• 7018 Citations
  • 43 Scopus h-Index
1982 …2019
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Research Output 1982 2019

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2019

3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines

Xu, K., Ganapathy, K., Andl, T., Wang, Z., Copland, J. A. III., Chakrabarti, R. & Florczyk, S. J., Oct 1 2019, In : Biomaterials. 217, 119311.

Research output: Contribution to journalArticle

Alginate
Chitosan
Scaffolds
Prostatic Neoplasms
Cells

Aberrant lipid metabolism as a therapeutic target in liver cancer

Pope, E. D., Kimbrough, E. O., Vemireddy, L. P., Surapaneni, P. K., Copland, J. A. III. & Mody, K., Jun 3 2019, In : Expert opinion on therapeutic targets. 23, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

Liver Neoplasms
Lipid Metabolism
Liver
Hepatocellular Carcinoma
Fatty Acids
4 Citations (Scopus)

Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies

Landa, I., Pozdeyev, N., Korch, C., Marlow, L. A., Smallridge, R. C., Copland, J. A. III., Henderson, Y. C., Lai, S. Y., Clayman, G. L., Onoda, N., Tan, A. C., Garcia-Rendueles, M. E. R., Knauf, J. A., Haugen, B. R., Fagin, J. A. & Schweppe, R. E., Jan 1 2019, In : Clinical Cancer Research. 25, 10, p. 3141-3151 11 p.

Research output: Contribution to journalArticle

Medical Genetics
Thyroid Neoplasms
Cell Line
Neoplasms
Mutation

Pomalidomide alters pancreatic macrophage populations to generate an immune-responsive environment at precancerous and cancerous lesions

Bastea, L. I., Liou, G. Y., Pandey, V., Fleming, A. K., Von Roemeling, C. A., Doeppler, H., Li, Z., Qiu, Y., Edenfield, B., Copland, J. A. III., Tun, H. W. & Storz, P., Apr 1 2019, In : Cancer Research. 79, 7, p. 1535-1548 14 p.

Research output: Contribution to journalArticle

Open Access
Macrophages
Pancreatic Neoplasms
Population
Immunosuppressive Agents
Neoplasms
2018
7 Citations (Scopus)

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

von Roemeling, C. A., Caulfield, T., Marlow, L., Bok, I., Wen, J., Miller, J. L., Hughes, R., Hazlehurst, L., Pinkerton, A. B., Radisky, D. C., Tun, H. W., Kim, Y. S. B., Lane, A. L. & Copland, J. A. III., Jan 1 2018, In : Oncotarget. 9, 1, p. 3-20 18 p.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Drug Design
Enzyme Inhibitors
Drug Discovery
Toxicology
33 Citations (Scopus)

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

Breast Neoplasms
Atlases
Long Noncoding RNA
Decision Trees
Genome
73 Citations (Scopus)

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

Atlases
Genes
Genome
Survival
Neoplasms
24 Citations (Scopus)

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

Genes
Tumors
Neoplasms
Computational methods
Chromatin
7 Citations (Scopus)

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

Transforming Growth Factors
Neoplasms
Sequence Deletion
Genes
Gastrointestinal Neoplasms
110 Citations (Scopus)

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

Tumors
Tissue
Histology
Methylation
Oncology
1 Citation (Scopus)

Combined alkylation and histone deacetylase inhibition with EDO-S101 has significant therapeutic activity against brain tumors in preclinical models

Qiu, Y., Li, Z., Copland, J. A. III., Mehrling, T. & Tun, H. W., Jun 15 2018, In : Oncotarget. 9, 46, p. 28155-28164 10 p.

Research output: Contribution to journalArticle

Histone Deacetylases
Alkylation
Brain Neoplasms
Central Nervous System
Triple Negative Breast Neoplasms
32 Citations (Scopus)

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

Adenocarcinoma
Neoplasms
Genome
Chromosomal Instability
Rectum
30 Citations (Scopus)

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer Cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

Alternative Splicing
Neoplasms
Exons
Exome
Peptides
129 Citations (Scopus)

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

Neoplasm Genes
Tumors
Genes
Mutation
Neoplasms
7 Citations (Scopus)

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell Reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

Genes
Neoplasms
Squamous Cell Neoplasms
Tumors
Atlases
2 Citations (Scopus)

Cytokeratin-8 in anaplastic thyroid carcinoma: More than a simple structural cytoskeletal protein

Guo, D., Xu, Q., Pabla, S., Koomen, J., Biddinger, P., Sharma, A., Pabla, S., Pacholczyk, R., Chang, C. C., Friedrich, K., Mohammed, K., Smallridge, R. C., Copland, J. A. III., She, J. X. & Weinberger, P. M., Feb 14 2018, In : International Journal of Molecular Sciences. 19, 2, 577.

Research output: Contribution to journalArticle

Keratin-8
keratins
Keratin
Cytoskeletal Proteins
cancer
2 Citations (Scopus)

Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types

Tailor, P. D., Kodeboyina, S. K., Bai, S., Patel, N., Sharma, S., Ratnani, A., Copland, J. A. III., She, J. X. & Sharma, A., Apr 1 2018, In : Oncotarget. 9, 25, p. 17876-17888 13 p.

Research output: Contribution to journalArticle

Kallikreins
Renal Cell Carcinoma
Biomarkers
Genes
Neoplasms
7 Citations (Scopus)

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A. III., McLaughlin, S. A., Moreno Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R. M., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L. M., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

decitabine
Triple Negative Breast Neoplasms
Methyltransferases
DNA
Biomarkers
34 Citations (Scopus)

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

Human Development
Phosphotransferases
Genes
Gene expression
Tumors
27 Citations (Scopus)

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 194-212.e6

Research output: Contribution to journalArticle

Squamous Cell Carcinoma
MicroRNAs
Mutation
Epithelial Cells
Squamous Cell Neoplasms
40 Citations (Scopus)

Genomic and Functional Approaches to Understanding Cancer Aneuploidy

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 676-689.e3

Research output: Contribution to journalArticle

Aneuploidy
Chromosomes
Neoplasms
Genome
Mutation Rate
9 Citations (Scopus)

Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 213-226.e3

Research output: Contribution to journalArticle

Ubiquitin
Genes
Neoplasms
Tumors
Amplification
66 Citations (Scopus)

lncRNA Epigenetic Landscape Analysis Identifies EPIC1 as an Oncogenic lncRNA that Interacts with MYC and Promotes Cell-Cycle Progression in Cancer

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer Cell. 33, 4, p. 706-720.e9

Research output: Contribution to journalArticle

Long Noncoding RNA
Epigenomics
Cell Cycle
Genes
Neoplasms
16 Citations (Scopus)

Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 172-180.e3

Research output: Contribution to journalArticle

Atlases
Learning systems
Tumors
Genes
Chemical activation
64 Citations (Scopus)

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 338-354.e15

Research output: Contribution to journalArticle

Learning systems
Tumors
Neoplasms
Stem cells
Logistics
3 Citations (Scopus)

Methodology, Criteria, and Characterization of Patient-Matched Thyroid Cell Lines and Patient-Derived Tumor Xenografts

Marlow, L. A., Rohl, S. D., Miller, J. L., Knauf, J. A., Fagin, J. A., Ryder, M., Milosevic, D., Netzel, B. C., Grebe, S. K., Reddi, H. V., Smallridge, R. C. & Copland, J. A. III., Sep 1 2018, In : Journal of Clinical Endocrinology and Metabolism. 103, 9, p. 3169-3182 14 p.

Research output: Contribution to journalArticle

Thyroid Neoplasms
Heterografts
Tumors
Thyroid Gland
Cells
14 Citations (Scopus)

Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 255-269.e4

Research output: Contribution to journalArticle

Tumors
Carbohydrates
Oncology
Metabolism
Vitamins
128 Citations (Scopus)

Oncogenic Signaling Pathways in The Cancer Genome Atlas

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 321-337.e10

Research output: Contribution to journalArticle

Atlases
Tumors
Genes
Genome
Neoplasms
29 Citations (Scopus)

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

The Cancer Genome Atlas Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 282-300.e2

Research output: Contribution to journalArticle

Atlases
Oncogenes
Genome
Neoplasms
Neoplasm Genes
49 Citations (Scopus)

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 297-312.e12

Research output: Contribution to journalArticle

Long Noncoding RNA
Neoplasm Genes
Tumors
Genes
Neoplasms
63 Citations (Scopus)

Pathogenic Germline Variants in 10,389 Adult Cancers

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 355-370.e14

Research output: Contribution to journalArticle

Gene expression
Automatic teller machines
Tumors
Neoplasms
Genes

Patient derived renal cell carcinoma xenografts exhibit distinct sensitivity patterns in response to antiangiogenic therapy and constitute a suitable tool for biomarker development

Schueler, J., Klingner, K., Bug, D., Zoeller, C., Maier, A., Dong, M., Willecke, K., Peille, A. L., Steiner, E., Landesfeind, M., Copland, J. A. III., Siegers, G. M., Haferkamp, A., Boehm, K., Tsaur, I. & Schneider, M., Jul 24 2018, In : Oncotarget. 9, 57, p. 30946-30961 16 p.

Research output: Contribution to journalArticle

Renal Cell Carcinoma
Heterografts
Biomarkers
Serum
Therapeutics
31 Citations (Scopus)

Perspective on Oncogenic Processes at the End of the Beginning of Cancer Genomics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 305-320.e10

Research output: Contribution to journalArticle

Genomics
Tumors
Genes
Neoplasms
Atlases
43 Citations (Scopus)

Scalable Open Science Approach for Mutation Calling of Tumor Exomes Using Multiple Genomic Pipelines

MC3 Working Group & The Cancer Genome Atlas Research Network, Mar 28 2018, In : Cell Systems. 6, 3, p. 271-281.e7

Research output: Contribution to journalArticle

Exome
Mutation
Atlases
Neoplasms
Genomics
29 Citations (Scopus)

Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 282-296.e4

Research output: Contribution to journalArticle

Genes
Mutation
Neoplasms
Tumors
RNA
45 Citations (Scopus)

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 181-193.e7

Research output: Contribution to journalArticle

Tumor-Infiltrating Lymphocytes
Lymphocytes
Pathology
Tumors
Learning
20 Citations (Scopus)

Systematic Analysis of Splice-Site-Creating Mutations in Cancer

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 270-281.e3

Research output: Contribution to journalArticle

Tumors
Mutation
Neoplasms
Bioelectric potentials
Bioinformatics
1 Citation (Scopus)

Targeting the cyclin dependent kinase and retinoblastoma axis overcomes standard of care resistance in BRAFV600E-mutant melanoma

Harris, A. L., Lee, S. E., Dawson, L. K., Marlow, L. A., Edenfield, B. H., Durham, W. F., Flotte, T. J., Thompson, M., Small, D. L., Synnott, A. J., Markovic, S. N. & Copland, J. A. III., Jan 1 2018, In : Oncotarget. 9, 13, p. 10905-10919 15 p.

Research output: Contribution to journalArticle

Cyclin-Dependent Kinases
Retinoblastoma
Standard of Care
Melanoma
Heterografts
50 Citations (Scopus)

The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell Reports. 23, 1, p. 313-326.e5

Research output: Contribution to journalArticle

Atlases
Renal Cell Carcinoma
Genes
Cells
Genome
198 Citations (Scopus)

The Immune Landscape of Cancer

The Cancer Genome Atlas Research Network, Apr 17 2018, In : Immunity. 48, 4, p. 812-830.e14

Research output: Contribution to journalArticle

Neoplasms
Genetic Epigenesis
Lymphocytes
Th2 Cells
Th1 Cells
2017
10 Citations (Scopus)

Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma

Weinberger, P., Ponny, S. R., Xu, H., Bai, S., Smallridge, R. C., Copland, J. A. III. & Sharma, A., Feb 1 2017, In : Thyroid. 27, 2, p. 236-252 17 p.

Research output: Contribution to journalArticle

Cell Division
Cell Cycle
Genes
Gene Expression
Anaplastic Thyroid Carcinoma
1 Citation (Scopus)

Comprehensive genomic profiling of a rare thyroid follicular dendritic cell sarcoma

Davila, J. I., Starr, J. S., Attia, S., Wang, C., Knudson, R. A., Necela, B. M., Sarangi, V., Sun, Z. D., Ren, Y., Casler, J. D., Menke, D. M., Oliver, G. R., Joseph, R. W., Copland, J. A. III., Parker, A., Kocher, J-P., Thompson, E. A., Smallridge, R. C. & Asmann, Y., Sep 15 2017, In : Rare Tumors. 9, 2, p. 50-53 4 p., 6834.

Research output: Contribution to journalArticle

Follicular Dendritic Cell Sarcoma
Missense Mutation
Mutation
Gene Fusion
Neoplasms
10 Citations (Scopus)

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

Yu, J., Qin, B., Moyer, A. M., Sinnwell, J. P., Thompson, K. J., Copland, J. A. III., Marlow, L. A., Miller, J. L., Yin, P., Gao, B., Minter-Dykhouse, K., Tang, X., McLaughlin, S. A., Moreno Aspitia, A., Schweitzer, A., Lu, Y., Hubbard, J., Northfelt, D. W., Gray, R. J., Hunt, K. & 10 others, Conners, A. L., Suman, V. J., Kalari, K. R., Ingle, J. N., Lou, Z., Visscher, D. W., Weinshilboum, R. M., Boughey, J. C., Goetz, M. P. & Wang, L. M., Dec 6 2017, In : Breast cancer research : BCR. 19, 1, 1 p.

Research output: Contribution to journalArticle

Heterografts
Breast Neoplasms
Biopsy
Drug Therapy
Neoplasms
4 Citations (Scopus)
Lymphoma
Central Nervous System
Monoclonal Antibodies
Therapeutics
5 Citations (Scopus)

Phase 2 trial of everolimus and letrozole in relapsed estrogen receptor-positive high-grade ovarian cancers

Colon-Otero, G., Weroha, S. J., Foster, N. R., Haluska, P., Hou, X., Wahner Hendrickson, A. E., Jatoi, A., Block, M. S., Dinh, T. A., Robertson, M. W. & Copland, J. A. III., Jul 1 2017, In : Gynecologic Oncology. 146, 1, p. 64-68 5 p.

Research output: Contribution to journalArticle

letrozole
Estrogen Receptors
Ovarian Neoplasms
Heterografts
Neoplasms
16 Citations (Scopus)

Stearoyl-CoA desaturase regulates sorafenib resistance via modulation of ER stress-induced differentiation

Ma, M. K. F., Lau, E. Y. T., Leung, D. H. W., Lo, J., Ho, N. P. Y., Cheng, L. K. W., Ma, S., Lin, C. H., Copland, J. A. III., Ding, J., Lo, R. C. L., Ng, I. O. L. & Lee, T. K. W., 2017, (Accepted/In press) In : Journal of Hepatology.

Research output: Contribution to journalArticle

Stearoyl-CoA Desaturase
Endoplasmic Reticulum Stress
Neoplastic Stem Cells
Hepatocellular Carcinoma
Liver
13 Citations (Scopus)

Targeting MYC as a therapeutic intervention for anaplastic thyroid cancer

Enomoto, K., Zhu, X., Park, S., Zhao, L., Zhu, Y. J., Willingham, M. C., Qi, J., Copland, J. A. III., Meltzer, P. & Cheng, S. Y., Jul 1 2017, In : Journal of Clinical Endocrinology and Metabolism. 102, 7, p. 2268-2280 13 p.

Research output: Contribution to journalArticle

Cells
Tumors
Transcription
Heterografts
Histones
14 Citations (Scopus)

Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer

Goetz, M. P., Kalari, K. R., Suman, V. J., Moyer, A. M., Yu, J., Visscher, D. W., Dockter, T. J., Vedell, P. T., Sinnwell, J. P., Tang, X., Thompson, K. J., McLaughlin, S. A., Moreno Aspitia, A., Copland, J. A. III., Northfelt, D. W., Gray, R. J., Hunt, K., Conners, A., Weinshilboum, R. M., Wang, L. M. & 1 others, Boughey, J. C., Jul 1 2017, In : Journal of the National Cancer Institute. 109, 7, djw306.

Research output: Contribution to journalArticle

Neoadjuvant Therapy
Heterografts
Breast Neoplasms
Drug Therapy
Neoplasms
2016
4 Citations (Scopus)

MYC is a crucial mediator of TGFβ-induced invasion in basal breast cancer

Cichon, M. A., Moruzzi, M. E., Shqau, T. A., Miller, E., Mehner, C., Ethier, S. P., Copland, J. A. III., Radisky, E. S. & Radisky, D. C., Jun 15 2016, In : Cancer Research. 76, 12, p. 3520-3530 11 p.

Research output: Contribution to journalArticle

Breast Neoplasms
Neoplasm Metastasis
Autocrine Communication
Paracrine Communication
Breast
3 Citations (Scopus)

Novel patient-derived xenograft mouse model for pancreatic acinar cell carcinoma demonstrates single agent activity of oxaliplatin

Hall, J. C., Marlow, L. A., Mathias, A. C., Dawson, L. K., Durham, W. F., Meshaw, K. A., Mullin, R. J., Synnott, A. J., Small, D. L., Krishna, M., Hoff, D., Schüler, J., Hart, S., Couch, F. J., Colon-Otero, G. & Copland, J. A. III., May 10 2016, In : Journal of Translational Medicine. 14, 1, 129.

Research output: Contribution to journalArticle

oxaliplatin
Acinar Cell Carcinoma
Heterografts
Tumors
Cells