John D. Fryer, PhD

Associate Professor

  • 2887 Citations
  • 29 Scopus h-Index
19992020

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  • 24 Similar Profiles
Apolipoproteins E Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Brain Medicine & Life Sciences
Proteins Medicine & Life Sciences
Nicotinic Receptors Medicine & Life Sciences
Pathology Medicine & Life Sciences
Astrocytes Medicine & Life Sciences

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Projects 2006 2020

Functions of human and mouse Trem2 in vivo

Fryer, J. D.

National Institutes of Health

4/1/163/31/18

Project: Research projectExploratory/Developmental Grants

Alzheimer Disease
Lipoprotein Receptors
Apolipoprotein E4
tau Proteins
Frontotemporal Dementia

The role of Clusterin in cerebral amyloid angiopathy

Fryer, J. D.

National Institutes of Health

9/30/158/31/20

Project: Research projectResearch Project

Cerebral Amyloid Angiopathy
Clusterin
Alzheimer Disease
Brain
Blood Vessels
Clusterin
Alzheimer Disease
Cerebral Amyloid Angiopathy
Apolipoproteins E
Amyloid

Understanding the Mechanisms of TDP-43 Function

Zhang, Y. & Fryer, J. D.

National Institutes of Health

2/15/131/31/16

Project: Research projectExploratory/Developmental Grants

Tyrosine
Phosphorylation
Frontotemporal Dementia
Bacterial Artificial Chromosomes
Amyotrophic Lateral Sclerosis

The role of capicua in spinocerebellar ataxia type 1

Fryer, J. D.

National Institutes of Health

6/1/065/31/09

Project: Research projectPostdoctoral Individual National Research Service Award

Spinocerebellar Ataxias
Microarray Analysis
Neurodegenerative Diseases
Drosophila
Mammals

Research Output 1999 2017

  • 2887 Citations
  • 29 Scopus h-Index
  • 62 Article

Capicua deficiency induces autoimmunity and promotes follicular helper T cell differentiation via derepression of ETV5

Park, S., Lee, S., Lee, C. G., Park, G. Y., Hong, H., Lee, J. S., Kim, Y. M., Lee, S. B., Hwang, D., Choi, Y. S., Fryer, J. D., Im, S. H., Lee, S. W. & Lee, Y. Jul 12 2017 In : Nature Communications. 8, 16037

Research output: Contribution to journalArticle

Helper-Inducer T-Lymphocytes
Autoimmunity
Cell Differentiation
cells
T-cells

Derivation and validation of the automated search algorithms to identify cognitive impairment and dementia in electronic health records

Amra, S., O'Horo, J. C., Singh, T. D., Wilson, G. A., Kashyap, R., Petersen, R., Roberts, R. O., Fryer, J. D., Rabinstein, A. A. & Gajic, O. Feb 1 2017 In : Journal of Critical Care. 37, p. 202-205 4 p.

Research output: Contribution to journalArticle

Electronic Health Records
Dementia
Intensive Care Units
International Classification of Diseases
Critical Illness
1 Citations

Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans

Lu, H. C. , Tan, Q. , Rousseaux, M. W. C. , Wang, W. , Kim, J. Y. , Richman, R. , Wan, Y. W. , Yeh, S. Y. , Patel, J. M. , Liu, X. , Lin, T. , Lee, Y. , Fryer, J. D. , Han, J. , Chahrour, M. , Finnell, R. H. , Lei, Y. , Zurita-Jimenez, M. E. , Ahimaz, P. , Anyane-Yeboa, K. & 17 others Van Maldergem, L., Lehalle, D., Jean-Marcais, N., Mosca-Boidron, A. L., Thevenon, J., Cousin, M. A., Bro, D. E., Lanpher, B. C., Klee, E. W., Alexander, N., Bainbridge, M. N., Orr, H. T., Sillitoe, R. V., Ljungberg, M. C., Liu, Z., Schaaf, C. P. & Zoghbi, H. Y. Mar 30 2017 In : Nature Genetics. 49, 4, p. 527-536 10 p.

Research output: Contribution to journalArticle

Phenotype
Mutation
Genes
Middle Hypothalamus
Pervasive Child Development Disorders
1 Citations

Lipocalin-2 protects the brain during inflammatory conditions

Kang, S. S., Ren, Y., Liu, C. C., Kurti, A., Baker, K. E., Bu, G., Asmann, Y. & Fryer, J. D. Jan 10 2017 In : Molecular Psychiatry.

Research output: Contribution to journalArticle

Lipocalins
Lipopolysaccharides
Brain
Central Nervous System
Cytokines
1 Citations

Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways

Wojtas, A. M., Kang, S. S., Olley, B. M., Gatherer, M., Shinohara, M., Lozano, P. A., Liu, C. C., Kurti, A., Baker, K. E., Dickson, D. W., Yue, M., Petrucelli, L., Bu, G., Carare, R. O. & Fryer, J. D. Aug 15 2017 In : Proceedings of the National Academy of Sciences of the United States of America. 114, 33, p. E6962-E6971

Research output: Contribution to journalArticle

Clusterin
Amyloid
Drainage
Cerebral Amyloid Angiopathy
Alzheimer Disease