• 19030 Citations
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1974 …2019
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Research Output 1979 2019

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Article
2019
1 Citation (Scopus)

AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle

Koh, J. H., Hancock, C. R., Han, D. H., Holloszy, J. O., Nair, K. S. & Dasari, S., May 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 5, p. E931-E939

Research output: Contribution to journalArticle

Glucose Transporter Type 4
Peroxisome Proliferator-Activated Receptors
AMP-Activated Protein Kinases
Skeletal Muscle
Exercise
4 Citations (Scopus)

FOXO transcription factors are critical regulators of diabetes-related muscle atrophy

O’Neill, B. T., Bhardwaj, G., Penniman, C. M., Krumpoch, M. T., Suarez Beltran, P. A., Klaus, K., Poro, K., Li, M., Pan, H., Dreyfuss, J. M., Nair, K. S. & Ronald Kahn, C., Mar 1 2019, In : Diabetes. 68, 3, p. 556-570 15 p.

Research output: Contribution to journalArticle

Muscular Atrophy
Transcription Factors
Insulin
Muscles
Experimental Diabetes Mellitus
2 Citations (Scopus)

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction

Chaanine, A. H., Joyce, L. D., Stulak, J. M., Maltais, S., Joyce, D. L., Dearani, J. A., Klaus, K., Nair, K. S., Hajjar, R. J. & Redfield, M. M., Feb 1 2019, In : Circulation. Heart failure. 12, 2, p. e005131

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Myocardial Ischemia
Heart Failure
Pressure
Organelle Biogenesis

TFAM enhances fat oxidation and attenuates high-fat diet-induced insulin resistance in skeletal muscle

Koh, J. H., Johnson, M. L., Dasari, S., LeBrasseur, N. K., Vuckovic, I., Henderson, G. C., Cooper, S. A., Manjunatha, S., Ruegsegger, G. N., Shulman, G. I., Lanza, I. R. & Nair, K. S., Aug 1 2019, In : Diabetes. 68, 8, p. 1552-1564 13 p.

Research output: Contribution to journalArticle

High Fat Diet
Insulin Resistance
Skeletal Muscle
Fats
Muscles
2018
1 Citation (Scopus)

A novel triple-tracer approach to assess postprandial protein turnover

Moran, A., Toffolo, G., Schiavon, M., Vella, A., Klaus, K., Cobelli, C. & Nair, K. S., Oct 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E469-E477

Research output: Contribution to journalArticle

Phenylalanine
Proteins
Meals
Blood Proteins
Proteome
Diffusion tensor imaging
Diffusion Tensor Imaging
Anisotropy
Brain
Pons
2 Citations (Scopus)

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P. P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

Metabolome
Second Pregnancy Trimester
First Pregnancy Trimester
Fetal Development
Child Development
4 Citations (Scopus)

Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies

Gonsalves, W., Ramakrishnan, V., Hitosugi, T. D., Ghosh, T., Jevremovic, D., Dutta, T., Sakrikar, D., Petterson, X. M., Wellik, L., Kumar, S. K. & Nair, K. S., Jan 11 2018, In : JCI insight. 3, 1

Research output: Contribution to journalArticle

Open Access
Plasma Cells
Glutamine
Disease Progression
Multiple Myeloma
Neoplasms
3 Citations (Scopus)
Young Adult
Brain
Glucose
Metabolism
Exercise
1 Citation (Scopus)

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M. D., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Jan 1 2018, (Accepted/In press) In : Clinical Endocrinology.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Body Composition
Bone Density
Clinical Trials
Fats
2017
13 Citations (Scopus)
Longitudinal Studies
Liver
Insulin Resistance
Diet
Fast Foods
13 Citations (Scopus)
Metabolomics
Polycystic Ovary Syndrome
Metabolic Networks and Pathways
Insulin Resistance
Branched Chain Amino Acids
85 Citations (Scopus)

Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

Robinson, M. M., Dasari, S., Konopka, A. R., Johnson, M. L., Manjunatha, S., Esponda, R. R., Carter, R. E., Lanza, I. R. & Nair, K. S., Mar 7 2017, In : Cell Metabolism. 25, 3, p. 581-592 12 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Protein Biosynthesis
Proteome
Exercise
DNA Methylation
15 Citations (Scopus)

Insulin Regulation of Proteostasis and Clinical Implications

James, H. A., O'Neill, B. T. & Nair, K. S., 2017, (Accepted/In press) In : Cell Metabolism.

Research output: Contribution to journalArticle

Proteome
Homeostasis
Insulin
Diabetes Complications
Post Translational Protein Processing
7 Citations (Scopus)

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload-Induced Left Ventricular Remodeling

Chaanine, A. H., Nair, K. S., Bergen, R. H., Klaus, K., Guenzel, A. J., Hajjar, R. J. & Redfield, M. M., Jun 15 2017, In : Journal of the American Heart Association. 6, 6

Research output: Contribution to journalArticle

Ventricular Remodeling
Organelle Biogenesis
Sodium-Calcium Exchanger
Pressure
Autophagy
2016
39 Citations (Scopus)

1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Folmes, C., Wang, X., Lanza, I. R., Schaible, N. S., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C. & Kumar, R., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1514-1528 15 p., 15.

Research output: Contribution to journalArticle

Calcitriol
Oxygen Consumption
Muscle Cells
Muscle
Skeletal Muscle
9 Citations (Scopus)

Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice

Zabielski, P., Lanza, I. R., Gopala, S., Heppelmann, C. J. H., Bergen, H. R. B. III., Dasari, S. & Nair, K. S., Mar 1 2016, In : Diabetes. 65, 3, p. 561-573 13 p.

Research output: Contribution to journalArticle

Proteome
Skeletal Muscle
Insulin
Fatty Acids
Oxidative Stress
4 Citations (Scopus)
Pregnancy-Associated Plasma Protein-A
Gene expression
Muscle
Skeletal Muscle
Phenotype
1 Citation (Scopus)

Effect of dehydroepiandrosterone and testosterone supplementation on systemic lipolysis

Espinosa De Ycaza, A. E., Rizza, R. A., Nair, K. S. & Jensen, M. D., Apr 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 4, p. 1719-1728 10 p.

Research output: Contribution to journalArticle

Dehydroepiandrosterone
Lipolysis
Testosterone
Meals
Glucose Tolerance Test
13 Citations (Scopus)

FOXO3A regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

Chaanine, A. H., Kohlbrenner, E., Gamb, S. I., Guenzel, A. J., Klaus, K., Fayyaz, A. U., Nair, K. S., Hajjar, R. J. & Redfield, M. M., Dec 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 6, p. H1540-H1559

Research output: Contribution to journalArticle

Mitochondrial Dynamics
Phenylephrine
Heart Failure
Cardiac Myocytes
Calcium
16 Citations (Scopus)

Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus

Manjunatha, S., Distelmaier, K., Dasari, S., Carter, R. E., Kudva, Y. C. & Nair, K. S., Sep 1 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

Type 1 Diabetes Mellitus
Proteomics
HDL Cholesterol
Cholesterol
Ultracentrifugation
18 Citations (Scopus)

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Konopka, A. R., Esponda, R. R., Robinson, M. M., Johnson, M. L., Carter, R. E., Schiavon, M., Cobelli, C., Wondisford, F. E., Lanza, I. R. & Nair, K. S., May 17 2016, In : Cell Reports. 15, 7, p. 1394-1400 7 p.

Research output: Contribution to journalArticle

Prediabetic State
Metformin
Glucagon
Glucose
Cross-Over Studies
14 Citations (Scopus)

Impact of long-term poor and good glycemic control on metabolomics alterations in type 1 diabetic people

Dutta, T., Kudva, Y. C., Persson, X. M. T., Schenck, L. A., Charles Ford, G., Singh, R. J., Carter, R. E. & Nair, K. S., Mar 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 4, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

Metabolomics
Medical problems
Type 1 Diabetes Mellitus
Metabolites
Glycosylated Hemoglobin A
31 Citations (Scopus)

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

O'Neill, B. T., Lee, K. Y., Klaus, K., Softic, S., Krumpoch, M. T., Fentz, J., Stanford, K. I., Robinson, M. M., Cai, W., Kleinridders, A., Pereira, R. O., Hirshman, M. F., Abel, E. D., Accili, D., Goodyear, L. J., Nair, K. S. & Kahn, C. R., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

IGF Type 1 Receptor
Insulin
Muscles
Autophagy
Muscle Proteins

John Stuart Garrow, MD, PhD, FRCP(E), FRCP (London) (1929-2016)

Bray, G. A. & Nair, S., 2016, (Accepted/In press) In : Obesity.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I. & Nair, K. S., Jan 1 2016, In : Diabetes. 65, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

Caloric Restriction
Insulin Resistance
Thioredoxins
Skeletal Muscle
Glucose
118 Citations (Scopus)

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

Sud, M., Fahy, E., Cotter, D., Azam, K., Vadivelu, I., Burant, C., Edison, A., Fiehn, O., Higashi, R., Nair, K. S., Sumner, S. & Subramaniam, S., 2016, In : Nucleic Acids Research. 44, D1, p. D463-D470

Research output: Contribution to journalArticle

Metabolomics
Mass Spectrometry
Spectrum Analysis
Magnetic Resonance Spectroscopy
Databases
24 Citations (Scopus)

Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans

Lalia, A. Z., Dasari, S., Johnson, M. L., Robinson, M. M., Konopka, A. R., DIstelmaier, K., Port, J. D., Glavin, M. T., Esponda, R. R., Nair, K. S. & Lanza, I. R., Feb 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 626-634 9 p.

Research output: Contribution to journalArticle

Adiposity
Insulin Resistance
Insulin
Fats
Abdominal Subcutaneous Fat
8 Citations (Scopus)
Peptide Fragments
Skeletal Muscle
Insulin
Proteolysis
Molecular Weight
2015
6 Citations (Scopus)

Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins

Hines, K. M., Ford, G. C., Klaus, K. A., Irving, B. A., Ford, B. L., Johnson, K. L., Lanza, I. R. & Nair, K. S., May 28 2015, In : Analytical and Bioanalytical Chemistry. 407, 14, p. 4045-4052 8 p., 8641.

Research output: Contribution to journalArticle

Muscle Proteins
Isotopes
Mass spectrometry
Mass Spectrometry
Electrophoresis, Gel, Two-Dimensional
4 Citations (Scopus)

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Acosta, A., Camilleri, M., Shin, A., Vazquez Roque, M. I., Iturrino, J., Lanza, I. R., Nair, K. S., Burton, D., O'Neill, J., Eckert, D., Carlson, P., Vella, A. & Zinsmeister, A. R., Apr 1 2015, In : Obesity. 23, 4, p. 898-906 9 p.

Research output: Contribution to journalArticle

Stomach
Obesity
Body Weight
Genes
Meals
23 Citations (Scopus)

Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet - A pilot study

Jourdan, M., Nair, K. S., Carter, R. E., Schimke, J., Ford, G. C., Marc, J., Aussel, C. & Cynober, L., Jun 1 2015, In : Clinical Nutrition. 34, 3, p. 449-456 8 p.

Research output: Contribution to journalArticle

Citrulline
Protein-Restricted Diet
Muscle Proteins
Proteins
Amino Acids
35 Citations (Scopus)

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age

Irving, B. A., Lanza, I. R., Henderson, G. C., Rao, R. R., Spiegelman, B. M. & Nair, K. S., Apr 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 4, p. 1654-1663 10 p.

Research output: Contribution to journalArticle

Resistance Training
Muscle
Skeletal Muscle
Mitochondrial Proteins
Muscle Strength
40 Citations (Scopus)

Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training

Konopka, A. R., Asante, A., Lanza, I. R., Robinson, M. M., Johnson, M. L., Dalla Man, C., Cobelli, C., Amols, M. H., Irving, B. A. & Nair, K. S., Jun 1 2015, In : Diabetes. 64, 6, p. 2104-2115 12 p.

Research output: Contribution to journalArticle

Exercise
Phenotype
Meals
Insulin Resistance
Obesity
182 Citations (Scopus)

Detection and quantitation of circulating human irisin by tandem mass spectrometry

Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P. & Spiegelman, B. M., Oct 6 2015, In : Cell Metabolism. 22, 4, p. 734-740 7 p.

Research output: Contribution to journalArticle

Tandem Mass Spectrometry
Initiator Codon
Insurance Benefits
Isotopes
Cognition
30 Citations (Scopus)

Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging

Johnson, M. L., Irving, B. A., Lanza, I. R., Vendelbo, M. H., Konopka, A. R., Robinson, M. M., Henderson, G. C., Klaus, K. A., Morse, D. M., Heppelmann, C., Bergen, H. R. B. III., Dasari, S., Schimke, J. M., Jakaitis, D. R. & Nair, K. S., Nov 1 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1386-1393 8 p.

Research output: Contribution to journalArticle

Mitochondrial Proteins
Acetylation
Proteolysis
Exercise
Muscle Proteins
29 Citations (Scopus)

Effect of insulin sensitizer therapy on amino acids and their metabolites

Irving, B. A., Carter, R. E., Soop, M., Weymiller, A., Syed, H., Karakelides, H., Bhagra, S., Short, K. R., Tatpati, L., Barazzoni, R. & Nair, K. S., Jun 1 2015, In : Metabolism: Clinical and Experimental. 64, 6, p. 720-728 9 p.

Research output: Contribution to journalArticle

Insulin
Amino Acids
Therapeutics
Insulin Resistance
Fasting
19 Citations (Scopus)

Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women

Hebert, S. L., Marquet-De Rougé, P., Lanza, I. R., McCrady-Spitzer, S. K., Levine, J. A., Middha, S., Carter, R. E., Klaus, K. A., Therneau, T. M., Highsmith, W. E. J. & Nair, K. S., Nov 1 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1409-1417 9 p.

Research output: Contribution to journalArticle

Mitochondrial DNA
Muscles
Citrate (si)-Synthase
Muscle Proteins
Sequence Deletion

Statement of principle

Cefalu, W. T., Nair, K. S., Seaquist, E. R., Zierath, J., Boulton, A. J. M., LeRoith, D., Harrell, R. M., Grunberger, G., Wartofsky, L., Gore, A. C., Wierman, M. E., Hammes, S. R., Lange, C. A. & Santen, R. J., Feb 1 2015, In : Hormones and Cancer. 6, 1, p. 1 1 p.

Research output: Contribution to journalArticle

2014
64 Citations (Scopus)

Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size

Xiao, Y. X., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S. & Jensen, M. D., Feb 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 2

Research output: Contribution to journalArticle

Cell Size
Adipocytes
Citrate (si)-Synthase
Obesity
Fats
9 Citations (Scopus)

Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration

Walrand, S., Short, K. R., Heemstra, L. A., Novak, C. M., Levine, J. A., Coenen-Schimke, J. M. & Nair, K. S., 2014, In : FASEB Journal. 28, 3, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

Thyroid Hormones
Rats
Homeostasis
Energy Metabolism
Hyperthyroidism
12 Citations (Scopus)
Mitochondrial Genes
Skeletal Muscle
Age Groups
Gene Expression
Genes
27 Citations (Scopus)

Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling

Vendelbo, M. H., Møller, A. B., Christensen, B., Nellemann, B., Clasen, B. F. F., Nair, K. S., Jørgensen, J. O. L., Jessen, N. & Møller, N., Jul 14 2014, In : PLoS One. 9, 7, e102031.

Research output: Contribution to journalArticle

Sirolimus
Phenylalanine
phenylalanine
fasting
Muscle
34 Citations (Scopus)

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, J. P., Wrann, C. D., Rao, R. R., Nair, K. S., Jedrychowski, M. P., You, J. S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., Wu, Z., Glass, D. J., Piao, X. & Spiegelman, B. M., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. 15756-15761 6 p.

Research output: Contribution to journalArticle

G-Protein-Coupled Receptors
Hypertrophy
Muscles
Anabolic Agents
Collagen Type III
26 Citations (Scopus)

High insulin combined with essential amino acids stimulates skeletal muscle mitochondrial protein synthesis while decreasing insulin sensitivity in healthy humans

Robinson, M. M., Soop, M., Sohn, T. S., Morse, D. M., Schimke, J. M., Klaus, K. A. & Nair, K. S., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. E2574-E2583

Research output: Contribution to journalArticle

Essential Amino Acids
Muscle Proteins
Mitochondrial Proteins
Muscle
Insulin Resistance
12 Citations (Scopus)

Impact of insulin deprivation and treatment on sphingolipid distribution in different muscle subcellular compartments of streptozotocin-diabetic C57Bl/6 mice

Zabielski, P., Blachnio-Zabielska, A., Lanza, I. R., Gopala, S., Manjunatha, S., Jakaitis, D. R., Persson, X. M., Gransee, J., Klaus, K. A., Schimke, J. M., Jensen, M. D. & Nair, K. S., 2014, In : American Journal of Physiology - Endocrinology and Metabolism. 306, 5

Research output: Contribution to journalArticle

Sphingolipids
Streptozocin
Insulin
Ceramides
Muscles
9 Citations (Scopus)

Induction of hyperandrogenism in lean reproductive-age women stimulates proatherogenic inflammation

González, F., Nair, K. S., Basal, E., Bearson, D. M., Schimke, J. M. & Blair, H. E., Sep 17 2014, In : Hormone and Metabolic Research. 47, 6, p. 439-444 6 p.

Research output: Contribution to journalArticle

Hyperandrogenism
Interleukin-6
Fasting
Inflammation
Glucose
9 Citations (Scopus)

Leucine modulates dynamic phosphorylation events in insulin signaling pathway and enhances insulin-dependent glycogen synthesis in human skeletal muscle cells

Di Camillo, B., Eduati, F., Nair, K. S., Avogaro, A. & Toffolo, G. M., Mar 20 2014, In : BMC Cell Biology. 15, 1, 9.

Research output: Contribution to journalArticle

Glycogen
Leucine
Muscle Cells
Skeletal Muscle
Phosphorylation
354 Citations (Scopus)

Protein intake and exercise for optimal muscle function with aging: Recommendations from the ESPEN Expert Group

Deutz, N. E. P., Bauer, J. M., Barazzoni, R., Biolo, G., Boirie, Y., Bosy-Westphal, A., Cederholm, T., Cruz-Jentoft, A., Krznariç, Z., Nair, K. S., Singer, P., Teta, D., Tipton, K. & Calder, P. C., Dec 1 2014, In : Clinical Nutrition. 33, 6, p. 929-936 8 p.

Research output: Contribution to journalArticle

Exercise
Muscles
Sarcopenia
Proteins
Muscle Strength
1 Citation (Scopus)

Statement of principle

Cefalu, W. T., Nair, K. S., Seaquist, E. R., Zierath, J., Boulton, A. J. M., LeRoith, D., Harrell, R. M., Grunberger, G., Wartofsky, L., Gore, A. C., Wierman, M. E., Hammes, S. R., Lange, C. A. & Santen, R. J., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. 4376 1 p.

Research output: Contribution to journalArticle