• 10866 Citations
  • 50 Scopus h-Index
1993 …2019
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Research Output 1993 2019

Article
25 Citations (Scopus)

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

Tiedemann, R. L., Putiri, E. L., Lee, J. H., Hlady, R. A., Kashiwagi, K., Ordog, T., Zhang, Z., Liu, C., Choi, J. H. & Robertson, K. D., Nov 20 2014, In : Cell Reports. 9, 4, p. 1554-1566 13 p.

Research output: Contribution to journalArticle

Methylation
Methyltransferases
Human Genome
Genes
Personnel
1 Citation (Scopus)

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity

Wang, L., Marek, G. W., Hlady, R. A., Wagner, R. T., Zhao, X., Clark, V. C., Fan, A. X., Liu, C., Brantly, M. & Robertson, K. D., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

alpha 1-Antitrypsin Deficiency
Deficiency Diseases
Epigenomics
5-Methylcytosine
Liver Diseases
41 Citations (Scopus)

An EBF3-mediated transcriptional program that induces cell cycle arrest and apoptosis

Zhao, L. Y., Niu, Y., Santiago, A., Liu, J., Albert, S. H., Robertson, K. D. & Liao, D., Oct 1 2006, In : Cancer Research. 66, 19, p. 9445-9452 8 p.

Research output: Contribution to journalArticle

Cell Cycle Checkpoints
Apoptosis
decitabine
Neoplasms
Brain Neoplasms
56 Citations (Scopus)

A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding

Gopalakrishnan, S., Van Emburgh, B. O., Shan, J., Su, Z., Fields, C. R., Vieweg, J., Hamazaki, T., Schwartz, P. H., Terada, N. & Robertson, K. D., Oct 2009, In : Molecular Cancer Research. 7, 10, p. 1622-1634 13 p.

Research output: Contribution to journalArticle

DNA Methylation
DNA
Genomic Imprinting
Neoplasms
Genomic Instability
7 Citations (Scopus)

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma

Wu, Q., Pi, L., Le Trinh, T., Zuo, C., Xia, M., Jiao, Y., Hou, Z., Jo, S., Puszyk, W., Pham, K., Nelson, D. R., Robertson, K. D., Ostrov, D., Rameshwar, P., Xia, C. Q. & Liu, C., 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Glypicans
Hepatocellular Carcinoma
Vaccines
Therapeutics
Cytotoxic T-Lymphocytes
93 Citations (Scopus)

Azacitidine induces demethylation of the Epstein-Barr virus genome in tumors

Chan, A. T. C., Tao, Q., Robertson, K. D., Flinn, I. W., Mann, R. B., Klencke, B., Kwan, W. H., Leung, T. W. T., Johnson, P. J. & Ambinder, R. F., 2004, In : Journal of Clinical Oncology. 22, 8, p. 1373-1381 9 p.

Research output: Contribution to journalArticle

Azacitidine
Human Herpesvirus 4
Genome
Methylation
Immunohistochemistry
123 Citations (Scopus)

Butyrate suppresses colonic inflammation through HDAC1-dependent fas upregulation and fas-mediated apoptosis of T cells

Zimmerman, M. A., Singh, N., Martin, P. M., Thangaraju, M., Ganapathy, V., Waller, J. L., Shi, H., Robertson, K. D., Munn, D. H. & Liu, K., Jun 15 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 12

Research output: Contribution to journalArticle

Histone Deacetylase 1
Butyrates
Up-Regulation
Apoptosis
Inflammation

CAME: Identification of chromatin accessibility from nucleosome occupancy and methylome sequencing

Piao, Y., Lee, S. K., Lee, E. J., Robertson, K. D., Shi, H., Ryu, K. H. & Choi, J. H., Apr 15 2017, In : Bioinformatics. 33, 8, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Methylation
Nucleosomes
Chromatin
Accessibility
Sequencing
219 Citations (Scopus)

Chromatin remodeling, histone modifications, and DNA methylation - How does it all fit together?

Geiman, T. M. & Robertson, K. D., 2002, In : Journal of Cellular Biochemistry. 87, 2, p. 117-125 9 p.

Research output: Contribution to journalArticle

Histone Code
Chromatin Assembly and Disassembly
DNA Methylation
Methylation
Histones
43 Citations (Scopus)

Comparative epigenomics of human and mouse mammary tumors

Demircan, B., Dyer, L. M., Gerace, M., Lobenhofer, E. K., Robertson, K. D. & Brown, K. D., Jan 2009, In : Genes Chromosomes and Cancer. 48, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

Epigenomics
Breast Neoplasms
decitabine
Tumor Suppressor Genes
trichostatin A
57 Citations (Scopus)

CpG methylation of the major Epstein-Barr virus latency promoter in Burkitt's lymphoma and Hodgkin's disease

Robertson, K. D., Manns, A., Swinnen, L. J., Zong, J. C., Gulley, M. L. & Ambinder, R. F., Oct 15 1996, In : Blood. 88, 8, p. 3129-3136 8 p.

Research output: Contribution to journalArticle

Virus Latency
Methylation
Burkitt Lymphoma
Human Herpesvirus 4
Hodgkin Disease
120 Citations (Scopus)

Defective de novo methylation of viral and cellular DNA sequences in ICF syndrome cells

Tao, Q., Huang, H., Geiman, T. M., Lim, C. Y., Fu, L., Qiu, G. H. & Robertson, K. D., Sep 1 2002, In : Human Molecular Genetics. 11, 18, p. 2091-2102 12 p.

Research output: Contribution to journalArticle

Viral DNA
Methylation
Mutation
Neoplasm Genes
Testicular Neoplasms
152 Citations (Scopus)

Differential mRNA expression of the human DNA methyltransferases (DNMTs) 1, 3a and 3b during the G0/G1 to S phase transition in normal and tumor cells

Robertson, K. D., Keyomarsi, K., Gonzales, F. A., Velicescu, M. & Jones, P. A., May 15 2000, In : Nucleic Acids Research. 28, 10, p. 2108-2113 6 p.

Research output: Contribution to journalArticle

Phase Transition
S Phase
Methylation
Messenger RNA
Neoplasms
15 Citations (Scopus)

Dimethyl sulfoxide stimulates the catalytic activity of de novo DNA methyltransferase 3a (Dnmt3a) in vitro

Yokochi, T. & Robertson, K. D., Aug 2004, In : Bioorganic Chemistry. 32, 4, p. 234-243 10 p.

Research output: Contribution to journalArticle

Dimethyl Sulfoxide
Catalyst activity
DNA
Methyltransferases
S-Adenosylmethionine
47 Citations (Scopus)

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Putiri, E. L., Tiedemann, R. L., Thompson, J. J., Liu, C., Ho, T. H., Choi, J. H. & Robertson, K. D., Jun 23 2014, In : Genome Biology. 15, 6, R81.

Research output: Contribution to journalArticle

5-Methylcytosine
chromatin
cancer
protein
gene
11 Citations (Scopus)

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome Biology. 19, 1, 43.

Research output: Contribution to journalArticle

Glioma
Cues
stem cells
Stem Cells
stem
15 Citations (Scopus)

DMB (DNMT-magnetic beads) assay: measuring DNA methyltransferase activity in vitro.

Yokochi, T. & Robertson, K. D., 2004, In : Methods in molecular biology (Clifton, N.J.). 287, p. 285-296 12 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA
DNA Methylation
Chromatin
Immobilized Nucleic Acids
434 Citations (Scopus)

DNA methylation: Past, present and future directions

Robertson, K. D. & Jones, P. A., 2000, In : Carcinogenesis. 21, 3, p. 461-467 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Methylation
Genome
X Chromosome Inactivation
Factor X
216 Citations (Scopus)

DNA methylation: Superior or subordinate in the epigenetic hierarchy?

Jin, B., Li, Y. & Robertson, K. D., Jun 2011, In : Genes and Cancer. 2, 6, p. 607-617 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Methyltransferases
Histone Code
Untranslated RNA
547 Citations (Scopus)

DNA methylation, methyltransferases, and cancer

Robertson, K. D., May 28 2001, In : Oncogene. 20, 24 REV. ISS. 3, p. 3139-3155 17 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
Methylation
Chromatin
DNA
6 Citations (Scopus)

DNA methylation age is accelerated in alcohol dependence

Rosen, A. D., Robertson, K. D., Hlady, R. A., Muench, C., Lee, J., Philibert, R., Horvath, S., Kaminsky, Z. A. & Lohoff, F. W., Dec 1 2018, In : Translational Psychiatry. 8, 1, 182.

Research output: Contribution to journalArticle

DNA Methylation
Alcoholism
Epigenomics
Alcohol Drinking
Prefrontal Cortex
337 Citations (Scopus)

DNA methylation and chromatin - Unraveling the tangled web

Robertson, K. D., Aug 12 2002, In : Oncogene. 21, 35 REV. ISS. 3, p. 5361-5379 19 p.

Research output: Contribution to journalArticle

DNA Methylation
Chromatin
DNA
Methyltransferases
Methylation
1595 Citations (Scopus)

DNA methylation and human disease

Robertson, K. D., Aug 2005, In : Nature Reviews Genetics. 6, 8, p. 597-610 14 p.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
human diseases
Epigenomics
epigenetics
73 Citations (Scopus)

DNA methylation and the Epstein-Barr virus

Ambinder, R. F., Robertson, K. D. & Tao, Q., Oct 1999, In : Seminars in Cancer Biology. 9, 5, p. 369-375 7 p.

Research output: Contribution to journalArticle

DNA Methylation
Human Herpesvirus 4
Methylation
DNA Viruses
Viral Antigens
165 Citations (Scopus)

DNA methylation in development and human disease

Gopalakrishnan, S., Van Emburgh, B. O. & Robertson, K. D., Dec 1 2008, In : Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 647, 1-2, p. 30-38 9 p.

Research output: Contribution to journalArticle

Human Development
DNA Methylation
Epigenomics
Histone Code
Neoplastic Stem Cells
775 Citations (Scopus)

DNA methylation in health and disease

Robertson, K. D. & Wolffe, A. P., Oct 2000, In : Nature Reviews Genetics. 1, 1, p. 11-19 9 p.

Research output: Contribution to journalArticle

DNA methylation
DNA Methylation
Rett Syndrome
Fragile X Syndrome
Chromatin Assembly and Disassembly
224 Citations (Scopus)

DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3B

Palii, S. S., Van Emburgh, B. O., Sankpal, U. T., Brown, K. D. & Robertson, K. D., Jan 2008, In : Molecular and Cellular Biology. 28, 2, p. 752-771 20 p.

Research output: Contribution to journalArticle

decitabine
DNA Methylation
DNA Damage
Genome
Ataxia Telangiectasia

DNA methylation of individual repetitive elements in hepatitis C virus infection-induced hepatocellular carcinoma

Zheng, Y., Hlady, R. A., Joyce, B. T., Robertson, K. D., He, C., Nannini, D. R., Kibbe, W. A., Achenbach, C. J., Murphy, R. L., Roberts, L. R. & Hou, L., Oct 21 2019, In : Clinical Epigenetics. 11, 1, 145.

Research output: Contribution to journalArticle

Open Access
Virus Diseases
DNA Methylation
Hepacivirus
Hepatocellular Carcinoma
Methylation
47 Citations (Scopus)

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma

Liu, H., Dong, H., Robertson, K. D. & Liu, C., Feb 2011, In : American Journal of Pathology. 178, 2, p. 652-661 10 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
DNA Methylation
Ligases
Urea
Hepatocellular Carcinoma
153 Citations (Scopus)

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function

Jin, B., Tao, Q., Peng, J., Soo, H. M., Wu, W., Ying, J., Fields, C. R., Delmas, A. I., Liu, X., Qiu, J. & Robertson, K. D., Mar 1 2008, In : Human Molecular Genetics. 17, 5, p. 690-709 20 p.

Research output: Contribution to journalArticle

Neurogenesis
Epigenomics
Gene Expression
Mutation
DNA Methylation
193 Citations (Scopus)

DNA methyltransferases, DNA damage repair, and cancer

Jin, B. & Robertson, K. D., 2013, In : Advances in Experimental Medicine and Biology. 754, p. 3-29 27 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
DNA Repair
DNA Damage
Repair
75 Citations (Scopus)

DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer

Jin, B., Yao, B., Li, J. L., Fields, C. R., Delmas, A. L., Liu, C. & Robertson, K. D., 2009, In : Cancer Research. 69, 18, p. 7412-7421 10 p.

Research output: Contribution to journalArticle

Histone Code
Colonic Neoplasms
Genes
Epigenomics
Methylation
741 Citations (Scopus)

DNMT1 forms a complex with RB, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters

Robertson, K. D., Ait-Si-Ali, S., Yokochi, T., Wade, P. A., Jones, P. L. & Wolffe, A. P., Jul 2000, In : Nature Genetics. 25, 3, p. 338-342 5 p.

Research output: Contribution to journalArticle

Methyltransferases
Methylation
CpG Islands
Histone Deacetylases
Retinoblastoma
39 Citations (Scopus)

DNMT1 knockout delivers a strong blow to genome stability and cell viability

Brown, K. D. & Robertson, K. D., Mar 2007, In : Nature Genetics. 39, 3, p. 289-290 2 p.

Research output: Contribution to journalArticle

Genomic Instability
Cell Survival
Gene Targeting
Methyltransferases
Genome
83 Citations (Scopus)

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

Gopalakrishnan, S., Sullivan, B. A., Trazzi, S., Della Valle, G. & Robertson, K. D., 2009, In : Human Molecular Genetics. 18, 17, p. 3178-3193 16 p.

Research output: Contribution to journalArticle

Histone Code
DNA Methylation
Chromosomal Instability
Mitosis
Chromatin
80 Citations (Scopus)

DNMT3B interacts with hSNF2H chromatin remodeling enzyme, HDACs 1 and 2, and components of the histone methylation system

Geiman, T. M., Sankpal, U. T., Robertson, A. K., Zhao, Y., Zhao, Y. & Robertson, K. D., May 28 2004, In : Biochemical and Biophysical Research Communications. 318, 2, p. 544-555 12 p.

Research output: Contribution to journalArticle

Methylation
Chromatin Assembly and Disassembly
Methyltransferases
Histones
Chromatin
71 Citations (Scopus)

Doxorubicin inhibits DNMT1, resulting in conditional apoptosis

Yokochi, T. & Robertson, K. D., Dec 2004, In : Molecular Pharmacology. 66, 6, p. 1415-1420 6 p.

Research output: Contribution to journalArticle

Doxorubicin
Intercalating Agents
Apoptosis
DNA
Neoplasms
16 Citations (Scopus)

Dynamic interrelationships between DNA replication, methylation, and repair

Robertson, K. D. & Jones, P. A., 1997, In : American Journal of Human Genetics. 61, 6, p. 1220-1224 5 p.

Research output: Contribution to journalArticle

DNA Methylation
DNA Replication
DNA Repair
23 Citations (Scopus)

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J. H., Choi, J. H., Ho, T. H. & Robertson, K. D., 2016, In : Oncotarget. 7, 2, p. 1927-1946 20 p.

Research output: Contribution to journalArticle

DNA Methylation
Renal Cell Carcinoma
Developmental Genes
Phenotype
Cell Line
57 Citations (Scopus)

Effects of chromatin structure on the enzymatic and DNA binding functions of DNA methyltransferases DNMT1 and Dnmt3a in vitro

Robertson, A. K., Geiman, T. M., Sankpal, U. T., Hager, G. L. & Robertson, K. D., Sep 10 2004, In : Biochemical and Biophysical Research Communications. 322, 1, p. 110-118 9 p.

Research output: Contribution to journalArticle

Methyltransferases
Chromatin
Chromatin Assembly and Disassembly
Epigenomics
DNA

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

Zhong, J., Ye, Z., Clark, C. R., Lenz, S. W., Nguyen, J. H., Yan, H. D., Robertson, K. D., Farrugia, G., Zhang, Z., Ordog, T. & Lee, J. H., Mar 29 2019, In : BMC genomics. 20, 1, 249.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Chromatin
Epigenomics
Temperature
36 Citations (Scopus)

Epigenetic control of tumor suppression

Palii, S. S. & Robertson, K. D., 2007, In : Critical Reviews in Eukaryotic Gene Expression. 17, 4, p. 295-316 22 p.

Research output: Contribution to journalArticle

Epigenomics
Neoplasms
Tumor Suppressor Genes
Methylation
Histone Code
43 Citations (Scopus)

Epigenetic mechanisms and genome stability

Putiri, E. L. & Robertson, K. D., Aug 2011, In : Clinical Epigenetics. 2, 2, p. 299-314 16 p.

Research output: Contribution to journalArticle

Genomic Instability
Epigenomics
Chromatin
Centromere
DNA Repair
34 Citations (Scopus)

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis

Hlady, R. A., Tiedemann, R. L., Puszyk, W., Zendejas, I., Roberts, L. R., Choi, J. H., Liu, C. & Robertson, K. D., 2014, In : Oncotarget. 5, 19, p. 9425-9443 19 p.

Research output: Contribution to journalArticle

Epigenomics
Hepatitis
Alcoholism
Hepatocellular Carcinoma
Infection
68 Citations (Scopus)

Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression

Ai, L., Kim, W. J., Kim, T. Y., Fields, C. R., Massoll, N. A., Robertson, K. D. & Brown, K. D., Aug 15 2006, In : Cancer Research. 66, 16, p. 7899-7909 11 p.

Research output: Contribution to journalArticle

Cystatin M
Epigenomics
Breast Neoplasms
Neoplasms
Breast

Epigenetics of gastrointestinal diseases: notes from a workshop

Marks, D. L., Olson, R. L., Urrutia, R., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R. C., Sarmento, O., Bamidele, A. O., Faubion, W. A., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., Robertson, K. D. & 3 others, Kisiel, J. B., Pin, C. L. & Fernandez-Zapico, M. E., Apr 3 2018, In : Epigenetics. 13, 4, p. 449-457 9 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Epigenomics
Education
DNA Methylation
Biomarkers
115 Citations (Scopus)

Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma

Kim, T. Y., Zhong, S., Fields, C. R., Kim, J. H. & Robertson, K. D., Aug 1 2006, In : Cancer Research. 66, 15, p. 7490-7501 12 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Glioma
decitabine
Histones
134 Citations (Scopus)

Epstein-Barr virus (EBV) in endemic Burkitt's lymphoma: Molecular analysis of primary tumor tissue

Tao, Q., Robertson, K. D., Manns, A., Hildesheim, A. & Ambinder, R. F., Feb 15 1998, In : Blood. 91, 4, p. 1373-1381 9 p.

Research output: Contribution to journalArticle

Burkitt Lymphoma
Human Herpesvirus 4
Viruses
Tumors
Methylation
49 Citations (Scopus)

Epstein-Barr virus as a therapeutic target in Hodgkin's disease and nasopharyngeal carcinoma

Ambinder, R. F., Robertson, K. D., Moore, S. M. & Yang, J., Aug 1996, In : Seminars in Cancer Biology. 7, 4, p. 217-226 10 p.

Research output: Contribution to journalArticle

Human Herpesvirus 4
Hodgkin Disease
Neoplasms
Oncogenic Viruses
Ganciclovir
1 Citation (Scopus)

Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma

Zhao, X., Sun, W., Puszyk, W. M., Wallet, S., Hochwald, S., Robertson, K. D. & Liu, C., 2017, In : Tumor Biology. 39, 5

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Focal Adhesion Protein-Tyrosine Kinases
Pancreatic Neoplasms
Apoptosis
Matched-Pair Analysis