Keith Anthony Josephs, MD, MST, MSc

  • 23720 Citations
  • 78 Scopus h-Index
20002020
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Research Output 2000 2019

  • 23720 Citations
  • 78 Scopus h-Index
  • 392 Article
  • 10 Chapter
  • 5 Review article
  • 3 Comment/debate
2019
4 Citations (Scopus)
Lewy Body Disease
Atrophy
Occipital Lobe
Lewy Bodies
Atlases

An Evaluation of the Progressive Supranuclear Palsy Speech/Language Variant

Whitwell, J. L., Stevens, C. A., Duffy, J. R., Clark, H., Machulda, M. M., Strand, E. A., Martin, P. R., Utianski, R., Botha, H., Spychalla, A. J., Senjem, M. L., Schwarz, C., Jack, C. R. J., Ali, F., Hassan, A. & Josephs, K. A., Jan 1 2019, In : Movement Disorders Clinical Practice.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Language
Parkinsonian Disorders
Mesencephalon
Language Disorders
1 Citation (Scopus)
Tauopathies
DNA-Binding Proteins
Atrophy
Brain
Amygdala

Clinical and neuroimaging characteristics of clinically unclassifiable primary progressive aphasia

Utianski, R., Botha, H., Martin, P. R., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Butts, A., Lowe, V., Jack, C. R. J., Senjem, M. L., Spychalla, A. J., Whitwell, J. L. & Josephs, K. A., Oct 1 2019, In : Brain and Language. 197, 104676.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
speech disorder
Neuroimaging
diagnostic
visualization

Clinicopathologic subtype of Alzheimer's disease presenting as corticobasal syndrome

Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., Wszolek, Z. K., van Gerpen, J., Graff Radford, N. R. & Dickson, D. W., Sep 1 2019, In : Alzheimer's and Dementia. 15, 9, p. 1218-1228 11 p.

Research output: Contribution to journalArticle

Alzheimer Disease
Substantia Nigra
Pathology
Extremities
Apraxias

Cross-sectional associations of tau-PET signal with cognition in cognitively unimpaired adults

Lowe, V., Bruinsma, T. J., Wiste, H. J., Min, H. K., Weigand, S. D., Fang, P., Senjem, M. L., Therneau, T. M., Boeve, B. F., Josephs, K. A., Pandey, M., Murray, M. E., Kantarci, K. M., Jones, D. T., Vemuri, P. D., Graff-Radford, J., Schwarz, C., Machulda, M. M., Mielke, M. M., Roberts, R. O. & 3 others, Knopman, D. S., Petersen, R. C. & Jack, C. R. J., Jul 2 2019, In : Neurology. 93, 1, p. e29-e39

Research output: Contribution to journalArticle

Entorhinal Cortex
Temporal Lobe
Cognition
Amyloid
Brain
Open Access
Frontotemporal Lobar Degeneration
Neurites
Inclusion Bodies
Mutation
Blood Vessels

Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers

Dickson, D. W., Baker, M. C., Jackson, J. L., Dejesus-Hernandez, M., Finch, N. C. A., Tian, S., Heckman, M. G., Pottier, C., Gendron, T. F., Murray, M. E., Ren, Y., Reddy, J. S., Graff-Radford, N. R., Boeve, B. F., Petersen, R. C., Knopman, D. S., Josephs, K. A., Petrucelli, L., Oskarsson, B., Sheppard, J. W. & 3 others, Asmann, Y. W., Rademakers, R. & Van Blitterswijk, M., Oct 8 2019, In : Acta Neuropathologica Communications. 7, 1, 150.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Motor Neuron Disease
Monomeric GTP-Binding Proteins
Dipeptides
GTP Phosphohydrolase Activators
6 Citations (Scopus)

Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD

Pottier, C., Ren, Y., Perkerson, R. B., Baker, M., Jenkins, G. D., Van Blitterswijk, M., DeJesus-Hernandez, M., van Rooij, J. G. J., Murray, M. E., Christopher, E., McDonnell, S. K., Fogarty, Z., Batzler, A., Tian, S., Vicente, C. T., Matchett, B., Karydas, A. M., Hsiung, G. Y. R., Seelaar, H., Mol, M. O. & 85 others, Finger, E. C., Graff, C., Öijerstedt, L., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Prudlo, J., Rizzu, P., Simon-Sanchez, J., Edbauer, D., Roeber, S., Diehl-Schmid, J., Evers, B. M., King, A., Mesulam, M. M., Weintraub, S., Geula, C., Bieniek, K. F., Petrucelli, L., Ahern, G. L., Reiman, E. M., Woodruff, B. K., Caselli, R. J., Huey, E. D., Farlow, M. R., Grafman, J., Mead, S., Grinberg, L. T., Spina, S., Grossman, M., Irwin, D. J., Lee, E. B., Suh, E. R., Snowden, J., Mann, D., Taner, N., Uitti, R. J., Wszolek, Z. K., Josephs, K. A., Parisi, J. E., Knopman, D. S., Petersen, R. C., Hodges, J. R., Piguet, O., Geier, E. G., Yokoyama, J. S., Rissman, R. A., Rogaeva, E., Keith, J., Zinman, L., Tartaglia, M. C., Cairns, N. J., Cruchaga, C., Ghetti, B., Kofler, J., Lopez, O. L., Beach, T. G., Arzberger, T., Herms, J., Honig, L. S., Vonsattel, J. P., Halliday, G. M., Kwok, J. B., White, C. L., Gearing, M., Glass, J., Rollinson, S., Pickering-Brown, S., Rohrer, J. D., Trojanowski, J. Q., Van Deerlin, V., Bigio, E. H., Troakes, C., Al-Sarraj, S., Asmann, Y., Miller, B. L., Graff Radford, N. R., Boeve, B. F., Seeley, W. W., Mackenzie, I. R. A., van Swieten, J. C., Dickson, D. W., Biernacka, J. M. & Rademakers, R. V., Jan 1 2019, In : Acta neuropathologica.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Genome
Genes
Mutation
1 Citation (Scopus)

Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia

International Frontotemporal Dementia Genomics Consortium, Jan 1 2019, In : Nature Medicine. 25, 1, p. 152-164 13 p.

Research output: Contribution to journalArticle

Gene Regulatory Networks
Dementia
Genes
MicroRNAs
Pharmaceutical Databases
1 Citation (Scopus)

LATE to the PART-y

Josephs, K. A., Mackenzie, I., Frosch, M. P., Bigio, E. H., Neumann, M., Arai, T., Dugger, B. N., Ghetti, B., Grossman, M., Hasegawa, M., Herrup, K., Holton, J., Jellinger, K., Lashley, T., McAleese, K. E., Parisi, J. E., Revesz, T., Saito, Y., Vonsattel, J. P., Whitwell, J. L. & 2 others, Wisniewski, T. & Hu, W., Sep 1 2019, In : Brain : a journal of neurology. 142, 9, p. e47

Research output: Contribution to journalArticle

Open Access
1 Citation (Scopus)

Longitudinal tau-PET uptake and atrophy in atypical Alzheimer's disease

Sintini, I., Martin, P. R., Graff-Radford, J., Senjem, M. L., Schwarz, C., Machulda, M. M., Spychalla, A. J., Drubach, D., Knopman, D. S., Petersen, R. C., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : NeuroImage: Clinical. 23, 101823.

Research output: Contribution to journalArticle

Open Access
Atrophy
Alzheimer Disease
Frontal Lobe
Occipital Lobe
Disease Progression
1 Citation (Scopus)

Multimodal neuroimaging relationships in progressive supranuclear palsy

Sintini, I., Schwarz, C., Senjem, M. L., Reid, R. I., Botha, H., Ali, F., Ahlskog, J. E., Jack, C. R. J., Lowe, V., Josephs, K. A. & Whitwell, J. L., Jan 1 2019, In : Parkinsonism and Related Disorders.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Diffusion Tensor Imaging
Anisotropy
Neuroimaging
Red Nucleus

Neuropathologic basis of frontotemporal dementia in progressive supranuclear palsy

Sakae, N., Josephs, K. A., Litvan, I., Murray, M. E., Duara, R., Uitti, R. J., Wszolek, Z. K., Graff Radford, N. R. & Dickson, D. W., Jan 1 2019, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Open Access
Progressive Supranuclear Palsy
Frontotemporal Dementia
Pathology
Neuroglia
4 Citations (Scopus)

Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains

Josephs, K. A., Murray, M. E., Tosakulwong, N., Weigand, S. D., Serie, A. M., Perkerson, R. B., Matchett, B. J., Jack, C. R. J., Knopman, D. S., Petersen, R. C., Parisi, J. E., Petrucelli, L., Baker, M., Rademakers, R. V., Whitwell, J. L. & Dickson, D. W., Jan 1 2019, (Accepted/In press) In : Acta Neuropathologica.

Research output: Contribution to journalArticle

Amygdala
Frontotemporal Lobar Degeneration
Brain
Neuroimaging
Hippocampus
1 Citation (Scopus)

Primary progressive aphasias and apraxia of speech

Botha, H. & Josephs, K. A., Feb 1 2019, In : CONTINUUM Lifelong Learning in Neurology. 25, 1, p. 101-127 27 p.

Research output: Contribution to journalReview article

Primary Progressive Aphasia
Apraxias
Speech Disorders
Language Disorders
Broca Aphasia

Progressive agrammatic aphasia without apraxia of speech as a distinct syndrome

Tetzloff, K. A., Duffy, J. R., Clark, H., Utianski, R., Strand, E. A., Machulda, M. M., Botha, H., Martin, P. R., Schwarz, C., Senjem, M. L., Reid, R. I., Gunter, J. L., Spychalla, A. J., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V., Josephs, K. A. & Whitwell, J. L., Aug 1 2019, In : Brain : a journal of neurology. 142, 8, p. 2466-2482 17 p.

Research output: Contribution to journalArticle

Apraxias
Aphasia
Broca Aphasia
Parkinsonian Disorders
Neuroimaging

Progressive supranuclear palsy is not associated with neurogenic orthostatic hypotension

van Gerpen, J. A., Al-Shaikh, R. H., Tipton, P. W., Wszolek, Z. K., Uitti, R. J., Ferman, T. J., Dickson, D. W., Benarroch, E. E., Singer, W., Cutsforth-Gregory, J. K., Heckman, M. G., Brushaber, D. E., Josephs, K. A., Low, P. A., Ahlskog, J. E. & Cheshire, W. P., Oct 1 2019, In : Neurology. 93, 14, p. e1339-e1347

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Orthostatic Hypotension
Adrenergic Agents
Multiple System Atrophy
Lewy Body Disease
2 Citations (Scopus)
Primary Progressive Aphasia
Agnosia
Language
Apraxias
Deafness

Rare Tauopathies

Ali, F. & Josephs, K. A., Jan 1 2019, In : Seminars in Neurology. 39, 2, p. 264-273 10 p.

Research output: Contribution to journalArticle

Open Access
Tauopathies
Microtubules
Pathology
Phenotype
tau Proteins
19 Citations (Scopus)

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases

Espay, A. J., Vizcarra, J. A., Marsili, L., Lang, A. E., Simon, D. K., Merola, A., Josephs, K. A., Fasano, A., Morgante, F., Savica, R., Greenamyre, J. T., Cambi, F., Yamasaki, T. R., Tanner, C. M., Gan-Or, Z., Litvan, I., Mata, I. F., Zabetian, C. P., Brundin, P., Fernandez, H. H. & 7 others, Standaert, D. G., Kauffman, M. A., Schwarzschild, M. A., Sardi, S. P., Sherer, T., Perry, G. & Leverenz, J. B., Feb 12 2019, In : Neurology. 92, 7, p. 329-337 9 p.

Research output: Contribution to journalArticle

Parkinson Disease
Alzheimer Disease
Synucleins
Proteins
Lewy Body Disease
11 Citations (Scopus)

Sensitivity and Specificity of Diagnostic Criteria for Progressive Supranuclear Palsy

Ali, F., Martin, P. R., Botha, H., Ahlskog, J. E., Bower, J. H., Masumoto, J. Y., Maraganore, D., Hassan, A., Eggers, S. D., Boeve, B. F., Knopman, D. S., Drubach, D., Petersen, R. C., Dunkley, E. D., Van Gerpen, J. A., Uitti, R., Whitwell, J. L., Dickson, D. W. & Josephs, K. A., Jan 1 2019, In : Movement Disorders.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Sensitivity and Specificity
Phenotype
Parkinsonian Disorders
Neurodegenerative Diseases
3 Citations (Scopus)
alpha-Synuclein
Amyloid
Blood Vessels
Pathology
Apolipoprotein E4
1 Citation (Scopus)

The influence of β-amyloid on [ 18 F]AV-1451 in semantic variant of primary progressive aphasia

Whitwell, J. L., Martin, P. R., Duffy, J. R., Clark, H., Machulda, M. M., Schwarz, C., Weigand, S. D., Sintini, I., Senjem, M. L., Taner, N., Botha, H., Utianski, R., Graff-Radford, J., Jones, D. T., Boeve, B. F., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Feb 12 2019, In : Neurology. 92, 7, p. e710-e722

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Amyloid
Alzheimer Disease
Temporal Lobe

The role of age on tau PET uptake and gray matter atrophy in atypical Alzheimer's disease

Whitwell, J. L., Martin, P., Graff-Radford, J., Machulda, M. M., Senjem, M. L., Schwarz, C., Weigand, S. D., Spychalla, A. J., Drubach, D., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jan 1 2019, In : Alzheimer's and Dementia.

Research output: Contribution to journalArticle

Amyloid
Atrophy
Alzheimer Disease
Parietal Lobe
Positron-Emission Tomography

Transient epileptic amnesia: A treatable cause of spells associated with persistent cognitive symptoms

Ramanan, V. K., Morris, K. A., Graff-Radford, J., Jones, D. T., Burkholder, D. B., Britton, J. W., Josephs, K. A., Boeve, B. F. & Savica, R., Jan 1 2019, In : Frontiers in Neurology. 10, AUG, 939.

Research output: Contribution to journalArticle

Open Access
Neurobehavioral Manifestations
Amnesia
Electroencephalography
Behavioral Symptoms
Seizures
1 Citation (Scopus)
Progressive Supranuclear Palsy
Movement Disorders
Phenotype
Paralysis
Gait
2018
16 Citations (Scopus)

[18F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease

Whitwell, J. L., Graff-Radford, J., Tosakulwong, N., Weigand, S. D., Machulda, M. M., Senjem, M. L., Schwarz, C., Spychalla, A. J., Jones, D. T., Drubach, D., Knopman, D. S., Boeve, B. F., Taner, N., Petersen, R. C., Lowe, V., Jack, C. R. J. & Josephs, K. A., Feb 1 2018, In : Annals of Neurology. 83, 2, p. 248-257 10 p.

Research output: Contribution to journalArticle

Cluster Analysis
Alzheimer Disease
Apolipoprotein E4
Entorhinal Cortex
Neocortex
14 Citations (Scopus)

[18F]AV-1451 tau-PET and primary progressive aphasia

Josephs, K. A., Martin, P. R., Botha, H., Schwarz, C., Duffy, J. R., Clark, H., Machulda, M. M., Graff-Radford, J., Weigand, S. D., Senjem, M. L., Utianski, R., Drubach, D., Boeve, B. F., Jones, D. T., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Whitwell, J. L., Jan 1 2018, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Semantics
Principal Component Analysis
4 Citations (Scopus)

[18F] AV-1451 uptake in corticobasal syndrome: the influence of beta-amyloid and clinical presentation

Ali, F., Whitwell, J. L., Martin, P. R., Senjem, M. L., Knopman, D. S., Jack, C. R. J., Lowe, V., Petersen, R. C., Boeve, B. F. & Josephs, K. A., Mar 1 2018, (Accepted/In press) In : Journal of Neurology. p. 1-10 10 p.

Research output: Contribution to journalArticle

Amyloid
Apraxias
Alzheimer Disease
Tauopathies
Pathology
9 Citations (Scopus)

A neuropsychiatric analysis of the Cotard delusion

Sahoo, A. & Josephs, K. A., Dec 1 2018, In : Journal of Neuropsychiatry and Clinical Neurosciences. 30, 1, p. 58-65 8 p.

Research output: Contribution to journalArticle

Delusions
Neuroimaging
Electronic Health Records
Fluid Therapy
Patient Rights
8 Citations (Scopus)

Association of Apolipoprotein e ϵ4 with Transactive Response DNA-Binding Protein 43

Wennberg, A. M., Tosakulwong, N., Lesnick, T. G., Murray, M. E., Whitwell, J. L., Liesinger, A. M., Petrucelli, L., Boeve, B. F., Parisi, J. E., Knopman, D. S., Petersen, R. C., Dickson, D. W. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : JAMA Neurology. p. E1-E8

Research output: Contribution to journalArticle

Apolipoproteins
DNA-Binding Proteins
Apolipoprotein E4
Alzheimer Disease
Apolipoproteins E
2 Citations (Scopus)

Clinical and imaging progression over 10 years in a patient with primary progressive apraxia of speech and autopsy-confirmed corticobasal degeneration

Tetzloff, K. A., Duffy, J. R., Strand, E. A., Machulda, M. M., Boland, S. M., Utianski, R., Botha, H., Senjem, M. L., Schwarz, C., Josephs, K. A. & Whitwell, J. L., May 26 2018, (Accepted/In press) In : Neurocase. p. 1-10 10 p.

Research output: Contribution to journalArticle

Apraxias
Autopsy
Motor Cortex
Neuroimaging
Broca Aphasia

Clinical Progression in Four Cases of Primary Progressive Apraxia of Speech

Utianski, R., Duffy, J. R., Clark, H., Strand, E. A., Boland, S. M., Machulda, M. M., Whitwell, J. L. & Josephs, K. A., Nov 21 2018, In : American Journal of Speech-Language Pathology. 27, 4, p. 1303-1318 16 p.

Research output: Contribution to journalArticle

Apraxias
Aphasia
speech disorder
Dysarthria
Phonetics
7 Citations (Scopus)

Corticobasal degeneration with TDP-43 pathology presenting with progressive supranuclear palsy syndrome: a distinct clinicopathologic subtype

Koga, S., Kouri, N., Walton, R. L., Ebbert, M. T. W., Josephs, K. A., Litvan, I., Graff Radford, N. R., Ahlskog, J. E., Uitti, R. J., Van Gerpen, J. A., Boeve, B. F., Parks, A., Ross, O. A. & Dickson, D. W., Jun 20 2018, (Accepted/In press) In : Acta Neuropathologica. p. 1-16 16 p.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Pathology
Subthalamic Nucleus
Mesencephalon
Paralysis
10 Citations (Scopus)

CXCR4 involvement in neurodegenerative diseases

International FTD-Genomics Consortium (IFGC), International Parkinson's Disease Genetics Consortium (IPDGC), International Genomics of Alzheimer's Project (IGAP), Dec 1 2018, In : Translational Psychiatry. 8, 1, 73.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Neurodegenerative Diseases
Parkinson Disease
Frontotemporal Dementia
Brain
10 Citations (Scopus)

Diffuse Lewy body disease manifesting as corticobasal syndrome: A rare form of Lewy body disease

Kasanuki, K., Josephs, K. A., Ferman, T. J., Murray, M. E., Koga, S., Konno, T., Sakae, N., Parks, A., Uitti, R. J., Van Gerpen, J. A., Graff Radford, N. R., Wszolek, Z. K. & Dickson, D. W., Jul 17 2018, In : Neurology. 91, 3, p. e268-e279

Research output: Contribution to journalArticle

Lewy Body Disease
Synucleins
Progressive Supranuclear Palsy
Lewy Bodies
Motor Cortex
2 Citations (Scopus)

Disrupted functional connectivity in primary progressive apraxia of speech

Botha, H., Utianski, R., Whitwell, J. L., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Tosakulwong, N., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Josephs, K. A. & Jones, D. T., Jan 1 2018, In : NeuroImage: Clinical. 18, p. 617-629 13 p.

Research output: Contribution to journalArticle

Apraxias
Motor Cortex
Language
Short-Term Memory
Speech Disorders
Primary Progressive Aphasia
Apraxias
speech disorder
Electroencephalography
Aphasia
3 Citations (Scopus)
Temporal Lobe
Alzheimer Disease
Brain
Neurofibrillary Tangles
Tomography
9 Citations (Scopus)

FDG-PET in tau-negative amnestic dementia resembles that of autopsy-proven hippocampal sclerosis

Botha, H., Mantyh, W. G., Murray, M. E., Knopman, D. S., Przybelski, S. A., Wiste, H. J., Graff-Radford, J., Josephs, K. A., Schwarz, C., Kremers, W. K., Boeve, B. F., Petersen, R. C., Machulda, M. M., Parisi, J. E., Dickson, D. W., Lowe, V., Jack, C. R. J. & Jones, D. T., Apr 1 2018, In : Brain. 141, 4, p. 1201-1217 17 p.

Research output: Contribution to journalArticle

Sclerosis
Dementia
Autopsy
Amyloid
Fluorodeoxyglucose F18
1 Citation (Scopus)

Fitting TDP-43 into the APOE ε4 and neurodegeneration story

Josephs, K. A., Sep 1 2018, In : The Lancet Neurology. 17, 9, p. 735-737 3 p.

Research output: Contribution to journalComment/debate

11 Citations (Scopus)
Amyloid
Positron-Emission Tomography
Atrophy
Alzheimer Disease
Neuroimaging
7 Citations (Scopus)

Longitudinal structural and molecular neuroimaging in agrammatic primary progressive aphasia

Tetzloff, K. A., Duffy, J. R., Clark, H., Strand, E. A., Machulda, M. M., Schwarz, C., Senjem, M. L., Reid, R. I., Spychalla, A. J., Tosakulwong, N., Lowe, V., Jack, C. R. J., Josephs, K. A. & Whitwell, J. L., Jan 1 2018, In : Brain. 141, 1, p. 302-317 16 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Apraxias
Neuroimaging
Aphasia
Motor Cortex

Molecular neuroimaging in primary progressive aphasia with predominant agraphia

Utianski, R., Duffy, J. R., Savica, R., Whitwell, J. L., Machulda, M. M. & Josephs, K. A., Mar 25 2018, (Accepted/In press) In : Neurocase. p. 1-3 3 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Agraphia
Neuroimaging
Positron-Emission Tomography
Tauopathies
2 Citations (Scopus)

MRI Outperforms [18F]AV-1451 PET as a Longitudinal Biomarker in Progressive Supranuclear Palsy

Whitwell, J. L., Tosakulwong, N., Schwarz, C., Botha, H., Senjem, M. L., Spychalla, A. J., Ahlskog, J. E., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jan 1 2018, (Accepted/In press) In : Movement Disorders.

Research output: Contribution to journalArticle

Progressive Supranuclear Palsy
Mesencephalon
Biomarkers
Atrophy
Sample Size

Non-right handed primary progressive apraxia of speech

Botha, H., Duffy, J. R., Whitwell, J. L., Strand, E. A., Machulda, M. M., Spychalla, A. J., Tosakulwong, N., Senjem, M. L., Knopman, D. S., Petersen, R. C., Jack, C. R. J., Lowe, V. & Josephs, K. A., Jul 15 2018, In : Journal of the Neurological Sciences. 390, p. 246-254 9 p.

Research output: Contribution to journalArticle

Apraxias
Functional Laterality
Research
Population
2 Citations (Scopus)

Patterns of Neuropsychological Dysfunction and Cortical Volume Changes in Logopenic Aphasia

Owens, T. E., Machulda, M. M., Duffy, J. R., Strand, E. A., Clark, H., Boland, S., Martin, P. R., Lowe, V., Jack, C. R. J., Whitwell, J. L. & Josephs, K. A., Jan 1 2018, In : Journal of Alzheimer's Disease. 66, 3, p. 1015-1025 11 p.

Research output: Contribution to journalArticle

Primary Progressive Aphasia
Aphasia
Atrophy
Language
Occipital Lobe
12 Citations (Scopus)

Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study

Pottier, C., Zhou, X., Perkerson, R. B., Baker, M., Jenkins, G. D., Serie, D. J., Ghidoni, R., Benussi, L., Binetti, G., López de Munain, A., Zulaica, M., Moreno, F., Le Ber, I., Pasquier, F., Hannequin, D., Sánchez-Valle, R., Antonell, A., Lladó, A., Parsons, T. M., Finch, N. C. A. & 113 others, Finger, E. C., Lippa, C. F., Huey, E. D., Neumann, M., Heutink, P., Synofzik, M., Wilke, C., Rissman, R. A., Slawek, J., Sitek, E., Johannsen, P., Nielsen, J. E., Ren, Y., Van Blitterswijk, M., DeJesus-Hernandez, M., Christopher, E., Murray, M. E., Bieniek, K. F., Evers, B. M., Ferrari, C., Rollinson, S., Richardson, A., Scarpini, E., Fumagalli, G. G., Padovani, A., Hardy, J., Momeni, P., Ferrari, R., Frangipane, F., Maletta, R., Anfossi, M., Gallo, M., Petrucelli, L., Suh, E. R., Lopez, O. L., Wong, T. H., van Rooij, J. G. J., Seelaar, H., Mead, S., Caselli, R. J., Reiman, E. M., Noel Sabbagh, M., Kjolby, M., Nykjaer, A., Karydas, A. M., Boxer, A. L., Grinberg, L. T., Grafman, J., Spina, S., Oblak, A., Mesulam, M. M., Weintraub, S., Geula, C., Hodges, J. R., Piguet, O., Brooks, W. S., Irwin, D. J., Trojanowski, J. Q., Lee, E. B., Josephs, K. A., Parisi, J. E., Taner, N., Knopman, D. S., Nacmias, B., Piaceri, I., Bagnoli, S., Sorbi, S., Gearing, M., Glass, J., Beach, T. G., Black, S. E., Masellis, M., Rogaeva, E., Vonsattel, J. P., Honig, L. S., Kofler, J., Bruni, A. C., Snowden, J., Mann, D., Pickering-Brown, S., Diehl-Schmid, J., Winkelmann, J., Galimberti, D., Graff, C., Öijerstedt, L., Troakes, C., Al-Sarraj, S., Cruchaga, C., Cairns, N. J., Rohrer, J. D., Halliday, G. M., Kwok, J. B., van Swieten, J. C., White, C. L., Ghetti, B., Murell, J. R., Mackenzie, I. R. A., Hsiung, G. Y. R., Borroni, B., Rossi, G., Tagliavini, F., Wszolek, Z. K., Petersen, R. C., Bigio, E. H., Grossman, M., Van Deerlin, V. M., Seeley, W. W., Miller, B. L., Graff Radford, N. R., Boeve, B. F., Dickson, D. W., Biernacka, J. M. & Rademakers, R. V., Jun 1 2018, In : The Lancet Neurology. 17, 6, p. 548-558 11 p.

Research output: Contribution to journalArticle

Frontotemporal Lobar Degeneration
Inborn Genetic Diseases
Genome-Wide Association Study
Age of Onset
Meta-Analysis
9 Citations (Scopus)

Prosodic and phonetic subtypes of primary progressive apraxia of speech

Utianski, R., Duffy, J. R., Clark, H., Strand, E. A., Botha, H., Schwarz, C., Machulda, M. M., Senjem, M. L., Spychalla, A. J., Jack, C. R. J., Petersen, R. C., Lowe, V., Whitwell, J. L. & Josephs, K. A., Sep 1 2018, In : Brain and Language. 184, p. 54-65 12 p.

Research output: Contribution to journalArticle

Apraxias
Phonetics
phonetics
Motor Cortex
Frontal Lobe