John C Jr. Burnett

Lyle, M. A., Iyer, S. R., Redfield, M. M., Reddy, Y. N. V., Felker, G. M., Cappola, T. P., Hernandez, A. F., Scott, C. G., Burnett, J. C. & Pereira, N. L., Jan 1 2019, (Accepted/In press) In : JACC: Heart Failure.

Research output: Contribution to journal › Article

Neprilysin

Heart Failure

Confidence Intervals

Body Mass Index

Smoking

4 Citations (Scopus)

CRRL269

Chen, Y., Harty, G. J., Zheng, Y., Iyer, S. R., Sugihara, S., Sangaralingham, S. J., Ichiki, T., Grande, J. P., Lee, H. C., Wang, X. & Burnett, J. C. J., May 10 2019, In : Circulation research. 124, 10, p. 1462-1472 11 p.

Research output: Contribution to journal › Article

Open Access

Acute Kidney Injury

C-Type Natriuretic Peptide

Kidney

Apoptosis

Protective Agents

3 Citations (Scopus)

Design, Synthesis, and Actions of an Innovative Bispecific Designer Peptide

Meems, L. M. G., Andersen, I. A., Pan, S., Harty, G., Chen, Y., Zheng, Y., Harders, G. E., Ichiki, T., Heublein, D. M., Iyer, S. R., Sangaralingham, S. J., Mc Cormick, D. J. & Burnett, J. C. J., Apr 1 2019, In : Hypertension (Dallas, Tex. : 1979). 73, 4, p. 900-909 10 p.

Research output: Contribution to journal › Article

Peptides

Cardiovascular Diseases

Therapeutics

Canidae

Ligands

5 Citations (Scopus)

Differential Regulation of ANP and BNP in Acute Decompensated Heart Failure: Deficiency of ANP

Reginauld, S. H., Cannone, V., Iyer, S., Scott, C., Bailey, K., Schaefer, J., Chen, Y., Sangaralingham, S. J. & Burnett, J. C., Oct 2019, In : JACC: Heart Failure. 7, 10, p. 891-898 8 p.

Research output: Contribution to journal › Article

Brain Natriuretic Peptide

Atrial Natriuretic Factor

Heart Failure

peptide B

Body Mass Index

4 Citations (Scopus)

Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor

Hansen, L. H., Madsen, T. D., Goth, C. K., Clausen, H., Chen, Y., Dzhoyashvili, N., Iyer, S. R., Sangaralingham, S. J., Burnett, J. C. J., Rehfeld, J. F., Vakhrushev, S. Y., Schjoldager, K. T. & Goetze, J. P., Jan 1 2019, In : Journal of Biological Chemistry. 294, 34, p. 12567-12578 12 p.

Research output: Contribution to journal › Review article

Open Access

Atrial Natriuretic Factor

Polysaccharides

Degradation

Glycosylation

Natriuretic Peptides

13 Citations (Scopus)

Effect of Neprilysin Inhibition on Various Natriuretic Peptide Assays

Ibrahim, N. E., McCarthy, C. P., Shrestha, S., Gaggin, H. K., Mukai, R., Szymonifka, J., Apple, F. S., Burnett, J. C. J., Iyer, S. & Januzzi, J. L., Mar 26 2019, In : Journal of the American College of Cardiology. 73, 11, p. 1273-1284 12 p.

Research output: Contribution to journal › Article

Neprilysin

Natriuretic Peptides

Atrial Natriuretic Factor

Brain Natriuretic Peptide

C-Type Natriuretic Peptide

5 Citations (Scopus)

Effect of Testosterone on Natriuretic Peptide Levels

Bachmann, K. N., Huang, S., Lee, H., Dichtel, L. E., Gupta, D. K., Burnett, J. C. J., Miller, K. K., Wang, T. J. & Finkelstein, J. S., Mar 26 2019, In : Journal of the American College of Cardiology. 73, 11, p. 1288-1296 9 p.

Research output: Contribution to journal › Article

Natriuretic Peptides

Testosterone

Gels

Steroids

Placebos

High doses of ANP and BNP exacerbate lipolysis in humans and the lipolytic effect of BNP is associated with cardiac triglyceride content in pigs

Bartels, E. D., Guo, S., Kousholt, B. S., Larsen, J. R., Hasenkam, J. M., Burnett, J. C. J., Nielsen, L. B., Ashina, M. & Goetze, J. P., Feb 1 2019, In : Peptides. 112, p. 43-47 5 p.

Research output: Contribution to journal › Article

Lipolysis

Atrial Natriuretic Factor

Natriuretic Peptides

Nonesterified Fatty Acids

Triglycerides

Myocardial Aging, the Cardiac Atria, and BNP: What Does it All Mean?

Burnett, J. C. J., Ma, X. & McKie, P., Oct 8 2019, In : Journal of the American College of Cardiology. 74, 14, p. 1801-1803 3 p.

Research output: Contribution to journal › Editorial

Brain Natriuretic Peptide

NT-proBNP, race and endothelial function in the Multi-Ethnic Study of Atherosclerosis

Yang, S., Huang, S., Daniels, L. B., Yeboah, J., Lima, J. A. C., Cannone, V., Burnett, J. C. J., Beckman, J. A., Carr, J. J., Wang, T. J. & Gupta, D. K., Jan 1 2019, In : Heart.

Research output: Contribution to journal › Article

Natriuretic Peptides

Dilatation

Asian Americans

Atherosclerosis

African Americans

Soluble Neprilysin in the General Population: Clinical Determinants and Its Relationship to Cardiovascular Disease

Reddy, Y. N. V., Iyer, S. R., Scott, C. G., Rodeheffer, R. J., Bailey, K., Jenkins, G., Batzler, A., Redfield, M. M., Burnett, J. C. & Pereira, N. L., Aug 6 2019, In : Journal of the American Heart Association. 8, 15, p. e012943

Research output: Contribution to journal › Article

Open Access

Neprilysin

Cardiovascular Diseases

Population

Natriuretic Peptides

Heart Failure

The Kidney, Bone Marrow, and Heart Connection in Acute Kidney Injury: Role of Galecin-3

Chen, Y. & Burnett, J. C., Oct 2019, In : JACC: Basic to Translational Science. 4, 6, p. 733-735 3 p.

Research output: Contribution to journal › Editorial

Open Access

Galectin 3

Acute Kidney Injury

Bone Marrow

Inflammation

Kidney

2018

2 Citations (Scopus)

A Human Study to Evaluate Safety, Tolerability, and Cyclic GMP Activating Properties of Cenderitide in Subjects With Stable Chronic Heart Failure

Kawakami, R., Lee, C. Y. W., Scott, C., Bailey, K. R., Schirger, J. A., Chen, H. H., Benike, S. L., Cannone, V., Martin, F. L., Sangaralingham, S. J., Ichiki, T. & Burnett, J. C. J., Jan 1 2018, (Accepted/In press) In : Clinical Pharmacology and Therapeutics.

Research output: Contribution to journal › Article

Cyclic GMP

Heart Failure

Safety

Natriuretic Peptides

C-Type Natriuretic Peptide

4 Citations (Scopus)

Aldosterone, Hypertension, and Antihypertensive Therapy: Insights From a General Population

Cannone, V., Buglioni, A., Sangaralingham, S. J., Scott, C., Bailey, K. R., Rodeheffer, R., Redfield, M. M., Sarzani, R. & Burnett, J. C. J., Aug 1 2018, In : Mayo Clinic Proceedings. 93, 8, p. 980-990 11 p.

Research output: Contribution to journal › Article

Aldosterone

Antihypertensive Agents

Hypertension

Population

Atrial Natriuretic Factor

1 Citation (Scopus)

Bioactive Signaling in Next-Generation Pharmacotherapies for Heart Failure: A Review

Oatmen, K. E., Zile, M. R., Burnett, J. C. J. & Spinale, F. G., Jan 1 2018, (Accepted/In press) In : JAMA Cardiology.

Research output: Contribution to journal › Article

Heart Failure

Neprilysin

Angiotensin Receptors

Drug Therapy

Peptidyl-Dipeptidase A

7 Citations (Scopus)

CRRL269: a novel designer and renal-enhancing pGC-A peptide activator

Chen, Y., Harty, G. J., Huntley, B. K., Iyer, S. R., Heublein, D. M., Harders, G. E., Meems, L., Pan, S., Sangaralingham, S. J., Ichiki, T. & Burnett, J. C. J., Mar 1 2018, In : American journal of physiology. Regulatory, integrative and comparative physiology. 314, 3, p. R407-R414

Research output: Contribution to journal › Article

Kidney

Peptides

Canidae

Natriuretic Peptides

Renin-Angiotensin System

3 Citations (Scopus)

Natriuretic peptide based therapeutics for heart failure: Cenderitide: A novel first-in-class designer natriuretic peptide

Ichiki, T., Dzhoyashvili, N. & Burnett, J. C. J., Jan 1 2018, (Accepted/In press) In : International Journal of Cardiology.

Research output: Contribution to journal › Article

Natriuretic Peptides

Peptide Receptors

Heart Failure

C-Type Natriuretic Peptide

Guanylate Cyclase

6 Citations (Scopus)

Particulate guanylyl cyclase A/cGMP signaling pathway in the kidney: Physiologic and therapeutic indications

Chen, Y. & Burnett, J. C. J., Apr 1 2018, In : International Journal of Molecular Sciences. 19, 4, 1006.

Research output: Contribution to journal › Review article

guanosines

kidneys

particulates

indication

Kidney

1 Citation (Scopus)

Relaxing With C-Type Natriuretic Peptide, the Guanylyl Cyclase B Receptor, and Pericytes

Sangaralingham, S. J. & Burnett, J. C. J., Jul 31 2018, In : Circulation. 138, 5, p. 509-512 4 p.

Research output: Contribution to journal › Editorial

Guanylate Cyclase-Coupled Receptors

C-Type Natriuretic Peptide

Pericytes

Natriuretic Peptides

Hypertension

2017

5 Citations (Scopus)

A favorable cardiometabolic profile is associated with the G allele of the genetic variant rs5068 in African Americans: The Multi-Ethnic Study of Atherosclerosis (MESA)

Cannone, V., Scott, C. G., Decker, P. A., Larson, N., Palmas, W., Taylor, K. D., Wang, T. J., Gupta, D. K., Bielinski, S. J. & Burnett, J. C. J., Dec 1 2017, In : PLoS One. 12, 12, e0189858.

Research output: Contribution to journal › Article

Atrial Natriuretic Factor

African Americans

atherosclerosis

Atherosclerosis

Brain Natriuretic Peptide

10 Citations (Scopus)

Atrial natriuretic peptide: Old but new therapeutic in cardiovascular diseases

Ichiki, T. & Burnett, J. C. J., 2017, In : Circulation Journal. 81, 7, p. 913-919 7 p.

Research output: Contribution to journal › Review article

Atrial Natriuretic Factor

Cardiovascular Diseases

Therapeutics

Heart Failure

Neprilysin

14 Citations (Scopus)

Biochemistry, therapeutics, and biomarker implications of neprilysin in cardiorenal disease

Chen, Y. & Burnett, J. C. J., Jan 1 2017, In : Clinical Chemistry. 63, 1, p. 108-115 8 p.

Research output: Contribution to journal › Review article

Neprilysin

Biochemistry

Biomarkers

Natriuretic Peptides

Therapeutics

1 Citation (Scopus)

BLAST-AHF: Insights into biased AT1 ligands and heart failure. Beginning of the end or end of the beginning?

Sugihara, S. & Burnett, J. C. J., Aug 7 2017, In : European Heart Journal. 38, 30, p. 2374-2376 3 p.

Research output: Contribution to journal › Review article

16 Citations (Scopus)

Differences in Natriuretic Peptide Levels by Race/Ethnicity (From the Multi-Ethnic Study of Atherosclerosis)

Gupta, D. K., Daniels, L. B., Cheng, S., deFilippi, C. R., Criqui, M. H., Maisel, A. S., Lima, J. A., Bahrami, H., Greenland, P., Cushman, M., Tracy, R., Siscovick, D., Bertoni, A. G., Cannone, V., Burnett, J. C. J., Carr, J. J. & Wang, T. J., 2017, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journal › Article

Natriuretic Peptides

Brain Natriuretic Peptide

Atherosclerosis

Hispanic Americans

Linear Models

5 Citations (Scopus)

Divergent effects of a designer natriuretic peptide CD-NP in the regulation of adipose tissue and metabolism

Glöde, A., Naumann, J., Gnad, T., Cannone, V., Kilic, A., Burnett, J. C. J. & Pfeifer, A., Mar 1 2017, In : Molecular Metabolism. 6, 3, p. 276-287 12 p.

Research output: Contribution to journal › Article

White Adipose Tissue

Adipose Tissue

Brown Adipocytes

Natriuretic Peptides

Obesity

3 Citations (Scopus)

Early activation of deleterious molecular pathways in the kidney in experimental heart failure with atrial remodeling

Ichiki, T., Huntley, B. K., Harty, G. J., Sangaralingham, S. J. & Burnett, J. C. J., May 1 2017, In : Physiological Reports. 5, 9, e13283.

Research output: Contribution to journal › Article

Atrial Remodeling

Heart Failure

Kidney

Kidney Cortex

Genes

11 Citations (Scopus)

Experimental cardiac radiation exposure induces ventricular diastolic dysfunction with preserved ejection fraction

Saiki, H., Moulay, G., Guenzel, A. J., Liu, W., Decklever, T. D., Classic, K. L., Pham, L., Chen, H. H., Burnett, J. C. J., Russell, S. J. & Redfield, M. M., Aug 11 2017, In : American Journal of Physiology - Heart and Circulatory Physiology. 313, 2, p. H392-H407

Research output: Contribution to journal › Article

Ventricular Dysfunction

Heart Failure

Cardiac Myocytes

Oxidative Stress

Fibrosis

4 Citations (Scopus)

Neurohumoral modulation during waon therapy in chronic heart failure: Subanalysis of Waon-CHF study

Ichiki, T., 2017, In : Circulation Journal. 81, 5, p. 700-716 17 p.

Research output: Contribution to journal › Article

Heart Failure

Aldosterone

Renin-Angiotensin System

Therapeutics

C-Type Natriuretic Peptide

2016

2 Citations (Scopus)

Arterial remodeling in B-type natriuretic peptide knock-out females

Holditch, S. J., Schreiber, C. A., Burnett, J. C. J. & Ikeda, Y. H., May 10 2016, In : Scientific Reports. 6, 25623.

Research output: Contribution to journal › Article

Brain Natriuretic Peptide

Vasculitis

Sex Characteristics

Polyarteritis Nodosa

Arteritis

13 Citations (Scopus)

Biomarker-based risk prediction in the community

Abou Ezzeddine, O., McKie, P., Scott, C. G., Rodeheffer, R. J., Chen, H. H., Michael Felker, G., Jaffe, A. S., Burnett, J. C. J. & Redfield, M. M., Nov 1 2016, In : European Journal of Heart Failure. 18, 11, p. 1342-1350 9 p.

Research output: Contribution to journal › Article

Biomarkers

Brain Natriuretic Peptide

Heart Failure

Troponin I

Galectin 3

20 Citations (Scopus)

Cardiorenal fibrosis and dysfunction in aging: Imbalance in mediators and regulators of collagen

Sangaralingham, S. J., Wang, B. H., Huang, L., Kumfu, S., Ichiki, T., Krum, H. & Burnett, J. C. J., Feb 1 2016, In : Peptides. 76, p. 108-114 7 p.

Research output: Contribution to journal › Article

Aldosterone

Natriuretic Peptides

Angiotensins

Fibrosis

Collagen

14 Citations (Scopus)

Cenderitide: structural requirements for the creation of a novel dual particulate guanylyl cyclase receptor agonist with renal-enhancing in vivo and ex vivo actions

Lee, C. Y. W., Huntley, B. K., Mc Cormick, D. J., Ichiki, T., Sangaralingham, S. J., Lisy, O. & Burnett, J. C. J., Apr 1 2016, In : European heart journal. Cardiovascular pharmacotherapy. 2, 2, p. 98-105 8 p.

Research output: Contribution to journal › Article

Guanylate Cyclase-Coupled Receptors

C-Type Natriuretic Peptide

Kidney

Cyclic GMP

Guanylate Cyclase

14 Citations (Scopus)

Chronic Peptide Therapy With B-Type Natriuretic Peptide in Patients With Pre-Clinical Diastolic Dysfunction (Stage B Heart Failure)

Wan, S. H., McKie, P., Schirger, J. A., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. J. & Chen, H. H., Jul 1 2016, In : JACC: Heart Failure. 4, 7, p. 539-547 9 p.

Research output: Contribution to journal › Article

Brain Natriuretic Peptide

Heart Failure

Peptides

Tachyphylaxis

Therapeutics

16 Citations (Scopus)

Chronic subcutaneous brain natriuretic peptide therapy in asymptomatic systolic heart failure

McKie, P., Schirger, J. A., Benike, S. L., Harstad, L. K., Slusser, J. P., Hodge, D. O., Redfield, M. M., Burnett, J. C. J. & Chen, H. H., 2016, (Accepted/In press) In : European Journal of Heart Failure.

Research output: Contribution to journal › Article

Systolic Heart Failure

Brain Natriuretic Peptide

Placebos

Glomerular Filtration Rate

Sodium

3 Citations (Scopus)

Effect of Neurohormonal Blockade Drug Therapy on Outcomes and Left Ventricular Function and Structure After Left Ventricular Assist Device Implantation

Grupper, A., Zhao, Y. M., Sajgalik, P., Joyce, L. D., Park, S. J., Pereira, N. L., Stulak, J. M., Burnett, J. C. J., Edwards, B. S., Daly, R. C., Kushwaha, S. S. & Schirger, J. A., Jan 18 2016, (Accepted/In press) In : American Journal of Cardiology.

Research output: Contribution to journal › Article

Heart-Assist Devices

Left Ventricular Function

Drug Therapy

Heart Failure

Patient Readmission

21 Citations (Scopus)

Elevation of circulating but not myocardial FGF23 in human acute decompensated heart failure

Andersen, I. A., Huntley, B. K., Sandberg, S. S., Heublein, D. M. & Burnett, J. C. J., May 1 2016, In : Nephrology Dialysis Transplantation. 31, 5, p. 767-772 6 p.

Research output: Contribution to journal › Article

Heart Failure

fibroblast growth factor 23

Gene Expression

Brain Natriuretic Peptide

Glomerular Filtration Rate

17 Citations (Scopus)

Innovative Therapeutics: Designer Natriuretic Peptides

Meems, L. M. G. & Burnett, J. C. J., 2016, In : JACC: Basic to Translational Science. 1, 7, p. 557-567 11 p.

Research output: Contribution to journal › Review article

Natriuretic Peptides

Peptides

Cardiovascular Diseases

Therapeutics

Homeostasis

16 Citations (Scopus)

Insulin/glucose induces natriuretic peptide clearance receptor in human adipocytes: A metabolic link with the cardiac natriuretic pathway

Bordicchia, M., Ceresiani, M., Pavani, M., Minardi, D., Polito, M., Wabitsch, M., Cannone, V., Burnett, J. C. J., Dessì-Fulgheri, P. & Sarzani, R., Jul 1 2016, In : American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 311, 1, p. R104-R114

Research output: Contribution to journal › Article

Natriuretic Peptides

Peptide Receptors

Adipocytes

Insulin

Glucose

4 Citations (Scopus)

In vivo Evaluation of Cenderitide-Eluting Stent (CES) II

Huang, Y., Ng, X. W., Lim, S. G., Chen, H. H., Burnett, J. C. J., Boey, Y. C. F. & Venkatraman, S. S., Feb 1 2016, In : Annals of Biomedical Engineering. 44, 2, p. 432-441 10 p.

Research output: Contribution to journal › Article

Stents

Struts

Plasmas

Endothelial cells

Peptides

20 Citations (Scopus)

New pharmacological strategies to increase cGMP

Buglioni, A. & Burnett, J. C. J., Jan 14 2016, In : Annual Review of Medicine. 67, p. 229-243 15 p.

Research output: Contribution to journal › Article

Cyclic GMP

Pharmacology

Guanylate Cyclase

Enzyme Activation

Second Messenger Systems

21 Citations (Scopus)

NT-proBNP: The Gold Standard Biomarker in Heart Failure

McKie, P. & Burnett, J. C. J., Dec 6 2016, In : Journal of the American College of Cardiology. 68, 22, p. 2437-2439 3 p.

Research output: Contribution to journal › Editorial

Natriuretic Peptides

Heart Failure

Biomarkers

pro-brain natriuretic peptide (1-76)

15 Citations (Scopus)

Saxagliptin and tadalafil differentially alter cyclic guanosine monophosphate (cGMP) signaling and left ventricular function in aortic-banded mini-swine

Hiemstra, J. A., Lee, D. I., Chakir, K., Gutiérrez-Aguilar, M., Marshall, K. D., Zgoda, P. J., Rivera, N. C., Dozier, D. G., Ferguson, B. S., Heublein, D. M., Burnett, J. C. J., Scherf, C., Ivey, J. R., Minervini, G., McDonald, K. S., Baines, C. P., Krenz, M., Domeier, T. L. & Emter, C. A., 2016, In : Journal of the American Heart Association. 5, 4, e003277.

Research output: Contribution to journal › Article

Cyclic GMP

Left Ventricular Function

Swine

Heart Failure

Type 5 Cyclic Nucleotide Phosphodiesterases

2015

12 Citations (Scopus)

Aldosterone predicts cardiovascular, renal, and metabolic disease in the general community: A 4-year follow-up

Buglioni, A., Cannone, V., Sangaralingham, S. J., Heublein, D. M., Scott, C. G., Bailey, K. R., Rodeheffer, R. J., Sarzani, R. & Burnett, J. C. J., Dec 1 2015, In : Journal of the American Heart Association. 4, 12, e002505.

Research output: Contribution to journal › Article

Metabolic Diseases

Aldosterone

Cardiovascular Diseases

Kidney

Hypertension

Biomarkers, mineralocorticoid receptor antagonism, and cardiorenal remodeling

Fiuzat, M. & Burnett, J. C. J., Jan 1 2015, In : JACC: Heart Failure. 3, 1, p. 68 1 p.

Research output: Contribution to journal › Article

Galectin 3

Mineralocorticoid Receptors

Spironolactone

Ventricular Remodeling

Interleukin-1 Receptors

26 Citations (Scopus)

B-type natriuretic peptide deletion leads to progressive hypertension, associated organ damage, and reduced survival: Novel model for human hypertension

Holditch, S. J., Schreiber, C. A., Nini, R., Tonne, J. M., Peng, K-W., Geurts, A., Jacob, H. J., Burnett, J. C. J., Cataliotti, A. & Ikeda, Y. H., Jul 4 2015, In : Hypertension. 66, 1, p. 199-210 12 p.

Research output: Contribution to journal › Article

Brain Natriuretic Peptide

Hypertension

Survival

Hypertrophy

Fibrosis

45 Citations (Scopus)

Circulating aldosterone and natriuretic peptides in the general community relationship to cardiorenal and metabolic disease

Buglioni, A., Cannone, V., Cataliotti, A., Sangaralingham, S. J., Heublein, D. M., Scott, C. G., Bailey, K. R., Rodeheffer, R. J., Dessì-Fulgheri, P., Sarzani, R. & Burnett, J. C. J., Jan 20 2015, In : Hypertension. 65, 1, p. 45-53 9 p.

Research output: Contribution to journal › Article

Natriuretic Peptides

Metabolic Diseases

Aldosterone

Odds Ratio

Confidence Intervals

John C Jr. Burnett, MD