John D. Fryer, PhD

  • 4436 Citations
  • 39 Scopus h-Index
19992020
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Research Output 1999 2019

  • 4436 Citations
  • 39 Scopus h-Index
  • 77 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article
2019
8 Citations (Scopus)

Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy

Chew, J., Cook, C., Gendron, T. D., Jansen-West, K., Del Rosso, G., Daughrity, L. M., Castanedes-Casey, M., Kurti, A., Stankowski, J. N., Disney, M. D., Rothstein, J. D., Dickson, D. W., Fryer, J. D., Zhang, Y. & Petrucelli, L., Feb 15 2019, In : Molecular neurodegeneration. 14, 1, 1 p.

Research output: Contribution to journalArticle

TDP-43 Proteinopathies
Dipeptides
RNA
Proteins
Antisense RNA

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R. V., Deture, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta neuropathologica communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Dependovirus
Phosphorylation
Tauopathies
Brain
Progressive Supranuclear Palsy
11 Citations (Scopus)

Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity

Zhang, Y. J., Guo, L., Gonzales, P. K., Gendron, T. F., Wu, Y., Jansen-West, K., O’Raw, A. D., Pickles, S. R., Prudencio, M., Carlomagno, Y., Gachechiladze, M. A., Ludwig, C., Tian, R., Chew, J., DeTure, M., Lin, W. L., Tong, J., Daughrity, L. M., Yue, M., Song, Y. & 15 others, Andersen, J. W., Castanedes-Casey, M., Kurti, A., Datta, A., Antognetti, G., McCampbell, A., Rademakers, R., Oskarsson, B., Dickson, D. W., Kampmann, M., Ward, M. E., Fryer, J. D., Link, C. D., Shorter, J. & Petrucelli, L., Feb 15 2019, In : Science. 363, 6428, eaav2606.

Research output: Contribution to journalArticle

Double-Stranded RNA
Heterochromatin
Proline
Arginine
Proteins
2 Citations (Scopus)

Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight

Ebbert, M. T. W., Jensen, T. D., Jansen-West, K., Sens, J. P., Reddy, J. S., Ridge, P. G., Kauwe, J. S. K., Belzil, V., Pregent, L., Carrasquillo, M. M., Keene, D., Larson, E., Crane, P., Asmann, Y., Taner, N., Younkin, S. G., Ross, O. A., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., May 20 2019, In : Genome biology. 20, 1, 97.

Research output: Contribution to journalArticle

Open Access
gene
Technology
Alzheimer disease
Genes
Alzheimer Disease
2018
1 Citation (Scopus)

A matter of balance

Gitler, A. D. & Fryer, J. D., Aug 21 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

RNA-Binding Proteins
Defects
Frontotemporal Dementia With Motor Neuron Disease
12 Citations (Scopus)

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 others, Dickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature Communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Apolipoprotein E2
Tauopathies
pathology
Pathology
mice
11 Citations (Scopus)

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Lipopolysaccharides
Myeloid Cells
Neurodegenerative Diseases
Up-Regulation
14 Citations (Scopus)

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. D., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular Neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

Technology
Nucleotides
Nanopores
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats
2 Citations (Scopus)

Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity

Nicholson, A. M., Zhou, X., Perkerson, R. B., Parsons, T. M., Chew, J., Brooks, M., DeJesus-Hernandez, M., Finch, N. C. A., Matchett, B. J., Kurti, A., Jansen-West, K. R., Perkerson, E., Daughrity, L., Castanedes-Casey, M., Rousseau, L., Phillips, V., Hu, F., Gendron, T. D., Murray, M. E., Dickson, D. W. & 3 others, Fryer, J. D., Petrucelli, L. & Rademakers, R. V., May 31 2018, In : Acta Neuropathologica Communications. 6, 1, 1 p.

Research output: Contribution to journalArticle

Open Access
Frontotemporal Lobar Degeneration
Frontotemporal Dementia
Phenotype
Mutation
Dipeptides
14 Citations (Scopus)

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Kang, S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J-P., Petrucelli, L. & Fryer, J. D., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

Amyloid
Tauopathies
Alzheimer Disease
Amyloidosis
Disease Susceptibility
39 Citations (Scopus)

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

Zhang, Y., Gendron, T. D., Ebbert, M. T. W., O’Raw, A. D., Yue, M., Jansen-West, K., Zhang, X., Prudencio, M., Chew, J., Cook, C., Daughrity, L. M., Tong, J., Song, Y., Pickles, S. R., Castanedes-Casey, M., Kurti, A., Rademakers, R. V., Oskarsson, B., Dickson, D. W., Hu, W. & 3 others, Gitler, A. D., Fryer, J. D. & Petrucelli, L., Jun 25 2018, (Accepted/In press) In : Nature Medicine. p. 1-7 7 p.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
Protein Biosynthesis
Dipeptides
Proteins
Brain
13 Citations (Scopus)

Potentially Modifiable Risk Factors for Long-Term Cognitive Impairment After Critical Illness: A Systematic Review

Sakusic, A., O'Horo, J. C., Dziadzko, M., Volha, D., Ali, R., Singh, T. D., Kashyap, R., Farrell, A. M., Fryer, J. D., Petersen, R. C., Gajic, O. & Rabinstein, A., Jan 1 2018, In : Mayo Clinic Proceedings. 93, 1, p. 68-82 15 p.

Research output: Contribution to journalReview article

Critical Illness
Intensive Care Units
Delirium
Critical Care
Survivors
3 Citations (Scopus)

Risk Factors for Persistent Cognitive Impairment After Critical Illness, Nested Case-Control Study

Sakusic, A., Gajic, O., Singh, T. D., O'Horo, J. C., Jenkins, G., Wilson, G. A., Petersen, R. C., Fryer, J. D., Kashyap, R. & Rabinstein, A., Dec 1 2018, In : Critical Care Medicine. 46, 12, p. 1977-1984 8 p.

Research output: Contribution to journalArticle

Critical Illness
Case-Control Studies
Hospitalization
Comorbidity
Cognitive Dysfunction

TRIO gene segregation in a family with cerebellar ataxia

Hanna Al Shaikh, R., Caulfield, T., Strongosky, A. J., Matthew, M., Jansen-West, K. R., Prudencio, M., Fryer, J. D., Petrucelli, L., Uitti, R. J. & Wszolek, Z. K., Jan 1 2018, (Accepted/In press) In : Neurologia i Neurochirurgia Polska.

Research output: Contribution to journalArticle

Cerebellar Ataxia
Ataxia
Genes
Mothers
Exome
2017
9 Citations (Scopus)

Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Park, S., Lee, S., Lee, C. G., Park, G. Y., Hong, H., Lee, J. S., Kim, Y. M., Lee, S. B., Hwang, D., Choi, Y. S., Fryer, J. D., Im, S. H., Lee, S. W. & Lee, Y., Jul 12 2017, In : Nature Communications. 8, 16037.

Research output: Contribution to journalArticle

T-cells
Helper-Inducer T-Lymphocytes
Autoimmunity
Germinal Center
Cell Differentiation
11 Citations (Scopus)

Derivation and validation of the automated search algorithms to identify cognitive impairment and dementia in electronic health records

Amra, S., O'Horo, J. C., Singh, T. D., Wilson, G. A., Kashyap, R., Petersen, R. C., Roberts, R. O., Fryer, J. D., Rabinstein, A. & Gajic, O., Feb 1 2017, In : Journal of Critical Care. 37, p. 202-205 4 p.

Research output: Contribution to journalArticle

Electronic Health Records
Dementia
Intensive Care Units
International Classification of Diseases
Critical Illness
26 Citations (Scopus)

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans

Lu, H. C., Tan, Q., Rousseaux, M. W. C., Wang, W., Kim, J. Y., Richman, R., Wan, Y. W., Yeh, S. Y., Patel, J. M., Liu, X., Lin, T., Lee, Y., Fryer, J. D., Han, J., Chahrour, M., Finnell, R. H., Lei, Y., Zurita-Jimenez, M. E., Ahimaz, P., Anyane-Yeboa, K. & 17 others, Van Maldergem, L., Lehalle, D., Jean-Marcais, N., Mosca-Boidron, A. L., Thevenon, J., Cousin, M. A., Bro, D. E., Lanpher, B., Klee, E. W., Alexander, N., Bainbridge, M. N., Orr, H. T., Sillitoe, R. V., Ljungberg, M. C., Liu, Z., Schaaf, C. P. & Zoghbi, H. Y., Mar 30 2017, In : Nature Genetics. 49, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Middle Hypothalamus
Attention Deficit Disorder with Hyperactivity
Interpersonal Relations
24 Citations (Scopus)

Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice

Allen, J. M., Mailing, L. J., Cohrs, J., Salmonson, C., Fryer, J. D., Nehra, V., Hale, V. L., Kashyap, P. C., White, B. A. & Woods, J. A., Sep 19 2017, (Accepted/In press) In : Gut Microbes. p. 1-16 16 p.

Research output: Contribution to journalArticle

Germ-Free Life
Microbiota
Colitis
Exercise
Tissue Donors
22 Citations (Scopus)

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S., Ren, Y., Liu, C-C., Kurti, A., Baker, K. E., Bu, G. D., Asmann, Y. & Fryer, J. D., Jan 10 2017, (Accepted/In press) In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Lipopolysaccharides
Central Nervous System
Brain
Cytokines
Sepsis
23 Citations (Scopus)

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C-C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G. D., Carare, R. O. & Fryer, J. D., Aug 15 2017, In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

Clusterin
Cerebral Amyloid Angiopathy
Amyloid
Drainage
Alzheimer Disease
3 Citations (Scopus)

Neonatal AAV delivery of alpha-synuclein induces pathology in the adult mouse brain

Delenclos, M., Faroqi, A. H., Yue, M., Kurti, A., Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Fryer, J. D. & McLean, P. J., Jun 23 2017, In : Acta neuropathologica communications. 5, 1, 1 p.

Research output: Contribution to journalArticle

Synucleins
Dependovirus
alpha-Synuclein
Pathology
Brain
47 Citations (Scopus)

Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis

Gendron, T. D., Chew, J., Stankowski, J. N., Hayes, L. R., Zhang, Y., Prudencio, M., Carlomagno, Y., Daughrity, L. M., Jansen-West, K., Perkerson, E. A., O'Raw, A., Cook, C., Pregent, L., Belzil, V., Van Blitterswijk, M., Tabassian, L. J., Lee, C. W., Yue, M., Tong, J., Song, Y. & 59 others, Castanedes-Casey, M., Rousseau, L., Phillips, V., Dickson, D. W., Rademakers, R. V., Fryer, J. D., Rush, B. K., Pedraza, O. D., Caputo, A. M., Desaro, P., Palmucci, C., Robertson, A., Heckman, M. G., Diehl, N. N., Wiggs, E., Tierney, M., Braun, L., Farren, J., Lacomis, D., Ladha, S., Fournier, C. N., McCluskey, L. F., Elman, L. B., Toledo, J. B., McBride, J. D., Tiloca, C., Morelli, C., Poletti, B., Solca, F., Prelle, A., Wuu, J., Jockel-Balsarotti, J., Rigo, F., Ambrose, C., Datta, A., Yang, W., Raitcheva, D., Antognetti, G., McCampbell, A., Van Swieten, J. C., Miller, B. L., Boxer, A. L., Brown, R. H., Bowser, R., Miller, T. M., Trojanowski, J. Q., Grossman, M., Berry, J. D., Hu, W. T., Ratti, A., Traynor, B. J., Disney, M. D., Benatar, M., Silani, V., Glass, J. D., Floeter, M. K., Rothstein, J. D., Boylan, K. B. & Petrucelli, L., Mar 29 2017, In : Science Translational Medicine. 9, 383, eaai7866.

Research output: Contribution to journalArticle

Amyotrophic Lateral Sclerosis
RNA
Proteins
Antisense Oligonucleotides
Therapeutics
52 Citations (Scopus)

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Zhong, L., Chen, X. F., Wang, T., Wang, Z., Liao, C., Wang, Z., Huang, R., Wang, D., Li, X., Wu, L., Jia, L., Zheng, H., Painter, M., Atagi, Y., Liu, C-C., Zhang, Y. W., Fryer, J. D., Xu, H. & Bu, G. D., Mar 6 2017, In : The Journal of experimental medicine. 214, 3, p. 597-607 11 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Cytokines
Cell Surface Receptors
Phosphatidylinositol 3-Kinases
8 Citations (Scopus)

Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice

Rogers, J. T., Liu, C-C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T. & Bu, G. D., May 1 2017, In : Neurobiology of Aging. 53, p. 112-121 10 p.

Research output: Contribution to journalArticle

Ibuprofen
Cognition
Neuronal Plasticity
Astrocytes
Anti-Inflammatory Agents
136 Citations (Scopus)

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

Mackenzie, I. R., Nicholson, A. M., Sarkar, M., Messing, J., Purice, M. D., Pottier, C., Annu, K., Baker, M., Perkerson, R. B., Kurti, A., Matchett, B. J., Mittag, T., Temirov, J., Hsiung, G. Y. R., Krieger, C., Murray, M. E., Kato, M., Fryer, J. D., Petrucelli, L., Zinman, L. & 22 others, Weintraub, S., Mesulam, M., Keith, J., Zivkovic, S. A., Hirsch-Reinshagen, V., Roos, R. P., Züchner, S., Graff Radford, N. R., Petersen, R. C., Caselli, R. J., Wszolek, Z. K., Finger, E., Lippa, C., Lacomis, D., Stewart, H., Dickson, D. W., Kim, H. J., Rogaeva, E., Bigio, E., Boylan, K. B., Taylor, J. P. & Rademakers, R. V., Aug 16 2017, In : Neuron. 95, 4, p. 808-816.e9

Research output: Contribution to journalArticle

Mutation
DNA-Binding Proteins
Hyalin
Phase Transition
Amyotrophic Lateral Sclerosis
48 Citations (Scopus)

TREM2 promotes microglial survival by activating wnt/β-catenin pathway

Zheng, H., Jia, L., Liu, C-C., Rong, Z., Zhong, L., Yang, L., Chen, X. F., Fryer, J. D., Wang, X., Zhang, Y. W., Xu, H. & Bu, G. D., Feb 15 2017, In : Journal of Neuroscience. 37, 7, p. 1772-1784 13 p.

Research output: Contribution to journalArticle

Catenins
Wnt Signaling Pathway
Myeloid Cells
Microglia
Alzheimer Disease
2016
42 Citations (Scopus)

ABCA7 deficiency accelerates amyloid-βgeneration and alzheimer’s neuronal pathology

Sakae, N., Liu, C-C., Shinohara, M., Frisch-Daiello, J., Ma, L., Yamazaki, Y., Tachibana, M., Younkin, L., Kurti, A., Carrasquillo, M. M., Zou, F., Sevlever, D., Bisceglio, G., Gan, M., Fol, R., Knight, P., Wang, M., Han, X., Fryer, J. D., Fitzgerald, M. L. & 4 others, Ohyagi, Y., Younkin, S. G., Bu, G. D. & Kanekiyo, T., Mar 30 2016, In : Journal of Neuroscience. 36, 13, p. 3848-3859 12 p.

Research output: Contribution to journalArticle

Amyloid beta-Protein Precursor
Amyloid
Pathology
Alzheimer Disease
Brain
28 Citations (Scopus)

APOE2 eases cognitive decline during Aging: Clinical and preclinical evaluations

Shinohara, M., Kanekiyo, T., Yang, L., Linthicum, D., Shinohara, M., Fu, Y., Price, L., Frisch-Daiello, J. L., Han, X., Fryer, J. D. & Bu, G. D., 2016, (Accepted/In press) In : Annals of Neurology.

Research output: Contribution to journalArticle

Apolipoproteins E
Apolipoprotein E2
Cholesterol
Amyloid
Alleles
104 Citations (Scopus)

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

Zhang, Y., Gendron, T. D., Grima, J. C., Sasaguri, H., Jansen-West, K., Xu, Y. F., Katzman, R. B., Gass, J., Murray, M. E., Shinohara, M., Lin, W. L., Garrett, A., Stankowski, J. N., Daughrity, L., Tong, J., Perkerson, E. A., Yue, M., Chew, J., Castanedes-Casey, M., Kurti, A. & 16 others, Wang, Z. S., Liesinger, A. M., Baker, J. D., Jiang, J., Lagier-Tourenne, C., Edbauer, D., Cleveland, D. W., Rademakers, R. V., Boylan, K. B., Bu, G. D., Link, C. D., Dickey, C. A., Rothstein, J. D., Dickson, D. W., Fryer, J. D. & Petrucelli, L., May 1 2016, In : Nature Neuroscience. 19, 5, p. 668-677 10 p.

Research output: Contribution to journalArticle

Nucleocytoplasmic Transport Proteins
Cell Nucleus Active Transport
Pathology
Ubiquitinated Proteins
Xeroderma Pigmentosum
22 Citations (Scopus)

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., Deture, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C-C., Zhao, N., Painter, M. M., Petersen, R. C., Fryer, J. D., Crook, J., Dickson, D. W., Bu, G. D. & Kanekiyo, T., May 14 2016, (Accepted/In press) In : Acta Neuropathologica. p. 1-10 10 p.

Research output: Contribution to journalArticle

Cerebral Amyloid Angiopathy
Alzheimer Disease
Apolipoproteins E
Temporal Lobe
Amyloid
25 Citations (Scopus)

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Zheng, H., Liu, C-C., Atagi, Y., Chen, X. F., Jia, L., Yang, L., He, W., Zhang, X., Kang, S., Rosenberry, T. L., Fryer, J. D., Zhang, Y. W., Xu, H. & Bu, G. D., Jun 1 2016, In : Neurobiology of Aging. 42, p. 132-141 10 p.

Research output: Contribution to journalArticle

Microglia
Myeloid Cells
Alzheimer Disease
Lipopolysaccharides
Amyloid
2015
134 Citations (Scopus)

Apolipoprotein E is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2)

Atagi, Y., Liu, C-C., Painter, M. M., Chen, X. F., Verbeeck, C., Zheng, H., Li, X., Rademakers, R. V., Kang, S., Xu, H., Younkin, S. G., Das, P., Fryer, J. D. & Bu, G. D., Oct 23 2015, In : Journal of Biological Chemistry. 290, 43, p. 26043-26050 8 p.

Research output: Contribution to journalArticle

Apolipoproteins E
Myeloid Cells
Ligands
Microglia
Phagocytosis
163 Citations (Scopus)

C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits

Chew, J., Gendron, T. D., Prudencio, M., Sasaguri, H., Zhang, Y., Castanedes-Casey, M., Lee, C. W., Jansen-West, K., Kurti, A., Murray, M. E., Bieniek, K. F., Bauer, P. O., Whitelaw, E. C., Rousseau, L., Stankowski, J. N., Stetler, C., Daughrity, L. M., Perkerson, E. A., Desaro, P., Johnston, A. & 7 others, Overstreet, K., Edbauer, D., Rademakers, R. V., Boylan, K. B., Dickson, D. W., Fryer, J. D. & Petrucelli, L., Jun 5 2015, In : Science. 348, 6239, p. 1151-1154 4 p.

Research output: Contribution to journalArticle

Pathology
Brain
glycylproline
Animal Disease Models
Nuclear RNA
12 Citations (Scopus)

Deficiency of Capicua disrupts bile acid homeostasis

Kim, E., Park, S., Choi, N., Lee, J., Yoe, J., Kim, S., Jung, H. Y., Kim, K. T., Kang, H., Fryer, J. D., Zoghbi, H. Y., Hwang, D. & Lee, Y., Feb 5 2015, In : Scientific Reports. 5, 8272.

Research output: Contribution to journalArticle

Bile Acids and Salts
Homeostasis
Retinoid X Receptor alpha
Liver
CCAAT-Enhancer-Binding Protein-beta
5 Citations (Scopus)

Identification of plexin A4 as a novel clusterin receptor links two Alzheimer's disease risk genes

Kang, S., Kurti, A., Wojtas, A., Baker, K. E., Liu, C-C., Kanekiyo, T., Deming, Y., Cruchaga, C., Estus, S., Bu, G. D. & Fryer, J. D., 2015, In : Human Molecular Genetics. 25, 16, p. 3467-3475 9 p.

Research output: Contribution to journalArticle

Clusterin
Alzheimer Disease
Genes
Brain
Cerebrospinal Fluid
70 Citations (Scopus)

Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice

Yue, M., Hinkle, K. M., Davies, P., Trushina, E. D., Fiesel, F., Christenson, T. A., Schroeder, A. S., Zhang, L., Bowles, E., Behrouz, B., Lincoln, S. J., Beevers, J. E., Milnerwood, A. J., Kurti, A., McLean, P. J., Fryer, J. D., Springer, W., Dickson, D. W., Farrer, M. J. & Melrose, H. L., Jun 1 2015, In : Neurobiology of Disease. 78, p. 172-195 24 p.

Research output: Contribution to journalArticle

Mutation
Dopamine
Phosphotransferases
Mitochondrial Dynamics
Microdialysis
25 Citations (Scopus)

Tau deposition drives neuropathological, inflammatory and behavioral abnormalities independently of neuronal loss in a novel mouse model

Cook, C., Kang, S., Carlomagno, Y., Lin, W. L., Yue, M., Kurti, A., Shinohara, M., Jansen-West, K., Perkerson, E., Castanedes-Casey, M., Rousseau, L., Phillips, V., Bu, G. D., Dickson, D. W., Petrucelli, L. & Fryer, J. D., 2015, In : Human Molecular Genetics. 24, 21, p. 6198-6212 15 p.

Research output: Contribution to journalArticle

Tauopathies
Dependovirus
tau Proteins
Endopeptidase K
Inborn Genetic Diseases
48 Citations (Scopus)

TREM2 in CNS homeostasis and neurodegenerative disease

Painter, M. M., Atagi, Y., Liu, C-C., Rademakers, R. V., Xu, H., Fryer, J. D. & Bu, G. D., Sep 4 2015, In : Molecular Neurodegeneration. 10, 1, 43.

Research output: Contribution to journalArticle

Central Nervous System Diseases
Myeloid Cells
Neurodegenerative Diseases
Homeostasis
Proteins
67 Citations (Scopus)

Voluntary and forced exercise differentially alters the gut microbiome in C57BL/6J Mice

Allen, J. M., Miller, M. E. B., Pence, B. D., Whitlock, K., Nehra, V., Gaskins, H. R., White, B. A., Fryer, J. D. & Woods, J. A., Apr 15 2015, In : Journal of Applied Physiology. 118, 8, p. 1059-1066 8 p.

Research output: Contribution to journalArticle

Inbred C57BL Mouse
Running
Gastrointestinal Microbiome
Colitis
Feces
2014
74 Citations (Scopus)

Deficiency in LRP6-Mediated Wnt Signaling Contributes to Synaptic Abnormalities and Amyloid Pathology in Alzheimer's Disease

Liu, C-C., Tsai, C. W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., Estus, S., Hoe, H. S., Fryer, J. D., Kanekiyo, T. & Bu, G. D., Oct 1 2014, In : Neuron. 84, 1, p. 63-77 15 p.

Research output: Contribution to journalArticle

Low Density Lipoprotein Receptor-Related Protein-6
Amyloid
Alzheimer Disease
Pathology
Protein Deficiency
103 Citations (Scopus)

Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition

Kang, S., Jeraldo, P. R., Kurti, A., Miller, M. E. B., Cook, M. D., Whitlock, K., Goldenfeld, N., Woods, J. A., White, B. A., Chia, N. D. & Fryer, J. D., Sep 13 2014, In : Molecular Neurodegeneration. 9, 1, 36.

Research output: Contribution to journalArticle

High Fat Diet
Cognition
Anxiety
Diet
Gastrointestinal Microbiome
51 Citations (Scopus)

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Kang, S., Kurti, A., Fair, D. A. & Fryer, J. D., Sep 12 2014, In : Journal of Neuroinflammation. 11, 1, 156.

Research output: Contribution to journalArticle

Obesity
Mothers
High Fat Diet
Lactation
Encephalitis
86 Citations (Scopus)

Large-scale topology and the default mode network in the mouse connectome

Stafford, J. M., Jarrett, B. R., Miranda-Dominguez, O., Mills, B. D., Cain, N., Mihalas, S., Lahvis, G. P., Lattal, K. M., Mitchell, S. H., David, S. V., Fryer, J. D., Nigg, J. T. & Fair, D. A., Dec 30 2014, In : Proceedings of the National Academy of Sciences of the United States of America. 111, 52, p. 18745-18750 6 p.

Research output: Contribution to journalArticle

Connectome
Brain
Primates
Rodentia
Magnetic Resonance Imaging
19 Citations (Scopus)

Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia

Cook, C., Dunmore, J. H., Murray, M. E., Scheffel, K., Shukoor, N., Tong, J., Castanedes-Casey, M., Phillips, V., Rousseau, L., Penuliar, M. S., Kurti, A., Dickson, D. W., Petrucelli, L. & Fryer, J. D., Jul 2014, In : Neurobiology of Aging. 35, 7, p. 1769-1777 9 p.

Research output: Contribution to journalArticle

Frontotemporal Dementia
Amygdala
Transgenic Mice
Fear
Learning
2012
56 Citations (Scopus)

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

Di Malta, C., Fryer, J. D., Settembre, C. & Ballabio, A., Aug 28 2012, In : Proceedings of the National Academy of Sciences of the United States of America. 109, 35

Research output: Contribution to journalArticle

Astrocytes
Multiple Sulfatase Deficiency Disease
Neurons
Sulfatases
Nerve Degeneration
18 Citations (Scopus)

Autophagy in astrocytes: A novel culprit in lysosomal storage disorders

Di Malta, C., Fryer, J. D., Settembre, C. & Ballabio, A., Dec 2012, In : Autophagy. 8, 12, p. 1871-1872 2 p.

Research output: Contribution to journalArticle

Autophagy
Astrocytes
Multiple Sulfatase Deficiency Disease
Neurons
Lysosomes
2011
47 Citations (Scopus)

ATXN1 Protein Family and CIC Regulate Extracellular Matrix Remodeling and Lung Alveolarization

Lee, Y., Fryer, J. D., Kang, H., Crespo-Barreto, J., Bowman, A. B., Gao, Y., Kahle, J. J., Hong, J. S., Kheradmand, F., Orr, H. T., Finegold, M. J. & Zoghbi, H. Y., Oct 18 2011, In : Developmental Cell. 21, 4, p. 746-757 12 p.

Research output: Contribution to journalArticle

Matrix Metalloproteinases
Extracellular Matrix
Genes
Lung
Defects
87 Citations (Scopus)

Exercise and genetic rescue of SCA1 via the transcriptional repressor Capicua

Fryer, J. D., Yu, P., Kang, H., Mandel-Brehm, C., Carter, A. N., Crespo-Barreto, J., Gao, Y., Flora, A., Shaw, C., Orr, H. T. & Zoghbi, H. Y., Nov 4 2011, In : Science. 334, 6056, p. 690-693 4 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
Neurodegenerative Diseases
Phenotype
Poisons
Ataxia
21 Citations (Scopus)

The modulating effect of mechanical changes in lipid bilayers caused by apoE-containing lipoproteins on Aβ induced membrane disruption

Legleiter, J., Fryer, J. D., Holtzman, D. M. & Kowalewski, T., Oct 19 2011, In : ACS Chemical Neuroscience. 2, 10, p. 588-599 12 p.

Research output: Contribution to journalArticle

Lipid bilayers
Lipid Bilayers
Apolipoproteins E
Apolipoprotein E4
Lipoproteins
2010
76 Citations (Scopus)

Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis

Crespo-Barreto, J., Fryer, J. D., Shaw, C. A., Orr, H. T. & Zoghbi, H. Y., Jul 2010, In : PLoS Genetics. 6, 7, p. 1-17 17 p.

Research output: Contribution to journalArticle

Spinocerebellar Ataxias
pathogenesis
neurodegenerative diseases
gene expression
disease models