John D. Fryer, PhD

  • 4393 Citations
  • 39 Scopus h-Index
19992020
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Research Output 1999 2019

  • 4393 Citations
  • 39 Scopus h-Index
  • 77 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
11 Citations (Scopus)

5-Hydroxytryptamine interaction with the nicotinic acetylcholine receptor

Blanton, M. P., McCardy, E. A., Fryer, J. D., Liu, M. & Lukas, R. J., Feb 18 2000, In : European Journal of Pharmacology. 389, 2-3, p. 155-163 9 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Serotonin
Cholinergic Receptors
Inhibitory Concentration 50
Torpedo
272 Citations (Scopus)

ABCA1 is required for normal central nervous system apoE levels and for lipidation of astrocyte-secreted apoE

Wahrle, S. E., Jiang, H., Parsadanian, M., Legleiter, J., Han, X., Fryer, J. D., Kowalewski, T. & Holtzman, D. M., Sep 24 2004, In : Journal of Biological Chemistry. 279, 39, p. 40987-40993 7 p.

Research output: Contribution to journalArticle

Neurology
Apolipoproteins E
Astrocytes
Central Nervous System
Lipoproteins
41 Citations (Scopus)

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C-C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. D. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Pathology
Alzheimer Disease
Brain
8 Citations (Scopus)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. D., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 1 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Dipeptides
RNA
Proteins
Antisense RNA

Alzheimer research forum live discussion: Making a biomark on Alzheimer disease

Ciallella, J., Clish, C. B., De Leon, M., Fagan, A., Fagan, T., Shaw, L., Siddiqi, H., Trojanowski, J., Lombardo, N. E., Fryer, J. D., Kinoshita, J. & Lynn, P., 2005, In : Journal of Alzheimer's Disease. 8, 4, p. 393-399 7 p.

Research output: Contribution to journalArticle

112 Citations (Scopus)

Antidepressants noncompetitively inhibit nicotinic acetylcholine receptor function

Fryer, J. D. & Lukas, R. J., 1999, In : Journal of Neurochemistry. 72, 3, p. 1117-1124 8 p.

Research output: Contribution to journalArticle

Sertraline
Paroxetine
Fluoxetine
Nicotinic Receptors
Antidepressive Agents
131 Citations (Scopus)

A partial loss of function allele of Methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

Samaco, R. C., Fryer, J. D., Ren, J., Fyffe, S., Chao, H. T., Sun, Y., Greer, J. J., Zoghbi, H. Y. & Neul, J. L., Jun 15 2008, In : Human Molecular Genetics. 17, 12, p. 1718-1727 10 p.

Research output: Contribution to journalArticle

Methyl-CpG-Binding Protein 2
Alleles
Intellectual Disability
Angelman Syndrome
Rett Syndrome
41 Citations (Scopus)

ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-β pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis

Fagan, A. M., Christopher, E., Taylor, J. W., Parsadanian, M., Spinner, M., Watson, M., Fryer, J. D., Wahrle, S., Bales, K. R., Paul, S. M. & Holtzman, D. M., Oct 2004, In : American Journal of Pathology. 165, 4, p. 1413-1422 10 p.

Research output: Contribution to journalArticle

Amyloid
Alzheimer Disease
Cholesterol
Pathology
Brain
28 Citations (Scopus)

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Apolipoproteins E
Apolipoprotein E2
Cholesterol
Amyloid
Alleles
12 Citations (Scopus)

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature Communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Apolipoprotein E2
Tauopathies
pathology
Pathology
mice
134 Citations (Scopus)

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Atagi, Y., Liu, C-C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R. V., Kang, S., Xu, H., Younkin, S. G., Das, P., Fryer, J. D. & Bu, G. D., Oct 23 2015, In : Journal of Biological Chemistry. 290, 43, p. 26043-26050 8 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Myeloid Cells
Ligands
Microglia
Phagocytosis
117 Citations (Scopus)

Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice

Fryer, J. D., Taylor, J. W., DeMattos, R. B., Bales, K. R., Paul, S. M., Parsadanian, M. & Holtzman, D. M., Aug 27 2003, In : Journal of Neuroscience. 23, 21, p. 7889-7896 8 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Amyloid beta-Protein Precursor
Apolipoproteins E
Transgenic Mice
Hemorrhage
52 Citations (Scopus)

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Di Malta, C., Fryer, J. D., Settembre, C. & Ballabio, A., Aug 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 35

Research output: Contribution to journalArticle

Astrocytes
Multiple Sulfatase Deficiency Disease
Neurons
Sulfatases
Nerve Degeneration
113 Citations (Scopus)

A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice

Sadowski, M., Pankiewicz, J., Scholtzova, H., Ripellino, J. A., Li, Y., Schmidt, S. D., Mathews, P. M., Fryer, J. D., Holtzman, D. M., Sigurdsson, E. M. & Wisniewski, T., Sep 2004, In : American Journal of Pathology. 165, 3, p. 937-948 12 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Apolipoproteins E
Amyloid
Transgenic Mice
Alzheimer Disease
196 Citations (Scopus)

ATAXIN-1 Interacts with the Repressor Capicua in Its Native Complex to Cause SCA1 Neuropathology

Lam, Y. C., Bowman, A. B., Jafar-Nejad, P., Lim, J., Richman, R., Fryer, J. D., Hyun, E. D., Duvick, L. A., Orr, H. T., Botas, J. & Zoghbi, H. Y., Dec 29 2006, In : Cell. 127, 7, p. 1335-1347 13 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Proteins
Neurodegenerative diseases
Neurodegenerative Diseases
Cerebellum
45 Citations (Scopus)

ATXN1 Protein Family and CIC Regulate Extracellular Matrix Remodeling and Lung Alveolarization

Lee, Y., Fryer, J. D., Kang, H., Crespo-Barreto, J., Bowman, A. B., Gao, Y., Kahle, J. J., Hong, J. S., Kheradmand, F., Orr, H. T., Finegold, M. J. & Zoghbi, H. Y., Oct 18 2011, In : Developmental Cell. 21, 4, p. 746-757 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Extracellular Matrix
Genes
Lung
Defects
18 Citations (Scopus)

Autophagy in astrocytes: A novel culprit in lysosomal storage disorders

Di Malta, C., Fryer, J. D., Settembre, C. & Ballabio, A., Dec 2012, In : Autophagy. 8, 12, p. 1871-1872 2 p.

Research output: Contribution to journalArticle

Autophagy
Astrocytes
Multiple Sulfatase Deficiency Disease
Neurons
Lysosomes
10 Citations (Scopus)

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Lipopolysaccharides
Myeloid Cells
Neurodegenerative Diseases
Up-Regulation
103 Citations (Scopus)

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y., Gendron, T. D., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A. & 16 others, Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R. V., Boylan, K. B., Bu, G. D., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D. & Petrucelli, L., May 1 2016, In : Nature Neuroscience. 19, 5, p. 668-677 10 p.

Research output: Contribution to journalArticle

Nucleocytoplasmic Transport Proteins
Cell Nucleus Active Transport
Pathology
Ubiquitinated Proteins
Xeroderma Pigmentosum
161 Citations (Scopus)

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Chew, J., Gendron, T. D., Prudencio, M., Sasaguri, H., Zhang, Y., Castanedes-Casey, M., Lee, C. W., Jansen-West, K., Kurti, A., Murray, M. E., Bieniek, K. F., Bauer, P. O., Whitelaw, E. C., Rousseau, L., Stankowski, J. N., Stetler, C., Daughrity, L. M., Perkerson, E. A., Desaro, P., Johnston, A. & 7 others, Overstreet, K., Edbauer, D., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Fryer, J. D. & Petrucelli, L., Jun 5 2015, In : Science. 348, 6239, p. 1151-1154 4 p.

Research output: Contribution to journalArticle

Pathology
Brain
glycylproline
Animal Disease Models
Nuclear RNA
9 Citations (Scopus)

Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Park, S., Lee, S., Lee, C. G., Park, G. Y., Hong, H., Lee, J. S., Kim, Y. M., Lee, S. B., Hwang, D., Choi, Y. S., Fryer, J. D., Im, S. H., Lee, S. W. & Lee, Y., Jul 12 2017, In : Nature Communications. 8, 16037.

Research output: Contribution to journalArticle

T-cells
Helper-Inducer T-Lymphocytes
Autoimmunity
Germinal Center
Cell Differentiation
89 Citations (Scopus)

Characterization of Human α4β2-Nicotinic Acetylcholine Receptors Stably and Heterologously Expressed in Native Nicotinic Receptor-Null SH-EP1 Human Epithelial Cells

Eaton, J. B., Peng, J. H., Schroeder, K. M., George, A. A., Fryer, J. D., Krishnan, C., Buhlman, L., Kuo, Y. P., Steinlein, O. & Lukas, R. J., Dec 2003, In : Molecular Pharmacology. 64, 6, p. 1283-1294 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
epibatidine
Epithelial Cells
Nicotine
Binding Sites
163 Citations (Scopus)

Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia

Han, B. H., DeMattos, R. B., Dugan, L. L., Kim-Han, J. S., Brendza, R. P., Fryer, J. D., Kierson, M., Cirrito, J., Quick, K., Harmony, J. A. K., Aronow, B. J. & Holtzman, D. M., 2001, In : Nature Medicine. 7, 3, p. 338-343 6 p.

Research output: Contribution to journalArticle

Clusterin
Caspase 3
Brain Injuries
Brain
Ischemia
74 Citations (Scopus)

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Liu, C-C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T. & Bu, G. D., Oct 1 2014, In : Neuron. 84, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Amyloid
Alzheimer Disease
Pathology
Protein Deficiency
12 Citations (Scopus)

Deficiency of Capicua disrupts bile acid homeostasis

Kim, E., Park, S., Choi, N., Lee, J., Yoe, J., Kim, S., Jung, H. Y., Kim, K. T., Kang, H., Fryer, J. D., Zoghbi, H. Y., Hwang, D. & Lee, Y., Feb 5 2015, In : Scientific Reports. 5, 8272.

Research output: Contribution to journalArticle

Bile Acids and Salts
Homeostasis
Retinoid X Receptor alpha
Liver
CCAAT-Enhancer-Binding Protein-beta
10 Citations (Scopus)

Derivation and validation of the automated search algorithms to identify cognitive impairment and dementia in electronic health records

Amra, S., O'Horo, J. C., Singh, T. D., Wilson, G. A., Kashyap, R., Petersen, R. C., Roberts, R. O., Fryer, J. D., Rabinstein, A. & Gajic, O., Feb 1 2017, In : Journal of Critical Care. 37, p. 202-205 4 p.

Research output: Contribution to journalArticle

Electronic Health Records
Dementia
Intensive Care Units
International Classification of Diseases
Critical Illness
101 Citations (Scopus)

Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

Kang, S., Jeraldo, P. R., Kurti, A., Miller, M. E. B., Cook, M. D., Whitlock, K., Goldenfeld, N., Woods, J. A., White, B. A., Chia, N. D. & Fryer, J. D., Sep 13 2014, In : Molecular Neurodegeneration. 9, 1, 36.

Research output: Contribution to journalArticle

High Fat Diet
Cognition
Anxiety
Diet
Gastrointestinal Microbiome
51 Citations (Scopus)

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Kang, S., Kurti, A., Fair, D. A. & Fryer, J. D., Sep 12 2014, In : Journal of Neuroinflammation. 11, 1, 156.

Research output: Contribution to journalArticle

Obesity
Mothers
High Fat Diet
Lactation
Encephalitis
106 Citations (Scopus)

Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Fagan, A. M., Younkin, L. H., Morris, J. C., Fryer, J. D., Cole, T. G., Younkin, S. G. & Holtzman, D. M., 2000, In : Annals of Neurology. 48, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lipoproteins
Cerebrospinal Fluid
Genotype
Alzheimer Disease
24 Citations (Scopus)

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans

Lu, H. C., Tan, Q., Rousseaux, M. W. C., Wang, W., Kim, J. Y., Richman, R., Wan, Y. W., Yeh, S. Y., Patel, J. M., Liu, X., Lin, T., Lee, Y., Fryer, J. D., Han, J., Chahrour, M., Finnell, R. H., Lei, Y., Zurita-Jimenez, M. E., Ahimaz, P., Anyane-Yeboa, K. & 17 others, Van Maldergem, L., Lehalle, D., Jean-Marcais, N., Mosca-Boidron, A. L., Thevenon, J., Cousin, M. A., Bro, D. E., Lanpher, B., Klee, E. W., Alexander, N., Bainbridge, M. N., Orr, H. T., Sillitoe, R. V., Ljungberg, M. C., Liu, Z., Schaaf, C. P. & Zoghbi, H. Y., Mar 30 2017, In : Nature Genetics. 49, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Middle Hypothalamus
Attention Deficit Disorder with Hyperactivity
Interpersonal Relations
53 Citations (Scopus)

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Bowman, A. B., Lam, Y. C., Jafar-Nejad, P., Chen, H. K., Richman, R., Samaco, R. C., Fryer, J. D., Kahle, J. J., Orr, H. T. & Zoghbi, H. Y., Mar 2007, In : Nature Genetics. 39, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Glutamine
Neurodegenerative Diseases
Ships
polyglutamine

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R. V., Deture, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta neuropathologica communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Dependovirus
Phosphorylation
Tauopathies
Brain
Progressive Supranuclear Palsy

Erratum: Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells (Molecular Pharmacology (2003) 64 (1283-1294))

Eaton, J. B., Peng, J. H., Schroeder, K. M., George, A. A., Fryer, J. D., Krishnan, C., Buhlman, L., Kuo, Y. P., Steinlein, O. & Lukas, R. J., Jul 2004, In : Molecular Pharmacology. 66, 1, p. 197 1 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Epithelial Cells
Pharmacology
86 Citations (Scopus)

Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua

Fryer, J. D., Yu, P., Kang, H., Mandel-Brehm, C., Carter, A. N., Crespo-Barreto, J., Gao, Y., Flora, A., Shaw, C., Orr, H. T. & Zoghbi, H. Y., Nov 4 2011, In : Science. 334, 6056, p. 690-693 4 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Neurodegenerative Diseases
Phenotype
Poisons
Ataxia
22 Citations (Scopus)

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

Allen, J. M., Mailing, L. J., Cohrs, J., Salmonson, C., Fryer, J. D., Nehra, V., Hale, V. L., Kashyap, P. C., White, B. A. & Woods, J. A., Sep 19 2017, (Accepted/In press) In : Gut Microbes. p. 1-16 16 p.

Research output: Contribution to journalArticle

Germ-Free Life
Microbiota
Colitis
Exercise
Tissue Donors
9 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y., Guo, L., Gonzales, P. K., Gendron, T. D., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins
15 Citations (Scopus)

High-affinity epibatidine binding of functional, human α7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells

Peng, J. H., Fryer, J. D., Hurst, R. S., Schroeder, K. M., George, A. A., Morrissy, S., Groppi, V. E., Leonard, S. S. & Lukas, R. J., Apr 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

epibatidine
Nicotinic Receptors
Nicotine
Bungarotoxins
Binding Sites
200 Citations (Scopus)

Human apolipoprotein E4 alters the amyloid-β 40: 42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M. & Holtzman, D. M., Mar 16 2005, In : Journal of Neuroscience. 25, 11, p. 2803-2810 8 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Apolipoprotein E4
Amyloid beta-Protein Precursor
Amyloid
Apolipoproteins E
8 Citations (Scopus)

Huntingtin's critical cleavage

Fryer, J. D. & Zoghbi, H. Y., Sep 2006, In : Nature Neuroscience. 9, 9, p. 1088-1089 2 p.

Research output: Contribution to journalArticle

Caspase 6
Huntington Disease
Huntingtin Protein
5 Citations (Scopus)

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C-C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. D. & Fryer, J. D., 2015, In : Human Molecular Genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

Clusterin
Alzheimer Disease
Genes
Brain
Cerebrospinal Fluid
22 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
47 Citations (Scopus)

Inducible, heterologous expression of human α7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line

Peng, J. H., Lucero, L., Fryer, J. D., Herl, J., Leonard, S. S. & Lukas, R. J., Apr 17 1999, In : Brain Research. 825, 1-2, p. 172-179 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Tetracycline
Nicotine
Up-Regulation
Bungarotoxins
85 Citations (Scopus)

Large-scale topology and the default mode network in the mouse connectome

Stafford, J. M., Jarrett, B. R., Miranda-Dominguez, O., Mills, B. D., Cain, N., Mihalas, S., Lahvis, G. P., Lattal, K. M., Mitchell, S. H., David, S. V., Fryer, J. D., Nigg, J. T. & Fair, D. A., Dec 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 52, p. 18745-18750 6 p.

Research output: Contribution to journalArticle

Connectome
Brain
Primates
Rodentia
Magnetic Resonance Imaging
21 Citations (Scopus)

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Lipopolysaccharides
Central Nervous System
Brain
Cytokines
Sepsis
13 Citations (Scopus)

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. D., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular Neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

Technology
Nucleotides
Nanopores
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats
23 Citations (Scopus)

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C-C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G. D., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

Clusterin
Cerebral Amyloid Angiopathy
Amyloid
Drainage
Alzheimer Disease
2 Citations (Scopus)

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Nicholson, A. M., Zhou, X., Perkerson, R. B., Parsons, T. M., Chew, J., Brooks, M., DeJesus-Hernandez, M., Finch, N. C. A., Matchett, B. J., Kurti, A., Jansen-West, K. R., Perkerson, E., Daughrity, L., Castanedes-Casey, M., Rousseau, L., Phillips, V., Hu, F., Gendron, T. D., Murray, M. E., Dickson, D. W. & 3 others, Fryer, J. D., Petrucelli, L. & Rademakers, R. V., May 31 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Phenotype
Mutation
Dipeptides
82 Citations (Scopus)

Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

Lee, J. M., Yin, K. J., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Sep 1 2003, In : Annals of Neurology. 54, 3, p. 379-382 4 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Animal Models
Hemorrhage
Amyloid beta-Peptides
46 Citations (Scopus)

Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

Lee, J. M., Yin, K., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Mar 15 2005, In : Journal of the Neurological Sciences. 229-230, p. 249-254 6 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Hemorrhage
Cerebral Hemorrhage
Amyloid
14 Citations (Scopus)

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Kang, S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J-P., Petrucelli, L. & Fryer, J. D., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

Amyloid
Tauopathies
Alzheimer Disease
Amyloidosis
Disease Susceptibility