• 7038 Citations
  • 41 Scopus h-Index
1983 …2020
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Research Output 1983 2018

  • 7038 Citations
  • 41 Scopus h-Index
  • 88 Article
  • 1 Chapter
  • 1 Review article
2018
4 Citations (Scopus)

A Novel Signaling Complex between TROY and EGFR Mediates Glioblastoma Cell Invasion

Ding, Z., Roos, A., Kloss, J., Dhruv, H., Peng, S., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Feb 1 2018, In : Molecular Cancer Research. 16, 2, p. 322-332 11 p.

Research output: Contribution to journalArticle

Glioblastoma
temozolomide
Neoplasms
Epidermal Growth Factor
Survival
3 Citations (Scopus)

EGFRvIII–Stat5 signaling enhances glioblastoma cell migration and survival

Roos, A., Dhruv, H. D., Peng, S., Inge, L. J., Tuncali, S., Pineda, M., Millard, N., Mayo, Z., Eschbacher, J. M., Loftus, J. C., Winkles, J. A. & Tran, N., Jul 1 2018, In : Molecular Cancer Research. 16, 7, p. 1185-1195 11 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Movement
Cell Survival
Neoplasms
Pimozide

PDZ-RhoGEF Is a Signaling Effector for TROY-Induced Glioblastoma Cell Invasion and Survival

Ding, Z., Dhruv, H., Kwiatkowska-Piwowarczyk, A., Ruggieri, R., Kloss, J., Symons, M., Pirrotte, P., Eschbacher, J. M., Tran, N. & Loftus, J. C., Oct 1 2018, In : Neoplasia (United States). 20, 10, p. 1045-1058 14 p.

Research output: Contribution to journalArticle

Rho Guanine Nucleotide Exchange Factors
Glioblastoma
Cell Survival
Glioma
Cell Movement
2017
10 Citations (Scopus)

Identification of aurintricarboxylic acid as a selective inhibitor of the TWEAK-Fn14 signaling pathway in glioblastoma cells

Roos, A., Dhruv, H. D., Mathews, I. T., Inge, L. J., Tuncali, S., Hartman, L. K., Chow, D., Millard, N., Yin, H. H., Kloss, J., Loftus, J. C., Winkles, J. A., Berens, M. E. & Tran, N., 2017, In : Oncotarget. 8, 7, p. 12234-12246 13 p.

Research output: Contribution to journalArticle

Aurintricarboxylic Acid
Glioblastoma
Glioma
temozolomide
Cell Survival
36 Citations (Scopus)

Molecular and microenvironmental determinants of glioma stem-like cell survival and invasion

Roos, A., Ding, Z., Loftus, J. C. & Tran, N., Jun 16 2017, In : Frontiers in Oncology. 7, JUN, 120.

Research output: Contribution to journalReview article

Glioma
Cell Survival
Stem Cells
Glioblastoma
Cues

Platelet membrane αllbβ3 (glycoprotein ilb-iiia)

Loftus, J. C., Jan 1 2017, Integrins: The Biological Problems. CRC Press, p. 55-82 28 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Platelet Membrane Glycoproteins
Platelets
Blood Platelets
Platelet Aggregation
Cell Adhesion
47 Citations (Scopus)

Radiogenomics to characterize regional genetic heterogeneity in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Baxter, L. C., Gaw, N., Ranjbar, S., Plasencia, J., Dueck, A., Peng, S., Smith, K. A., Nakaji, P., Karis, J. P., Quarles, C. C., Wu, T., Loftus, J. C., Jenkins, R. B., Sicotte, H., Kollmeyer, T. M., O'Neill, B. P., Elmquist, W. & 7 others, Hoxworth, J. M., Frakes, D., Sarkaria, J. N., Swanson, K., Tran, N., Li, J. & Mitchell, J. R., 2017, In : Neuro-Oncology. 19, 1, p. 128-137 10 p.

Research output: Contribution to journalArticle

Genetic Heterogeneity
Glioblastoma
erbB-1 Genes
Neoplasms
Biopsy
2016
6 Citations (Scopus)

Propentofylline inhibits glioblastoma cell invasion and survival by targeting the TROY signaling pathway

Dhruv, H. D., Roos, A., Tomboc, P. J., Tuncali, S., Chavez, A., Mathews, I., Berens, M. E., Loftus, J. C. & Tran, N., Feb 1 2016, In : Journal of Neuro-Oncology. 126, 3, p. 397-404 8 p.

Research output: Contribution to journalArticle

Glioblastoma
Cell Survival
temozolomide
Glioma
Alzheimer Disease
9 Citations (Scopus)

SGEF is regulated via TWEAK/Fn14/NF-κB signaling and promotes survival by modulation of the DNA repair response to temozolomide

Fortin Ensign, S. P., Roos, A., Mathews, I. T., Dhruv, H. D., Tuncali, S., Sarkaria, J. N., Symons, M. H., Loftus, J. C., Berens, M. E. & Tran, N., Mar 1 2016, In : Molecular Cancer Research. 14, 3, p. 302-312 11 p.

Research output: Contribution to journalArticle

temozolomide
DNA Repair
Glioblastoma
Glioma
Therapeutics
2015
41 Citations (Scopus)

Multi-parametric MRI and texture analysis to visualize spatial histologic heterogeneity and tumor extent in glioblastoma

Hu, L. S., Ning, S., Eschbacher, J. M., Gaw, N., Dueck, A., Smith, K. A., Nakaji, P., Plasencia, J., Ranjbar, S., Price, S. J., Tran, N., Loftus, J. C., Jenkins, R. B., O'Neill, B. P., Elmquist, W., Baxter, L. C., Gao, F., Frakes, D., Karis, J. P., Zwart, C. & 5 others, Swanson, K., Sarkaria, J. N., Wu, T., Mitchell, J. R. & Li, J., Nov 1 2015, In : PLoS One. 10, 11, e0141506.

Research output: Contribution to journalArticle

Glioblastoma
Magnetic resonance imaging
Tumors
Textures
texture
2014
6 Citations (Scopus)

Differential expression of microRNAs as predictors of glioblastoma phenotypes

Bradley, B. S., Loftus, J. C., Mielke, C. J. & Dinu, V., Jan 18 2014, In : BMC Bioinformatics. 15, 1, 21.

Research output: Contribution to journalArticle

MicroRNA
Differential Expression
Glioblastoma
MicroRNAs
Phenotype
31 Citations (Scopus)

Targeting aPKC disables oncogenic signaling by both the EGFR and the proinflammatory cytokine TNFα in glioblastoma

Kusne, Y., Carrera-Silva, E. A., Perry, A. S., Rushing, E. J., Mandell, E. K., Dietrich, J. D., Errasti, A. E., Gibbs, D., Berens, M. E., Loftus, J. C., Hulme, C., Yang, W., Lu, Z., Aldape, K., Sanai, N., Rothlin, C. V. & Ghosh, S., Aug 12 2014, In : Science Signaling. 7, 338, ra75.

Research output: Contribution to journalArticle

Glioblastoma
Epidermal Growth Factor Receptor
Tumor Necrosis Factor-alpha
Cytokines
Tumors
2013
1 Citation (Scopus)

New insights into the functional consequences of ephrin A3 mutations in non-small cell lung cancer

Whitsett, T. G., Loftus, J. C., Winkles, J. A. & Tran, N., 2013, In : Translational Lung Cancer Research. 2, 1, p. 3-5 3 p.

Research output: Contribution to journalArticle

Ephrin-A3
Non-Small Cell Lung Carcinoma
Mutation
29 Citations (Scopus)

Reciprocal Activation of Transcription Factors Underlies the Dichotomy between Proliferation and Invasion of Glioma Cells

Dhruv, H. D., McDonough Winslow, W. S., Armstrong, B., Tuncali, S., Eschbacher, J., Kislin, K., Loftus, J. C., Tran, N. & Berens, M. E., Aug 15 2013, In : PLoS One. 8, 8, e72134.

Research output: Contribution to journalArticle

Glioma
Transcription Factors
transcription factors
Chemical activation
Cells
15 Citations (Scopus)

Structural basis and targeting of the interaction between fibroblast growth factor-inducible 14 and tumor necrosis factor-like weak inducer of apoptosis

Dhruv, H., Loftus, J. C., Narang, P., Petit, J. L., Fameree, M., Burton, J., Tchegho, G., Chow, D., Yin, H., Al-Abed, Y., Berens, M. E., Tran, N. & Meurice, N., Nov 8 2013, In : Journal of Biological Chemistry. 288, 45, p. 32261-32276 16 p.

Research output: Contribution to journalArticle

Fibroblast Growth Factors
Tumor Necrosis Factor-alpha
Apoptosis
Small Molecule Libraries
Molecules
20 Citations (Scopus)
TNF Receptor-Associated Factor 2
Tumor Necrosis Factor Receptor-Associated Peptides and Proteins
Guanine Nucleotide Exchange Factors
src Homology Domains
Fibroblast Growth Factors
23 Citations (Scopus)

TROY (TNFRSF19) promotes glioblastoma survival signaling and therapeutic resistance

Loftus, J. C., Dhruv, H., Tuncali, S., Kloss, J., Yang, Z., Schumacher, C. A., Cao, B., Williams, B. O., Eschbacher, J. M., Ross, J. T. D. & Tran, N., Aug 2013, In : Molecular Cancer Research. 11, 8, p. 865-874 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Survival
Therapeutics
Astrocytes
Cell Movement
2012
55 Citations (Scopus)

Cdc42 and the guanine nucleotide exchange factors Ect2 and trio mediate Fn14-induced migration and invasion of glioblastoma cells

Fortin, S. P., Ennis, M. J., Schumacher, C. A., Zylstra-Diegel, C. R., Williams, B. O., Ross, J. T. D., Winkles, J. A., Loftus, J. C., Symons, M. H. & Tran, N., Jul 2012, In : Molecular Cancer Research. 10, 7, p. 958-968 11 p.

Research output: Contribution to journalArticle

Guanine Nucleotide Exchange Factors
Glioblastoma
Glioma
Cell Movement
Astrocytes
35 Citations (Scopus)

Elevated expression of Fn14 in non-small cell lung cancer correlates with activated EGFR and promotes tumor cell migration and invasion

Whitsett, T. G., Cheng, E., Inge, L., Asrani, K., Jameson, N. M., Hostetter, G., Weiss, G. J., Kingsley, C. B., Loftus, J. C., Bremner, R., Tran, N. & Winkles, J. A., Jul 2012, In : American Journal of Pathology. 181, 1, p. 111-120 10 p.

Research output: Contribution to journalArticle

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Cell Movement
Protein-Tyrosine Kinases
Neoplasms
47 Citations (Scopus)

MiRNA expression profiling in migrating Glioblastoma cells: Regulation of cell migration and invasion by miR-23b via targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K. M., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J., Kim, S., Berens, M. E. & Tran, N., Jun 22 2012, In : PLoS One. 7, 6, e39818.

Research output: Contribution to journalArticle

cell invasion
Glioblastoma
MicroRNAs
cell movement
Glioma
2011
16 Citations (Scopus)

The Pyk2 FERM regulates Pyk2 complex formation and phosphorylation

Riggs, D., Yang, Z., Kloss, J. & Loftus, J. C., Jan 2011, In : Cellular Signalling. 23, 1, p. 288-296 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Focal Adhesion Protein-Tyrosine Kinases
Growth Factor Receptors
G-Protein-Coupled Receptors
Cell Adhesion
2010
10 Citations (Scopus)

Structural conservation in band 4.1, ezrin, radixin, moesin (FERM) domains as a guide to identify inhibitors of the proline-rich tyrosine kinase 2

Meurice, N., Wang, L., Lipinski, C. A., Yang, Z., Hulme, C. & Loftus, J. C., 2010, In : Journal of Medicinal Chemistry. 53, 2, p. 669-677 9 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Focal Adhesion Protein-Tyrosine Kinases
Glioma
Site-Directed Mutagenesis
Protein-Tyrosine Kinases
66 Citations (Scopus)

Targeting Pyk2 for therapeutic intervention

Lipinski, C. A. & Loftus, J. C., Jan 2010, In : Expert Opinion on Therapeutic Targets. 14, 1, p. 95-108 14 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Protein-Tyrosine Kinases
Adhesion
Oncology
Cell Movement
41 Citations (Scopus)

TROY (TNFRSF19) is overexpressed in advanced glial tumors and promotes glioblastoma cell invasion via Pyk2-Rac1 signaling

Paulino, V. M., Yang, Z., Kloss, J., Ennis, M. J., Armstrong, B. A., Loftus, J. C. & Tran, N., Nov 2010, In : Molecular Cancer Research. 8, 11, p. 1558-1567 10 p.

Research output: Contribution to journalArticle

Glioblastoma
Glioma
Neuroglia
Neoplasms
Tumor Necrosis Factors
2009
7 Citations (Scopus)

Differential effects of Pyk2 and FAK on the hypertrophic response of cardiac myocytes

Menashi, E. B. & Loftus, J. C., Aug 2009, In : Cell and Tissue Research. 337, 2, p. 243-255 13 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Focal Adhesion Protein-Tyrosine Kinases
Cardiac Myocytes
Atrial Natriuretic Factor
Phenylephrine
24 Citations (Scopus)

The Pyk2 FERM domain as a target to inhibit glioma migration

Loftus, J. C., Yang, Z., Tran, N., Kloss, J., Viso, C., Berens, M. E. & Lipinski, C. A., Jun 2009, In : Molecular Cancer Therapeutics. 8, 6, p. 1505-1514 10 p.

Research output: Contribution to journalArticle

Glioma
Phosphorylation
Epitopes
Cell Migration Inhibition
Immunoglobulin Variable Region
42 Citations (Scopus)

Tumor necrosis factor-like weak inducer of apoptosis stimulation of glioma cell survival is dependent on Akt2 function

Fortin, S. P., Ennis, M. J., Savitch, B. A., Carpentieri, D., McDonough, W. S., Winkles, J. A., Loftus, J. C., Kingsley, C., Hostetter, G. & Tran, N., Nov 2009, In : Molecular Cancer Research. 7, 11, p. 1871-1881 11 p.

Research output: Contribution to journalArticle

Glioma
Cell Survival
Tumor Necrosis Factor-alpha
Apoptosis
Small Interfering RNA
2008
18 Citations (Scopus)

Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts

Lipinski, C. A., Tran, N., Viso, C., Kloss, J., Yang, Z., Berens, M. E. & Loftus, J. C., 2008, In : Journal of Neuro-Oncology. 90, 2, p. 181-189 9 p.

Research output: Contribution to journalArticle

Heterografts
Glioma
Disease Progression
Focal Adhesion Protein-Tyrosine Kinases
Tumor Microenvironment
2006

Bringing molecular biology to bear on adhesion prevention: Postsurgical adhesion reduction using intraperitoneal inoculation of hyaluronic acid-inducing adenoviral vector in a murine model

Hammer, R. A., Morse, A. N., Cornella, J. L., Keller, R. S., Hentz, J., McDonald, J. A. & Loftus, J. C., Mar 2006, In : Journal of Gynecologic Surgery. 22, 1, p. 7-18 12 p.

Research output: Contribution to journalArticle

Hyaluronic Acid
Molecular Biology
Adenoviridae
Nonparametric Statistics
Genetic Therapy
20 Citations (Scopus)

Critical role of the FERM domain in Pyk2 stimulated glioma cell migration

Lipinski, C. A., Tran, N., Dooley, A., Pang, Y-P., Rohl, C., Kloss, J., Yang, Z., McDonough, W., Craig, D., Berens, M. E. & Loftus, J. C., Oct 27 2006, In : Biochemical and Biophysical Research Communications. 349, 3, p. 939-947 9 p.

Research output: Contribution to journalArticle

Phosphorylation
Glioma
Cell Movement
Mutagenesis
Chemotherapy
136 Citations (Scopus)

Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-κB and correlate with poor patient outcome

Tran, N., McDonough, W. S., Savitch, B. A., Fortin, S. P., Winkles, J. A., Symons, M., Nakada, M., Cunliffe, H. E., Hostetter, G., Hoelzinger, D. B., Rennert, J. L., Michaelson, J. S., Burkly, L. C., Lipinski, C. A., Loftus, J. C., Mariani, L. & Berens, M. E., Oct 1 2006, In : Cancer Research. 66, 19, p. 9535-9542 8 p.

Research output: Contribution to journalArticle

Glioma
Biochemical Phenomena
Genetic Phenomena
Tumor Necrosis Factor Receptors
Genetic Promoter Regions
2005
51 Citations (Scopus)

Targeted measles virus vector displaying echistatin infects endothelial cells via αvβ3 and leads to tumor regression

Hallak, L. K., Merchan, J. R., Storgard, C. M., Loftus, J. C. & Russell, S. J., Jun 15 2005, In : Cancer Research. 65, 12, p. 5292-5300 9 p.

Research output: Contribution to journalArticle

Endogenous Retroviruses
Measles virus
Endothelial Cells
Neoplasms
Integrins
98 Citations (Scopus)

The tyrosine kinase Pyk2 promotes migration and invasion of glioma cells

Lipinski, C. A., Tran, N., Menashi, E., Rohl, C., Kloss, J., Bay, R. C., Berens, M. E. & Loftus, J. C., May 2005, In : Neoplasia. 7, 5, p. 435-445 11 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Glioma
Protein-Tyrosine Kinases
Cell Movement
Glioblastoma
3 Citations (Scopus)

Validation of a mouse adhesion reduction model using Seprafilm®

Morse, A. N., Hammer, R. A., Cornella, J. L. & Loftus, J. C., Dec 2005, In : Journal of Gynecologic Surgery. 21, 4, p. 147-153 7 p.

Research output: Contribution to journalArticle

Carboxymethylcellulose Sodium
Hyaluronic Acid
Cecum
Membranes
Research Personnel
2004
13 Citations (Scopus)

Effects of raloxifene hydrochloride on endometrial cancer cells in vitro

Hibner, M., Magrina, J. F., Lefler, S. R., Cornella, J. L., Pizarro, A. R. & Loftus, J. C., Jun 2004, In : Gynecologic Oncology. 93, 3, p. 642-646 5 p.

Research output: Contribution to journalArticle

Endometrial Neoplasms
Estradiol
Growth
Confidence Intervals
In Vitro Techniques
2003
2 Citations (Scopus)

A mutation in the integrin αIIb subunit that selectively inhibits αIIbβ3 receptor function

Perkins, K. B. & Loftus, J. C., Nov 2003, In : Thrombosis and Haemostasis. 90, 5, p. 853-862 10 p.

Research output: Contribution to journalArticle

Integrins
Ligands
Mutation
Blood Platelets
Fibrinogen Receptors
61 Citations (Scopus)

Differential role of proline-rich tyrosine kinase 2 and focal adhesion kinase in determining glioblastoma migration and proliferation

Lipinski, C. A., Tran, N., Bay, C., Kloss, J., McDonough, W. S., Beaudry, C., Berens, M. E. & Loftus, J. C., Mar 1 2003, In : Molecular Cancer Research. 1, 5, p. 323-332 10 p.

Research output: Contribution to journalArticle

Focal Adhesion Kinase 2
Focal Adhesion Protein-Tyrosine Kinases
Glioblastoma
Glioma
Cell Line
2002
18 Citations (Scopus)

A lethal perinatal cardiac phenotype resulting from altered integrin function in cardiomyocytes

Valencik, M. L., Keller, R. S., Loftus, J. C. & McDonald, J. A., Aug 2002, In : Journal of Cardiac Failure. 8, 4, p. 262-272 11 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Integrins
Phenotype
Transgenes
Maintenance
214 Citations (Scopus)

Cardiac myocyte-specific excision of the β1 integrin gene results in myocardial fibrosis and cardiac failure

Shai, S. Y., Harpf, A. E., Babbitt, C. J., Jordan, M. C., Fishbein, M. C., Chen, J., Omura, M., Leil, T. A., Becker, K. D., Jiang, M., Smith, D. J., Cherry, S. R., Loftus, J. C. & Ross, R. S., Mar 8 2002, In : Circulation Research. 90, 4, p. 458-464 7 p.

Research output: Contribution to journalArticle

Cardiac Myocytes
Integrins
Fibrosis
Heart Failure
Genes
6 Citations (Scopus)

In vitro selection of fibronectin gain-of-function mutations

Tani, P. H., Loftus, J. C. & Bowditch, R. D., Jul 1 2002, In : Biochemical Journal. 365, 1, p. 287-294 8 p.

Research output: Contribution to journalArticle

Fibronectins
Integrins
Mutation
Bacteriophages
Substitution reactions
12 Citations (Scopus)

Many αIIbβ3 autoepitopes in chronic immune thrombocytopenic purpura are localized to αIIb between amino acids L1 and Q459

Mcmillan, R., Wang, L., Lopez-Dee, J., Jiu, S. & Loftus, J. C., 2002, In : British Journal of Haematology. 118, 4, p. 1132-1136 5 p.

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Autoantibodies
Cricetulus
Ovary
Amino Acids
2001
22 Citations (Scopus)

Autoantibodies to αIIbβ3 in patients with chronic immune thrombocytopenic purpura bind primarily to epitopes on αIIb

McMillan, R., Lopez-Dee, J. & Loftus, J. C., Apr 1 2001, In : Blood. 97, 7, p. 2171-2172 2 p.

Research output: Contribution to journalArticle

Idiopathic Thrombocytopenic Purpura
Platelets
Autoantibodies
Epitopes
Blood Platelets
76 Citations (Scopus)

Disruption of integrin function in the murine myocardium leads to perinatal lethality, fibrosis, and abnormal cardiac performance

Keller, R. S., Shai, S. Y., Babbitt, C. J., Pham, C. G., Solaro, R. J., Valencik, M. L., Loftus, J. C. & Ross, R. S., 2001, In : American Journal of Pathology. 158, 3, p. 1079-1090 12 p.

Research output: Contribution to journalArticle

Integrins
Myocardium
Fibrosis
Transgenes
Transgenic Mice
236 Citations (Scopus)

Inhibition of focal adhesion kinase expression or activity disrupts epidermal growth factor-stimulated signaling promoting the migration of invasive human carcinoma cells

Hauck, C. R., Sieg, D. J., Hsia, D. A., Loftus, J. C., Gaarde, W. A., Monia, B. P. & Schlaepfer, D. D., Oct 1 2001, In : Cancer Research. 61, 19, p. 7079-7090 12 p.

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Epidermal Growth Factor
Carcinoma
Cell Movement
Phosphotransferases
2000
16 Citations (Scopus)

Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin α(IIb)β3: Further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery

Rahman, S., Flynn, G., Aitken, A., Patel, Y., Hussain, F., Lu, X., Loftus, J. C., French, D., Wijelath, E., Strand, K. & Savidge, G. F., Feb 1 2000, In : Biochemical Journal. 345, 3, p. 701-709 9 p.

Research output: Contribution to journalArticle

Snake Venoms
Integrins
Ligands
Proteins
Venoms
980 Citations (Scopus)

Ligand binding to integrins

Plow, E. F., Haas, T. A., Zhang, L., Loftus, J. C. & Smith, J. W., Jul 21 2000, In : Journal of Biological Chemistry. 275, 29, p. 21785-21788 4 p.

Research output: Contribution to journalArticle

Integrins
Animals
Binding Sites
Ligands
103 Citations (Scopus)

Striated muscle-specific β(1D)-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway

Pham, C. G., Harpf, A. E., Keller, R. S., Vu, H. T., Shai, S. Y., Loftus, J. C. & Ross, R. S., 2000, In : American Journal of Physiology - Heart and Circulatory Physiology. 279, 6 48-6

Research output: Contribution to journalArticle

Focal Adhesion Protein-Tyrosine Kinases
Striated Muscle
Cardiac Myocytes
Integrins
Adrenergic Agents
1999
29 Citations (Scopus)

A mutation in the α subunit of the platelet integrin α(IIb)β3 identifies a novel region important for ligand binding

Tozer, E. C., Baker, E. K., Ginsberg, M. H. & Loftus, J. C., Feb 1 1999, In : Blood. 93, 3, p. 918-924 7 p.

Research output: Contribution to journalArticle

Platelets
Integrins
Blood Platelets
Ligands
Mutation
1998
149 Citations (Scopus)

β Integrins participate in the hypertrophic response of rat ventricular myocytes

Ross, R. S., Pham, C., Shai, S. Y., Goldhaber, J. I., Fenczik, C., Glembotski, C. C., Ginsberg, M. H. & Loftus, J. C., Jun 15 1998, In : Circulation Research. 82, 11, p. 1160-1172 13 p.

Research output: Contribution to journalArticle

Integrins
Muscle Cells
Atrial Natriuretic Factor
Atrial Myosins
Extracellular Matrix Proteins
1997
63 Citations (Scopus)

A genetic analysis of integrin function: Glanzmann thrombasthenia in vitro

Baker, E. K., Tozer, E. C., Pfaff, M., Shattil, S. J., Loftus, J. C. & Ginsberg, M. H., Mar 4 1997, In : Proceedings of the National Academy of Sciences of the United States of America. 94, 5, p. 1973-1978 6 p.

Research output: Contribution to journalArticle

Thrombasthenia
Integrins
Mutation
Ligands
In Vitro Techniques