Research output

Research output per year 2009 2012 2017 2018 2020 2021 2021

• 24 Article
• 5 Review article
• 1 Comment/debate

Research output per year

Research output per year

Search results

• 2021

  Intestinal goblet cells sample and deliver lumenal antigens by regulated endocytic uptake and transcytosis

  Gustafsson, J. K., Davis, J. E., Rappai, T., McDonald, K. G., Kulkarni, D. H., Knoop, K. A., Hogan, S. P., Fitzpatrick, J. A. J., Lencer, W. I. & Newberry, R. D., Oct 2021, In: eLife. 10, e67292.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Transcytosis 100%
  • Goblet Cells 89%
  • Antigens 47%
  • Acetylcholine 40%
  • Mucins 20%

• Regulation of oral antigen delivery early in life: Implications for oral tolerance and food allergy

  Yokanovich, L. T., Newberry, R. D. & Knoop, K. A., Apr 2021, In: Clinical and Experimental Allergy. 51, 4, p. 518-526 9 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Food Hypersensitivity 100%
  • Allergens 80%
  • Food 59%
  • Antigens 54%
  • Breast Feeding 42%
  1 Scopus citations

• Regulatory T Cells Developing Peri-Weaning Are Continually Required to Restrain Th2 Systemic Responses Later in Life

  Knoop, K. A., McDonald, K. G., Hsieh, C. S., Tarr, P. I. & Newberry, R. D., Feb 3 2021, In: Frontiers in immunology. 11, 603059.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Weaning 100%
  • Regulatory T-Lymphocytes 92%
  • Food Hypersensitivity 18%
  • Interleukin-13 17%
  • Allergic Rhinitis 17%
  1 Scopus citations

• Sepsis, Cytokine Storms, and Immunopathology: The Divide between Neonates and Adults

  Greenfield, K. G., Badovinac, V. P., Griffith, T. S. & Knoop, K. A., Jun 1 2021, In: ImmunoHorizons. 5, 6, p. 512-522 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Sepsis 100%
  • Newborn Infant 95%
  • Cytokines 76%
  • Neonatal Sepsis 65%
  • Theoretical Models 40%
• 2020

  A Potential Role for Stress-Induced Microbial Alterations in IgA-Associated Irritable Bowel Syndrome with Diarrhea

  Rengarajan, S., Knoop, K. A., Rengarajan, A., Chai, J. N., Grajales-Reyes, J. G., Samineni, V. K., Russler-Germain, E. V., Ranganathan, P., Fasano, A., Sayuk, G. S., Gereau, R. W., Kau, A. L., Knights, D., Kashyap, P. C., Ciorba, M. A., Newberry, R. D. & Hsieh, C. S., Oct 20 2020, In: Cell Reports Medicine. 1, 7, 100124.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Irritable Bowel Syndrome 100%
  • Immunoglobulin A 81%
  • Diarrhea 72%
  • Bacteria 47%
  • Immunity 42%
  1 Scopus citations

• Goblet cell associated antigen passages support the induction and maintenance of oral tolerance

  Kulkarni, D. H., Gustafsson, J. K., Knoop, K. A., McDonald, K. G., Bidani, S. S., Davis, J. E., Floyd, A. N., Hogan, S. P., Hsieh, C. S. & Newberry, R. D., Mar 1 2020, In: Mucosal Immunology. 13, 2, p. 271-282 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Goblet Cells 100%
  • Maintenance 58%
  • Antigens 53%
  • Mucous Membrane 36%
  • Antigen-Presenting Cells 15%
  23 Scopus citations

• In vivo labeling of epithelial cell–associated antigen passages in the murine intestine

  Knoop, K. A., Kulkarni, D. H., McDonald, K. G., Gustafsson, J. K., Davis, J. E., Floyd, A. N. & Newberry, R. D., Mar 1 2020, In: Lab Animal. 49, 3, p. 79-88 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intestines 100%
  • intestines 91%
  • antigens 82%
  • Antigens 70%
  • mice 63%
  2 Scopus citations

• Maternal activation of the EGFR prevents translocation of gut-residing pathogenic Escherichia coli in a model of late-onset neonatal sepsis

  Knoop, K. A., Coughlin, P. E., Floyd, A. N., Malick Ndao, I., Hall-Moore, C., Shaikh, N., Gasparrini, A. J., Rusconi, B., Escobedo, M., Good, M., Warner, B. B., Tarr, P. I. & Newberry, R. D., Apr 7 2020, In: Proceedings of the National Academy of Sciences of the United States of America. 117, 14, p. 7941-7949 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Neonatal Sepsis 100%
  • Epidermal Growth Factor 74%
  • Goblet Cells 60%
  • Escherichia coli 53%
  • Mothers 48%
  8 Scopus citations

• Synchronization of mothers and offspring promotes tolerance and limits allergy

  Knoop, K. A., McDonald, K. G., Coughlin, P. E., Kulkarni, D. H., Gustafsson, J. K., Rusconi, B., John, V., Malick Ndao, I., Beigelman, A., Good, M., Warner, B. B., Elson, C. O., Hsieh, C. S., Hogan, S. P., Tarr, P. I. & Newberry, R. D., Aug 6 2020, In: JCI Insight. 5, 15, e137943.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Hypersensitivity 100%
  • Mothers 77%
  • Antigens 77%
  • Colon 65%
  • Immune System 64%
  5 Scopus citations

• Understanding the elements of maternal protection from systemic bacterial infections during early life

  Kleist, S. A. & Knoop, K. A., Apr 2020, In: Nutrients. 12, 4, 1045.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • sepsis (infection) 100%
  • bacterial infections 76%
  • Bacterial Infections 64%
  • Sepsis 55%
  • Mothers 43%
• 2019

  IL-13–induced intestinal secretory epithelial cell antigen passages are required for IgE-mediated food-induced anaphylaxis

  Noah, T. K., Knoop, K. A., McDonald, K. G., Gustafsson, J. K., Waggoner, L., Vanoni, S., Batie, M., Arora, K., Naren, A. P., Wang, Y. H., Lukacs, N. W., Munitz, A., Helmrath, M. A., Mahe, M. M., Newberry, R. D. & Hogan, S. P., Oct 2019, In: Journal of Allergy and Clinical Immunology. 144, 4, p. 1058-1073.e3

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Anaphylaxis 100%
  • Immunoglobulin E 85%
  • Epithelial Cells 65%
  • Food 64%
  • Antigens 58%
  12 Scopus citations

• Predicting risk of postoperative disease recurrence in Crohn's disease: Patients with indolent Crohn's disease have distinct whole transcriptome profiles at the time of first surgery

  Cushing, K. C., McLean, R., McDonald, K. G., Gustafsson, J. K., Knoop, K. A., Kulkarni, D. H., Sartor, R. B. & Newberry, R. D., Jan 1 2019, In: Inflammatory bowel diseases. 25, 1, p. 180-193 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Crohn Disease 100%
  • Transcriptome 96%
  • Recurrence 60%
  • Cluster Analysis 35%
  • Forests 31%
  5 Scopus citations
• 2018

  Goblet cell associated antigen passages are inhibited during Salmonella typhimur/cium infection to prevent pathogen dissemination and limit responses to dietary antigens article

  Kulkarni, D. H., McDonald, K. G., Knoop, K. A., Gustafsson, J. K., Kozlowski, K. M., Hunstad, D. A., Miller, M. J. & Newberry, R. D., Jul 1 2018, In: Mucosal Immunology. 11, 4, p. 1103-1113 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Goblet Cells 100%
  • Salmonella 87%
  • Antigens 53%
  • Infections 39%
  • Anti-Bacterial Agents 14%
  25 Scopus citations

• Goblet cells: multifaceted players in immunity at mucosal surfaces

  Knoop, K. A. & Newberry, R. D., Nov 1 2018, In: Mucosal Immunology. 11, 6, p. 1551-1557 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Mucosal Immunity 100%
  • Goblet Cells 96%
  • Antigen-Presenting Cells 25%
  • Maintenance 16%
  • Antigens 15%
  48 Scopus citations

• Inherited nongenetic influences on the gut microbiome and immune system

  Knoop, K. A., Holtz, L. R. & Newberry, R. D., Dec 1 2018, In: Birth Defects Research. 110, 20, p. 1494-1503 10 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Plastic Property 100%
  • Gastrointestinal Microbiome 85%
  • Immune System 68%
  • Homeostasis 25%
  • Health 25%
  2 Scopus citations
• 2017

  Antibiotics promote the sampling of luminal antigens and bacteria via colonic goblet cell associated antigen passages

  Knoop, K. A., Gustafsson, J. K., McDonald, K. G., Kulkarni, D. H., Kassel, R. & Newberry, R. D., Jul 4 2017, In: Gut Microbes. 8, 4, p. 400-411 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Goblet Cells 100%
  • Bacteria 56%
  • Anti-Bacterial Agents 54%
  • Antigens 53%
  • Bacterial Translocation 15%
  24 Scopus citations

• CCR6 promotes steady-state mononuclear phagocyte association with the intestinal epithelium, imprinting and immune surveillance

  McDonald, K. G., Wheeler, L. W., McDole, J. R., Joerger, S., Gustafsson, J. K., Kulkarni, D. H., Knoop, K. A., Williams, I. R., Miller, M. J. & Newberry, R. D., Dec 2017, In: Immunology. 152, 4, p. 613-627 15 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Intestinal Mucosa 100%
  • Phagocytes 99%
  • Mucous Membrane 47%
  • Antigens 30%
  • Epithelium 27%
  8 Scopus citations

• Helicobacter species are potent drivers of colonic T cell responses in homeostasis and inflammation

  Chai, J. N., Peng, Y., Rengarajan, S., Solomon, B. D., Ai, T. L., Shen, Z., Perry, J. S. A., Knoop, K. A., Tanoue, T., Narushima, S., Honda, K., Elson, C. O., Newberry, R. D., Stappenbeck, T. S., Kau, A. L., Peterson, D. A., Fox, J. G. & Hsieh, C. S., 2017, In: Science Immunology. 2, 13, eaal5068.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Eragrostis 100%
  • Helicobacter 83%
  • Regulatory T-Lymphocytes 59%
  • Colitis 49%
  • Homeostasis 44%
  51 Scopus citations

• Microbial antigen encounter during a preweaning interval is critical for tolerance to gut bacteria

  Knoop, K. A., Gustafsson, J. K., McDonald, K. G., Kulkarni, D. H., Coughlin, P. E., McCrate, S., Kim, D., Hsieh, C. S., Hogan, S. P., Elson, C. O., Tarr, P. I. & Newberry, R. D., 2017, In: Science Immunology. 2, 18, eaao1314.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacteria 100%
  • Antigens 93%
  • Immune System 70%
  • Gastrointestinal Microbiome 29%
  • Gastrointestinal Tract 25%
  68 Scopus citations
• 2016

  Antibiotics promote inflammation through the translocation of native commensal colonic bacteria

  Knoop, K. A., McDonald, K. G., Kulkarni, D. H. & Newberry, R. D., Jul 2016, In: Gut. 65, 7, p. 1100-1109 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Bacterial Translocation 100%
  • Bacteria 67%
  • Anti-Bacterial Agents 65%
  • Inflammation 58%
  • Goblet Cells 44%
  103 Scopus citations

• Characterization and application of two RANK-specific antibodies with different biological activities

  Chypre, M., Seaman, J., Cordeiro, O. G., Willen, L., Knoop, K. A., Buchanan, A., Sainson, R. C. A., Williams, I. R., Yagita, H., Schneider, P. & Mueller, C. G., Mar 1 2016, In: Immunology Letters. 171, p. 5-14 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Langerhans Cells 100%
  • Antibodies 92%
  • Biomedical Research 41%
  • Bacteriophages 41%
  • Immunization 35%
  3 Scopus citations
• 2015

  Microbial sensing by goblet cells controls immune surveillance of luminal antigens in the colon

  Knoop, K. A., McDonald, K. G., McCrate, S., McDole, J. R. & Newberry, R. D., Jan 11 2015, In: Mucosal Immunology. 8, 1, p. 198-210 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Goblet Cells 100%
  • Colon 67%
  • Antigens 53%
  • Acetylcholine 22%
  • Antigen-Presenting Cells 12%
  115 Scopus citations
• 2014

  Mind the GAPs: Insights into intestinal epithelial barrier maintenance and luminal antigen delivery

  Miller, M. J., Knoop, K. A. & Newberry, R. D., May 2014, In: Mucosal Immunology. 7, 3, p. 452-454 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access
  6 Scopus citations
• 2013

  Transepithelial antigen delivery in the small intestine: Different paths, different outcomes

  Knoop, K. A., Miller, M. J. & Newberry, R. D., Mar 2013, In: Current Opinion in Gastroenterology. 29, 2, p. 112-118 7 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Small Intestine 100%
  • Antigens 69%
  • Epithelium 25%
  • Dendritic Cells 19%
  • Peripheral Tolerance 15%
  39 Scopus citations
• 2012

  Goblet cells deliver luminal antigen to CD103 ⁺ dendritic cells in the small intestine

  McDole, J. R., Wheeler, L. W., McDonald, K. G., Wang, B., Konjufca, V., Knoop, K. A., Newberry, R. D. & Miller, M. J., Mar 15 2012, In: Nature. 483, 7389, p. 345-349 5 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • alpha E integrins 100%
  • Goblet Cells 60%
  • Small Intestine 46%
  • Dendritic Cells 45%
  • Antigens 27%
  520 Scopus citations

• Isolated lymphoid follicles are dynamic reservoirs for the induction of intestinal IgA

  Knoop, K. A. & Newberry, R. D., 2012, In: Frontiers in immunology. 3, MAY, p. 1-7 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunoglobulin A 100%
  • Peyer's Patches 34%
  • Hyperplasia 23%
  • Immunity 21%
  • Homeostasis 19%
  30 Scopus citations

• The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells

  Kanaya, T., Hase, K., Takahashi, D., Fukuda, S., Hoshino, K., Sasaki, I., Hemmi, H., Knoop, K. A., Kumar, N., Sato, M., Katsuno, T., Yokosuka, O., Toyooka, K., Nakai, K., Sakamoto, A., Kitahara, Y., Jinnohara, T., Mcsorley, S. J., Kaisho, T., Williams, I. R., & 1 othersOhno, H., Aug 2012, In: Nature immunology. 13, 8, p. 729-736 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Proto-Oncogene Proteins c-ets 100%
  • Cell Differentiation 52%
  • Cell Lineage 33%
  • Transcytosis 21%
  • Mucosal Immunity 19%
  131 Scopus citations
• 2011

  CCR6^hiCD11c^int B cells promote M-cell differentiation in Peyer's patch

  Ebisawa, M., Hase, K., Takahashi, D., Kitamura, H., Knoop, K. A., Williams, I. R. & Ohno, H., Apr 2011, In: International Immunology. 23, 4, p. 261-269 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peyer's Patches 100%
  • Cell Differentiation 62%
  • B-Lymphocytes 59%
  • B-Lymphocyte Subsets 32%
  • Helper-Inducer T-Lymphocytes 26%
  42 Scopus citations

• Distinct developmental requirements for isolated lymphoid follicle formation in the small and large intestine: RANKL is essential only in the small intestine

  Knoop, K. A., Butler, B. R., Kumar, N., Newberry, R. D. & Williams, I. R., Oct 2011, In: American Journal of Pathology. 179, 4, p. 1861-1871 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • RANK Ligand 100%
  • Large Intestine 89%
  • Small Intestine 68%
  • Stromal Cells 25%
  • B-Lymphocytes 19%
  33 Scopus citations
• 2009

  RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium

  Knoop, K. A., Kumar, N., Butler, B. R., Sakthivel, S. K., Taylor, R. T., Nochi, T., Akiba, H., Yagita, H., Kiyono, H. & Williams, I. R., Nov 1 2009, In: Journal of Immunology. 183, 9, p. 5738-5747 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Peyer's Patches 100%
  • Intestinal Mucosa 81%
  • Antigens 48%
  • Epithelial Cells 41%
  • Yersinia 26%
  198 Scopus citations