Jonathan A Leighton, MD &ndash; Research Output

2019

Family History Associates With Increased Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases

Samadder, N. J., Valentine, J. F., Guthery, S., Singh, H., Bernstein, C. N., Leighton, J. A., Wan, Y., Wong, J., Boucher, K., Pappas, L., Rowe, K., Burt, R. W., Curtin, K. & Smith, K. R., Jan 1 2019, In : Clinical Gastroenterology and Hepatology.

Research output: Contribution to journal › Article

Inflammatory Bowel Diseases

Colorectal Neoplasms

Incidence

Population Surveillance

Databases

1 Citation (Scopus)

Novel Genetic Risk Variants Can Predict Anti-TNF Agent Response in Patients with Inflammatory Bowel Disease

Wang, M. H., Friton, J. J., Raffals, L. E. H., Leighton, J. A., Pasha, S. F., Picco, M. F., Cushing, K. C., Monroe, K., Nix, B. D., Newberry, R. D. & Faubion, W. A., Aug 14 2019, In : Journal of Crohn's and Colitis. 13, 8, p. 1036-1043 8 p., jjz017.

Research output: Contribution to journal › Article

Inflammatory Bowel Diseases

Tumor Necrosis Factor-alpha

Genetic Loci

Odds Ratio

Therapeutics

1 Citation (Scopus)

The Clinician's Guide to Suspected Small Bowel Bleeding

Kuo, J. R., Pasha, S. F. & Leighton, J. A., Apr 1 2019, In : The American Journal of Gastroenterology. 114, 4, p. 591-598 8 p.

Research output: Contribution to journal › Article

Hemorrhage

Capsule Endoscopy

Equipment and Supplies

2018

2 Citations (Scopus)

Impact of feedback on adenoma detection rates: Outcomes of quality improvement program

Gurudu, S. R., Boroff, E. S., Crowell, M. D., Atia, M., Umar, S. B., Leighton, J. A., Faigel, D. O. & Ramirez, F. C., Mar 1 2018, In : Journal of Gastroenterology and Hepatology (Australia). 33, 3, p. 645-649 5 p.

Research output: Contribution to journal › Article

Quality Improvement

Adenoma

Colonoscopy

Endoscopy

Outcome Assessment (Health Care)

4 Citations (Scopus)

Is the level of cleanliness using segmental boston bowel preparation scale associated with a higher adenoma detection rate?

Adike, A., Buras, M. R., Gurudu, S. R., Leighton, J. A., Faigel, D. O., Ruff, K. C., Umar, S. B. & Ramirez, F. C., Mar 5 2018, In : Annals of Gastroenterology. 31, 2, p. 217-223 7 p.

Research output: Contribution to journal › Article

Adenoma

Polyps

Odds Ratio

Confidence Intervals

Colonoscopy

4 Citations (Scopus)

Utility of video capsule endoscopy for longitudinal monitoring of Crohn's disease activity in the small bowel: a prospective study

Melmed, G. Y., Dubinsky, M. C., Rubin, D. T., Fleisher, M., Pasha, S. F., Sakuraba, A., Tiongco, F., Shafran, I., Fernandez-Urien, I., Rosa, B., Papageorgiou, N. P. & Leighton, J. A., Jan 1 2018, (Accepted/In press) In : Gastrointestinal Endoscopy.

Research output: Contribution to journal › Article

Capsule Endoscopy

Crohn Disease

Prospective Studies

Leukocyte L1 Antigen Complex

Blood Sedimentation

2017

19 Citations (Scopus)

Comparing diagnostic yield of a novel pan-enteric video capsule endoscope with ileocolonoscopy in patients with active Crohn's disease: a feasibility study

Leighton, J. A., Helper, D. J., Gralnek, I. M., Dotan, I., Fernandez-Urien, I., Lahat, A., Malik, P., Mullin, G. E. & Rosa, B., Jan 1 2017, In : Gastrointestinal Endoscopy. 85, 1, p. 196-205.e1

Research output: Contribution to journal › Article

Capsule Endoscopes

Feasibility Studies

Crohn Disease

Colon

Capsules

1 Citation (Scopus)

Duodenal gangliocytic paraganglioma: Endoscopy, sonography and F-18 FDG PET/CT imaging

Yang, M., Leighton, J. A., Faigel, D. O. & Katariya, N. N., 2017, (Accepted/In press) In : Digestive and Liver Disease.

Research output: Contribution to journal › Article

Paraganglioma

Endoscopy

Ultrasonography

2 Citations (Scopus)

Evidence-based guide on capsule endoscopy for small bowel bleeding

Pasha, S. F. & Leighton, J. A., Feb 1 2017, In : Gastroenterology and Hepatology. 13, 2, p. 88-93 6 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Hemorrhage

Capsules

Triage

Routine Diagnostic Tests

5 Citations (Scopus)

Identification of antibody against SNRPB, small nuclear ribonucleoprotein-associated proteins B and B', as an autoantibody marker in Crohn's disease using an immunoproteomics approach

Wang, H., Demirkan, G., Bian, X., Wallstrom, G., Barker, K., Karthikeyan, K., Tang, Y., Pasha, S. F., Leighton, J. A., Qiu, J. & LaBaer, J., 2017, In : Journal of Crohn's and Colitis. 11, 7, p. 848-856 9 p.

Research output: Contribution to journal › Article

snRNP Core Proteins

Crohn Disease

Autoantibodies

Antibodies

Protein Array Analysis

4 Citations (Scopus)

Optimizing the quality of endoscopy in inflammatory bowel disease: focus on surveillance and management of colorectal dysplasia using interactive image- and video-based teaching

Optimizing Quality of Endoscopy in IBD Group, Dec 1 2017, In : Gastrointestinal Endoscopy. 86, 6, p. 1107-1117.e1

Research output: Contribution to journal › Article

Inflammatory Bowel Diseases

Endoscopy

Teaching

Gastrointestinal Endoscopy

Terminology

8 Citations (Scopus)

The receptor tyrosine kinase AXL promotes migration and invasion in colorectal cancer

Uribe, D. J., Mandell, E. K., Watson, A., Martinez, J. D., Leighton, J. A., Ghosh, S. & Rothlin, C. V., Jul 1 2017, In : PLoS One. 12, 7, e0179979.

Research output: Contribution to journal › Article

Receptor Protein-Tyrosine Kinases

colorectal neoplasms

tyrosine

Colorectal Neoplasms

phosphotransferases (kinases)

2016

Response to Perez-Cuadrado Robles

Gerson, L. B., Fidler, J. L., Cave, D. R. & Leighton, J. A., Feb 1 2016, In : American Journal of Gastroenterology. 111, 2, p. 294-295 2 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Gastrointestinal Hemorrhage

X Ray Computed Tomography

Colonoscopy

Disease Management

The Elusive Bleeder: Tips for Avoiding a Wild Goose Chase

Pasha, S. F. & Leighton, J. A., Feb 9 2016, (Accepted/In press) In : American Journal of Gastroenterology.

Research output: Contribution to journal › Article

Gastrointestinal Hemorrhage

X Ray Computed Tomography

Symptom Assessment

Gastrointestinal Diseases

Disease Management

2015

180 Citations (Scopus)

ACG Clinical Guideline: Diagnosis and Management of Small Bowel Bleeding

Gerson, L. B., Fidler, J. L., Cave, D. R. & Leighton, J. A., Sep 10 2015, In : American Journal of Gastroenterology. 110, 9, p. 1265-1287 23 p.

Research output: Contribution to journal › Article

Guidelines

Hemorrhage

Capsule Endoscopy

Colonoscopy

Endoscopy

14 Citations (Scopus)

Alternatives to Incomplete Colonoscopy

Villa, N. A., Pannala, R., Pasha, S. F. & Leighton, J. A., Nov 23 2015, In : Current Gastroenterology Reports. 17, 11, 43.

Research output: Contribution to journal › Article

Colonoscopy

Polyps

Colon

Colonoscopes

Patient Positioning

14 Citations (Scopus)

Double-balloon enteroscopy in Crohn's disease: Findings and impact on management in a multicenter retrospective study

Rahman, A., Ross, A., Leighton, J. A., Schembre, D., Gerson, L., Lo, S. K., Waxman, I., Dye, C. & Semrad, C., Jul 1 2015, In : Gastrointestinal Endoscopy. 82, 1, p. 102-107 6 p.

Research output: Contribution to journal › Article

Double-Balloon Enteroscopy

Crohn Disease

Multicenter Studies

Retrospective Studies

Capsule Endoscopy

14 Citations (Scopus)

Nonneoplastic polypectomy during screening colonoscopy: The impact on polyp detection rate, adenoma detection rate, and overall cost

Atia, M. A., Patel, N. C., Ratuapli, S. K., Boroff, E. S., Crowell, M. D., Gurudu, S. R., Faigel, D. O., Leighton, J. A. & Ramirez, F. C., Aug 1 2015, In : Gastrointestinal Endoscopy. 82, 2, p. 370-375.e1

Research output: Contribution to journal › Article

Colonoscopy

Polyps

Adenoma

Costs and Cost Analysis

Tertiary Care Centers

Preface

Kozarek, R. & Leighton, J. A., Jan 1 2015, In : Unknown Journal. p. v-vi

Research output: Contribution to journal › Article

2 Citations (Scopus)

The role of capsule endoscopy in evaluating both suspected and known Crohn's disease

Boroff, E. S. & Leighton, J. A., Jan 1 2015, In : Techniques in Gastrointestinal Endoscopy. 17, 1, p. 5-11 7 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Crohn Disease

Inflammatory Bowel Diseases

Capsule Endoscopes

Capsules

1 Citation (Scopus)

Using Hybrid Change Strategies to Improve the Patient Experience in Outpatient Specialty Care

Miranda, R., Glenn, S. W., Leighton, J. A., Pasha, S. F., Gurudu, S. R., Teaford, H. G., Mertz, L. E., Lee, H. R., Mamby, S. A., Johnson, M. F. & Raghu, T. S., Sep 1 2015, In : Journal of Healthcare Management. 60, 5, p. 363-376 14 p.

Research output: Contribution to journal › Article

Ambulatory Care

Government Regulation

Moving and Lifting Patients

Electronic Health Records

Medical Records

2014

Advances in capsule endoscopy in the diagnosis of Crohn's disease

Leighton, J. A., 2014, In : Gastroenterology and Hepatology. 10, 5, p. 319-321 3 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Crohn Disease

38 Citations (Scopus)

Capsule Endoscopy Is Superior to Small-bowel Follow-through and Equivalent to Ileocolonoscopy in Suspected Crohn's Disease

Leighton, J. A., Gralnek, I. M., Cohen, S. A., Toth, E., Cave, D. R., Wolf, D. C., Mullin, G. E., Ketover, S. R., Legnani, P. E., Seidman, E. G., Crowell, M. D., Bergwerk, A. J., Peled, R. & Eliakim, R., 2014, In : Clinical Gastroenterology and Hepatology. 12, 4, p. 609-615 7 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Crohn Disease

Inflammation

Intestinal Mucosa

Ileum

15 Citations (Scopus)

Evaluation and management of small-bowel tumors in the era of deep enteroscopy

Islam, R. S., Leighton, J. A. & Pasha, S. F., 2014, In : Gastrointestinal Endoscopy. 79, 5, p. 732-740 9 p.

Research output: Contribution to journal › Article

Ileal Neoplasms

Jejunal Neoplasms

Duodenal Neoplasms

Double-Balloon Enteroscopy

Capsule Endoscopy

3 Citations (Scopus)

Postcolonoscopy followup recommendations: Comparison with and without use of polyp pathology

Ratuapli, S. K., Gurudu, S. R., Atia, M. A., Crowell, M. D., Umar, S. B., Harrison, M. E., Leighton, J. A. & Ramirez, F. C., 2014, In : Diagnostic and Therapeutic Endoscopy. 2014, 683491.

Research output: Contribution to journal › Article

Colonoscopy

Polyps

Pathology

Adenomatous Polyps

Advisory Committees

14 Citations (Scopus)

Tyro3, Axl, and Mertk receptor signaling in inflammatory bowel disease and colitis-associated cancer

Rothlin, C. V., Leighton, J. A. & Ghosh, S., 2014, In : Inflammatory Bowel Diseases. 20, 8, p. 1472-1480 9 p.

Research output: Contribution to journal › Article

Colitis

Inflammatory Bowel Diseases

Inflammation

Ligands

Cytophagocytosis

2013

17 Citations (Scopus)

A multicenter, prospective, randomized comparison of a novel signal transmission capsule endoscope to an existing capsule endoscope

Choi, E. H., Mergener, K., Semrad, C., Fisher, L., Cave, D. R., Dodig, M., Burke, C., Leighton, J. A., Kastenberg, D., Simpson, P., Sul, J., Bhattacharya, K., Charles, R., Gerson, L., Weber, L., Eisen, G., Reidel, W., Vargo, J. J., Wakim-Fleming, J. & Lo, S. K., Aug 2013, In : Gastrointestinal Endoscopy. 78, 2, p. 325-332 8 p.

Research output: Contribution to journal › Article

Capsule Endoscopes

Capsules

Hemorrhage

Bleeding Time

Human Body

25 Citations (Scopus)

Capsule endoscopy in patients with implantable electromedical devices is safe

Harris, L. A., Hansel, S. L., Rajan, E., Srivathsan, K., Rea, R., Crowell, M. D., Fleischer, D. E., Pasha, S. F., Gurudu, S. R., Heigh, R. I., Shiff, A. D., Post, J. K. & Leighton, J. A., 2013, In : Gastroenterology Research and Practice. 2013, 959234.

Research output: Contribution to journal › Article

Capsule Endoscopy

Capsules

Equipment and Supplies

Celiac Disease

Crohn Disease

8 Citations (Scopus)

Downregulation of hematopoietic MUC1 during Experimental colitis increases tumor-promoting myeloid-derived suppressor cells

Poh, T. W., Madsen, C. S., Gorman, J. E., Marler, R. J., Leighton, J. A., Cohen, P. A. & Gendler, S. J., Sep 15 2013, In : Clinical Cancer Research. 19, 18, p. 5039-5052 14 p.

Research output: Contribution to journal › Article

Colitis

Down-Regulation

Neoplasms

Inflammatory Bowel Diseases

Colon

10 Citations (Scopus)

Endoscopic Techniques for Small Bowel Imaging

Pasha, S. F. & Leighton, J. A., Jan 2013, In : Radiologic Clinics of North America. 51, 1, p. 177-187 11 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Therapeutics

6 Citations (Scopus)

Impact of fentanyl in lieu of meperidine on endoscopy unit efficiency: A prospective comparative study in patients undergoing EGD

Dzeletovic, I., Harrison, M. E., Crowell, M. D., Ramirez, F. C., Yows, C. R., Harris, L. A., Pasha, S. F., Gurudu, S. R., Leighton, J. A. & Heigh, R. I., Jun 2013, In : Gastrointestinal Endoscopy. 77, 6, p. 883-887 5 p.

Research output: Contribution to journal › Article

Meperidine

Fentanyl

Endoscopy

Prospective Studies

Intubation

56 Citations (Scopus)

Polyp and adenoma detection rates in the proximal and distal colon

Boroff, E. S., Gurudu, S. R., Hentz, J. G., Leighton, J. A. & Ramirez, F. C., Jun 2013, In : American Journal of Gastroenterology. 108, 6, p. 993-999 7 p.

Research output: Contribution to journal › Article

Polyps

Adenoma

Colon

Transverse Colon

Colonoscopy

56 Citations (Scopus)

Procedure time and the determination of polypoid abnormalities with experience: Implementation of a chromoendoscopy program for surveillance colonoscopy for ulcerative colitis

Picco, M. F., Pasha, S. F., Leighton, J. A., Bruining, D., Loftus, Jr, E. V., Thomas, C. S., Crook, J., Krishna, M. & Wallace, M., Aug 2013, In : Inflammatory Bowel Diseases. 19, 9, p. 1913-1920 8 p.

Research output: Contribution to journal › Article

Colonoscopy

Ulcerative Colitis

Endoscopy

Light

Polyps

Quality commitment: The newly established american college of gastroenterology quality council to meet the needs of clinical gastroenterology

Kane, S., Leighton, J. A., Kefalas, C., Cohen, L., Katz, P., Rizk, M., Pike, I., Lashner, B., Ho, I., Pochapin, M., Seabrook, M., Greenwald, D., Demarco, D. & Johnson, D., Jan 2013, In : American Journal of Gastroenterology. 108, 1, p. 7-9 3 p.

Research output: Contribution to journal › Article

Quality of Health Care

Medical Societies

Gastroenterology

75 Citations (Scopus)

T Cell-Derived Protein S Engages TAM Receptor Signaling in Dendritic Cells to Control the Magnitude of the Immune Response

CarreraSilva, E., Chan, P., Joannas, L., Errasti, A., Gagliani, N., Bosurgi, L., Jabbour, M., Perry, A., Smith-Chakmakova, F., Mucida, D., Cheroutre, H., Burstyn-Cohen, T., Leighton, J. A., Lemke, G., Ghosh, S. & Rothlin, C., Jul 25 2013, In : Immunity. 39, 1, p. 160-170 11 p.

Research output: Contribution to journal › Article

Protein S

Dendritic Cells

T-Lymphocytes

Adaptive Immunity

Receptor Protein-Tyrosine Kinases

3 Citations (Scopus)

The Dilemma of Incomplete Colonoscopy: What Is the Next Best Test?

Atia, M. A., Ramirez, F. C. & Leighton, J. A., May 2013, In : Clinical Gastroenterology and Hepatology. 11, 5, p. 541-542 2 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Colonoscopy

Colorectal Neoplasms

Decision Making

2012

18 Citations (Scopus)

Comparison of single- Versus double-balloon assisted-colonoscopy for colon examination after previous incomplete standard colonoscopy

Dzeletovic, I., Harrison, M. E., Pasha, S. F., Crowell, M. D., Decker, G. A., Gurudu, S. R. & Leighton, J. A., Oct 2012, In : Digestive Diseases and Sciences. 57, 10, p. 2680-2686 7 p.

Research output: Contribution to journal › Article

Colonoscopy

Colon

Intubation

Cecum

Polyps

113 Citations (Scopus)

Comparison of the yield and miss rate of narrow band imaging and white light endoscopy in patients undergoing screening or surveillance colonoscopy: A meta-analysis

Pasha, S. F., Leighton, J. A., Das, A., Harrison, M. E., Gurudu, S. R., Ramirez, F. C., Fleischer, D. E. & Sharma, V. K., Mar 2012, In : American Journal of Gastroenterology. 107, 3, p. 363-370 8 p.

Research output: Contribution to journal › Article

Narrow Band Imaging

Colonoscopy

Adenoma

Endoscopy

Meta-Analysis

10 Citations (Scopus)

Correlation of two capsule endoscopy scoring systems with fecal calprotectin: Does it really matter?

Gurudu, S. R. & Leighton, J. A., Apr 2012, In : Digestive Diseases and Sciences. 57, 4, p. 827-829 3 p.

Research output: Contribution to journal › Article

Leukocyte L1 Antigen Complex

Capsule Endoscopy

Feces

Crohn Disease

Small Intestine

Current place of capsule endoscopy in Crohn's disease

Islam, R. S., Patel, N. C. & Leighton, J. A., 2012, In : Inflammatory Bowel Disease Monitor. 12, 4, p. 143-148 6 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Crohn Disease

Ileum

Mucous Membrane

Inflammation

68 Citations (Scopus)

Emergence of Gastrointestinal Basidiobolomycosis in the United States, with a Review of Worldwide Cases

Vikram, H. R., Smilack, J. D., Leighton, J. A., Crowell, M. D. & De Petris, G., Jun 15 2012, In : Clinical Infectious Diseases. 54, 12, p. 1685-1691 7 p.

Research output: Contribution to journal › Article

Entomophthorales

Southwestern United States

Mycoses

Saudi Arabia

Centers for Disease Control and Prevention (U.S.)

84 Citations (Scopus)

Increased adenoma detection rate with system-wide implementation of a split-dose preparation for colonoscopy

Gurudu, S. R., Ramirez, F. C., Harrison, M. E., Leighton, J. A. & Crowell, M. D., Sep 2012, In : Gastrointestinal Endoscopy. 76, 3

Research output: Contribution to journal › Article

Colonoscopy

Adenoma

Polyps

Patient Compliance

Quality Improvement

2011

34 Citations (Scopus)

Adenoma detection rate is not influenced by the timing of colonoscopy when performed in half-day blocks

Gurudu, S. R., Ratuapli, S. K., Leighton, J. A., Heigh, R. I. & Crowell, M. D., 2011, In : American Journal of Gastroenterology. 106, 8, p. 1466-1471 6 p.

Research output: Contribution to journal › Article

Colonoscopy

Adenoma

Physicians

Fatigue

Appointments and Schedules

55 Citations (Scopus)

A grading scale to evaluate colon cleansing for the PillCam COLON capsule: A reliability study

Leighton, J. A. & Rex, D. K., 2011, In : Endoscopy. 43, 2, p. 123-127 5 p.

Research output: Contribution to journal › Article

Capsules

Colon

Observer Variation

Israel

Calibration

60 Citations (Scopus)

Performance of the patency capsule compared with nonenteroclysis radiologic examinations in patients with known or suspected intestinal strictures

Yadav, A., Heigh, R. I., Hara, A. K., Decker, G. A., Crowell, M. D., Gurudu, S. R., Pasha, S. F., Fleischer, D. E., Harris, L. A., Post, J. & Leighton, J. A., Oct 2011, In : Gastrointestinal Endoscopy. 74, 4, p. 834-839 6 p.

Research output: Contribution to journal › Article

Capsules

Pathologic Constriction

Capsule Endoscopy

Sensitivity and Specificity

ROC Curve

54 Citations (Scopus)

The role of endoscopic imaging of the small bowel in clinical practice

Leighton, J. A., Jan 2011, In : American Journal of Gastroenterology. 106, 1, p. 27-36 10 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Endoscopes

Celiac Disease

Inflammatory Bowel Diseases

Hemorrhage

2010

83 Citations (Scopus)

A retrograde-viewing device improves detection of adenomas in the colon: a prospective efficacy evaluation (with videos)

Waye, J. D., Heigh, R. I., Fleischer, D. E., Leighton, J. A., Gurudu, S., Aldrich, L. B., Li, J., Ramrakhiani, S., Edmundowicz, S. A., Early, D. S., Jonnalagadda, S., Bresalier, R. S., Kessler, W. R. & Rex, D. K., Mar 2010, In : Gastrointestinal Endoscopy. 71, 3, p. 551-556 6 p.

Research output: Contribution to journal › Article

Adenoma

Polyps

Colonoscopes

Colon

Equipment and Supplies

236 Citations (Scopus)

Capsule endoscopy has a significantly higher diagnostic yield in patients with suspected and established small-bowel crohn's disease: A meta-analysis

Dionisio, P. M., Gurudu, S. R., Leighton, J. A., Leontiadis, G. I., Fleischer, D. E., Hara, A. K., Heigh, R. I., Shiff, A. D. & Sharma, V. K., Jun 2010, In : American Journal of Gastroenterology. 105, 6, p. 1240-1248 9 p.

Research output: Contribution to journal › Article

Capsule Endoscopy

Crohn Disease

Meta-Analysis

Radiography

Tomography

7 Citations (Scopus)