 89, 9, p. 983-993 11 p.

Research output: Contribution to journalArticle

Tamoxifen
Cardiac Myocytes
Cell Cycle
Alleles
Homeodomain Proteins
167 Citations (Scopus)

Specific loss of histone H3 lysine 9 trimethylation and HP1γ/cohesin binding at D4Z4 repeats is associated with facioscapulohumeral dystrophy (FSHD)

Zeng, W., De Greef, J. C., Chen, Y. Y., Chien, R., Kong, X., Gregson, H. C., Winokur, S. T., Pyle, A., Robertson, K. D., Schmiesing, J. A., Kimonis, V. E., Balog, J., Frants, R. R., Ball, A. R., Lock, L. F., Donovan, P. J., Van Der Maarel, S. M. & Yokomori, K., Jul 2009, In : PLoS Genetics. 5, 7, e1000559.

Research output: Contribution to journalArticle

histones
Histones
contraction
Lysine
lysine
2008
165 Citations (Scopus)

DNA methylation in development and human disease

Gopalakrishnan, S., Van Emburgh, B. O. & Robertson, K. D., Dec 1 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 647, 1-2, p. 30-38 9 p.

Research output: Contribution to journalArticle

Human Development
DNA Methylation
Epigenomics
Histone Code
Neoplastic Stem Cells
224 Citations (Scopus)

DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B

Palii, S. S., Van Emburgh, B. O., Sankpal, U. T., Brown, K. D. & Robertson, K. D., Jan 2008, In : Molecular and Cellular Biology. 28, 2, p. 752-771 20 p.

Research output: Contribution to journalArticle

decitabine
DNA Methylation
DNA Damage
Genome
Ataxia Telangiectasia
153 Citations (Scopus)

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function

Jin, B., Tao, Q., Peng, J., Soo, H. M., Wu, W., Ying, J., Fields, C. R., Delmas, A. I., Liu, X., Qiu, J. & Robertson, K. D., Mar 1 2008, In : Human Molecular Genetics. 17, 5, p. 690-709 20 p.

Research output: Contribution to journalArticle

Neurogenesis
Epigenomics
Gene Expression
Mutation
DNA Methylation
47 Citations (Scopus)

Invasion suppressor cystatin E/M (CST6): High-level cell type-specific expression in normal brain and epigenetic silencing in gliomas

Qiu, J., Ai, L., Ramachandran, C., Yao, B., Gopalakrishnan, S., Fields, C. R., Delmas, A. L., Dyer, L. M., Melnick, S. J., Yachnis, A. T., Schwartz, P. H., Fine, H. A., Brown, K. D. & Robertson, K. D., Sep 2008, In : Laboratory Investigation. 88, 9, p. 910-925 16 p.

Research output: Contribution to journalArticle

Cystatin M
Epigenomics
Glioma
Brain
Brain Neoplasms
2007
39 Citations (Scopus)

DNMT1 knockout delivers a strong blow to genome stability and cell viability

Brown, K. D. & Robertson, K. D., Mar 2007, In : Nature Genetics. 39, 3, p. 289-290 2 p.

Research output: Contribution to journalArticle

Genomic Instability
Cell Survival
Gene Targeting
Methyltransferases
Genome
36 Citations (Scopus)

Epigenetic control of tumor suppression

Palii, S. S. & Robertson, K. D., 2007, In : Critical Reviews in Eukaryotic Gene Expression. 17, 4, p. 295-316 22 p.

Research output: Contribution to journalArticle

Epigenomics
Neoplasms
Tumor Suppressor Genes
Methylation
Histone Code
94 Citations (Scopus)

Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

Zhong, S., Fields, C. R., Su, N., Pan, Y. X. & Robertson, K. D., Apr 19 2007, In : Oncogene. 26, 18, p. 2621-2634 14 p.

Research output: Contribution to journalArticle

Gene Expression Profiling
DNA Methylation
Epigenomics
Non-Small Cell Lung Carcinoma
Histones
58 Citations (Scopus)

Potential advantages of DNA methyltransferase 1 (DNMT1)-targeted inhibition for cancer therapy

Jung, Y., Park, J., Kim, T. Y., Park, J. H., Jong, H. S., Im, S. A., Robertson, K. D., Bang, Y. J. & Kim, T. Y., Oct 2007, In : Journal of Molecular Medicine. 85, 10, p. 1137-1148 12 p.

Research output: Contribution to journalArticle

Methyltransferases
decitabine
DNA
Neoplasms
Therapeutics
80 Citations (Scopus)

The tumor suppressor Wnt inhibitory factor 1 is frequently methylated in nasopharyngeal and esophageal carcinomas

Chan, S. L., Cui, Y., Van Hasselt, A., Li, H., Srivastava, G., Jin, H., Ng, K. M., Wang, Y., Lee, K. Y., Tsao, G. S. W., Zhong, S., Robertson, K. D., Rha, S. Y., Chan, A. T. C. & Tao, Q., Jul 5 2007, In : Laboratory Investigation. 87, 7, p. 644-650 7 p.

Research output: Contribution to journalArticle

Wnt Proteins
Methylation
Epigenomics
Neoplasms
decitabine
2006
41 Citations (Scopus)

An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis

Zhao, L. Y., Niu, Y., Santiago, A., Liu, J., Albert, S. H., Robertson, K. D. & Liao, D., Oct 1 2006, In : Cancer Research. 66, 19, p. 9445-9452 8 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Apoptosis
decitabine
Neoplasms
Brain Neoplasms
68 Citations (Scopus)

Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression

Ai, L., Kim, W. J., Kim, T. Y., Fields, C. R., Massoll, N. A., Robertson, K. D. & Brown, K. D., Aug 15 2006, In : Cancer Research. 66, 16, p. 7899-7909 11 p.

Research output: Contribution to journalArticle

Cystatin M
Epigenomics
Breast Neoplasms
Neoplasms
Breast
115 Citations (Scopus)

Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma

Kim, T. Y., Zhong, S., Fields, C. R., Kim, J. H. & Robertson, K. D., Aug 1 2006, In : Cancer Research. 66, 15, p. 7490-7501 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Glioma
decitabine
Histones
65 Citations (Scopus)

Histone deacetylase inhibitors for cancer therapy

Kim, T. Y., Bang, Y. J. & Robertson, K. D., 2006, In : Epigenetics. 1, 1, p. 14-23 10 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Neoplasms
Therapeutics
Epigenomics
DNA Methylation
142 Citations (Scopus)

Inactivation of Wnt inhibitory factor-1 (WIF1) expression by epigenetic silencing is a common event in breast cancer

Ai, L., Tao, Q., Zhong, S., Fields, C. R., Kim, W. J., Lee, M. W., Cui, Y., Brown, K. D. & Robertson, K. D., Jul 2006, In : Carcinogenesis. 27, 7, p. 1341-1348 8 p.

Research output: Contribution to journalArticle

Wnt Proteins
Epigenomics
Breast Neoplasms
decitabine
Neoplasms
2005
1592 Citations (Scopus)

DNA methylation and human disease

Robertson, K. D., Aug 2005, In : Nature Reviews Genetics. 6, 8, p. 597-610 14 p.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
human diseases
Epigenomics
epigenetics
2004
93 Citations (Scopus)

Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors

Chan, A. T. C., Tao, Q., Robertson, K. D., Flinn, I. W., Mann, R. B., Klencke, B., Kwan, W. H., Leung, T. W. T., Johnson, P. J. & Ambinder, R. F., 2004, In : Journal of Clinical Oncology. 22, 8, p. 1373-1381 9 p.

Research output: Contribution to journalArticle

Azacitidine
Human Herpesvirus 4
Genome
Methylation
Immunohistochemistry
15 Citations (Scopus)

Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro

Yokochi, T. & Robertson, K. D., Aug 2004, In : Bioorganic Chemistry. 32, 4, p. 234-243 10 p.

Research output: Contribution to journalArticle

Dimethyl Sulfoxide
Catalyst activity
DNA
Methyltransferases
S-Adenosylmethionine
15 Citations (Scopus)

DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro.

Yokochi, T. & Robertson, K. D., 2004, In : Methods in molecular biology (Clifton, N.J.). 287, p. 285-296 12 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA
DNA Methylation
Chromatin
Immobilized Nucleic Acids
80 Citations (Scopus)

DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Zhao, Y., Zhao, Y. & Robertson, K. D., May 28 2004, In : Biochemical and Biophysical Research Communications. 318, 2, p. 544-555 12 p.

Research output: Contribution to journalArticle

Methylation
Chromatin Assembly and Disassembly
Methyltransferases
Histones
Chromatin
71 Citations (Scopus)

Doxorubicin inhibits DNMT1, resulting in conditional apoptosis

Yokochi, T. & Robertson, K. D., Dec 2004, In : Molecular Pharmacology. 66, 6, p. 1415-1420 6 p.

Research output: Contribution to journalArticle

Doxorubicin
Intercalating Agents
Apoptosis
DNA
Neoplasms
57 Citations (Scopus)

Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro

Robertson, A. K., Geiman, T. M., Sankpal, U. T., Hager, G. L. & Robertson, K. D., Sep 10 2004, In : Biochemical and Biophysical Research Communications. 322, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Chromatin
Chromatin Assembly and Disassembly
Epigenomics
DNA
147 Citations (Scopus)

Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern

Espada, J., Ballestar, E., Fraga, M. F., Villar-Garea, A., Juarranz, A., Stockert, J. C., Robertson, K. D., Fuks, F. & Esteller, M., Aug 27 2004, In : Journal of Biological Chemistry. 279, 35, p. 37175-37184 10 p.

Research output: Contribution to journalArticle

Histone Code
Methyltransferases
Histones
Maintenance
DNA
91 Citations (Scopus)

Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Chen, Y., Mazumdar, M., Heale, J. T., Schmiesing, J. A., Kim, W., Yokomori, K., Zhao, Y. & Robertson, K. D., 2004, In : Nucleic Acids Research. 32, 9, p. 2716-2729 14 p.

Research output: Contribution to journalArticle

Methyltransferases
Chromosomes
Genomic Instability
DNA Methylation
Mitosis
98 Citations (Scopus)

Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription

Ling, Y., Sankpal, U. T., Robertson, A. K., McNally, J. G., Karpova, T. & Robertson, K. D., 2004, In : Nucleic Acids Research. 32, 2, p. 598-610 13 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Sumoylation
Methyltransferases
Genomic Imprinting
Ubiquitin-Protein Ligases
2003
70 Citations (Scopus)

Stealth technology: How Epstein-Barr virus utilizes DNA methylation to cloak itself from immune detection

Tao, Q. & Robertson, K. D., Oct 2003, In : Clinical Immunology. 109, 1, p. 53-63 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Human Herpesvirus 4
Technology
Immune System
Genome
2002
219 Citations (Scopus)

Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?

Geiman, T. M. & Robertson, K. D., 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Histone Code
Chromatin Assembly and Disassembly
DNA Methylation
Methylation
Histones
120 Citations (Scopus)

Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells

Tao, Q., Huang, H., Geiman, T. M., Lim, C. Y., Fu, L., Qiu, G. H. & Robertson, K. D., Sep 1 2002, In : Human Molecular Genetics. 11, 18, p. 2091-2102 12 p.

Research output: Contribution to journalArticle

Viral DNA
Methylation
Mutation
Neoplasm Genes
Testicular Neoplasms
337 Citations (Scopus)

DNA methylation and chromatin - Unraveling the tangled web

Robertson, K. D., Aug 12 2002, In : Oncogene. 21, 35 REV. ISS. 3, p. 5361-5379 19 p.

Research output: Contribution to journalArticle

DNA Methylation
Chromatin
DNA
Methyltransferases
Methylation
117 Citations (Scopus)

Preferential methylation of unmethylated DNA by mammalian de novo DNA methyltransferase Dnmt3a

Yokochi, T. & Robertson, K. D., Apr 5 2002, In : Journal of Biological Chemistry. 277, 14, p. 11735-11745 11 p.

Research output: Contribution to journalArticle

Methylation
Methyltransferases
DNA Methylation
DNA
Substrates
2001
547 Citations (Scopus)

DNA methylation, methyltransferases, and cancer

Robertson, K. D., May 28 2001, In : Oncogene. 20, 24 REV. ISS. 3, p. 3139-3155 17 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
Methylation
Chromatin
DNA
2000
152 Citations (Scopus)

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

Robertson, K. D., Keyomarsi, K., Gonzales, F. A., Velicescu, M. & Jones, P. A., May 15 2000, In : Nucleic Acids Research. 28, 10, p. 2108-2113 6 p.

Research output: Contribution to journalArticle

Phase Transition
S Phase
Methylation
Messenger RNA
Neoplasms
434 Citations (Scopus)

DNA methylation: Past, present and future directions

Robertson, K. D. & Jones, P. A., 2000, In : Carcinogenesis. 21, 3, p. 461-467 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Methylation
Genome
X Chromosome Inactivation
Factor X
775 Citations (Scopus)

DNA methylation in health and disease

Robertson, K. D. & Wolffe, A. P., Oct 2000, In : Nature Reviews Genetics. 1, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
Rett Syndrome
Fragile X Syndrome
Chromatin Assembly and Disassembly
741 Citations (Scopus)

DNMT1 forms a complex with RB, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L. & Wolffe, A. P., Jul 2000, In : Nature Genetics. 25, 3, p. 338-342 5 p.

Research output: Contribution to journalArticle

Methyltransferases
Methylation
CpG Islands
Histone Deacetylases
Retinoblastoma
60 Citations (Scopus)

The gene for a novel transmembrane protein containing epidermal growth factor and follistatin domains is frequently hypermethylated in human tumor cells

Liang, G., Robertson, K. D., Talmadge, C., Sumegi, J. & Jones, P. A., Sep 1 2000, In : Cancer Research. 60, 17, p. 4907-4912 6 p.

Research output: Contribution to journalArticle

Follistatin
Epidermal Growth Factor
Colon
CpG Islands
Tumor Cell Line
25 Citations (Scopus)
Viral Gene Expression Regulation
Molecular Sequence Data
Virus Latency
CpG Islands
Epstein-Barr Virus Infections
1999
73 Citations (Scopus)

DNA methylation and the Epstein-Barr virus

Ambinder, R. F., Robertson, K. D. & Tao, Q., Oct 1999, In : Seminars in Cancer Biology. 9, 5, p. 369-375 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Human Herpesvirus 4
Methylation
DNA Viruses
Viral Antigens
88 Citations (Scopus)

Methylation status of the Epstein-Barr virus major latent promoter C in latrogenic B cell lymphoproliferative disease: Application of PCR-based analysis

Qian, T., Swinnen, L. J., Yang, J., Srivastava, G., Robertson, K. D. & Ambinder, R. F., Aug 1999, In : American Journal of Pathology. 155, 2, p. 619-625 7 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Methylation
B-Lymphocytes
Polymerase Chain Reaction
Lymphoma
109 Citations (Scopus)

Roles of cell division and gene transcription in the methylation of CpG islands

Bender, C. M., Gonzalgo, M. L., Gonzales, F. A., Nguyen, C. T., Robertson, K. D. & Jones, P. A., Oct 1999, In : Molecular and Cellular Biology. 19, 10, p. 6690-6698 9 p.

Research output: Contribution to journalArticle

CpG Islands
Cell Division
Methylation
Exons
Genes
640 Citations (Scopus)

The human DNA methyltransferases (DNMTs) 1, 3a and 3b: Coordinate mRNA expression in normal tissues and overexpression in tumors

Robertson, K. D., Uzvolgyi, E., Liang, G., Talmadge, C., Sumegi, J., Gonzales, F. A. & Jones, P. A., Jun 1 1999, In : Nucleic Acids Research. 27, 11, p. 2291-2298 8 p.

Research output: Contribution to journalArticle

Methyltransferases
Messenger RNA
Methylation
Chromosomes
X Chromosome Inactivation
80 Citations (Scopus)

Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus

Robertson, K. D. & Jones, P. A., Jul 1 1999, In : Oncogene. 18, 26, p. 3810-3820 11 p.

Research output: Contribution to journalArticle

Alternative Splicing
Cell Cycle
RNA Splice Sites
Introns
Pancreas
1998
133 Citations (Scopus)

Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: Molecular analysis of primary tumor tissue

Tao, Q., Robertson, K. D., Manns, A., Hildesheim, A. & Ambinder, R. F., Feb 15 1998, In : Blood. 91, 4, p. 1373-1381 9 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Human Herpesvirus 4
Viruses
Tumors
Methylation
58 Citations (Scopus)

The Epstein-Barr virus major latent promoter Qp is constitutively active, hypomethylated, and methylation sensitive

Tao, Q., Robertson, K. D., Manns, A., Hildesheim, A. & Ambinder, R. F., Sep 1998, In : Journal of Virology. 72, 9, p. 7075-7083 9 p.

Research output: Contribution to journalArticle

Human herpesvirus 4
Human Herpesvirus 4
methylation
Methylation
promoter regions
322 Citations (Scopus)
cdc Genes
decitabine
DNA Methylation
Regulator Genes
Islands
1997
16 Citations (Scopus)

Dynamic interrelationships between DNA replication, methylation, and repair

Robertson, K. D. & Jones, P. A., 1997, In : American Journal of Human Genetics. 61, 6, p. 1220-1224 5 p.

Research output: Contribution to journalArticle

DNA Methylation
DNA Replication
DNA Repair
42 Citations (Scopus)
Virus Latency
Human herpesvirus 4
Human Herpesvirus 4
Genetic Promoter Regions
methylation
58 Citations (Scopus)

Methylation of the Epstein-Barr virus genome in normal lymphocytes

Robertson, K. D. & Ambinder, R. F., Dec 1 1997, In : Blood. 90, 11, p. 4480-4484 5 p.

Research output: Contribution to journalArticle

Methylation
Lymphocytes
Human Herpesvirus 4
Viruses
Genes