John D. Fryer, PhD

  • 5025 Citations
  • 40 Scopus h-Index
19992020

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Article
2020

Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ42 in triggering receptor expressed on myeloid cells 2 loss-of-function murine models

Rong, Z., Cheng, B., Zhong, L., Ye, X., Li, X., Jia, L., Li, Y., Shue, F., Wang, N., Cheng, Y., Huang, X., Liu, C-C., Fryer, J. D., Wang, X., Zhang, Y. W. & Zheng, H., 2020, (Accepted/In press) In : FASEB Journal.

Research output: Contribution to journalArticle

APOE4 exacerbates α-synuclein pathology and related toxicity independent of amyloid

Zhao, N., Attrebi, O. N., Ren, Y., Qiao, W., Sonustun, B., Martens, Y. A., Meneses, A. D., Li, F., Shue, F., Zheng, J., van Ingelgom, A. J., Davis, M. D., Kurti, A., Knight, J. A., Linares, C., Chen, Y., Delenclos, M., Liu, C. C., Fryer, J. D., Asmann, Y. W. & 4 others, McLean, P. J., Dickson, D. W., Ross, O. A. & Bu, G., Feb 5 2020, In : Science translational medicine. 12, 529, eaay1809.

Research output: Contribution to journalArticle

7 Scopus citations

Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo

Todd, T. W., McEachin, Z. T., Chew, J., Burch, A. R., Jansen-West, K., Tong, J., Yue, M., Song, Y., Castanedes-Casey, M., Kurti, A., Dunmore, J. H., Fryer, J. D., Zhang, Y. J., San Millan, B., Teijeira Bautista, S., Arias, M., Dickson, D., Gendron, T. F., Sobrido, M. J., Disney, M. D. & 3 others, Bassell, G. J., Rossoll, W. & Petrucelli, L., May 5 2020, In : Cell reports. 31, 5, 107616.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2019

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. F., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. J. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 9.

Research output: Contribution to journalArticle

14 Scopus citations

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R., DeTure, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Open Access

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

31 Scopus citations

Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

Ebbert, M. T. W., Jensen, T. D., Jansen-West, K., Sens, J. P., Reddy, J. S., Ridge, P. G., Kauwe, J. S. K., Belzil, V., Pregent, L., Carrasquillo, M. M., Keene, D., Larson, E., Crane, P., Asmann, Y. W., Ertekin-Taner, N., Younkin, S. G., Ross, O. A., Rademakers, R., Petrucelli, L. & Fryer, J. D., May 20 2019, In : Genome biology. 20, 1, 97.

Research output: Contribution to journalArticle

Open Access
8 Scopus citations
2018

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C. C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff-Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

22 Scopus citations

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

14 Scopus citations

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. F., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

21 Scopus citations

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Nicholson, A. M., Zhou, X., Perkerson, R. B., Parsons, T. M., Chew, J., Brooks, M., DeJesus-Hernandez, M., Finch, N. C. A., Matchett, B. J., Kurti, A., Jansen-West, K. R., Perkerson, E., Daughrity, L., Castanedes-Casey, M., Rousseau, L., Phillips, V., Hu, F., Gendron, T. F., Murray, M. E., Dickson, D. W. & 3 others, Fryer, J. D., Petrucelli, L. & Rademakers, R., May 31 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Kang, S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J-P., Petrucelli, L. & Fryer, J. D., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

30 Scopus citations

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Zhang, Y. J., Gendron, T. F., Ebbert, M. T. W., O’Raw, A. D., Yue, M., Jansen-West, K., Zhang, X., Prudencio, M., Chew, J., Cook, C. N., Daughrity, L. M., Tong, J., Song, Y., Pickles, S. R., Castanedes-Casey, M., Kurti, A., Rademakers, R., Oskarsson, B., Dickson, D. W., Hu, W. & 3 others, Gitler, A. D., Fryer, J. D. & Petrucelli, L., Aug 1 2018, In : Nature Medicine. 24, 8, p. 1136-1142 7 p.

Research output: Contribution to journalArticle

59 Scopus citations

Risk Factors for Persistent Cognitive Impairment After Critical Illness, Nested Case-Control Study

Sakusic, A., Gajic, O., Singh, T. D., O'Horo, J. C., Jenkins, G., Wilson, G. A., Petersen, R. C., Fryer, J. D., Kashyap, R. & Rabinstein, A., Dec 1 2018, In : Critical Care Medicine. 46, 12, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

9 Scopus citations

TRIO gene segregation in a family with cerebellar ataxia

Hanna Al Shaikh, R., Caulfield, T., Strongosky, A. J., Matthew, M., Jansen-West, K. R., Prudencio, M., Fryer, J. D., Petrucelli, L., Uitti, R. J. & Wszolek, Z. K., Nov 1 2018, In : Neurologia i neurochirurgia polska. 52, 6, p. 743-749 7 p.

Research output: Contribution to journalArticle

2017

Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Park, S., Lee, S., Lee, C. G., Park, G. Y., Hong, H., Lee, J. S., Kim, Y. M., Lee, S. B., Hwang, D., Choi, Y. S., Fryer, J. D., Im, S. H., Lee, S. W. & Lee, Y., Jul 12 2017, In : Nature communications. 8, 16037.

Research output: Contribution to journalArticle

13 Scopus citations

Derivation and validation of the automated search algorithms to identify cognitive impairment and dementia in electronic health records

Amra, S., O'Horo, J. C., Singh, T. D., Wilson, G. A., Kashyap, R., Petersen, R. C., Roberts, R. O., Fryer, J. D., Rabinstein, A. & Gajic, O., Feb 1 2017, In : Journal of Critical Care. 37, p. 202-205 4 p.

Research output: Contribution to journalArticle

14 Scopus citations

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans

Lu, H. C., Tan, Q., Rousseaux, M. W. C., Wang, W., Kim, J. Y., Richman, R., Wan, Y. W., Yeh, S. Y., Patel, J. M., Liu, X., Lin, T., Lee, Y., Fryer, J. D., Han, J., Chahrour, M., Finnell, R. H., Lei, Y., Zurita-Jimenez, M. E., Ahimaz, P., Anyane-Yeboa, K. & 17 others, Van Maldergem, L., Lehalle, D., Jean-Marcais, N., Mosca-Boidron, A. L., Thevenon, J., Cousin, M. A., Bro, D. E., Lanpher, B., Klee, E. W., Alexander, N., Bainbridge, M. N., Orr, H. T., Sillitoe, R. V., Ljungberg, M. C., Liu, Z., Schaaf, C. P. & Zoghbi, H. Y., Mar 30 2017, In : Nature Genetics. 49, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

40 Scopus citations

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

Allen, J. M., Mailing, L. J., Cohrs, J., Salmonson, C., Fryer, J. D., Nehra, V., Hale, V. L., Kashyap, P. C., White, B. A. & Woods, J. A., Sep 19 2017, (Accepted/In press) In : Gut Microbes. p. 1-16 16 p.

Research output: Contribution to journalArticle

30 Scopus citations

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

31 Scopus citations

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S. S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C. C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

32 Scopus citations

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta Neuropathologica Communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

5 Scopus citations

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. F., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y. J., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R., Fryer, J. D., Rush, B. K., Pedraza, O., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science translational medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

58 Scopus citations

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C. C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

73 Scopus citations

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

11 Scopus citations

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Mackenzie, I. R., Nicholson, A. M., Sarkar, M., Messing, J., Purice, M. D., Pottier, C., Annu, K., Baker, M., Perkerson, R. B., Kurti, A., Matchett, B. J., Mittag, T., Temirov, J., Hsiung, G. Y. R., Krieger, C., Murray, M. E., Kato, M., Fryer, J. D., Petrucelli, L., Zinman, L. & 22 others, Weintraub, S., Mesulam, M., Keith, J., Zivkovic, S. A., Hirsch-Reinshagen, V., Roos, R. P., Züchner, S., Graff-Radford, N. R., Petersen, R. C., Caselli, R. J., Wszolek, Z. K., Finger, E., Lippa, C., Lacomis, D., Stewart, H., Dickson, D. W., Kim, H. J., Rogaeva, E., Bigio, E., Boylan, K. B., Taylor, J. P. & Rademakers, R., Aug 16 2017, In : Neuron. 95, 4, p. 808-816.e9

Research output: Contribution to journalArticle

182 Scopus citations

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

69 Scopus citations
2016

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C. C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

47 Scopus citations

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

36 Scopus citations

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y., Gendron, T. D., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A. & 16 others, Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R. V., Boylan, K. B., Bu, G. D., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D. & Petrucelli, L., May 1 2016, In : Nature Neuroscience. 19, 5, p. 668-677 10 p.

Research output: Contribution to journalArticle

124 Scopus citations

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S. S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C. C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. & Fryer, J. D., 2016, In : Human molecular genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., DeTure, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C. C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J. E., Dickson, D. W., Bu, G. & Kanekiyo, T., Aug 1 2016, In : Acta neuropathologica. 132, 2, p. 225-234 10 p.

Research output: Contribution to journalArticle

28 Scopus citations

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C-C., Atagi, Y., Chen, X. F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S., Rosenberry, T. L., Fryer, J. D., Zhang, Y. W., Xu, H. & Bu, G. D., Jun 1 2016, In : Neurobiology of Aging. 42, p. 132-141 10 p.

Research output: Contribution to journalArticle

34 Scopus citations
2015

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Atagi, Y., Liu, C-C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R. V., Kang, S., Xu, H., Younkin, S. G., Das, P., Fryer, J. D. & Bu, G. D., Oct 23 2015, In : Journal of Biological Chemistry. 290, 43, p. 26043-26050 8 p.

Research output: Contribution to journalArticle

162 Scopus citations

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Chew, J., Gendron, T. D., Prudencio, M., Sasaguri, H., Zhang, Y., Castanedes-Casey, M., Lee, C. W., Jansen-West, K., Kurti, A., Murray, M. E., Bieniek, K. F., Bauer, P. O., Whitelaw, E. C., Rousseau, L., Stankowski, J. N., Stetler, C., Daughrity, L. M., Perkerson, E. A., Desaro, P., Johnston, A. & 7 others, Overstreet, K., Edbauer, D., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Fryer, J. D. & Petrucelli, L., Jun 5 2015, In : Science. 348, 6239, p. 1151-1154 4 p.

Research output: Contribution to journalArticle

185 Scopus citations

Deficiency of Capicua disrupts bile acid homeostasis

Kim, E., Park, S., Choi, N., Lee, J., Yoe, J., Kim, S., Jung, H. Y., Kim, K. T., Kang, H., Fryer, J. D., Zoghbi, H. Y., Hwang, D. & Lee, Y., Feb 5 2015, In : Scientific reports. 5, 8272.

Research output: Contribution to journalArticle

19 Scopus citations

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

86 Scopus citations

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Cook, C., Kang, S. S., Carlomagno, Y., Lin, W. L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., Rousseau, L., Phillips, V., Bu, G., Dickson, D. W., Petrucelli, L. & Fryer, J. D., 2015, In : Human molecular genetics. 24, 21, p. 6198-6212 15 p.

Research output: Contribution to journalArticle

26 Scopus citations

Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J Mice

Allen, J. M., Miller, M. E. B., Pence, B. D., Whitlock, K., Nehra, V., Gaskins, H. R., White, B. A., Fryer, J. D. & Woods, J. A., Apr 15 2015, In : Journal of Applied Physiology. 118, 8, p. 1059-1066 8 p.

Research output: Contribution to journalArticle

85 Scopus citations
2014

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Liu, C. C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T. & Bu, G., Oct 1 2014, In : Neuron. 84, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

91 Scopus citations

Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

Kang, S. S., Jeraldo, P. R., Kurti, A., Miller, M. E. B., Cook, M. D., Whitlock, K., Goldenfeld, N., Woods, J. A., White, B. A., Chia, N. & Fryer, J. D., Sep 13 2014, In : Molecular neurodegeneration. 9, 1, 36.

Research output: Contribution to journalArticle

126 Scopus citations

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Kang, S. S., Kurti, A., Fair, D. A. & Fryer, J. D., Sep 12 2014, In : Journal of Neuroinflammation. 11, 1, 156.

Research output: Contribution to journalArticle

61 Scopus citations

Large-scale topology and the default mode network in the mouse connectome

Stafford, J. M., Jarrett, B. R., Miranda-Dominguez, O., Mills, B. D., Cain, N., Mihalas, S., Lahvis, G. P., Lattal, K. M., Mitchell, S. H., David, S. V., Fryer, J. D., Nigg, J. T. & Fair, D. A., Dec 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 52, p. 18745-18750 6 p.

Research output: Contribution to journalArticle

101 Scopus citations

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

Cook, C., Dunmore, J. H., Murray, M. E., Scheffel, K., Shukoor, N., Tong, J., Castanedes-Casey, M., Phillips, V., Rousseau, L., Penuliar, M. S., Kurti, A., Dickson, D. W., Petrucelli, L. & Fryer, J. D., Jul 1 2014, In : Neurobiology of aging. 35, 7, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

21 Scopus citations
2012

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Di Malta, C., Fryer, J. D., Settembre, C. & Ballabio, A., Aug 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 35, p. E2334-E2342

Research output: Contribution to journalArticle

62 Scopus citations
2011

ATXN1 Protein Family and CIC Regulate Extracellular Matrix Remodeling and Lung Alveolarization

Lee, Y., Fryer, J. D., Kang, H., Crespo-Barreto, J., Bowman, A. B., Gao, Y., Kahle, J. J., Hong, J. S., Kheradmand, F., Orr, H. T., Finegold, M. J. & Zoghbi, H. Y., Oct 18 2011, In : Developmental Cell. 21, 4, p. 746-757 12 p.

Research output: Contribution to journalArticle

54 Scopus citations

Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua

Fryer, J. D., Yu, P., Kang, H., Mandel-Brehm, C., Carter, A. N., Crespo-Barreto, J., Gao, Y., Flora, A., Shaw, C., Orr, H. T. & Zoghbi, H. Y., Nov 4 2011, In : Science. 334, 6056, p. 690-693 4 p.

Research output: Contribution to journalArticle

93 Scopus citations

The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption

Legleiter, J., Fryer, J. D., Holtzman, D. M. & Kowalewski, T., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 588-599 12 p.

Research output: Contribution to journalArticle

23 Scopus citations
2010

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis

Crespo-Barreto, J., Fryer, J. D., Shaw, C. A., Orr, H. T. & Zoghbi, H. Y., Jul 2010, In : PLoS genetics. 6, 7, p. 1-17 17 p.

Research output: Contribution to journalArticle

82 Scopus citations
2008

A partial loss of function allele of Methyl-CpG-binding protein 2 predicts a human neurodevelopmental syndrome

Samaco, R. C., Fryer, J. D., Ren, J., Fyffe, S., Chao, H. T., Sun, Y., Greer, J. J., Zoghbi, H. Y. & Neul, J. L., Jun 15 2008, In : Human molecular genetics. 17, 12, p. 1718-1727 10 p.

Research output: Contribution to journalArticle

139 Scopus citations