• 20350 Citations
  • 79 Scopus h-Index
1974 …2020

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2020

GDF15 mediates the effects of metformin on body weight and energy balance

Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., Goldspink, D. A., Miedzybrodzka, E. L., Konopka, A. R., Esponda, R. R., Huang, J. T. J., Tung, Y. C. L., Rodriguez-Cuenca, S., Tomaz, R. A., Harding, H. P., Melvin, A. & 13 others, Yeo, G. S. H., Preiss, D., Vidal-Puig, A., Vallier, L., Nair, K. S., Wareham, N. J., Ron, D., Gribble, F. M., Reimann, F., Sattar, N., Savage, D. B., Allan, B. B. & O’Rahilly, S., Feb 20 2020, In : Nature. 578, 7795, p. 444-448 5 p.

Research output: Contribution to journalArticle

17 Scopus citations

Higher unacylated ghrelin and insulin sensitivity following dietary restriction and weight loss in obese humans

Barazzoni, R., Gortan Cappellari, G., Zanetti, M., Klaus, K. A., Semolic, A., Johnson, M. L. & Nair, K. S., 2020, (Accepted/In press) In : Clinical Nutrition.

Research output: Contribution to journalArticle

Time-Restricted Eating Effects on Body Composition and Metabolic Measures in Humans who are Overweight: A Feasibility Study

Chow, L. S., Manoogian, E. N. C., Alvear, A., Fleischer, J. G., Thor, H., Dietsche, K., Wang, Q., Hodges, J. S., Esch, N., Malaeb, S., Harindhanavudhi, T., Nair, K. S., Panda, S. & Mashek, D. G., May 1 2020, In : Obesity. 28, 5, p. 860-869 10 p.

Research output: Contribution to journalArticle

3 Scopus citations
2019

AMPK and PPARβ positive feedback loop regulates endurance exercise training-mediated GLUT4 expression in skeletal muscle

Koh, J. H., Hancock, C. R., Han, D. H., Holloszy, J. O., Nair, K. S. & Dasari, S., May 1 2019, In : American journal of physiology. Endocrinology and metabolism. 316, 5, p. E931-E939

Research output: Contribution to journalArticle

4 Scopus citations

Exercise and metformin counteract altered mitochondrial function in the insulinresistant brain

Ruegsegger, G. N., Vanderboom, P. M., Dasari, S., Klaus, K. A., Kabiraj, P., McCarthy, C. B., Lucchinetti, C. F. & Nair, K. S., Sep 19 2019, In : JCI Insight. 4, 18, e130681.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

FOXO transcription factors are critical regulators of diabetes-related muscle atrophy

O’Neill, B. T., Bhardwaj, G., Penniman, C. M., Krumpoch, M. T., Suarez Beltran, P. A., Klaus, K., Poro, K., Li, M., Pan, H., Dreyfuss, J. M., Nair, K. S. & Ronald Kahn, C., Mar 1 2019, In : Diabetes. 68, 3, p. 556-570 15 p.

Research output: Contribution to journalArticle

13 Scopus citations

Insulin deficiency and intranasal insulin alter brain mitochondrial function: a potential factor for dementia in diabetes

Ruegsegger, G. N., Manjunatha, S., Summer, P., Gopala, S., Zabeilski, P., Dasari, S., Vanderboom, P. M., Lanza, I. R., Klaus, K. A. & Nair, K. S., Mar 1 2019, In : FASEB Journal. 33, 3, p. 4458-4472 15 p.

Research output: Contribution to journalArticle

5 Scopus citations

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force

Ferreira, D. M. S., Cheng, A. J., Agudelo, L. Z., Cervenka, I., Chaillou, T., Correia, J. C., Porsmyr-Palmertz, M., Izadi, M., Hansson, A., Martínez-Redondo, V., Valente-Silva, P., Pettersson-Klein, A. T., Estall, J. L., Robinson, M. M., Nair, K. S., Lanner, J. T. & Ruas, J. L., Oct 31 2019, In : Skeletal Muscle. 9, 1, 26.

Research output: Contribution to journalArticle

Open Access

Mitochondrial Morphology, Dynamics, and Function in Human Pressure Overload or Ischemic Heart Disease With Preserved or Reduced Ejection Fraction

Chaanine, A. H., Joyce, L. D., Stulak, J. M., Maltais, S., Joyce, D., Dearani, J., Klaus, K., Nair, K. S., Hajjar, R. J. & Redfield, M. M., Feb 1 2019, In : Circulation. Heart failure. 12, 2, p. e005131

Research output: Contribution to journalArticle

9 Scopus citations

Sex-specific effects of dehydroepiandrosterone (DHEA) on bone mineral density and body composition: A pooled analysis of four clinical trials

Jankowski, C. M., Wolfe, P., Schmiege, S. J., Nair, K. S., Khosla, S., Jensen, M., von Muhlen, D., Laughlin, G. A., Kritz-Silverstein, D., Bergstrom, J., Bettencourt, R., Weiss, E. P., Villareal, D. T. & Kohrt, W. M., Feb 1 2019, In : Clinical Endocrinology. 90, 2, p. 293-300 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

TFAM enhances fat oxidation and attenuates high-fat diet-induced insulin resistance in skeletal muscle

Koh, J. H., Johnson, M. L., Dasari, S., LeBrasseur, N. K., Vuckovic, I., Henderson, G. C., Cooper, S. A., Manjunatha, S., Ruegsegger, G. N., Shulman, G. I., Lanza, I. R. & Nair, K. S., Aug 1 2019, In : Diabetes. 68, 8, p. 1552-1564 13 p.

Research output: Contribution to journalArticle

4 Scopus citations
2018

A novel triple-tracer approach to assess postprandial protein turnover

Moran, A., Toffolo, G., Schiavon, M., Vella, A., Klaus, K., Cobelli, C. & Nair, K. S., Oct 1 2018, In : American Journal of Physiology - Endocrinology and Metabolism. 315, 4, p. E469-E477

Research output: Contribution to journalArticle

2 Scopus citations

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

4 Scopus citations

Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies

Gonsalves, W. I., Ramakrishnan, V., Hitosugi, T., Ghosh, T., Jevremovic, D., Dutta, T., Sakrikar, D., Petterson, X. M., Wellik, L., Kumar, S. K. & Nair, K. S., Jan 11 2018, In : JCI Insight. 3, 1

Research output: Contribution to journalArticle

Open Access
6 Scopus citations
8 Scopus citations
2017

A longitudinal study of whole body, tissue, and cellular physiology in a mouse model of fibrosing NASH with high fidelity to the human condition

Krishnan, A., Abdullah, T. S., Mounajjed, T., Hartono, S., McConico, A., White, T., LeBrasseur, N., Lanza, I., Nair, S., Gores, G. & Charlton, M. R., Jun 8 2017, In : American Journal of Physiology - Gastrointestinal and Liver Physiology. 312, 6, p. G666-G680

Research output: Contribution to journalArticle

21 Scopus citations
16 Scopus citations

Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

Robinson, M. M., Dasari, S., Konopka, A. R., Johnson, M. L., Manjunatha, S., Esponda, R. R., Carter, R. E., Lanza, I. R. & Nair, K. S., Mar 7 2017, In : Cell Metabolism. 25, 3, p. 581-592 12 p.

Research output: Contribution to journalArticle

131 Scopus citations

Mitochondrial Integrity and Function in the Progression of Early Pressure Overload-Induced Left Ventricular Remodeling

Chaanine, A. H., Sreekumaran Nair, K., Bergen, R. H., Klaus, K., Guenzel, A. J., Hajjar, R. J. & Redfield, M. M., Jun 15 2017, In : Journal of the American Heart Association. 6, 6

Research output: Contribution to journalArticle

12 Scopus citations
2016

1α,25-dihydroxyvitamin D3 regulates mitochondrial oxygen consumption and dynamics in human skeletal muscle cells

Ryan, Z. C., Craig, T. A., Folmes, C. D., Wang, X., Lanza, I. R., Schaible, N. S., Salisbury, J. L., Nair, K. S., Terzic, A., Sieck, G. C. & Kumar, R., Jan 15 2016, In : Journal of Biological Chemistry. 291, 3, p. 1514-1528 15 p., 15.

Research output: Contribution to journalArticle

64 Scopus citations

Altered skeletal muscle mitochondrial proteome as the basis of disruption of mitochondrial function in diabetic mice

Zabielski, P., Lanza, I. R., Gopala, S., Heppelmann, C. J. H., Bergen, H. R., Dasari, S. & Nair, K. S., Mar 2016, In : Diabetes. 65, 3, p. 561-573 13 p.

Research output: Contribution to journalArticle

14 Scopus citations
5 Scopus citations

Effect of dehydroepiandrosterone and testosterone supplementation on systemic lipolysis

Espinosa De Ycaza, A. E., Rizza, R. A., Nair, K. S. & Jensen, M. D., Apr 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 4, p. 1719-1728 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

FOXO3A regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

Chaanine, A. H., Kohlbrenner, E., Gamb, S. I., Guenzel, A. J., Klaus, K., Fayyaz, A. U., Nair, K. S., Hajjar, R. J. & Redfield, M. M., Dec 1 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 6, p. H1540-H1559

Research output: Contribution to journalArticle

19 Scopus citations

Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus

Manjunatha, S., Distelmaier, K., Dasari, S., Carter, R. E., Kudva, Y. C. & Nair, K. S., Sep 1 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

26 Scopus citations

Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in Prediabetes

Konopka, A. R., Esponda, R. R., Robinson, M. M., Johnson, M. L., Carter, R. E., Schiavon, M., Cobelli, C., Wondisford, F. E., Lanza, I. R. & Nair, K. S., May 17 2016, In : Cell Reports. 15, 7, p. 1394-1400 7 p.

Research output: Contribution to journalArticle

20 Scopus citations

Impact of long-term poor and good glycemic control on metabolomics alterations in type 1 diabetic people

Dutta, T., Kudva, Y. C., Persson, X. M. T., Schenck, L. A., Charles Ford, G., Singh, R. J., Carter, R. E. & Nair, K. S., Mar 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 4, p. 1023-1033 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

O'Neill, B. T., Lee, K. Y., Klaus, K., Softic, S., Krumpoch, M. T., Fentz, J., Stanford, K. I., Robinson, M. M., Cai, W., Kleinridders, A., Pereira, R. O., Hirshman, M. F., Abel, E. D., Accili, D., Goodyear, L. J., Nair, K. S. & Kahn, C. R., Sep 1 2016, In : Journal of Clinical Investigation. 126, 9, p. 3433-3446 14 p.

Research output: Contribution to journalArticle

41 Scopus citations

John Stuart Garrow, MD, PhD, FRCP(E), FRCP (London) (1929-2016)

Bray, G. A. & Nair, S., 2016, (Accepted/In press) In : Obesity.

Research output: Contribution to journalArticle

Mechanism by which caloric restriction improves insulin sensitivity in sedentary obese adults

Johnson, M. L., Distelmaier, K., Lanza, I. R., Irving, B. A., Robinson, M. M., Konopka, A. R., Shulman, G. I. & Nair, K. S., Jan 1 2016, In : Diabetes. 65, 1, p. 74-84 11 p.

Research output: Contribution to journalArticle

46 Scopus citations

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

Sud, M., Fahy, E., Cotter, D., Azam, K., Vadivelu, I., Burant, C., Edison, A., Fiehn, O., Higashi, R., Nair, K. S., Sumner, S. & Subramaniam, S., 2016, In : Nucleic acids research. 44, D1, p. D463-D470

Research output: Contribution to journalArticle

164 Scopus citations

Predictors of whole-body insulin sensitivity across ages and adiposity in adult humans

Lalia, A. Z., Dasari, S., Johnson, M. L., Robinson, M. M., Konopka, A. R., DIstelmaier, K., Port, J. D., Glavin, M. T., Esponda, R. R., Nair, K. S. & Lanza, I. R., Feb 1 2016, In : Journal of Clinical Endocrinology and Metabolism. 101, 2, p. 626-634 9 p.

Research output: Contribution to journalArticle

26 Scopus citations
10 Scopus citations
2015

Application of high-resolution mass spectrometry to measure low abundance isotope enrichment in individual muscle proteins

Hines, K. M., Ford, G. C., Klaus, K. A., Irving, B. A., Ford, B. L., Johnson, K. L., Lanza, I. R. & Nair, K. S., May 28 2015, In : Analytical and Bioanalytical Chemistry. 407, 14, p. 4045-4052 8 p., 8641.

Research output: Contribution to journalArticle

6 Scopus citations

Association of UCP-3 rs1626521 with obesity and stomach functions in humans

Acosta, A., Camilleri, M., Shin, A., Vazquez-Roque, M. I., Iturrino, J., Lanza, I. R., Nair, K. S., Burton, D., O'Neill, J., Eckert, D., Carlson, P., Vella, A. & Zinsmeister, A. R., Apr 1 2015, In : Obesity. 23, 4, p. 898-906 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Citrulline stimulates muscle protein synthesis in the post-absorptive state in healthy people fed a low-protein diet - A pilot study

Jourdan, M., Nair, K. S., Carter, R. E., Schimke, J., Ford, G. C., Marc, J., Aussel, C. & Cynober, L., Jun 1 2015, In : Clinical Nutrition. 34, 3, p. 449-456 8 p.

Research output: Contribution to journalArticle

29 Scopus citations

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age

Irving, B. A., Lanza, I. R., Henderson, G. C., Rao, R. R., Spiegelman, B. M. & Sreekumaran Nair, K., Apr 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 4, p. 1654-1663 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean phenotype with aerobic exercise training

Konopka, A. R., Asante, A., Lanza, I. R., Robinson, M. M., Johnson, M. L., Dalla Man, C., Cobelli, C., Amols, M. H., Irving, B. A. & Nair, K. S., Jun 1 2015, In : Diabetes. 64, 6, p. 2104-2115 12 p.

Research output: Contribution to journalArticle

44 Scopus citations

Detection and quantitation of circulating human irisin by tandem mass spectrometry

Jedrychowski, M. P., Wrann, C. D., Paulo, J. A., Gerber, K. K., Szpyt, J., Robinson, M. M., Nair, K. S., Gygi, S. P. & Spiegelman, B. M., Oct 6 2015, In : Cell Metabolism. 22, 4, p. 734-740 7 p.

Research output: Contribution to journalArticle

216 Scopus citations

Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging

Johnson, M. L., Irving, B. A., Lanza, I. R., Vendelbo, M. H., Konopka, A. R., Robinson, M. M., Henderson, G. C., Klaus, K. A., Morse, D. M., Heppelmann, C., Bergen, H. R. B. III., Dasari, S., Schimke, J. M., Jakaitis, D. R. & Nair, K. S., Nov 1 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1386-1393 8 p.

Research output: Contribution to journalArticle

36 Scopus citations

Effect of insulin sensitizer therapy on amino acids and their metabolites

Irving, B. A., Carter, R. E., Soop, M., Weymiller, A., Syed, H., Karakelides, H., Bhagra, S., Short, K. R., Tatpati, L., Barazzoni, R. & Nair, K. S., Jun 1 2015, In : Metabolism: Clinical and Experimental. 64, 6, p. 720-728 9 p.

Research output: Contribution to journalArticle

36 Scopus citations

Mitochondrial Aging and Physical Decline: Insights From Three Generations of Women

Hebert, S. L., Marquet-De Rougé, P., Lanza, I. R., McCrady-Spitzer, S. K., Levine, J. A., Middha, S., Carter, R. E., Klaus, K. A., Therneau, T. M., Highsmith, E. W. & Nair, K. S., Nov 2015, In : Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 70, 11, p. 1409-1417 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Statement of principle

Cefalu, W. T., Nair, K. S., Seaquist, E. R., Zierath, J., Boulton, A. J. M., LeRoith, D., Harrell, R. M., Grunberger, G., Wartofsky, L., Gore, A. C., Wierman, M. E., Hammes, S. R., Lange, C. A. & Santen, R. J., Feb 1 2015, In : Hormones and Cancer. 6, 1, p. 1 1 p.

Research output: Contribution to journalArticle

2014

Adipocyte mitochondrial function is reduced in human obesity independent of fat cell size

Xiao, Y. X., Lanza, I. R., Swain, J. M., Sarr, M. G., Nair, K. S. & Jensen, M. D., Feb 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 2, p. E209-E216

Research output: Contribution to journalArticle

80 Scopus citations

Altered regulation of energy homeostasis in older rats in response to thyroid hormone administration

Walrand, S., Short, K. R., Heemstra, L. A., Novak, C. M., Levine, J. A., Coenen-Schimke, J. M. & Nair, K. S., Mar 2014, In : FASEB Journal. 28, 3, p. 1499-1510 12 p.

Research output: Contribution to journalArticle

9 Scopus citations
13 Scopus citations

Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling

Vendelbo, M. H., Møller, A. B., Christensen, B., Nellemann, B., Clasen, B. F. F., Nair, K. S., Jørgensen, J. O. L., Jessen, N. & Møller, N., Jul 14 2014, In : PloS one. 9, 7, e102031.

Research output: Contribution to journalArticle

32 Scopus citations

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, J. P., Wrann, C. D., Rao, R. R., Nair, S. K., Jedrychowski, M. P., You, J. S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., Wu, Z., Glass, D. J., Piao, X. & Spiegelman, B. M., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. 15756-15761 6 p.

Research output: Contribution to journalArticle

44 Scopus citations

High insulin combined with essential amino acids stimulates skeletal muscle mitochondrial protein synthesis while decreasing insulin sensitivity in healthy humans

Robinson, M. M., Soop, M., Sohn, T. S., Morse, D. M., Schimke, J. M., Klaus, K. A. & Nair, K. S., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. E2574-E2583

Research output: Contribution to journalArticle

31 Scopus citations