John D. Fryer, PhD

  • 4451 Citations
  • 40 Scopus h-Index
19992020
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Research Output 1999 2019

  • 4451 Citations
  • 40 Scopus h-Index
  • 77 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
68 Citations (Scopus)

Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J Mice

Allen, J. M., Miller, M. E. B., Pence, B. D., Whitlock, K., Nehra, V., Gaskins, H. R., White, B. A., Fryer, J. D. & Woods, J. A., Apr 15 2015, In : Journal of Applied Physiology. 118, 8, p. 1059-1066 8 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Running
Gastrointestinal Microbiome
Colitis
Feces

TRIO gene segregation in a family with cerebellar ataxia

Hanna Al Shaikh, R., Caulfield, T., Strongosky, A. J., Matthew, M., Jansen-West, K. R., Prudencio, M., Fryer, J. D., Petrucelli, L., Uitti, R. J. & Wszolek, Z. K., Jan 1 2018, (Accepted/In press) In : Neurologia i Neurochirurgia Polska.

Research output: Contribution to journalArticle

Cerebellar Ataxia
Ataxia
Genes
Mothers
Exome
48 Citations (Scopus)

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Myeloid Cells
Microglia
Alzheimer Disease
48 Citations (Scopus)

TREM2 in CNS homeostasis and neurodegenerative disease

Painter, M. M., Atagi, Y., Liu, C-C., Rademakers, R. V., Xu, H., Fryer, J. D. & Bu, G. D., Sep 4 2015, In : Molecular Neurodegeneration. 10, 1, 43.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Myeloid Cells
Neurodegenerative Diseases
Homeostasis
Proteins
23 Citations (Scopus)

Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function

Ferchmin, P. A., Lukas, R. J., Hann, R. M., Fryer, J. D., Eaton, J. B., Pagn, O. R., Rodríguez, A. D., Nicolau, Y., Rosado, M., Cortés, S. & Eterovi, V. A., Apr 1 2001, In : Journal of Neuroscience Research. 64, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Nicotine
Tobacco
tenocyclidine
Locomotion
138 Citations (Scopus)

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Mackenzie, I. R., Nicholson, A. M., Sarkar, M., Messing, J., Purice, M. D., Pottier, C., Annu, K., Baker, M., Perkerson, R. B., Kurti, A., Matchett, B. J., Mittag, T., Temirov, J., Hsiung, G. Y. R., Krieger, C., Murray, M. E., Kato, M., Fryer, J. D., Petrucelli, L., Zinman, L. & 22 others, Weintraub, S., Mesulam, M., Keith, J., Zivkovic, S. A., Hirsch-Reinshagen, V., Roos, R. P., Züchner, S., Graff Radford, N. R., Petersen, R. C., Caselli, R. J., Wszolek, Z. K., Finger, E., Lippa, C., Lacomis, D., Stewart, H., Dickson, D. W., Kim, H. J., Rogaeva, E., Bigio, E., Boylan, K. B., Taylor, J. P. & Rademakers, R. V., Aug 16 2017, In : Neuron. 95, 4, p. 808-816.e9

Research output: Contribution to journalArticle

Mutation
DNA-Binding Proteins
Hyalin
Phase Transition
Amyotrophic Lateral Sclerosis
21 Citations (Scopus)

The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption

Legleiter, J., Fryer, J. D., Holtzman, D. M. & Kowalewski, T., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 588-599 12 p.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Apolipoproteins E
Apolipoprotein E4
Lipoproteins
95 Citations (Scopus)

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G. D. & Holtzman, D. M., Jul 8 2005, In : Journal of Biological Chemistry. 280, 27, p. 25754-25759 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid Plaques
Neurology
Apolipoproteins E
Pathology
15 Citations (Scopus)

The bad seed in Alzheimer's disease

Fryer, J. D. & Holtzman, D. M., Jul 21 2005, In : Neuron. 47, 2, p. 167-168 2 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Seeds
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloid
25 Citations (Scopus)

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Cook, C., Kang, S., Carlomagno, Y., Lin, W. L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., Rousseau, L., Phillips, V., Bu, G. D., Dickson, D. W., Petrucelli, L. & Fryer, J. D., 2015, In : Human Molecular Genetics. 24, 21, p. 6198-6212 15 p.

Research output: Contribution to journalArticle

Tauopathies
Dependovirus
tau Proteins
Endopeptidase K
Inborn Genetic Diseases
2 Citations (Scopus)

Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

Ebbert, M. T. W., Jensen, T. D., Jansen-West, K., Sens, J. P., Reddy, J. S., Ridge, P. G., Kauwe, J. S. K., Belzil, V., Pregent, L., Carrasquillo, M. M., Keene, D., Larson, E., Crane, P., Asmann, Y., Taner, N., Younkin, S. G., Ross, O. A., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., May 20 2019, In : Genome biology. 20, 1, 97.

Research output: Contribution to journalArticle

Open Access
gene
Technology
Alzheimer disease
Genes
Alzheimer Disease
8 Citations (Scopus)

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

Ibuprofen
Cognition
Neuronal Plasticity
Astrocytes
Anti-Inflammatory Agents
52 Citations (Scopus)

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C-C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G. D., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Cytokines
Cell Surface Receptors
Phosphatidylinositol 3-Kinases
19 Citations (Scopus)

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

Cook, C., Dunmore, J. H., Murray, M. E., Scheffel, K., Shukoor, N., Tong, J., Castanedes-Casey, M., Phillips, V., Rousseau, L., Penuliar, M. S., Kurti, A., Dickson, D. W., Petrucelli, L. & Fryer, J. D., Jul 2014, In : Neurobiology of Aging. 35, 7, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Amygdala
Transgenic Mice
Fear
Learning
3 Citations (Scopus)

Risk Factors for Persistent Cognitive Impairment After Critical Illness, Nested Case-Control Study

Sakusic, A., Gajic, O., Singh, T. D., O'Horo, J. C., Jenkins, G., Wilson, G. A., Petersen, R. C., Fryer, J. D., Kashyap, R. & Rabinstein, A., Dec 1 2018, In : Critical Care Medicine. 46, 12, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

Critical Illness
Case-Control Studies
Hospitalization
Comorbidity
Cognitive Dysfunction
111 Citations (Scopus)

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J. D., Sullivan, P. M., Fagan, A. M., Han, X. & Holtzman, D. M., 2001, In : Neurochemistry International. 39, 5-6, p. 415-425 11 p.

Research output: Contribution to journalArticle

Clusterin
Apolipoproteins E
Astrocytes
Transgenic Mice
Lipoproteins
70 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
59 Citations (Scopus)

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Morikawa, M., Fryer, J. D., Sullivan, P. M., Christopher, E. A., Wahrle, S. E., DeMattos, R. B., O'Dell, M. A., Fagan, A. M., Lashuel, H. A., Walz, T., Asai, K. & Holtzman, D. M., Jun 2005, In : Neurobiology of Disease. 19, 1-2, p. 66-76 11 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Amyloid
Astrocytes
Protein Isoforms
Apolipoprotein E3
42 Citations (Scopus)

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Zhang, Y., Gendron, T. D., Ebbert, M. T. W., O’Raw, A. D., Yue, M., Jansen-West, K., Zhang, X., Prudencio, M., Chew, J., Cook, C., Daughrity, L. M., Tong, J., Song, Y., Pickles, S. R., Castanedes-Casey, M., Kurti, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Hu, W. & 3 others, Gitler, A. D., Fryer, J. D. & Petrucelli, L., Jun 25 2018, (Accepted/In press) In : Nature Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Protein Biosynthesis
Dipeptides
Proteins
Brain
47 Citations (Scopus)

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. D., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R. V., Fryer, J. D., Rush, B. K., Pedraza, O. D., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science Translational Medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
RNA
Proteins
Antisense Oligonucleotides
Therapeutics

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.

Crespo-Barreto, J., Fryer, J. D., Shaw, C. A., Orr, H. T. & Zoghbi, H. Y., Jul 2010, In : PLoS Genetics. 6, 7

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
pathogenesis
neurodegenerative diseases
gene expression
disease models
76 Citations (Scopus)

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis

Crespo-Barreto, J., Fryer, J. D., Shaw, C. A., Orr, H. T. & Zoghbi, H. Y., Jul 2010, In : PLoS Genetics. 6, 7, p. 1-17 17 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
pathogenesis
neurodegenerative diseases
gene expression
disease models
25 Citations (Scopus)

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C-C., Atagi, Y., Chen, X. F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S., Rosenberry, T. L., Fryer, J. D., Zhang, Y. W., Xu, H. & Bu, G. D., Jun 1 2016, In : Neurobiology of Aging. 42, p. 132-141 10 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Alzheimer Disease
Lipopolysaccharides
Amyloid
88 Citations (Scopus)

Novel role for apolipoprotein E in the central nervous system: Modulation of sulfatide content

Han, X., Cheng, H., Fryer, J. D., Fagan, A. M. & Holtzman, D. M., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8043-8051 9 p.

Research output: Contribution to journalArticle

Sulfoglycosphingolipids
Neurology
Apolipoproteins E
Central Nervous System
Modulation
260 Citations (Scopus)
Ibogaine
Bupropion
Phencyclidine
Nicotinic Receptors
Muscles
28 Citations (Scopus)

Neurotoxicity of channel mutations in heterologously expressed α7-nicotinic acetylcholine receptors

Lukas, R. J., Lucero, L., Buisson, B., Galzi, J. L., Puchacz, E., Fryer, J. D., Changeux, J. P. & Bertrand, D., 2001, In : European Journal of Neuroscience. 13, 10, p. 1849-1860 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Mutation
Poisons
Neurons
Cell Line
3 Citations (Scopus)

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

Synucleins
Dependovirus
alpha-Synuclein
Pathology
Brain
15 Citations (Scopus)

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Kang, S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J-P., Petrucelli, L. & Fryer, J. D., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

Amyloid
Tauopathies
Alzheimer Disease
Amyloidosis
Disease Susceptibility
47 Citations (Scopus)

Matrix metalloproteinase-9 in cerebral-amyloid-angiopathy-related hemorrhage

Lee, J. M., Yin, K., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Mar 15 2005, In : Journal of the Neurological Sciences. 229-230, p. 249-254 6 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Hemorrhage
Cerebral Hemorrhage
Amyloid
82 Citations (Scopus)

Matrix metalloproteinase-9 and spontaneous hemorrhage in an animal model of cerebral amyloid angiopathy

Lee, J. M., Yin, K. J., Hsin, I., Chen, S., Fryer, J. D., Holtzman, D. M., Hsu, C. Y. & Xu, J., Sep 1 2003, In : Annals of Neurology. 54, 3, p. 379-382 4 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Matrix Metalloproteinase 9
Animal Models
Hemorrhage
Amyloid beta-Peptides
2 Citations (Scopus)

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Nicholson, A. M., Zhou, X., Perkerson, R. B., Parsons, T. M., Chew, J., Brooks, M., DeJesus-Hernandez, M., Finch, N. C. A., Matchett, B. J., Kurti, A., Jansen-West, K. R., Perkerson, E., Daughrity, L., Castanedes-Casey, M., Rousseau, L., Phillips, V., Hu, F., Gendron, T. D., Murray, M. E., Dickson, D. W. & 3 others, Fryer, J. D., Petrucelli, L. & Rademakers, R. V., May 31 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Phenotype
Mutation
Dipeptides
24 Citations (Scopus)

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C-C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G. D., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

Clusterin
Cerebral Amyloid Angiopathy
Amyloid
Drainage
Alzheimer Disease
14 Citations (Scopus)

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. D., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular Neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

Technology
Nucleotides
Nanopores
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats
22 Citations (Scopus)

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Lipopolysaccharides
Central Nervous System
Brain
Cytokines
Sepsis
86 Citations (Scopus)

Large-scale topology and the default mode network in the mouse connectome

Stafford, J. M., Jarrett, B. R., Miranda-Dominguez, O., Mills, B. D., Cain, N., Mihalas, S., Lahvis, G. P., Lattal, K. M., Mitchell, S. H., David, S. V., Fryer, J. D., Nigg, J. T. & Fair, D. A., Dec 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 52, p. 18745-18750 6 p.

Research output: Contribution to journalArticle

Connectome
Brain
Primates
Rodentia
Magnetic Resonance Imaging
47 Citations (Scopus)

Inducible, heterologous expression of human α7-nicotinic acetylcholine receptors in a native nicotinic receptor-null human clonal line

Peng, J. H., Lucero, L., Fryer, J. D., Herl, J., Leonard, S. S. & Lukas, R. J., Apr 17 1999, In : Brain Research. 825, 1-2, p. 172-179 8 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Tetracycline
Nicotine
Up-Regulation
Bungarotoxins
22 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
5 Citations (Scopus)

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C-C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. D. & Fryer, J. D., 2015, In : Human Molecular Genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

Clusterin
Alzheimer Disease
Genes
Brain
Cerebrospinal Fluid
8 Citations (Scopus)

Huntingtin's critical cleavage

Fryer, J. D. & Zoghbi, H. Y., Sep 2006, In : Nature Neuroscience. 9, 9, p. 1088-1089 2 p.

Research output: Contribution to journalArticle

Caspase 6
Huntington Disease
Huntingtin Protein
201 Citations (Scopus)

Human apolipoprotein E4 alters the amyloid-β 40: 42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model

Fryer, J. D., Simmons, K., Parsadanian, M., Bales, K. R., Paul, S. M., Sullivan, P. M. & Holtzman, D. M., Mar 16 2005, In : Journal of Neuroscience. 25, 11, p. 2803-2810 8 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Apolipoprotein E4
Amyloid beta-Protein Precursor
Amyloid
Apolipoproteins E
15 Citations (Scopus)

High-affinity epibatidine binding of functional, human α7-nicotinic acetylcholine receptors stably and heterologously expressed de novo in human SH-EP1 cells

Peng, J. H., Fryer, J. D., Hurst, R. S., Schroeder, K. M., George, A. A., Morrissy, S., Groppi, V. E., Leonard, S. S. & Lukas, R. J., Apr 2005, In : Journal of Pharmacology and Experimental Therapeutics. 313, 1, p. 24-35 12 p.

Research output: Contribution to journalArticle

epibatidine
Nicotinic Receptors
Nicotine
Bungarotoxins
Binding Sites
11 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins
24 Citations (Scopus)

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

Allen, J. M., Mailing, L. J., Cohrs, J., Salmonson, C., Fryer, J. D., Nehra, V., Hale, V. L., Kashyap, P. C., White, B. A. & Woods, J. A., Sep 19 2017, (Accepted/In press) In : Gut Microbes. p. 1-16 16 p.

Research output: Contribution to journalArticle

Germ-Free Life
Microbiota
Colitis
Exercise
Tissue Donors
87 Citations (Scopus)

Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua

Fryer, J. D., Yu, P., Kang, H., Mandel-Brehm, C., Carter, A. N., Crespo-Barreto, J., Gao, Y., Flora, A., Shaw, C., Orr, H. T. & Zoghbi, H. Y., Nov 4 2011, In : Science. 334, 6056, p. 690-693 4 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Neurodegenerative Diseases
Phenotype
Poisons
Ataxia

Erratum: Characterization of human α4β2-nicotinic acetylcholine receptors stably and heterologously expressed in native nicotinic receptor-null SH-EP1 human epithelial cells (Molecular Pharmacology (2003) 64 (1283-1294))

Eaton, J. B., Peng, J. H., Schroeder, K. M., George, A. A., Fryer, J. D., Krishnan, C., Buhlman, L., Kuo, Y. P., Steinlein, O. & Lukas, R. J., Jul 2004, In : Molecular Pharmacology. 66, 1, p. 197 1 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Epithelial Cells
Pharmacology

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R. V., Deture, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta neuropathologica communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Dependovirus
Phosphorylation
Tauopathies
Brain
Progressive Supranuclear Palsy
53 Citations (Scopus)

Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Bowman, A. B., Lam, Y. C., Jafar-Nejad, P., Chen, H. K., Richman, R., Samaco, R. C., Fryer, J. D., Kahle, J. J., Orr, H. T. & Zoghbi, H. Y., Mar 2007, In : Nature Genetics. 39, 3, p. 373-379 7 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Glutamine
Neurodegenerative Diseases
Ships
polyglutamine
26 Citations (Scopus)

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans

Lu, H. C., Tan, Q., Rousseaux, M. W. C., Wang, W., Kim, J. Y., Richman, R., Wan, Y. W., Yeh, S. Y., Patel, J. M., Liu, X., Lin, T., Lee, Y., Fryer, J. D., Han, J., Chahrour, M., Finnell, R. H., Lei, Y., Zurita-Jimenez, M. E., Ahimaz, P., Anyane-Yeboa, K. & 17 others, Van Maldergem, L., Lehalle, D., Jean-Marcais, N., Mosca-Boidron, A. L., Thevenon, J., Cousin, M. A., Bro, D. E., Lanpher, B., Klee, E. W., Alexander, N., Bainbridge, M. N., Orr, H. T., Sillitoe, R. V., Ljungberg, M. C., Liu, Z., Schaaf, C. P. & Zoghbi, H. Y., Mar 30 2017, In : Nature Genetics. 49, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Middle Hypothalamus
Attention Deficit Disorder with Hyperactivity
Interpersonal Relations
106 Citations (Scopus)

Differences in the Aβ40/Aβ42 ratio associated with cerebrospinal fluid lipoproteins as a function of apolipoprotein E genotype

Fagan, A. M., Younkin, L. H., Morris, J. C., Fryer, J. D., Cole, T. G., Younkin, S. G. & Holtzman, D. M., 2000, In : Annals of Neurology. 48, 2, p. 201-210 10 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Lipoproteins
Cerebrospinal Fluid
Genotype
Alzheimer Disease
53 Citations (Scopus)

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Kang, S., Kurti, A., Fair, D. A. & Fryer, J. D., Sep 12 2014, In : Journal of Neuroinflammation. 11, 1, 156.

Research output: Contribution to journalArticle

Obesity
Mothers
High Fat Diet
Lactation
Encephalitis