John D. Fryer, PhD

Associate Professor

  • 3624 Citations
  • 35 h-Index
19992020
If you made any changes in Pure, your changes will be visible here soon.

Fingerprint Fingerprint is based on mining the text of the experts' scientific documents to create an index of weighted terms, which defines the key subjects of each individual researcher.

  • 5 Similar Profiles
Apolipoproteins E Medicine & Life Sciences
Amyloid Medicine & Life Sciences
Alzheimer Disease Medicine & Life Sciences
Nicotinic Receptors Medicine & Life Sciences
Cerebral Amyloid Angiopathy Medicine & Life Sciences
Spinocerebellar Ataxias Medicine & Life Sciences
Astrocytes Medicine & Life Sciences
Pathology Medicine & Life Sciences

Network Recent external collaboration on country level. Dive into details by clicking on the dots.

Projects 2006 2020

The role of Clusterin in cerebral amyloid angiopathy

Fryer, J. D.

National Institutes of Health

9/30/158/31/20

Project: Research projectResearch Project

Cerebral Amyloid Angiopathy
Clusterin
Alzheimer Disease
Blood Vessels
Brain

Functions of human and mouse Trem2 in vivo

Fryer, J. D.

National Institutes of Health

4/1/163/31/18

Project: Research projectExploratory/Developmental Grants

Alzheimer Disease
Lipoprotein Receptors
Apolipoprotein E4
tau Proteins
Frontotemporal Dementia
Clusterin
Alzheimer Disease
Cerebral Amyloid Angiopathy
Apolipoproteins E
Amyloid

Understanding the Mechanisms of TDP-43 Function

Zhang, Y. & Fryer, J. D.

National Institutes of Health

2/15/131/31/16

Project: Research projectExploratory/Developmental Grants

Tyrosine
Phosphorylation
Frontotemporal Dementia
Bacterial Artificial Chromosomes
Amyotrophic Lateral Sclerosis

The role of capicua in spinocerebellar ataxia type 1

Fryer, J. D.

National Institutes of Health

6/1/065/31/09

Project: Research projectPostdoctoral Individual National Research Service Award

Spinocerebellar Ataxias
Ataxin-1
Purkinje Cells
Microarray Analysis
Neurodegenerative Diseases

Research Output 1999 2018

  • 3624 Citations
  • 35 h-Index
  • 72 Article
  • 1 Comment/debate
  • 1 Review article

A matter of balance

Gitler, A. D. & Fryer, J. D., Aug 21 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

RNA-Binding Proteins
Defects
Frontotemporal Dementia With Motor Neuron Disease

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 othersDickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Tauopathies
pathology
Apolipoproteins E
Pathology
mice
8 Citations

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Lipopolysaccharides
Myeloid Cells
Neurodegenerative Diseases
Up-Regulation

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. D., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

Technology
Nucleotides
Nanopores
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

Kang, S., Ebbert, M. T. W., Baker, K. E., Cook, C., Wang, X., Sens, J. P., Kocher, J-P., Petrucelli, L. & Fryer, J. D., Jan 1 2018, In : Journal of Experimental Medicine. 215, 9, p. 2235-2245 11 p.

Research output: Contribution to journalArticle

Amyloid
Tauopathies
Alzheimer Disease
Amyloidosis
Disease Susceptibility