Karen Elaine Hedin, PhD

  • 1319 Citations
  • 18 Scopus h-Index
1993 …2019
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Fingerprint Dive into the research topics where Karen Elaine Hedin is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

  • 4 Similar Profiles
T-Lymphocytes Medicine & Life Sciences
T-Cell Antigen Receptor Medicine & Life Sciences
CXCR4 Receptors Medicine & Life Sciences
T-cells Chemical Compounds
Chemokine CXCL12 Medicine & Life Sciences
Myeloid Cells Medicine & Life Sciences
Acute Myeloid Leukemia Medicine & Life Sciences
Chemokine Receptors Medicine & Life Sciences

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Projects 1999 2017

Osteoblasts
Acute Myeloid Leukemia
Bone Marrow
Apoptosis
Coculture Techniques
CXCR4 Receptors
Chemokine Receptors
Extracellular Signal-Regulated MAP Kinases
T-Lymphocytes
Chemokines

Research Output 1993 2019

  • 1319 Citations
  • 18 Scopus h-Index
  • 31 Article
14 Citations (Scopus)

GM-CSF inhibition reduces cytokine release syndrome and neuroinflammation but enhances CAR-T cell function in xenografts

Sterner, R. M., Sakemura, R., Cox, M. J., Yang, N., Khadka, R. H., Forsman, C. L., Hansen, M. J., Jin, F., Ayasoufi, K., Hefazi, M., Schick, K. J., Walters, D. K., Ahmed, O., Chappell, D., Sahmoud, T., Durrant, C., Nevala, W. K., Patnaik, M. M., Pease, L. R., Hedin, K. E. & 3 others, Kay, N. E., Johnson, A. J. & Kenderian, S., Feb 14 2019, In : Blood. 133, 7, p. 697-709 13 p.

Research output: Contribution to journalArticle

Granulocyte-Macrophage Colony-Stimulating Factor
T-Cell Antigen Receptor
Heterografts
Cytokines
Cell- and Tissue-Based Therapy
3 Citations (Scopus)

GRK2 mediates TCR-induced transactivation of CXCR4 and TCR–CXCR4 complex formation that drives PI3K/PREX1 signaling and T cell cytokine secretion

Dinkel, B. A., Kremer, K. N., Rollins, M. R., Medlyn, M. J. & Hedin, K. E., Jan 1 2018, In : Journal of Biological Chemistry. 293, 36, p. 14022-14039 18 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptor Kinase 2
Phosphatidylinositol 3-Kinase
T-cells
T-Cell Antigen Receptor
Transcriptional Activation
2 Citations (Scopus)

Tissue-nonspecific alkaline phosphatase is required for MC3T3 osteoblast-mediated protection of acute myeloid leukemia cells from apoptosis

Sterner, R. M., Kremer, K. N., Dudakovic, A., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Aug 1 2018, In : Journal of Immunology. 201, 3, p. 1086-1096 11 p.

Research output: Contribution to journalArticle

Myeloid Cells
Osteoblasts
Acute Myeloid Leukemia
Alkaline Phosphatase
Apoptosis
1 Citation (Scopus)

Histone deacetylase inhibitors reduce differentiating osteoblastmediated protection of acute myeloid leukemia cells from cytarabine

Sterner, R. M., Kremer, K. N., Al-Kali, A., Patnaik, M. M., Gangat, N., Litzow, M. R., Kaufmann, S. H., Westendorf, J. J., van Wijnen, A. J. & Hedin, K. E., Nov 1 2017, In : Oncotarget. 8, 55, p. 94569-94579 11 p.

Research output: Contribution to journalArticle

Histone Deacetylase Inhibitors
Cytarabine
Myeloid Cells
Acute Myeloid Leukemia
Osteoblasts
4 Citations (Scopus)

TCR-CXCR4 signaling stabilizes cytokine mRNA transcripts via a PREX1-Rac1 pathway: Implications for CTCL

Kremer, K. N., Dinkel, B. A., Sterner, R. M., Osborne, D. G., Jevremovic, D. & Hedin, K. E., Aug 24 2017, In : Blood. 130, 8, p. 982-994 13 p.

Research output: Contribution to journalArticle

Cutaneous T-Cell Lymphoma
T-cells
T-Cell Antigen Receptor
Cytokines
Messenger RNA