John D. Fryer, PhD

  • 4419 Citations
  • 39 Scopus h-Index
19992020
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Research Output 1999 2019

  • 4419 Citations
  • 39 Scopus h-Index
  • 77 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
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Article
3 Citations (Scopus)

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

Synucleins
Dependovirus
alpha-Synuclein
Pathology
Brain
28 Citations (Scopus)

Neurotoxicity of channel mutations in heterologously expressed α7-nicotinic acetylcholine receptors

Lukas, R. J., Lucero, L., Buisson, B., Galzi, J. L., Puchacz, E., Fryer, J. D., Changeux, J. P. & Bertrand, D., 2001, In : European Journal of Neuroscience. 13, 10, p. 1849-1860 12 p.

Research output: Contribution to journalArticle

Nicotinic Receptors
Mutation
Poisons
Neurons
Cell Line
260 Citations (Scopus)
Ibogaine
Bupropion
Phencyclidine
Nicotinic Receptors
Muscles
88 Citations (Scopus)

Novel role for apolipoprotein E in the central nervous system: Modulation of sulfatide content

Han, X., Cheng, H., Fryer, J. D., Fagan, A. M. & Holtzman, D. M., Mar 7 2003, In : Journal of Biological Chemistry. 278, 10, p. 8043-8051 9 p.

Research output: Contribution to journalArticle

Sulfoglycosphingolipids
Neurology
Apolipoproteins E
Central Nervous System
Modulation
25 Citations (Scopus)

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C-C., Atagi, Y., Chen, X. F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S., Rosenberry, T. L., Fryer, J. D., Zhang, Y. W., Xu, H. & Bu, G. D., Jun 1 2016, In : Neurobiology of Aging. 42, p. 132-141 10 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Alzheimer Disease
Lipopolysaccharides
Amyloid
76 Citations (Scopus)

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis

Crespo-Barreto, J., Fryer, J. D., Shaw, C. A., Orr, H. T. & Zoghbi, H. Y., Jul 2010, In : PLoS Genetics. 6, 7, p. 1-17 17 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
pathogenesis
neurodegenerative diseases
gene expression
disease models

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.

Crespo-Barreto, J., Fryer, J. D., Shaw, C. A., Orr, H. T. & Zoghbi, H. Y., Jul 2010, In : PLoS Genetics. 6, 7

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
pathogenesis
neurodegenerative diseases
gene expression
disease models
47 Citations (Scopus)

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. D., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R. V., Fryer, J. D., Rush, B. K., Pedraza, O. D., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science Translational Medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
RNA
Proteins
Antisense Oligonucleotides
Therapeutics
38 Citations (Scopus)

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Zhang, Y., Gendron, T. D., Ebbert, M. T. W., O’Raw, A. D., Yue, M., Jansen-West, K., Zhang, X., Prudencio, M., Chew, J., Cook, C., Daughrity, L. M., Tong, J., Song, Y., Pickles, S. R., Castanedes-Casey, M., Kurti, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Hu, W. & 3 others, Gitler, A. D., Fryer, J. D. & Petrucelli, L., Jun 25 2018, (Accepted/In press) In : Nature Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Protein Biosynthesis
Dipeptides
Proteins
Brain
59 Citations (Scopus)

Production and characterization of astrocyte-derived human apolipoprotein E isoforms from immortalized astrocytes and their interactions with amyloid-β

Morikawa, M., Fryer, J. D., Sullivan, P. M., Christopher, E. A., Wahrle, S. E., DeMattos, R. B., O'Dell, M. A., Fagan, A. M., Lashuel, H. A., Walz, T., Asai, K. & Holtzman, D. M., Jun 2005, In : Neurobiology of Disease. 19, 1-2, p. 66-76 11 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Amyloid
Astrocytes
Protein Isoforms
Apolipoprotein E3
70 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
111 Citations (Scopus)

Purification and characterization of astrocyte-secreted apolipoprotein E and J-containing lipoproteins from wild-type and human apoE transgenic mice

DeMattos, R. B., Brendza, R. P., Heuser, J. E., Kierson, M., Cirrito, J. R., Fryer, J. D., Sullivan, P. M., Fagan, A. M., Han, X. & Holtzman, D. M., 2001, In : Neurochemistry International. 39, 5-6, p. 415-425 11 p.

Research output: Contribution to journalArticle

Clusterin
Apolipoproteins E
Astrocytes
Transgenic Mice
Lipoproteins
3 Citations (Scopus)

Risk Factors for Persistent Cognitive Impairment After Critical Illness, Nested Case-Control Study

Sakusic, A., Gajic, O., Singh, T. D., O'Horo, J. C., Jenkins, G., Wilson, G. A., Petersen, R. C., Fryer, J. D., Kashyap, R. & Rabinstein, A., Dec 1 2018, In : Critical Care Medicine. 46, 12, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

Critical Illness
Case-Control Studies
Hospitalization
Comorbidity
Cognitive Dysfunction
19 Citations (Scopus)

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

Cook, C., Dunmore, J. H., Murray, M. E., Scheffel, K., Shukoor, N., Tong, J., Castanedes-Casey, M., Phillips, V., Rousseau, L., Penuliar, M. S., Kurti, A., Dickson, D. W., Petrucelli, L. & Fryer, J. D., Jul 2014, In : Neurobiology of Aging. 35, 7, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Amygdala
Transgenic Mice
Fear
Learning
52 Citations (Scopus)

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C-C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G. D., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Cytokines
Cell Surface Receptors
Phosphatidylinositol 3-Kinases
8 Citations (Scopus)

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

Ibuprofen
Cognition
Neuronal Plasticity
Astrocytes
Anti-Inflammatory Agents
2 Citations (Scopus)

Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

Ebbert, M. T. W., Jensen, T. D., Jansen-West, K., Sens, J. P., Reddy, J. S., Ridge, P. G., Kauwe, J. S. K., Belzil, V., Pregent, L., Carrasquillo, M. M., Keene, D., Larson, E., Crane, P., Asmann, Y., Taner, N., Younkin, S. G., Ross, O. A., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., May 20 2019, In : Genome biology. 20, 1, 97.

Research output: Contribution to journalArticle

Open Access
gene
Technology
Alzheimer disease
Genes
Alzheimer Disease
25 Citations (Scopus)

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Cook, C., Kang, S., Carlomagno, Y., Lin, W. L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., Rousseau, L., Phillips, V., Bu, G. D., Dickson, D. W., Petrucelli, L. & Fryer, J. D., 2015, In : Human Molecular Genetics. 24, 21, p. 6198-6212 15 p.

Research output: Contribution to journalArticle

Tauopathies
Dependovirus
tau Proteins
Endopeptidase K
Inborn Genetic Diseases
15 Citations (Scopus)

The bad seed in Alzheimer's disease

Fryer, J. D. & Holtzman, D. M., Jul 21 2005, In : Neuron. 47, 2, p. 167-168 2 p.

Research output: Contribution to journalArticle

Amyloid Plaques
Seeds
Alzheimer Disease
Amyloid beta-Protein Precursor
Amyloid
95 Citations (Scopus)

The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice

Fryer, J. D., DeMattos, R. B., McCormick, L. M., O'Dell, M. A., Spinner, M. L., Bales, K. R., Paul, S. M., Sullivan, P. M., Parsadanian, M., Bu, G. D. & Holtzman, D. M., Jul 8 2005, In : Journal of Biological Chemistry. 280, 27, p. 25754-25759 6 p.

Research output: Contribution to journalArticle

LDL Receptors
Amyloid Plaques
Neurology
Apolipoproteins E
Pathology
21 Citations (Scopus)

The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption

Legleiter, J., Fryer, J. D., Holtzman, D. M. & Kowalewski, T., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 588-599 12 p.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Apolipoproteins E
Apolipoprotein E4
Lipoproteins
135 Citations (Scopus)

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Mackenzie, I. R., Nicholson, A. M., Sarkar, M., Messing, J., Purice, M. D., Pottier, C., Annu, K., Baker, M., Perkerson, R. B., Kurti, A., Matchett, B. J., Mittag, T., Temirov, J., Hsiung, G. Y. R., Krieger, C., Murray, M. E., Kato, M., Fryer, J. D., Petrucelli, L., Zinman, L. & 22 others, Weintraub, S., Mesulam, M., Keith, J., Zivkovic, S. A., Hirsch-Reinshagen, V., Roos, R. P., Züchner, S., Graff Radford, N. R., Petersen, R. C., Caselli, R. J., Wszolek, Z. K., Finger, E., Lippa, C., Lacomis, D., Stewart, H., Dickson, D. W., Kim, H. J., Rogaeva, E., Bigio, E., Boylan, K. B., Taylor, J. P. & Rademakers, R. V., Aug 16 2017, In : Neuron. 95, 4, p. 808-816.e9

Research output: Contribution to journalArticle

Mutation
DNA-Binding Proteins
Hyalin
Phase Transition
Amyotrophic Lateral Sclerosis
23 Citations (Scopus)

Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function

Ferchmin, P. A., Lukas, R. J., Hann, R. M., Fryer, J. D., Eaton, J. B., Pagn, O. R., Rodríguez, A. D., Nicolau, Y., Rosado, M., Cortés, S. & Eterovi, V. A., Apr 1 2001, In : Journal of Neuroscience Research. 64, 1, p. 18-25 8 p.

Research output: Contribution to journalArticle

Cholinergic Receptors
Nicotine
Tobacco
tenocyclidine
Locomotion
48 Citations (Scopus)

TREM2 in CNS homeostasis and neurodegenerative disease

Painter, M. M., Atagi, Y., Liu, C-C., Rademakers, R. V., Xu, H., Fryer, J. D. & Bu, G. D., Sep 4 2015, In : Molecular Neurodegeneration. 10, 1, 43.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Myeloid Cells
Neurodegenerative Diseases
Homeostasis
Proteins
47 Citations (Scopus)

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Myeloid Cells
Microglia
Alzheimer Disease

TRIO gene segregation in a family with cerebellar ataxia

Hanna Al Shaikh, R., Caulfield, T., Strongosky, A. J., Matthew, M., Jansen-West, K. R., Prudencio, M., Fryer, J. D., Petrucelli, L., Uitti, R. J. & Wszolek, Z. K., Jan 1 2018, (Accepted/In press) In : Neurologia i Neurochirurgia Polska.

Research output: Contribution to journalArticle

Cerebellar Ataxia
Ataxia
Genes
Mothers
Exome
66 Citations (Scopus)

Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J Mice

Allen, J. M., Miller, M. E. B., Pence, B. D., Whitlock, K., Nehra, V., Gaskins, H. R., White, B. A., Fryer, J. D. & Woods, J. A., Apr 15 2015, In : Journal of Applied Physiology. 118, 8, p. 1059-1066 8 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Running
Gastrointestinal Microbiome
Colitis
Feces