John D. Fryer, PhD

Associate Professor

  • 3784 Citations
  • 36 h-Index
19992020
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Projects 2006 2020

The role of Clusterin in cerebral amyloid angiopathy

Fryer, J. D.

National Institutes of Health

9/30/158/31/20

Project: Research projectResearch Project

Cerebral Amyloid Angiopathy
Clusterin
Alzheimer Disease
Blood Vessels
Brain

Functions of human and mouse Trem2 in vivo

Fryer, J. D.

National Institutes of Health

4/1/163/31/18

Project: Research projectExploratory/Developmental Grants

Alzheimer Disease
Lipoprotein Receptors
Apolipoprotein E4
tau Proteins
Frontotemporal Dementia
Clusterin
Alzheimer Disease
Cerebral Amyloid Angiopathy
Apolipoproteins E
Amyloid

Understanding the Mechanisms of TDP-43 Function

Zhang, Y. & Fryer, J. D.

National Institutes of Health

2/15/131/31/16

Project: Research projectExploratory/Developmental Grants

Tyrosine
Phosphorylation
Frontotemporal Dementia
Bacterial Artificial Chromosomes
Amyotrophic Lateral Sclerosis

The role of capicua in spinocerebellar ataxia type 1

Fryer, J. D.

National Institutes of Health

6/1/065/31/09

Project: Research projectPostdoctoral Individual National Research Service Award

Spinocerebellar Ataxias
Ataxin-1
Purkinje Cells
Microarray Analysis
Neurodegenerative Diseases

Research Output 1999 2019

  • 3784 Citations
  • 36 h-Index
  • 73 Article
  • 1 Chapter
  • 1 Comment/debate
  • 1 Review article

Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant

Carlomagno, Y., Chung, D. E. C., Yue, M., Kurti, A., Avendano, N. M., Castanedes-Casey, M., Hinkle, K. M., Jansen-West, K., Daughrity, L. M., Tong, J., Phillips, V., Rademakers, R. V., Deture, M., Fryer, J. D., Dickson, D. W., Petrucelli, L. & Cook, C., Jan 23 2019, In : Acta Neuropathologica Communications. 7, 1, 1 p.

Research output: Contribution to journalArticle

Dependovirus
Phosphorylation
Tauopathies
Brain
Progressive Supranuclear Palsy

A matter of balance

Gitler, A. D. & Fryer, J. D., Aug 21 2018, In : eLife. 7

Research output: Contribution to journalComment/debate

RNA-Binding Proteins
Defects
Frontotemporal Dementia With Motor Neuron Disease
1 Citations

APOE ε2 is associated with increased tau pathology in primary tauopathy

Zhao, N., Liu, C-C., Van Ingelgom, A. J., Linares, C., Kurti, A., Knight, J. A., Heckman, M. G., Diehl, N. N., Shinohara, M., Martens, Y. A., Attrebi, O. N., Petrucelli, L., Fryer, J. D., Wszolek, Z. K., Graff Radford, N. R., Caselli, R. J., Sanchez-Contreras, M. Y., Rademakers, R. V., Murray, M. E., Koga, S. & 3 othersDickson, D. W., Ross, O. A. & Bu, G. D., Dec 1 2018, In : Nature communications. 9, 1, 4388.

Research output: Contribution to journalArticle

Tauopathies
pathology
Apolipoproteins E
Pathology
mice
8 Citations

Behavioral and transcriptomic analysis of Trem2-null mice: Not all knockout mice are created equal

Kang, S., Kurti, A., Baker, K. E., Liu, C-C., Colonna, M., Ulrich, J. D., Holtzman, D. M., Bu, G. D. & Fryer, J. D., Jan 15 2018, In : Human Molecular Genetics. 27, 2, p. 211-223 13 p.

Research output: Contribution to journalArticle

Knockout Mice
Lipopolysaccharides
Myeloid Cells
Neurodegenerative Diseases
Up-Regulation

Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: Implications for clinical use and genetic discovery efforts in human disease

Ebbert, M. T. W., Farrugia, S. L., Sens, J. P., Jansen-West, K., Gendron, T. D., Prudencio, M., McLaughlin, I. J., Bowman, B., Seetin, M., Dejesus-Hernandez, M., Jackson, J., Brown, P. H., Dickson, D. W., Van Blitterswijk, M., Rademakers, R. V., Petrucelli, L. & Fryer, J. D., Aug 21 2018, In : Molecular neurodegeneration. 13, 1, 46.

Research output: Contribution to journalArticle

Technology
Nucleotides
Nanopores
Plasmids
Clustered Regularly Interspaced Short Palindromic Repeats