• 20609 Citations
  • 80 Scopus h-Index
1974 …2020

Research output per year

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Research Output

Article

Effects of Adiposity and 30 Days of Caloric Restriction Upon Protein Metabolism in Moderately vs. Severely Obese Women

Henderson, G. C., Nadeau, D., Horton, E. S. & Nair, K. S., 2010, In : Obesity. 18, 6, p. 1135-1142 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

Effects of aging on in vivo synthesis of skeletal muscle myosin heavy- chain and sarcoplasmic protein in humans

Balagopal, P., Rooyackers, O. E., Adey, D. B., Ades, P. A. & Nair, K. S., 1997, In : American Journal of Physiology - Endocrinology and Metabolism. 273, 4 36-4, p. E790-E800

Research output: Contribution to journalArticle

434 Scopus citations

Effects of aging on mitochondrial DNA copy number and cytochrome c oxidase gene expression in rat skeletal muscle, liver, and heart

Barazzoni, R., Short, K. R. & Nair, K. S., Feb 4 2000, In : Journal of Biological Chemistry. 275, 5, p. 3343-3347 5 p.

Research output: Contribution to journalArticle

265 Scopus citations

Effects of caloric restriction on mitochondrial function and gene transcripts in rat muscle

Sreekumar, R., Unnikrishnan, J., Fu, A., Nygren, J., Short, K. R., Schimke, J., Barazzoni, R. & Nair, K. S., 2002, In : American Journal of Physiology - Endocrinology and Metabolism. 283, 1 46-1, p. E38-E43

Research output: Contribution to journalArticle

134 Scopus citations

Effects of free fatty acids and glycerol on splanchnic glucose metabolism and insulin extraction in nondiabetic humans

Shah, P., Vella, A., Basu, A., Basu, R., Adkins, A., Frederick Schwenk, W., Michael Johnson, C., Sreekumaran Nair, K., Jensen, M. D. & Rizza, R. A., 2002, In : Diabetes. 51, 2, p. 301-310 10 p.

Research output: Contribution to journalArticle

Open Access
60 Scopus citations

Effects of GH on urea, glucose and lipid metabolism, and insulin sensitivity during fasting in GH-deficient patients

Nørrelund, H., Djurhuus, C., Jørgensen, J. O. L., Nielsen, S., Nair, K. S., Schmitz, O., Christiansen, J. S. & Møller, N., Oct 1 2003, In : American Journal of Physiology - Endocrinology and Metabolism. 285, 4 48-4, p. E737-E743

Research output: Contribution to journalArticle

33 Scopus citations

Effects of growth hormone administration on protein dynamics and substrate metabolism during 4 weeks of dietary restriction in obese women

Nørrelund, H., Børglum, J., Jørgensen, J. O. L., Richelsen, B., Møller, N., Nair, K. S. & Christiansen, J. S., Apr 5 2000, In : Clinical Endocrinology. 52, 3, p. 305-312 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Effects of insulin deprivation and treatment on homocysteine metabolism in people with type 1 diabetes

Abu-Lebdeh, H. S., Barazzoni, R., Meek, S. E., Bigelow, M. L., Persson, X. M. T. & Nair, K. S., Jan 1 2006, In : Journal of Clinical Endocrinology and Metabolism. 91, 9, p. 3344-3348 5 p.

Research output: Contribution to journalArticle

25 Scopus citations
9 Scopus citations

Effects of lowering circulating free fatty acid levels on protein metabolism in adult growth hormone deficient patients

Nielsen, S., Jørgensen, J. O. L., Hartmund, T., Nørrelund, H., Nair, K. S., Christiansen, J. S. & Møller, N., Dec 2002, In : Growth Hormone and IGF Research. 12, 6, p. 425-433 9 p.

Research output: Contribution to journalArticle

13 Scopus citations

Effects of testosterone replacement on muscle mass and muscle protein synthesis in hypogonadal men - A clinical research center study

Brodsky, I. G., Balagopal, P. & Nair, K. S., Oct 21 1996, In : Journal of Clinical Endocrinology and Metabolism. 81, 10, p. 3469-3475 7 p.

Research output: Contribution to journalArticle

333 Scopus citations

Effects of type 2 diabetes and insulin on whole-body, splanchnic, and leg protein metabolism

Short, K. R., Irving, B. A., Basu, A., Johnson, C. M., Nair, K. S. & Basu, R., Dec 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 12, p. 4733-4741 9 p.

Research output: Contribution to journalArticle

4 Scopus citations

Effects of type 2 diabetes on the ability of insulin and glucose to regulate splanchnic and muscle glucose metabolism: Evidence for a defect in hepatic glucokinase activity

Basu, A., Basu, R., Shah, P., Vella, A., Johnson, C. M., Nair, K. S., Jensen, M. D., Schwenk, W. F. & Rizza, R. A., Feb 2000, In : Diabetes. 49, 2, p. 272-283 12 p.

Research output: Contribution to journalArticle

Open Access
146 Scopus citations

Effects on lipoprotein particles of long-term dehydroepiandrosterone in elderly men and women and testosterone in elderly men

Srinivasan, M., Irving, B. A., Frye, R. L., O'Brien, P., Hartman, S. J., McConnell, J. P. & Nair, K. S., Apr 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 4, p. 1617-1625 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Electron spray ionization mass spectrometry and 2D 31P NMR for monitoring 18O/16O isotope exchange and turnover rates of metabolic oligophosphates

Nemutlu, E., Juranic, N., Zhang, S., Ward, L. E., Dutta, T., Sreekumaran Nair, K., Terzic, A., Macura, S. & Dzeja, P. P., May 2012, In : Analytical and bioanalytical chemistry. 403, 3, p. 697-706 10 p.

Research output: Contribution to journalArticle

8 Scopus citations

Elevated free fatty acids impair glucose metabolism in women: Decreased stimulation of muscle glucose uptake and suppression of splanchnic glucose production during combined hyperinsulinemia and hyperglycemia

Shah, P., Vella, A., Basu, A., Basu, R., Adkins, A., Frederick Schwenk, W., Johnson, C. M., Sreekumaran Nair, K., Jensen, M. D. & Rizza, R. A., Jan 1 2003, In : Diabetes. 52, 1, p. 38-42 5 p.

Research output: Contribution to journalArticle

35 Scopus citations

Endurance exercise as a countermeasure for aging

Lanza, I. R., Short, D. K., Short, K. R., Raghavakaimal, S., Basu, R., Joyner, M. J., McConnell, J. P. & Nair, K. S., Nov 2008, In : Diabetes. 57, 11, p. 2933-2942 10 p.

Research output: Contribution to journalArticle

340 Scopus citations

Energy expenditure in uncontrolled insulin dependent diabetic patients

Nair, K. S., Garrow, J. S., Halliday, D. & Mahler, R. F., Jan 1 1983, In : Clinical Science. 64, 2, p. No.67

Research output: Contribution to journalArticle

Enhanced Protein Translation Underlies Improved Metabolic and Physical Adaptations to Different Exercise Training Modes in Young and Old Humans

Robinson, M. M., Dasari, S., Konopka, A. R., Johnson, M. L., Manjunatha, S., Esponda, R. R., Carter, R. E., Lanza, I. R. & Nair, K. S., Mar 7 2017, In : Cell Metabolism. 25, 3, p. 581-592 12 p.

Research output: Contribution to journalArticle

136 Scopus citations

Enhancement of muscle mitochondrial function by growth hormone

Short, K. R., Moller, N., Bigelow, M. L., Coenen-Schimke, J. & Nair, K. S., Feb 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 2, p. 597-604 8 p.

Research output: Contribution to journalArticle

59 Scopus citations

eNOS gene transfer to vascular smooth muscle cells inhibits cell proliferation via upregulation of p27 and p21 and not apoptosis

Sato, J., Nair, K., Hiddinga, J., Eberhardt, N. L., Fitzpatrick, L. A., Katusic, Z. S. & O'Brien, T., Sep 1 2000, In : Cardiovascular research. 47, 4, p. 697-706 10 p.

Research output: Contribution to journalArticle

68 Scopus citations

Evidence for a catabolic role of glucagon during an amino acid load

Charlton, M. R., Adey, D. B. & Nair, K. S., Jul 1 1996, In : Journal of Clinical Investigation. 98, 1, p. 90-99 10 p.

Research output: Contribution to journalArticle

Open Access
80 Scopus citations

Exercise and metformin counteract altered mitochondrial function in the insulinresistant brain

Ruegsegger, G. N., Vanderboom, P. M., Dasari, S., Klaus, K. A., Kabiraj, P., McCarthy, C. B., Lucchinetti, C. F. & Nair, K. S., Sep 19 2019, In : JCI Insight. 4, 18, e130681.

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

Exercise increases fat oxidation at rest unrelated to changes in energy balance or lipolysis

Calles-Escandón, J., Goran, M. I., O'Connell, M., Sreekumaran Nair, K. & Danforth, E., Jun 1996, In : American Journal of Physiology - Endocrinology and Metabolism. 270, 6 33-6, p. E1009-E1014

Research output: Contribution to journalArticle

46 Scopus citations

Failure of carbohydrate to spare leucine oxidation in obese subjects

Nair, K. S., Halliday, D., Ford, G. C., Heels, S. & Garrow, J. S., Dec 1 1987, In : International Journal of Obesity. 11, 5, p. 537-544 8 p.

Research output: Contribution to journalArticle

11 Scopus citations
16 Scopus citations

Failure of glyburide and insulin treatment to decrease leucine flux in obese type II diabetic patients

Welle, S. & Nair, K. S., 1990, In : International Journal of Obesity. 14, 8, p. 701-710 10 p.

Research output: Contribution to journalArticle

31 Scopus citations

Failure of insulin infusion to stimulate fractional muscle protein synthesis in type I diabetic patients. Anabolic effect of insulin and decreased proteolysis

Pacy, P. J., Nair, K. S., Ford, C. & Halliday, D., Jan 1 1989, In : Diabetes. 38, 5, p. 618-624 7 p.

Research output: Contribution to journalArticle

78 Scopus citations

Fasting increases human skeletal muscle net phenylalanine release and this is associated with decreased mTOR signaling

Vendelbo, M. H., Møller, A. B., Christensen, B., Nellemann, B., Clasen, B. F. F., Nair, K. S., Jørgensen, J. O. L., Jessen, N. & Møller, N., Jul 14 2014, In : PloS one. 9, 7, e102031.

Research output: Contribution to journalArticle

32 Scopus citations

Fatty acid metabolism in the elderly: Effects of dehydroepiandrosterone and testosterone replacement in hormonally deficient men and women

Koutsari, C., Ali, A. H., Nair, K. S., Rizza, R. A., O'Brien, P., Khosla, S. & Jensen, M. D., Sep 2009, In : Journal of Clinical Endocrinology and Metabolism. 94, 9, p. 3414-3423 10 p.

Research output: Contribution to journalArticle

21 Scopus citations

First and second trimester urinary metabolic profiles and fetal growth restriction: An exploratory nested case-control study within the infant development and environment study

Luthra, G., Vuckovic, I., Bangdiwala, A., Gray, H., Redmon, J. B., Barrett, E. S., Sathyanarayana, S., Nguyen, R. H. N., Swan, S. H., Zhang, S., Dzeja, P., Macura, S. I. & Nair, K. S., Feb 8 2018, In : BMC Pregnancy and Childbirth. 18, 1, 48.

Research output: Contribution to journalArticle

4 Scopus citations

FOXO3A regulates BNIP3 and modulates mitochondrial calcium, dynamics, and function in cardiac stress

Chaanine, A. H., Kohlbrenner, E., Gamb, S. I., Guenzel, A. J., Klaus, K., Fayyaz, A. U., Sreekumaran Nair, K., Hajjar, R. J. & Redfield, M. M., Dec 2016, In : American Journal of Physiology - Heart and Circulatory Physiology. 311, 6, p. H1540-H1559

Research output: Contribution to journalArticle

Open Access
19 Scopus citations

FOXO transcription factors are critical regulators of diabetes-related muscle atrophy

O’Neill, B. T., Bhardwaj, G., Penniman, C. M., Krumpoch, M. T., Suarez Beltran, P. A., Klaus, K., Poro, K., Li, M., Pan, H., Dreyfuss, J. M., Sreekumaran Nair, K. & Ronald Kahn, C., Mar 1 2019, In : Diabetes. 68, 3, p. 556-570 15 p.

Research output: Contribution to journalArticle

18 Scopus citations

Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus

Manjunatha, S., Distelmaier, K., Dasari, S., Carter, R. E., Kudva, Y. C. & Nair, K. S., Sep 1 2016, In : Metabolism: Clinical and Experimental. 65, 9, p. 1421-1431 11 p.

Research output: Contribution to journalArticle

27 Scopus citations

Functional heterogeneity of leucine pools in human skeletal muscle

Ljungqvist, O. H., Persson, M., Charles Ford, G. & Sreekumaran Nair, K., Dec 1 1997, In : American Journal of Physiology. 273, 3 PART 1, p. E521-E527

Research output: Contribution to journalArticle

8 Scopus citations

Functional heterogeneity of leucine pools in human skeletal muscle

Ljungqvist, O. H., Persson, M., Ford, G. C. & Nair, K. S., Sep 1997, In : American Journal of Physiology - Endocrinology and Metabolism. 273, 3 36-3, p. E564-E570

Research output: Contribution to journalArticle

83 Scopus citations

Functional impact of high protein intake on healthy elderly people

Walrand, S., Short, K. R., Bigelow, M. L., Sweatt, A. J., Hutson, S. M. & Nair, K. S., Oct 2008, In : American Journal of Physiology - Endocrinology and Metabolism. 295, 4, p. E921-E928

Research output: Contribution to journalArticle

79 Scopus citations

Function-based discovery of significant transcriptional temporal patterns in insulin stimulated muscle cells

Di Camillo, B., Irving, B. A., Schimke, J., Sanavia, T., Toffolo, G., Cobelli, C. & Nair, K. S., Mar 1 2012, In : PloS one. 7, 3, e32391.

Research output: Contribution to journalArticle

8 Scopus citations

GDF15 mediates the effects of metformin on body weight and energy balance

Coll, A. P., Chen, M., Taskar, P., Rimmington, D., Patel, S., Tadross, J. A., Cimino, I., Yang, M., Welsh, P., Virtue, S., Goldspink, D. A., Miedzybrodzka, E. L., Konopka, A. R., Esponda, R. R., Huang, J. T. J., Tung, Y. C. L., Rodriguez-Cuenca, S., Tomaz, R. A., Harding, H. P., Melvin, A. & 13 others, Yeo, G. S. H., Preiss, D., Vidal-Puig, A., Vallier, L., Nair, K. S., Wareham, N. J., Ron, D., Gribble, F. M., Reimann, F., Sattar, N., Savage, D. B., Allan, B. B. & O’Rahilly, S., Feb 20 2020, In : Nature. 578, 7795, p. 444-448 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

Gene expression profile in skeletal muscle of type 2 diabetes and the effect of insulin treatment

Sreekumar, R., Halvatsiotis, P., Schimke, J. C. & Sreekumaran Nair, K., 2002, In : Diabetes. 51, 6, p. 1913-1920 8 p.

Research output: Contribution to journalArticle

Open Access
208 Scopus citations

Glutamine-derived 2-hydroxyglutarate is associated with disease progression in plasma cell malignancies

Gonsalves, W. I., Ramakrishnan, V., Hitosugi, T., Ghosh, T., Jevremovic, D., Dutta, T., Sakrikar, D., Petterson, X. M., Wellik, L., Kumar, S. K. & Nair, K. S., Jan 11 2018, In : JCI Insight. 3, 1

Research output: Contribution to journalArticle

Open Access
7 Scopus citations

G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy

White, J. P., Wrann, C. D., Rao, R. R., Nair, S. K., Jedrychowski, M. P., You, J. S., Martínez-Redondo, V., Gygi, S. P., Ruas, J. L., Hornberger, T. A., Wu, Z., Glass, D. J., Piao, X. & Spiegelman, B. M., Nov 4 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 44, p. 15756-15761 6 p.

Research output: Contribution to journalArticle

45 Scopus citations

Heated dorsal hand vein sampling for metabolic studies: A reappraisal

Copeland, K. C., Kenney, F. A. & Nair, K. S., 1992, In : American Journal of Physiology - Endocrinology and Metabolism. 263, 5 26-5, p. E1010-E1014

Research output: Contribution to journalArticle

97 Scopus citations

Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements

Henderson, G. C., Dhatariya, K., Ford, G. C., Klaus, K. A., Basu, R., Rizza, R. A., Jensen, M. D., Khosla, S., O'Brien, P. & Nair, K. S., Feb 2009, In : FASEB Journal. 23, 2, p. 631-641 11 p.

Research output: Contribution to journalArticle

62 Scopus citations

Higher unacylated ghrelin and insulin sensitivity following dietary restriction and weight loss in obese humans

Barazzoni, R., Gortan Cappellari, G., Zanetti, M., Klaus, K. A., Semolic, A., Johnson, M. L. & Nair, K. S., 2020, (Accepted/In press) In : Clinical Nutrition.

Research output: Contribution to journalArticle

High insulin combined with essential amino acids stimulates skeletal muscle mitochondrial protein synthesis while decreasing insulin sensitivity in healthy humans

Robinson, M. M., Soop, M., Sohn, T. S., Morse, D. M., Schimke, J. M., Klaus, K. A. & Nair, K. S., Dec 1 2014, In : Journal of Clinical Endocrinology and Metabolism. 99, 12, p. E2574-E2583

Research output: Contribution to journalArticle

31 Scopus citations

High-performance liquid chromatographic technique for non-derivatized leucine purification: evidence for carbon isotope fractionation

Baumann, P. Q., Ebenstein, D. B., O'Rourke, B. D. & Nair, K. S., Jan 3 1992, In : Journal of Chromatography B: Biomedical Sciences and Applications. 573, 1, p. 11-16 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Hormonal and signaling role of branched-chain amino acids

Nair, K. S. & Short, K. R., Jun 2005, In : Journal of Nutrition. 135, 6 SUPPL., p. 1547S-1552S

Research output: Contribution to journalArticle

Open Access
84 Scopus citations

Hyperandrogenism sensitizes leukocytes to hyperglycemia to promote oxidative stress in lean reproductive-age women

González, F., Nair, K. S., Daniels, J. K., Basal, E., Schimke, J. M. & Blair, H. E., Aug 2012, In : Journal of Clinical Endocrinology and Metabolism. 97, 8, p. 2836-2843 8 p.

Research output: Contribution to journalArticle

46 Scopus citations

Hyperandrogenism sensitizes mononuclear cells to promote glucose-induced inflammation in lean reproductive-age women

González, F., Sreekumaran Nair, K., Daniels, J. K., Basal, E. & Schimke, J. M., Feb 2012, In : American Journal of Physiology - Endocrinology and Metabolism. 302, 3, p. 297-306 10 p.

Research output: Contribution to journalArticle

40 Scopus citations