• 10768 Citations
  • 50 Scopus h-Index
1993 …2019
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Research Output 1993 2019

2019
1 Citation (Scopus)

Alpha-1 Antitrypsin Deficiency Liver Disease, Mutational Homogeneity Modulated by Epigenetic Heterogeneity With Links to Obesity

Wang, L., Marek, G. W., Hlady, R. A., Wagner, R. T., Zhao, X., Clark, V. C., Fan, A. X., Liu, C., Brantly, M. & Robertson, K. D., Jan 1 2019, In : Hepatology.

Research output: Contribution to journalArticle

alpha 1-Antitrypsin Deficiency
Deficiency Diseases
Epigenomics
5-Methylcytosine
Liver Diseases

Enhanced and controlled chromatin extraction from FFPE tissues and the application to ChIP-seq

Zhong, J., Ye, Z., Clark, C. R., Lenz, S. W., Nguyen, J. H., Yan, H. D., Robertson, K. D., Farrugia, G., Zhang, Z., Ordog, T. & Lee, J. H., Mar 29 2019, In : BMC genomics. 20, 1, 249.

Research output: Contribution to journalArticle

Paraffin
Formaldehyde
Chromatin
Epigenomics
Temperature

In silico DNA methylation analysis identifies potential prognostic biomarkers in type 2 papillary renal cell carcinoma

Yang, M., Hlady, R. A., Zhou, D., Ho, T. H. & Robertson, K. D., Sep 1 2019, In : Cancer medicine. 8, 12, p. 5760-5768 9 p.

Research output: Contribution to journalArticle

Open Access
DNA Methylation
Renal Cell Carcinoma
Computer Simulation
Biomarkers
Methylation
6 Citations (Scopus)

Integrating the Epigenome to Identify Drivers of Hepatocellular Carcinoma

Hlady, R. A., Sathyanarayan, A., Thompson, J. J., Zhou, D., Wu, Q., Pham, K., Lee, J. H., Liu, C. & Robertson, K. D., Jan 1 2019, (Accepted/In press) In : Hepatology.

Research output: Contribution to journalArticle

Epigenomics
Hepatocellular Carcinoma
Histone Code
dimethylaniline monooxygenase (N-oxide forming)
Liver
1 Citation (Scopus)

Loss of SETD2 Induces a Metabolic Switch in Renal Cell Carcinoma Cell Lines toward Enhanced Oxidative Phosphorylation

Liu, J., Hanavan, P. D., Kras, K., Ruiz, Y. W., Castle, E. P., Lake, D. F., Chen, X., O'Brien, D., Luo, H., Robertson, K. D., Gu, H. & Ho, T. H., Jan 4 2019, In : Journal of Proteome Research. 18, 1, p. 331-340 10 p.

Research output: Contribution to journalArticle

Oxidative Phosphorylation
Renal Cell Carcinoma
Cells
Switches
Cell Line
2018
7 Citations (Scopus)

A Three-Pronged Epigenetic Approach to the Treatment of Hepatocellular Carcinoma

Hlady, R. A. & Robertson, K. D., Oct 1 2018, In : Hepatology. 68, 4, p. 1226-1228 3 p.

Research output: Contribution to journalEditorial

Epigenomics
Hepatocellular Carcinoma
10 Citations (Scopus)

Distinctive epigenomes characterize glioma stem cells and their response to differentiation cues

Zhou, D., Alver, B. M., Li, S., Hlady, R. A., Thompson, J. J., Schroeder, M. A., Lee, J. H., Qiu, J., Schwartz, P. H., Sarkaria, J. N. & Robertson, K. D., Mar 27 2018, In : Genome Biology. 19, 1, 43.

Research output: Contribution to journalArticle

Glioma
Cues
stem cells
Stem Cells
stem
6 Citations (Scopus)

DNA methylation age is accelerated in alcohol dependence

Rosen, A. D., Robertson, K. D., Hlady, R. A., Muench, C., Lee, J., Philibert, R., Horvath, S., Kaminsky, Z. A. & Lohoff, F. W., Dec 1 2018, In : Translational Psychiatry. 8, 1, 182.

Research output: Contribution to journalArticle

DNA Methylation
Alcoholism
Epigenomics
Alcohol Drinking
Prefrontal Cortex

Epigenetics of gastrointestinal diseases: notes from a workshop

Marks, D. L., Olson, R. L., Urrutia, R., Billadeau, D. D., Roy, N., Calin, G. A., Fabbri, M., Koutsioumpa, M., Iliopoulos, D., Ordog, T., Huebert, R. C., Sarmento, O., Bamidele, A. O., Faubion, W. A., Lomberk, G. L., Siveke, J., Ahuja, N., Iovanna, J., Hlady, R. A., Robertson, K. D. & 3 others, Kisiel, J. B., Pin, C. L. & Fernandez-Zapico, M. E., Apr 3 2018, In : Epigenetics. 13, 4, p. 449-457 9 p.

Research output: Contribution to journalArticle

Gastrointestinal Diseases
Epigenomics
Education
DNA Methylation
Biomarkers
6 Citations (Scopus)
Genetic Heterogeneity
Liver Neoplasms
Epigenomics
Liver Diseases
Homeostasis
1 Citation (Scopus)
Clustered Regularly Interspaced Short Palindromic Repeats
Epigenomics
Transcriptional Activation
Therapeutics
5 Citations (Scopus)

ZBTB24 is a transcriptional regulator that coordinates with DNMT3B to control DNA methylation

Thompson, J. J., Kaur, R., Sosa, C. P., Lee, J. H., Kashiwagi, K., Zhou, D. & Robertson, K. D., Nov 2 2018, In : Nucleic Acids Research. 46, 19, p. 10034-10051 18 p.

Research output: Contribution to journalArticle

DNA Methylation
Methyltransferases
Epigenomics
Genes
Nucleotide Motifs
2017
6 Citations (Scopus)

A Novel Vaccine Targeting Glypican-3 as a Treatment for Hepatocellular Carcinoma

Wu, Q., Pi, L., Le Trinh, T., Zuo, C., Xia, M., Jiao, Y., Hou, Z., Jo, S., Puszyk, W., Pham, K., Nelson, D. R., Robertson, K. D., Ostrov, D., Rameshwar, P., Xia, C. Q. & Liu, C., 2017, (Accepted/In press) In : Molecular Therapy.

Research output: Contribution to journalArticle

Glypicans
Hepatocellular Carcinoma
Vaccines
Therapeutics
Cytotoxic T-Lymphocytes

CAME: Identification of chromatin accessibility from nucleosome occupancy and methylome sequencing

Piao, Y., Lee, S. K., Lee, E. J., Robertson, K. D., Shi, H., Ryu, K. H. & Choi, J. H., Apr 15 2017, In : Bioinformatics. 33, 8, p. 1139-1146 8 p.

Research output: Contribution to journalArticle

Methylation
Nucleosomes
Chromatin
Accessibility
Sequencing
1 Citation (Scopus)

Focal adhesion kinase inhibitor PF573228 and death receptor 5 agonist lexatumumab synergistically induce apoptosis in pancreatic carcinoma

Zhao, X., Sun, W., Puszyk, W. M., Wallet, S., Hochwald, S., Robertson, K. D. & Liu, C., 2017, In : Tumor Biology. 39, 5

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Focal Adhesion Protein-Tyrosine Kinases
Pancreatic Neoplasms
Apoptosis
Matched-Pair Analysis
10 Citations (Scopus)

Initiation of aberrant DNA methylation patterns and heterogeneity in precancerous lesions of human hepatocellular cancer

Hlady, R. A., Zhou, D., Puszyk, W., Roberts, L. R., Liu, C. & Robertson, K. D., Jan 27 2017, (Accepted/In press) In : Epigenetics. p. 1-11 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Liver Neoplasms
Epigenomics
Disease Progression
Hepatocellular Carcinoma
5 Citations (Scopus)

Purification of nanogram-range immunoprecipitated DNA in ChIP-seq application

Zhong, J., Ye, Z., Lenz, S. W., Clark, C. R., Bharucha, A. E., Farrugia, G., Robertson, K. D., Zhang, Z., Ordog, T. & Lee, J. H., Dec 21 2017, In : BMC Genomics. 18, 1, 985.

Research output: Contribution to journalArticle

Chromatin Immunoprecipitation
DNA
Gene Library
Libraries
Buffers
2016
23 Citations (Scopus)

Dynamic reprogramming of DNA methylation in SETD2-deregulated renal cell carcinoma

Tiedemann, R. L., Hlady, R. A., Hanavan, P. D., Lake, D. F., Tibes, R., Lee, J. H., Choi, J. H., Ho, T. H. & Robertson, K. D., 2016, In : Oncotarget. 7, 2, p. 1927-1946 20 p.

Research output: Contribution to journalArticle

DNA Methylation
Renal Cell Carcinoma
Developmental Genes
Phenotype
Cell Line
10 Citations (Scopus)

High fat diet and exercise lead to a disrupted and pathogenic DNA methylome in mouse liver

Zhou, D., Hlady, R. A., Schafer, M. J., White, T. A., Liu, C., Choi, J. H., Miller, J. D., Roberts, L. R., LeBrasseur, N. K. & Robertson, K. D., Dec 22 2016, (Accepted/In press) In : Epigenetics. p. 1-15 15 p.

Research output: Contribution to journalArticle

High Fat Diet
Diet
Liver
DNA
DNA Methylation
1 Citation (Scopus)

Nucleosome positioning changes during human embryonic stem cell differentiation

Zhang, W., Li, Y., Kulik, M., Tiedemann, R. L., Robertson, K. D., Dalton, S. & Zhao, S., Jun 2 2016, In : Epigenetics. 11, 6, p. 426-437 12 p.

Research output: Contribution to journalArticle

Nucleosomes
Cell Differentiation
Base Composition
Chromatin
Smooth Muscle Myocytes
2 Citations (Scopus)

Role of DNA Methylation in Genome Stability

Zhou, D. & Robertson, K. D., Sep 21 2016, Genome Stability: From Virus to Human Application. Elsevier Inc., p. 409-424 16 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Genomic Instability
DNA Methylation
Genes
DNA Mismatch Repair
Repair
27 Citations (Scopus)
decitabine
Azacitidine
Myelodysplastic Syndromes
Acute Myeloid Leukemia
Epigenomics

Use of Chromatin Changes as Biomarkers

Hlady, R. A. & Robertson, K. D., Aug 24 2016, Chromatin Signaling and Diseases. Elsevier Inc., p. 403-421 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Biomarkers
Epigenomics
Chromatin
Genes
Transcription
2015

Bioinformatics strategies for identifying regions of epigenetic deregulation associated with aberrant transcript splicing and RNA-editing

Champion, M. D., Hlady, R. A., Yan, H. D., Evans, J., Nie, J., Lee, J. H., Bogenberger, J., Nandakumar, K., Davila, J., Moore, R., Nair, A., O'Brien, D., Zhu, Y. X., Kortum, K. M., Ordog, T., Zhang, Z., Joseph, R. W., Stewart, A. K., Kocher, J-P., Jonasch, E. & 3 others, Robertson, K. D., Tibes, R. & Ho, T. H., 2015, BIOINFORMATICS 2015 - 6th International Conference on Bioinformatics Models, Methods and Algorithms, Proceedings; Part of 8th International Joint Conference on Biomedical Engineering Systems and Technologies, BIOSTEC 2015. SciTePress, p. 163-170 8 p.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

RNA Editing
Deregulation
Bioinformatics
Computational Biology
RNA

ITagPlot: An accurate computation and interactive drawing tool for tag density plot

Kim, S. H., Ezenwoye, O., Cho, H. G., Robertson, K. D. & Choi, J. H., 2015, In : Bioinformatics. 31, 14, p. 2384-2387 4 p.

Research output: Contribution to journalArticle

Biological Phenomena
Graphical user interfaces
Cluster Analysis
Statistics
Engines
9 Citations (Scopus)

Small molecule inhibitor YM155-mediated activation of death receptor 5 is crucial for chemotherapy-induced apoptosis in pancreatic carcinoma

Zhao, X., Puszyk, W. M., Lu, Z., Ostrov, D. A., George, T. J., Robertson, K. D. & Liu, C., Jan 1 2015, In : Molecular Cancer Therapeutics. 14, 1, p. 80-89 10 p.

Research output: Contribution to journalArticle

TNF-Related Apoptosis-Inducing Ligand Receptors
Pancreatic Neoplasms
Apoptosis
Drug Therapy
gemcitabine
2014
25 Citations (Scopus)

Acute depletion redefines the division of labor among DNA methyltransferases in methylating the human genome

Tiedemann, R. L., Putiri, E. L., Lee, J. H., Hlady, R. A., Kashiwagi, K., Ordog, T., Zhang, Z., Liu, C., Choi, J. H. & Robertson, K. D., Nov 20 2014, In : Cell Reports. 9, 4, p. 1554-1566 13 p.

Research output: Contribution to journalArticle

Methylation
Methyltransferases
Human Genome
Genes
Personnel
46 Citations (Scopus)

Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Putiri, E. L., Tiedemann, R. L., Thompson, J. J., Liu, C., Ho, T. H., Choi, J. H. & Robertson, K. D., Jun 23 2014, In : Genome Biology. 15, 6, R81.

Research output: Contribution to journalArticle

5-Methylcytosine
chromatin
cancer
protein
gene
33 Citations (Scopus)

Epigenetic signatures of alcohol abuse and hepatitis infection during human hepatocarcinogenesis

Hlady, R. A., Tiedemann, R. L., Puszyk, W., Zendejas, I., Roberts, L. R., Choi, J. H., Liu, C. & Robertson, K. D., 2014, In : Oncotarget. 5, 19, p. 9425-9443 19 p.

Research output: Contribution to journalArticle

Epigenomics
Hepatitis
Alcoholism
Hepatocellular Carcinoma
Infection
7 Citations (Scopus)

Impact of human MLL/COMPASS and polycomb complexes on the DNA methylome

Putiri, E. L., Tiedemann, R. L., Liu, C., Choi, J. H. & Robertson, K. D., 2014, In : Oncotarget. 5, 15, p. 6338-6352 15 p.

Research output: Contribution to journalArticle

Histone Code
DNA Methylation
DNA
Post Translational Protein Processing
Polycomb Repressive Complex 2
2013
188 Citations (Scopus)

DNA methyltransferases, DNA damage repair, and cancer

Jin, B. & Robertson, K. D., 2013, In : Advances in Experimental Medicine and Biology. 754, p. 3-29 27 p.

Research output: Contribution to journalArticle

Methyltransferases
DNA Methylation
DNA Repair
DNA Damage
Repair
2012
122 Citations (Scopus)

Butyrate suppresses colonic inflammation through HDAC1-dependent fas upregulation and fas-mediated apoptosis of T cells

Zimmerman, M. A., Singh, N., Martin, P. M., Thangaraju, M., Ganapathy, V., Waller, J. L., Shi, H., Robertson, K. D., Munn, D. H. & Liu, K., Jun 15 2012, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 302, 12

Research output: Contribution to journalArticle

Histone Deacetylase 1
Butyrates
Up-Regulation
Apoptosis
Inflammation
33 Citations (Scopus)

Iron Regulator Hepcidin Exhibits Antiviral Activity against Hepatitis C Virus

Liu, H., Trinh, T. L., Dong, H., Robertson, K. D., Nelson, D. & Liu, C., Oct 22 2012, In : PLoS One. 7, 10, e46631.

Research output: Contribution to journalArticle

Hepcidins
Hepatitis C virus
Viruses
Hepacivirus
Antiviral Agents
76 Citations (Scopus)

Linking DNA Methyltransferases to Epigenetic Marks and Nucleosome Structure Genome-wide in Human Tumor Cells

Jin, B., Ernst, J., Tiedemann, R. L., Xu, H., Sureshchandra, S., Kellis, M., Dalton, S., Liu, C., Choi, J. H. & Robertson, K. D., Nov 29 2012, In : Cell Reports. 2, 5, p. 1411-1424 14 p.

Research output: Contribution to journalArticle

Nucleosomes
Methyltransferases
DNA Methylation
Epigenomics
Tumors
43 Citations (Scopus)

Molecular modeling of inhibitors of human DNa methyltransferase with a crystal structure: Discovery of a novel dnmt1 inhibitor

Yoo, J., Kim, J. H., Robertson, K. D. & Medina-Franco, J. L., 2012, In : Advances in Protein Chemistry and Structural Biology. 87, p. 219-247 29 p.

Research output: Contribution to journalArticle

Molecular modeling
Aurintricarboxylic Acid
Methyltransferases
Crystal structure
DNA
2011
212 Citations (Scopus)

DNA methylation: Superior or subordinate in the epigenetic hierarchy?

Jin, B., Li, Y. & Robertson, K. D., Jun 2011, In : Genes and Cancer. 2, 6, p. 607-617 11 p.

Research output: Contribution to journalArticle

DNA Methylation
Epigenomics
Methyltransferases
Histone Code
Untranslated RNA
46 Citations (Scopus)

DNA methylation suppresses expression of the urea cycle enzyme carbamoyl phosphate synthetase 1 (CPS1) in human hepatocellular carcinoma

Liu, H., Dong, H., Robertson, K. D. & Liu, C., Feb 2011, In : American Journal of Pathology. 178, 2, p. 652-661 10 p.

Research output: Contribution to journalArticle

Carbamyl Phosphate
DNA Methylation
Ligases
Urea
Hepatocellular Carcinoma
42 Citations (Scopus)

Epigenetic mechanisms and genome stability

Putiri, E. L. & Robertson, K. D., Aug 2011, In : Clinical Epigenetics. 2, 2, p. 299-314 16 p.

Research output: Contribution to journalArticle

Genomic Instability
Epigenomics
Chromatin
Centromere
DNA Repair
44 Citations (Scopus)

Modulation of Dnmt3b function in vitro by interactions with Dnmt3L, Dnmt3a and Dnmt3b splice variants

Van Emburgh, B. O. & Robertson, K. D., Jul 2011, In : Nucleic Acids Research. 39, 12, p. 4984-5002 19 p.

Research output: Contribution to journalArticle

Alternative Splicing
DNA
Protein Isoforms
Inborn Genetic Diseases
Aptitude
61 Citations (Scopus)

Rapid and transient recruitment of DNMT1 to DNA double-strand breaks is mediated by its interaction with multiple components of the DNA damage response machinery

Ha, K., Lee, G. E., Palii, S. S., Brown, K. D., Takeda, Y., Liu, K., Bhalla, K. N. & Robertson, K. D., Jan 2011, In : Human Molecular Genetics. 20, 1, p. 126-140 15 p.

Research output: Contribution to journalArticle

Double-Stranded DNA Breaks
Methyltransferases
DNA Damage
DNA
Genomic Instability
102 Citations (Scopus)

SIRT1 deacetylates the DNA methyltransferase 1 (DNMT1) protein and alters its activities

Peng, L., Yuan, Z., Ling, H., Fukasawa, K., Robertson, K. D., Olashaw, N., Koomen, J., Chen, J., Lane, W. S. & Seto, E., Dec 2011, In : Molecular and Cellular Biology. 31, 23, p. 4720-4734 15 p.

Research output: Contribution to journalArticle

Protein Methyltransferases
Methyltransferases
DNA
DNA Methylation
Lysine
40 Citations (Scopus)

Targeted bisulfite sequencing by solution hybrid selection and massively parallel sequencing

Lee, E. J., Pei, L., Srivastava, G., Joshi, T., Kushwaha, G., Choi, J. H., Robertson, K. D., Wang, X., Colbourne, J. K., Zhang, L., Schroth, G. P., Xu, D., Zhang, K. & Shi, H., Oct 2011, In : Nucleic Acids Research. 39, 19

Research output: Contribution to journalArticle

High-Throughput Nucleotide Sequencing
CpG Islands
Cell Line
Nucleic Acid Regulatory Sequences
Methylation
20 Citations (Scopus)

The transglutaminase 2 gene is aberrantly hypermethylated in glioma

Dyer, L. M., Schooler, K. P., Ai, L., Klop, C., Qiu, J., Robertson, K. D. & Brown, K. D., Feb 2011, In : Journal of Neuro-Oncology. 101, 3, p. 429-440 12 p.

Research output: Contribution to journalArticle

Glioma
Genes
Brain Neoplasms
Doxorubicin
decitabine
29 Citations (Scopus)

Verticillin A overcomes apoptosis resistance in human colon carcinoma through DNA methylation-dependent upregulation of BNIP3

Liu, F., Liu, Q., Yang, D., Bollag, W. B., Robertson, K. D., Wu, P. & Liu, K., Nov 1 2011, In : Cancer Research. 71, 21, p. 6807-6816 10 p.

Research output: Contribution to journalArticle

DNA Methylation
Colon
Up-Regulation
Apoptosis
Carcinoma
2009
54 Citations (Scopus)

A novel DNMT3B splice variant expressed in tumor and pluripotent cells modulates genomic DNA methylation patterns and displays altered DNA binding

Gopalakrishnan, S., Van Emburgh, B. O., Shan, J., Su, Z., Fields, C. R., Vieweg, J., Hamazaki, T., Schwartz, P. H., Terada, N. & Robertson, K. D., Oct 2009, In : Molecular Cancer Research. 7, 10, p. 1622-1634 13 p.

Research output: Contribution to journalArticle

DNA Methylation
DNA
Genomic Imprinting
Neoplasms
Genomic Instability
43 Citations (Scopus)

Comparative epigenomics of human and mouse mammary tumors

Demircan, B., Dyer, L. M., Gerace, M., Lobenhofer, E. K., Robertson, K. D. & Brown, K. D., Jan 2009, In : Genes Chromosomes and Cancer. 48, 1, p. 83-97 15 p.

Research output: Contribution to journalArticle

Epigenomics
Breast Neoplasms
decitabine
Tumor Suppressor Genes
trichostatin A
73 Citations (Scopus)

DNMT1 and DNMT3B modulate distinct polycomb-mediated histone modifications in colon cancer

Jin, B., Yao, B., Li, J. L., Fields, C. R., Delmas, A. L., Liu, C. & Robertson, K. D., 2009, In : Cancer Research. 69, 18, p. 7412-7421 10 p.

Research output: Contribution to journalArticle

Histone Code
Colonic Neoplasms
Genes
Epigenomics
Methylation
83 Citations (Scopus)

DNMT3B interacts with constitutive centromere protein CENP-C to modulate DNA methylation and the histone code at centromeric regions

Gopalakrishnan, S., Sullivan, B. A., Trazzi, S., Della Valle, G. & Robertson, K. D., 2009, In : Human Molecular Genetics. 18, 17, p. 3178-3193 16 p.

Research output: Contribution to journalArticle

Histone Code
DNA Methylation
Chromosomal Instability
Mitosis
Chromatin
1 Citation (Scopus)

Missteps in "tango" for epigenome targeting

Robertson, K. D. & Bhalla, K. N., 2009, In : Blood. 114, 13, p. 2569-2570 2 p.

Research output: Contribution to journalArticle

Azacitidine
Histone Deacetylase Inhibitors
Leukemia
Blood
Therapeutics
35 Citations (Scopus)

Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation

Takeda, M., Briggs, L. E., Wakimoto, H., Marks, M. H., Warren, S. A., Lu, J. T., Weinberg, E. O., Robertson, K. D., Chien, K. R. & Kasahara, H., Sep 2009, In : Laboratory Investigation. 89, 9, p. 983-993 11 p.

Research output: Contribution to journalArticle

Tamoxifen
Cardiac Myocytes
Cell Cycle
Alleles
Homeodomain Proteins