Keith Anthony Josephs, MD, MST, MSc

  • 25669 Citations
  • 82 Scopus h-Index
20002020

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2020

Brain volume and flortaucipir analysis of progressive supranuclear palsy clinical variants

Whitwell, J. L., Tosakulwong, N., Botha, H., Ali, F., Clark, H. M., Duffy, J. R., Utianski, R. L., Stevens, C. A., Weigand, S. D., Schwarz, C. G., Senjem, M. L., Jack, C. R., Lowe, V. J., Ahlskog, J. E., Dickson, D. W. & Josephs, K. A., 2020, In : NeuroImage: Clinical. 25, 102152.

Research output: Contribution to journalArticle

Open Access

Effect Modifiers of TDP-43-Associated Hippocampal Atrophy Rates in Patients with Alzheimer's Disease Neuropathological Changes

Buciuc, M., Wennberg, A. M., Weigand, S. D., Murray, M. E., Senjem, M. L., Spychalla, A. J., Boeve, B. F., Knopman, D. S., Jack, C. R., Kantarci, K., Parisi, J. E., Dickson, D. W., Petersen, R. C., Whitwell, J. L. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 73, 4, p. 1511-1523 13 p.

Research output: Contribution to journalArticle

Incidence and Trends of Progressive Supranuclear Palsy and Corticobasal Syndrome: A Population-Based Study

Stang, C. D., Turcano, P., Mielke, M. M., Josephs, K. A., Bower, J. H., Ahlskog, J. E., Boeve, B. F., Martin, P. R., Upadhyaya, S. G. & Savica, R., Jan 1 2020, In : Journal of Parkinson's disease. 10, 1, p. 179-184 6 p.

Research output: Contribution to journalArticle

1 Scopus citations

Ioflupane 123I (DAT scan) SPECT identifies dopamine receptor dysfunction early in the disease course in progressive apraxia of speech

Seckin, Z. I., Whitwell, J. L., Utianski, R. L., Botha, H., Ali, F., Duffy, J. R., Clark, H. M., Machulda, M. M., Jordan, L. G., Min, H. K., Lowe, V. J. & Josephs, K. A., Jan 1 2020, (Accepted/In press) In : Journal of Neurology.

Research output: Contribution to journalArticle

Longitudinal amyloid-β PET in atypical Alzheimer's disease and frontotemporal lobar degeneration

Whitwell, J. L., Tosakulwong, N., Weigand, S. D., Graff-Radford, J., Duffy, J. R., Clark, H. M., Machulda, M. M., Botha, H., Utianski, R. L., Schwarz, C. G., Senjem, M. L., Strand, E. A., Ertekin-Taner, N., Jack, C. R., Lowe, V. J. & Josephs, K. A., Jan 1 2020, In : Journal of Alzheimer's Disease. 74, 1, p. 377-389 13 p.

Research output: Contribution to journalArticle

Longitudinal flortaucipir ([18F]AV-1451) PET imaging in primary progressive apraxia of speech

Utianski, R. L., Martin, P. R., Botha, H., Schwarz, C. G., Duffy, J. R., Petersen, R. C., Knopman, D. S., Clark, H. M., Butts, A. M., Machulda, M. M., Jack, C. R., Lowe, V. J., Whitwell, J. L. & Josephs, K. A., Mar 2020, In : Cortex. 124, p. 33-43 11 p.

Research output: Contribution to journalArticle

MRI and flortaucipir relationships in Alzheimer's phenotypes are heterogeneous

Josephs, K. A., Tosakulwong, N., Graff-Radford, J., Weigand, S. D., Buciuc, M., Machulda, M. M., Jones, D. T., Schwarz, C. G., Senjem, M. L., Ertekin-Taner, N., Kantarci, K., Boeve, B. F., Knopman, D. S., Jack, C. R., Petersen, R. C., Lowe, V. J. & Whitwell, J. L., Jan 1 2020, (Accepted/In press) In : Annals of Clinical and Translational Neurology.

Research output: Contribution to journalArticle

Open Access

Neuroanatomical correlates of phonologic errors in logopenic progressive aphasia

Petroi, D., Duffy, J. R., Borgert, A., Strand, E. A., Machulda, M. M., Senjem, M. L., Jack, C. R., Josephs, K. A. & Whitwell, J. L., May 2020, In : Brain and Language. 204, 104773.

Research output: Contribution to journalArticle

Western Aphasia Battery-Revised Profiles in Primary Progressive Aphasia and Primary Progressive Apraxia of Speech

Clark, H. M., Utianski, R. L., Duffy, J. R., Strand, E. A., Botha, H., Josephs, K. A. & Whitwell, J. L., Feb 21 2020, In : American journal of speech-language pathology. 29, 1, p. 498-510 13 p.

Research output: Contribution to journalArticle

Open Access
2 Scopus citations
2019
5 Scopus citations

An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant

Whitwell, J. L., Stevens, C. A., Duffy, J. R., Clark, H., Machulda, M. M., Strand, E. A., Martin, P. R., Utianski, R., Botha, H., Spychalla, A. J., Senjem, M. L., Schwarz, C., Jack, C. R. J., Ali, F., Hassan, A. & Josephs, K. A., Jan 1 2019, In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

2 Scopus citations

Antemortem volume loss mirrors TDP-43 staging in older adults with non-frontotemporal lobar degeneration

Bejanin, A., Murray, M. E., Martin, P., Botha, H., Tosakulwong, N., Schwarz, C. G., Senjem, M. L., Chételat, G., Kantarci, K., Jack, C. R., Boeve, B. F., Knopman, D. S., Petersen, R. C., Giannini, C., Parisi, J. E., Dickson, D. W., Whitwell, J. L. & Josephs, K. A., Nov 1 2019, In : Brain. 142, 11, p. 3621-3635 15 p.

Research output: Contribution to journalArticle

4 Scopus citations
5 Scopus citations

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R., Botha, H., Martin, P. R., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Butts, A., Lowe, V., Jack, C. R. J., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 1 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

1 Scopus citations

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., Wszolek, Z. K., van Gerpen, J., Graff Radford, N. R. & Dickson, D. W., Sep 1 2019, In : Alzheimer's and Dementia. 15, 9, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V. J., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M. K., Murray, M. E., Kantarci, K., Jones, D. T., Vemuri, P., Graff-Radford, J., Schwarz, C. G., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

6 Scopus citations
Open Access

Dysphagia in Progressive Supranuclear Palsy

Clark, H. M., Stierwalt, J. A. G., Tosakulwong, N., Botha, H., Ali, F., Whitwell, J. L. & Josephs, K. A., Jan 1 2019, (Accepted/In press) In : Dysphagia.

Research output: Contribution to journalArticle

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Dickson, D. W., Baker, M. C., Jackson, J. L., Dejesus-Hernandez, M., Finch, N. C. A., Tian, S., Heckman, M. G., Pottier, C., Gendron, T. F., Murray, M. E., Ren, Y., Reddy, J. S., Graff-Radford, N. R., Boeve, B. F., Petersen, R. C., Knopman, D. S., Josephs, K. A., Petrucelli, L., Oskarsson, B., Sheppard, J. W. & 3 others, Asmann, Y. W., Rademakers, R. & Van Blitterswijk, M., Oct 8 2019, In : Acta Neuropathologica Communications. 7, 1, 150.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Genetic variation across RNA metabolism and cell death gene networks is implicated in the semantic variant of primary progressive aphasia

International FTD-Genomics Consortium (IFGC), Dec 1 2019, In : Scientific reports. 9, 1, 10854.

Research output: Contribution to journalArticle

Open Access

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 others, Finger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M. M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Ertekin-Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff-Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R., Jun 1 2019, In : Acta neuropathologica. 137, 6, p. 879-899 21 p.

Research output: Contribution to journalArticle

13 Scopus citations

How to apply the movement disorder society criteria for diagnosis of progressive supranuclear palsy

for the Movement Disorder Society-Endorsed PSP Study Group, Jan 1 2019, In : Movement Disorders. 34, 8, p. 1228-1232 5 p.

Research output: Contribution to journalArticle

21 Scopus citations

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

International Frontotemporal Dementia Genomics Consortium, Jan 1 2019, In : Nature Medicine. 25, 1, p. 152-164 13 p.

Research output: Contribution to journalArticle

7 Scopus citations

Incidence of frontotemporal disorders in Olmsted County: A population-based study

Turcano, P., Stang, C. D., Mielke, M. M., Martin, P. R., Upadhyaya, S. G., Josephs, K. A., Boeve, B. F., Knopman, D. S., Petersen, R. C. & Savica, R., Jan 1 2019, (Accepted/In press) In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C. G., Machulda, M. M., Spychalla, A. J., Drubach, D. A., Knopman, D. S., Petersen, R. C., Lowe, V. J., Jack, C. R., Josephs, K. A. & Whitwell, J. L., 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
5 Scopus citations

Multimodal neuroimaging relationships in progressive supranuclear palsy

Sintini, I., Schwarz, C., Senjem, M. L., Reid, R. I., Botha, H., Ali, F., Ahlskog, J. E., Jack, C. R. J., Lowe, V., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

2 Scopus citations

Neuropathologic basis of frontotemporal dementia in progressive supranuclear palsy

Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., Wszolek, Z. K., Graff Radford, N. R. & Dickson, D. W., Jan 1 2019, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Perkerson, R. B., Matchett, B. J., Jack, C. R., Knopman, D. S., Petersen, R. C., Parisi, J. E., Petrucelli, L., Baker, M., Rademakers, R., Whitwell, J. L. & Dickson, D. W., Feb 11 2019, In : Acta neuropathologica. 137, 2, p. 227-238 12 p.

Research output: Contribution to journalArticle

9 Scopus citations

Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome

Tetzloff, K. A., Duffy, J. R., Clark, H. M., Utianski, R. L., Strand, E. A., Machulda, M. M., Botha, H., Martin, P. R., Schwarz, C. G., Senjem, M. L., Reid, R. I., Gunter, J. L., Spychalla, A. J., Knopman, D. S., Petersen, R. C., Jack, C. R., Lowe, V. J., Josephs, K. A. & Whitwell, J. L., Aug 1 2019, In : Brain. 142, 8, p. 2466-2482 17 p.

Research output: Contribution to journalArticle

Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension

Van Gerpen, J. A., Al-Shaikh, R. H., Tipton, P. W., Wszolek, Z. K., Uitti, R. J., Ferman, T. J., Dickson, D. W., Benarroch, E. E., Singer, W., Cutsforth-Gregory, J. K., Heckman, M. G., Brushaber, D. E., Josephs, K. A., Low, P. A., Ahlskog, J. E. & Cheshire, W. P., Oct 1 2019, In : Neurology. 93, 14, p. E1339-E1347

Research output: Contribution to journalArticle

1 Scopus citations
2 Scopus citations

Rare Tauopathies

Ali, F. & Josephs, K. A., Jan 1 2019, In : Seminars in Neurology. 39, 2, p. 264-273 10 p.

Research output: Contribution to journalArticle

Open Access

Regional multimodal relationships between tau, hypometabolism, atrophy, and fractional anisotropy in atypical Alzheimer's disease

Sintini, I., Schwarz, C. G., Martin, P. R., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Reid, R. I., Spychalla, A. J., Drubach, D. A., Lowe, V. J., Jack, C. R., Josephs, K. A. & Whitwell, J. L., Apr 1 2019, In : Human Brain Mapping. 40, 5, p. 1618-1631 14 p.

Research output: Contribution to journalArticle

8 Scopus citations

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

Espay, A. J., Vizcarra, J. A., Marsili, L., Lang, A. E., Simon, D. K., Merola, A., Josephs, K. A., Fasano, A., Morgante, F., Savica, R., Greenamyre, J. T., Cambi, F., Yamasaki, T. R., Tanner, C. M., Gan-Or, Z., Litvan, I., Mata, I. F., Zabetian, C. P., Brundin, P., Fernandez, H. H. & 7 others, Standaert, D. G., Kauffman, M. A., Schwarzschild, M. A., Sardi, S. P., Sherer, T., Perry, G. & Leverenz, J. B., Feb 12 2019, In : Neurology. 92, 7, p. 329-337 9 p.

Research output: Contribution to journalArticle

30 Scopus citations

Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy

Ali, F., Martin, P. R., Botha, H., Ahlskog, J. E., Bower, J. H., Masumoto, J. Y., Maraganore, D., Hassan, A., Eggers, S. D., Boeve, B. F., Knopman, D. S., Drubach, D., Petersen, R. C., Dunkley, E. D., Van Gerpen, J. A., Uitti, R., Whitwell, J. L., Dickson, D. W. & Josephs, K. A., Jan 1 2019, In : Movement Disorders.

Research output: Contribution to journalArticle

18 Scopus citations

Submentalis Rapid Eye Movement Sleep Muscle Activity: A Potential Biomarker for Synucleinopathy

McCarter, S. J., Feemster, J. C., Tabatabai, G. M., Sandness, D. J., Timm, P. C., McCarter, A. R., Talley, H. N., Junna, M. R., Savica, R., Singer, W., Coon, E. A., Benarroch, E. E., Josephs, K. A., Boeve, B. F., Silber, M. H. & St. Louis, E. K., Dec 1 2019, In : Annals of neurology. 86, 6, p. 969-974 6 p.

Research output: Contribution to journalArticle

15 Scopus citations

The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia

Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H., Machulda, M. M., Schwarz, C., Weigand, S. D., Sintini, I., Senjem, M. L., Taner, N., Botha, H., Utianski, R., Graff-Radford, J., Jones, D. T., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Feb 12 2019, In : Neurology. 92, 7, p. e710-e722

Research output: Contribution to journalArticle

3 Scopus citations

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Whitwell, J. L., Martin, P., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Schwarz, C. G., Weigand, S. D., Spychalla, A. J., Drubach, D. A., Jack, C. R., Lowe, V. J. & Josephs, K. A., May 2019, In : Alzheimer's and Dementia. 15, 5, p. 675-685 11 p.

Research output: Contribution to journalArticle

2 Scopus citations

Transient epileptic amnesia: A treatable cause of spells associated with persistent cognitive symptoms

Ramanan, V. K., Morris, K. A., Graff-Radford, J., Jones, D. T., Burkholder, D. B., Britton, J. W., Josephs, K. A., Boeve, B. F. & Savica, R., Jan 1 2019, In : Frontiers in Neurology. 10, AUG, 939.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations
2018

[18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

Whitwell, J. L., Graff-Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C., Spychalla, A. J., Jones, D. T., Drubach, D., Knopman, D. S., Boeve, B. F., Taner, N., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., Feb 1 2018, In : Annals of Neurology. 83, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

22 Scopus citations

[18F]AV-1451 tau-PET and primary progressive aphasia

Josephs, K. A., Martin, P. R., Botha, H., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Graff-Radford, J., Weigand, S. D., Senjem, M. L., Utianski, R., Drubach, D., Boeve, B. F., Jones, D. T., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Whitwell, J. L., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

20 Scopus citations
7 Scopus citations

A neuropsychiatric analysis of the Cotard delusion

Sahoo, A. & Josephs, K. A., Dec 1 2018, In : Journal of Neuropsychiatry and Clinical Neurosciences. 30, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Association of Apolipoprotein e ϵ4 with Transactive Response DNA-Binding Protein 43

Wennberg, A. M., Tosakulwong, N., Lesnick, T. G., Murray, M. E., Whitwell, J. L., Liesinger, A. M., Petrucelli, L., Boeve, B. F., Parisi, J. E., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : JAMA Neurology. p. E1-E8

Research output: Contribution to journalArticle

16 Scopus citations

Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration

Tetzloff, K. A., Duffy, J. R., Strand, E. A., Machulda, M. M., Boland, S. M., Utianski, R., Botha, H., Senjem, M. L., Schwarz, C., Josephs, K. A. & Whitwell, J. L., May 26 2018, (Accepted/In press) In : Neurocase. p. 1-10 10 p.

Research output: Contribution to journalArticle

6 Scopus citations

Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech

Utianski, R., Duffy, J. R., Clark, H., Strand, E. A., Boland, S. M., Machulda, M. M., Whitwell, J. L. & Josephs, K. A., Nov 21 2018, In : American Journal of Speech-Language Pathology. 27, 4, p. 1303-1318 16 p.

Research output: Contribution to journalArticle

4 Scopus citations