John D. Fryer, PhD

  • 4393 Citations
  • 39 Scopus h-Index
19992020
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Research Output 1999 2019

  • 4393 Citations
  • 39 Scopus h-Index
  • 77 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
2007
53 Citations (Scopus)

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Bowman, A. B., Lam, Y. C., Jafar-Nejad, P., Chen, H. K., Richman, R., Samaco, R. C., Fryer, J. D., Kahle, J. J., Orr, H. T. & Zoghbi, H. Y., Mar 2007, In : Nature Genetics. 39, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Glutamine
Neurodegenerative Diseases
Ships
polyglutamine
2006
196 Citations (Scopus)

ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology

Lam, Y. C., Bowman, A. B., Jafar-Nejad, P., Lim, J., Richman, R., Fryer, J. D., Hyun, E. D., Duvick, L. A., Orr, H. T., Botas, J. & Zoghbi, H. Y., Dec 29 2006, In : Cell. 127, 7, p. 1335-1347 13 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Proteins
Neurodegenerative diseases
Neurodegenerative Diseases
Cerebellum
8 Citations (Scopus)

Huntingtin's critical cleavage

Fryer, J. D. & Zoghbi, H. Y., Sep 2006, In : Nature Neuroscience. 9, 9, p. 1088-1089 2 p.

Research output: Contribution to journalArticle

Caspase 6
Huntington Disease
Huntingtin Protein
2005

Alzheimer research forum live discussion: Making a biomark on Alzheimer disease

Ciallella, J., Clish, C. B., De Leon, M., Fagan, A., Fagan, T., Shaw, L., Siddiqi, H., Trojanowski, J., Lombardo, N. E., Fryer, J. D., Kinoshita, J. & Lynn, P., 2005, In : Journal of Alzheimer's Disease. 8, 4, p. 393-399 7 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)

High-affinity epibatidine binding of functional, human α7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells

Peng, J. H., Fryer, J. D., Hurst, R. S., Schroeder, K. M., George, A. A., Morrissy, S., Groppi, V. E., Leonard, S. S. & Lukas, R. J., Apr 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

epibatidine
Nicotinic Receptors
Nicotine
Bungarotoxins
Binding Sites
200 Citations (Scopus)

Human apolipoprotein E4 alters the amyloid-β 40: 42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M. & Holtzman, D. M., Mar 16 2005, In : Journal of Neuroscience. 25, 11, p. 2803-2810 8 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Apolipoprotein E4
Amyloid beta-Protein Precursor
Amyloid
Apolipoproteins E
46 Citations (Scopus)

Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

Lee, J. M., Yin, K., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Mar 15 2005, In : Journal of the Neurological Sciences. 229-230, p. 249-254 6 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Hemorrhage
Cerebral Hemorrhage
Amyloid
59 Citations (Scopus)

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Morikawa, M., Fryer, J. D., Sullivan, P. M., Christopher, E. A., Wahrle, S. E., DeMattos, R. B., O'Dell, M. A., Fagan, A. M., Lashuel, H. A., Walz, T., Asai, K. & Holtzman, D. M., Jun 2005, In : Neurobiology of Disease. 19, 1-2, p. 66-76 11 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Amyloid
Astrocytes
Protein Isoforms
Apolipoprotein E3
15 Citations (Scopus)

The bad seed in Alzheimer's disease

Fryer, J. D. & Holtzman, D. M., Jul 21 2005, In : Neuron. 47, 2, p. 167-168 2 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Seeds
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloid
95 Citations (Scopus)

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G. D. & Holtzman, D. M., Jul 8 2005, In : Journal of Biological Chemistry. 280, 27, p. 25754-25759 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid Plaques
Neurology
Apolipoproteins E
Pathology
2004
272 Citations (Scopus)

ABCA1 is required for normal central nervous system apoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T. & Holtzman, D. M., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 40987-40993 7 p.

Research output: Contribution to journalArticle

Neurology
Apolipoproteins E
Astrocytes
Central Nervous System
Lipoproteins
41 Citations (Scopus)

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-β pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

Fagan, A. M., Christopher, E., Taylor, J. W., Parsadanian, M., Spinner, M., Watson, M., Fryer, J. D., Wahrle, S., Bales, K. R., Paul, S. M. & Holtzman, D. M., Oct 2004, In : American Journal of Pathology. 165, 4, p. 1413-1422 10 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Cholesterol
Pathology
Brain
113 Citations (Scopus)

A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice

Sadowski, M., Pankiewicz, J., Scholtzova, H., Ripellino, J. A., Li, Y., Schmidt, S. D., Mathews, P. M., Fryer, J. D., Holtzman, D. M., Sigurdsson, E. M. & Wisniewski, T., Sep 2004, In : American Journal of Pathology. 165, 3, p. 937-948 12 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Apolipoproteins E
Amyloid
Transgenic Mice
Alzheimer Disease

Erratum: Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells (Molecular Pharmacology (2003) 64 (1283-1294))

Eaton, J. B., Peng, J. H., Schroeder, K. M., George, A. A., Fryer, J. D., Krishnan, C., Buhlman, L., Kuo, Y. P., Steinlein, O. & Lukas, R. J., Jul 2004, In : Molecular Pharmacology. 66, 1, p. 197 1 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Epithelial Cells
Pharmacology
2003
117 Citations (Scopus)

Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice

Fryer, J. D., Taylor, J. W., DeMattos, R. B., Bales, K. R., Paul, S. M., Parsadanian, M. & Holtzman, D. M., Aug 27 2003, In : Journal of Neuroscience. 23, 21, p. 7889-7896 8 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloid beta-Protein Precursor
Apolipoproteins E
Transgenic Mice
Hemorrhage
89 Citations (Scopus)

Characterization of Human α4β2-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed in Native Nicotinic Receptor-Null SH-EP1 Human Epithelial Cells

Eaton, J. B., Peng, J. H., Schroeder, K. M., George, A. A., Fryer, J. D., Krishnan, C., Buhlman, L., Kuo, Y. P., Steinlein, O. & Lukas, R. J., Dec 2003, In : Molecular Pharmacology. 64, 6, p. 1283-1294 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
epibatidine
Epithelial Cells
Nicotine
Binding Sites
82 Citations (Scopus)

Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

Lee, J. M., Yin, K. J., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Sep 1 2003, In : Annals of Neurology. 54, 3, p. 379-382 4 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Animal Models
Hemorrhage
Amyloid beta-Peptides
88 Citations (Scopus)

Novel role for apolipoprotein E in the central nervous system: Modulation of sulfatide content

Han, X., Cheng, H., Fryer, J. D., Fagan, A. M. & Holtzman, D. M., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8043-8051 9 p.

Research output: Contribution to journalArticle

Sulfoglycosphingolipids
Neurology
Apolipoproteins E
Central Nervous System
Modulation
2001
163 Citations (Scopus)

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia

Han, B. H., DeMattos, R. B., Dugan, L. L., Kim-Han, J. S., Brendza, R. P., Fryer, J. D., Kierson, M., Cirrito, J., Quick, K., Harmony, J. A. K., Aronow, B. J. & Holtzman, D. M., 2001, In : Nature Medicine. 7, 3, p. 338-343 6 p.

Research output: Contribution to journalArticle

Clusterin
Caspase 3
Brain Injuries
Brain
Ischemia
28 Citations (Scopus)

Neurotoxicity of channel mutations in heterologously expressed α7-nicotinic acetylcholine receptors

Lukas, R. J., Lucero, L., Buisson, B., Galzi, J. L., Puchacz, E., Fryer, J. D., Changeux, J. P. & Bertrand, D., 2001, In : European Journal of Neuroscience. 13, 10, p. 1849-1860 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Mutation
Poisons
Neurons
Cell Line
111 Citations (Scopus)

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J. D., Sullivan, P. M., Fagan, A. M., Han, X. & Holtzman, D. M., 2001, In : Neurochemistry International. 39, 5-6, p. 415-425 11 p.

Research output: Contribution to journalArticle

Clusterin
Apolipoproteins E
Astrocytes
Transgenic Mice
Lipoproteins
23 Citations (Scopus)

Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function

Ferchmin, P. A., Lukas, R. J., Hann, R. M., Fryer, J. D., Eaton, J. B., Pagn, O. R., Rodríguez, A. D., Nicolau, Y., Rosado, M., Cortés, S. & Eterovi, V. A., Apr 1 2001, In : Journal of Neuroscience Research. 64, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Nicotine
Tobacco
tenocyclidine
Locomotion
2000
11 Citations (Scopus)

5-Hydroxytryptamine interaction with the nicotinic acetylcholine receptor

Blanton, M. P., McCardy, E. A., Fryer, J. D., Liu, M. & Lukas, R. J., Feb 18 2000, In : European Journal of Pharmacology. 389, 2-3, p. 155-163 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Serotonin
Cholinergic Receptors
Inhibitory Concentration 50
Torpedo
106 Citations (Scopus)

Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Fagan, A. M., Younkin, L. H., Morris, J. C., Fryer, J. D., Cole, T. G., Younkin, S. G. & Holtzman, D. M., 2000, In : Annals of Neurology. 48, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lipoproteins
Cerebrospinal Fluid
Genotype
Alzheimer Disease
1999
112 Citations (Scopus)

Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function

Fryer, J. D. & Lukas, R. J., 1999, In : Journal of Neurochemistry. 72, 3, p. 1117-1124 8 p.

Research output: Contribution to journalArticle

Sertraline
Paroxetine
Fluoxetine
Nicotinic Receptors
Antidepressive Agents
47 Citations (Scopus)

Inducible, heterologous expression of human α7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line

Peng, J. H., Lucero, L., Fryer, J. D., Herl, J., Leonard, S. S. & Lukas, R. J., Apr 17 1999, In : Brain Research. 825, 1-2, p. 172-179 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Tetracycline
Nicotine
Up-Regulation
Bungarotoxins
260 Citations (Scopus)
Ibogaine
Bupropion
Phencyclidine
Nicotinic Receptors
Muscles