• 23166 Citations
  • 57 Scopus h-Index
1982 …2020

Research output per year

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Research Output

Article

3D porous chitosan-alginate scaffold stiffness promotes differential responses in prostate cancer cell lines

Xu, K., Ganapathy, K., Andl, T., Wang, Z., Copland, J. A. III., Chakrabarti, R. & Florczyk, S. J., Oct 1 2019, In : Biomaterials. 217, 119311.

Research output: Contribution to journalArticle

15 Scopus citations

3D porous chitosan-chondroitin sulfate scaffolds promote epithelial to mesenchymal transition in prostate cancer cells

Xu, K., Wang, Z., Copland, J. A., Chakrabarti, R. & Florczyk, S. J., Sep 2020, In : Biomaterials. 254, 120126.

Research output: Contribution to journalArticle

3-Phenylacetylamino-2, 6-Piperidinedione Inhibition of Rat Nb2 Lymphoma Cell Mitogenesis

Wood, J. C., Copland, J. A., Muldoon, T. G. & Hendry, L. B., Sep 1991, In : Proceedings of the Society for Experimental Biology and Medicine. 197, 4, p. 404-408 5 p.

Research output: Contribution to journalArticle

5 Scopus citations

Aberrant lipid metabolism as a therapeutic target in liver cancer

Pope, E. D., Kimbrough, E. O., Vemireddy, L. P., Surapaneni, P. K., Copland, J. A. & Mody, K., Jun 3 2019, In : Expert opinion on therapeutic targets. 23, 6, p. 473-483 11 p.

Research output: Contribution to journalArticle

8 Scopus citations

Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target

Von Roemeling, C. A., Marlow, L. A., Pinkerton, A. B., Crist, A., Miller, J., Tun, H. W., Smallridge, R. C. & Copland, J. A., May 1 2015, In : Journal of Clinical Endocrinology and Metabolism. 100, 5, p. E697-E709

Research output: Contribution to journalArticle

47 Scopus citations

Accelerated bottom-up drug design platform enables the discovery of novel stearoyl-CoA desaturase 1 inhibitors for cancer therapy

von Roemeling, C. A., Caulfield, T. R., Marlow, L., Bok, I., Wen, J., Miller, J. L., Hughes, R., Hazlehurst, L., Pinkerton, A. B., Radisky, D. C., Tun, H. W., Kim, Y. S. B., Lane, A. L. & Copland, J. A., 2018, In : Oncotarget. 9, 1, p. 3-20 18 p.

Research output: Contribution to journalArticle

8 Scopus citations

A Comprehensive Pan-Cancer Molecular Study of Gynecologic and Breast Cancers

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 690-705.e9

Research output: Contribution to journalArticle

117 Scopus citations

Anaplastic thyroid carcinoma: Pathogenesis and emerging therapies

Smallridge, R. C. & Copland, J. A., Aug 2010, In : Clinical Oncology. 22, 6, p. 486-497 12 p.

Research output: Contribution to journalArticle

213 Scopus citations

An effective personalized approach to a rare tumor: Prolonged survival in metastatic pancreatic acinar cell carcinoma based on genetic analysis and cell line development

Armstrong, M. D., von Hoff, D., Barber, B., Marlow, L. A., von Roemeling, C., Cooper, S. J., Travis, P., Campbell, E., Paz-Fumagalli, R., Copland, J. A. & Colon-Otero, G., 2011, In : Journal of Cancer. 2, 1, p. 142-152 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

An Integrated TCGA Pan-Cancer Clinical Data Resource to Drive High-Quality Survival Outcome Analytics

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 400-416.e11

Research output: Contribution to journalArticle

316 Scopus citations

A novel glucocorticoid receptor binding element within the murine c-myc promoter

Ma, T., Copland, J. A., Brasier, A. R. & Thompson, E. A., Jan 1 2000, In : Molecular Endocrinology. 14, 9, p. 1377-1386 10 p.

Research output: Contribution to journalArticle

Open Access
9 Scopus citations

Antiestrogenic piperidinediones designed prospectively using computer graphics and energy calculations of DNA-ligand complexes

Hendry, L. B., Chu, C. K., Copland, J. A. & Mahesh, V. B., Apr 1994, In : Journal of Steroid Biochemistry and Molecular Biology. 48, 5-6, p. 495-505 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

A p120 catenin isoform switch affects rho activity, induces tumor cell invasion, and predicts metastatic disease

Yanagisawa, M., Huveldt, D., Kreinest, P., Lohse, C. M., Cheville, J. C., Parker, A. S., Copland, J. A. & Anastasiadis, P. Z., Jun 27 2008, In : Journal of Biological Chemistry. 283, 26, p. 18344-18354 11 p.

Research output: Contribution to journalArticle

111 Scopus citations

A Pan-Cancer Analysis of Enhancer Expression in Nearly 9000 Patient Samples

The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 386-399.e12

Research output: Contribution to journalArticle

58 Scopus citations

A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily

The Cancer Genome Atlas Research Network, Oct 24 2018, In : Cell Systems. 7, 4, p. 422-437.e7

Research output: Contribution to journalArticle

30 Scopus citations

Atypical protein kinase Cτ plays a critical role in human lung cancer cell growth and tumorigenicity

Regala, R. P., Weems, C., Jamieson, L., Copland, J. A., Thompson, E. A. & Fields, A. P., Sep 2 2005, In : Journal of Biological Chemistry. 280, 35, p. 31109-31115 7 p.

Research output: Contribution to journalArticle

154 Scopus citations

Bioconjugated gold nanoparticles as a molecular based contrast agent: Implications for imaging of deep tumors using optoacoustic tomography

Copland, J. A., Eghtedari, M., Popov, V. L., Kotov, N., Mamedova, N., Motamedi, M. & Oraevsky, A. A., Sep 1 2004, In : Molecular Imaging and Biology. 6, 5, p. 341-349 9 p.

Research output: Contribution to journalArticle

282 Scopus citations

Blockade of transforming growth factor-beta (TGFβ) signaling inhibits osteoblastic tumorigenesis by a novel human prostate cancer cell line

Mishra, S., Tang, Y., Wang, L., Degraffenried, L., Yeh, I. T., Werner, S., Troyer, D., Copland, J. A. & Sun, L. Z., Sep 15 2011, In : Prostate. 71, 13, p. 1441-1454 14 p.

Research output: Contribution to journalArticle

20 Scopus citations

Breast cancer in latinas: Gene expression, differential response to treatments, and differential toxicities in latinas compared with other population groups

Patel, T. A., Colon-Otero, G., Hume, C. B., Copland, J. A. & Perez, E. A., 2010, In : Oncologist. 15, 5, p. 466-475 10 p.

Research output: Contribution to journalArticle

32 Scopus citations

Cell Cycle M-Phase Genes Are Highly Upregulated in Anaplastic Thyroid Carcinoma

Weinberger, P., Ponny, S. R., Xu, H., Bai, S., Smallridge, R., Copland, J. & Sharma, A., Feb 1 2017, In : Thyroid. 27, 2, p. 236-252 17 p.

Research output: Contribution to journalArticle

23 Scopus citations

Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer

The Cancer Genome Atlas Network, Apr 5 2018, In : Cell. 173, 2, p. 291-304.e6

Research output: Contribution to journalArticle

314 Scopus citations

C-lysine conjugates: pH-controlled light-activated reagents for efficient double-stranded DNA cleavage with implications for cancer therapy

Yang, W. Y., Breiner, B., Kovalenko, S. V., Ben, C., Singh, M., LeGrand, S. N., Sang, Q. X. A., Strouse, G. F., Copland, J. A. & Alabugin, I. V., Aug 19 2009, In : Journal of the American Chemical Society. 131, 32, p. 11458-11470 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

Combinatorial selection of a single stranded DNA thioaptamer targeting TGF-β1 protein

Kang, J., Lee, M. S., Copland, J. A., Luxon, B. A. & Gorenstein, D. G., Mar 15 2008, In : Bioorganic and Medicinal Chemistry Letters. 18, 6, p. 1835-1839 5 p.

Research output: Contribution to journalArticle

41 Scopus citations

Combined alkylation and histone deacetylase inhibition with EDO-S101 has significant therapeutic activity against brain tumors in preclinical models

Qiu, Y., Li, Z., Copland, J. A., Mehrling, T. & Tun, H. W., Jun 15 2018, In : Oncotarget. 9, 46, p. 28155-28164 10 p.

Research output: Contribution to journalArticle

2 Scopus citations

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas

The Cancer Genome Atlas Research Network, Apr 9 2018, In : Cancer cell. 33, 4, p. 721-735.e8

Research output: Contribution to journalArticle

90 Scopus citations

Complete remission with immunotherapy: Case report of a patient with metastatic bladder cancer to the humerus

Abdelhakam, D., Young, P. R., Jain, M. K., Nassar, A., Copland, J. A. & Tan, W., May 2020, In : Urology Case Reports. 30, 101130.

Research output: Contribution to journalArticle

Open Access

Comprehensive Analysis of Alternative Splicing Across Tumors from 8,705 Patients

The Cancer Genome Atlas Research Network, Aug 13 2018, In : Cancer cell. 34, 2, p. 211-224.e6

Research output: Contribution to journalArticle

129 Scopus citations

Comprehensive Characterization of Cancer Driver Genes and Mutations

The MC3 Working Group & The Cancer Genome Atlas Research Network, Apr 5 2018, In : Cell. 173, 2, p. 371-385.e18

Research output: Contribution to journalArticle

356 Scopus citations

Comprehensive genetic characterization of human thyroid cancer cell lines: A validated panel for preclinical studies

Landa, I., Pozdeyev, N., Korch, C., Marlow, L. A., Smallridge, R. C., Copland, J. A., Henderson, Y. C., Lai, S. Y., Clayman, G. L., Onoda, N., Tan, A. C., Garcia-Rendueles, M. E. R., Knauf, J. A., Haugen, B. R., Fagin, J. A. & Schweppe, R. E., 2019, In : Clinical Cancer Research. 25, 10, p. 3141-3151 11 p.

Research output: Contribution to journalArticle

19 Scopus citations

Comprehensive genomic profiling of a rare thyroid follicular dendritic cell sarcoma

Davila, J. I., Starr, J. S., Attia, S., Wang, C., Knudson, R. A., Necela, B. M., Sarangi, V., Sun, Z., Ren, Y., Casler, J. D., Menke, D. M., Oliver, G. R., Joseph, R. W., Copland, J. A., Parker, A. S., Kocher, J. P. A., Thompson, E. A., Smallridge, R. C. & Asmann, Y. W., Sep 15 2017, In : Rare Tumors. 9, 2, p. 50-53 4 p., 6834.

Research output: Contribution to journalArticle

1 Scopus citations

Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer

The Cancer Genome Atlas Research Network, Oct 30 2018, In : Cell reports. 25, 5, p. 1304-1317.e5

Research output: Contribution to journalArticle

49 Scopus citations

Cryptic estrogen binding protein complicates analysis of estrogen receptor distribution

Smanik, E. J., Copland, J. A. & Muldoon, T. G., Dec 14 1984, In : Biochemical and Biophysical Research Communications. 125, 2, p. 577-583 7 p.

Research output: Contribution to journalArticle

5 Scopus citations

Cytokeratin-8 in anaplastic thyroid carcinoma: More than a simple structural cytoskeletal protein

Guo, D., Xu, Q., Pabla, S., Koomen, J., Biddinger, P., Sharma, A., Pabla, S., Pacholczyk, R., Chang, C. C., Friedrich, K., Mohammed, K., Smallridge, R. C., Copland, J. A., She, J. X. & Weinberger, P. M., Feb 14 2018, In : International journal of molecular sciences. 19, 2, 577.

Research output: Contribution to journalArticle

2 Scopus citations

Cytoplasmic sequestration of p27 via AKT phosphorylation in renal cell carcinoma

Kim, J., Jonasch, E., Alexander, A., Short, J. D., Cai, S., Wen, S., Tsavachidou, D., Tamboli, P., Czerniak, B. A., Do, K. A., Wu, K. J., Marlow, L. A., Wood, C. G., Copland, J. A. & Walker, C. L., Jan 1 2009, In : Clinical Cancer Research. 15, 1, p. 81-90 10 p.

Research output: Contribution to journalArticle

46 Scopus citations

Defining the human kidney N-glycome in normal and cancer tissues using MALDI imaging mass spectrometry

Drake, R. R., McDowell, C., West, C., David, F., Powers, T. W., Nowling, T., Bruner, E., Mehta, A. S., Angel, P. M., Marlow, L. A., Tun, H. W. & Copland, J. A., Apr 1 2020, In : Journal of Mass Spectrometry. 55, 4, e4490.

Research output: Contribution to journalArticle

Open Access
3 Scopus citations

Demonstration of functional oxytocin receptors in human breast Hs578T cells and their up-regulation through a protein kinase C-dependent pathway

Copland, J. A., Jeng, Y. J., Strakova, Z., Ives, K. L., Hellmich, M. R. & Soloff, M. S., Jan 1 1999, In : Endocrinology. 140, 5, p. 2258-2267 10 p.

Research output: Contribution to journalArticle

Open Access
39 Scopus citations

Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification

Schweppe, R. E., Klopper, J. P., Korch, C., Pugazhenthi, U., Benezra, M., Knauf, J. A., Fagin, J. A., Marlow, L. A., Copland, J. A., Smallridge, R. C. & Haugen, B. R., Nov 2008, In : Journal of Clinical Endocrinology and Metabolism. 93, 11, p. 4331-4341 11 p.

Research output: Contribution to journalArticle

430 Scopus citations

Design of novel antiestrogens

Hendry, L. B., Chu, C. K., Rosser, M. L., Copland, J. A., Wood, J. C. & Mahesh, V. B., Jun 1994, In : Journal of Steroid Biochemistry and Molecular Biology. 49, 4-6, p. 269-280 12 p.

Research output: Contribution to journalArticle

24 Scopus citations

Detailed molecular fingerprinting of four new anaplastic thyroid carcinoma cell lines and their use for verification of RhoB as a molecular therapeutic target

Marlow, L. A., D'Innocenzi, J., Zhang, Y., Rohl, S. D., Cooper, S. J., Sebo, T., Grant, C., McIver, B., Kasperbauer, J. L., Wadsworth, J. T., Casler, J. D., Kennedy, P. W., Highsmith, W. E., Clark, O., Milosevic, D., Netzel, B., Cradic, K., Arora, S., Beaudry, C., Grebe, S. K. & 4 others, Silverberg, M. L., Azorsa, D. O., Smallridge, R. C. & Copland, J. A., Dec 2010, In : Journal of Clinical Endocrinology and Metabolism. 95, 12, p. 5338-5347 10 p.

Research output: Contribution to journalArticle

50 Scopus citations

Development of a multidisciplinary, multicampus subspecialty practice in endocrine cancers

Bible, K. C., Smallridge, R. C., Morris, J. C., Molina, J. R., Suman, V. J., Copland, J. A., Rubin, J., Menefee, M. E., Sideras, K., Maples, W. J., McIver, B., Fatourechi, V., Hay, I., Foote, R. L., Garces, Y. I., Kasperbauer, J. L., Thompson, G. B., Grant, C. S., Richards, M. L., Sebo, T. & 9 others, Lloyd, R., Eberhardt, N. L., Reddi, H. V., Casler, J. D., Karlin, N. J., Westphal, S. A., Richardson, R. L., Buckner, J. C. & Erlichman, C., May 2012, In : American Journal of Managed Care. 18, 5, p. e162-e167

Research output: Contribution to journalArticle

Diagnostic and prognostic biomarker potential of kallikrein family genes in different cancer types

Tailor, P. D., Kodeboyina, S. K., Bai, S., Patel, N., Sharma, S., Ratnani, A., Copland, J. A., She, J. X. & Sharma, A., Apr 1 2018, In : Oncotarget. 9, 25, p. 17876-17888 13 p.

Research output: Contribution to journalArticle

10 Scopus citations

Directed engineering of umbilical cord blood stem cells to produce C-peptide and insulin

Denner, L., Bodenburg, Y., Zhao, J. G., Howe, M., Cappo, J., Tilton, R. G., Copland, J. A., Forraz, N., McGuckin, C. & Urban, R., Jun 2007, In : Cell Proliferation. 40, 3, p. 367-380 14 p.

Research output: Contribution to journalArticle

65 Scopus citations
14 Scopus citations

Distinct E-cadherin-based complexes regulate cell behaviour through miRNA processing or Src and p120 catenin activity

Kourtidis, A., Ngok, S. P., Pulimeno, P., Feathers, R. W., Carpio, L. R., Baker, T. R., Carr, J. M., Yan, I. K., Borges, S., Perez, E. A., Storz, P., Copland, J. A., Patel, T., Thompson, E. A., Citi, S. & Anastasiadis, P. Z., Sep 1 2015, In : Nature Cell Biology. 17, 9, p. 1145-1157 13 p.

Research output: Contribution to journalArticle

55 Scopus citations

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

Yu, J., Qin, B., Moyer, A. M., Nowsheen, S., Liu, T., Qin, S., Zhuang, Y., Liu, D., Lu, S. W., Kalari, K. R., Visscher, D. W., Copland, J. A., McLaughlin, S. A., Moreno-Aspitia, A., Northfelt, D. W., Gray, R. J., Lou, Z., Suman, V. J., Weinshilboum, R., Boughey, J. C. & 2 others, Goetz, M. P. & Wang, L., Jun 1 2018, In : Journal of Clinical Investigation. 128, 6, p. 2376-2388 13 p.

Research output: Contribution to journalArticle

35 Scopus citations

Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

The Fusion Analysis Working Group & The Cancer Genome Atlas Research Network, Apr 3 2018, In : Cell reports. 23, 1, p. 227-238.e3

Research output: Contribution to journalArticle

109 Scopus citations

Dual inhibition of HDAC and EGFR signaling with CUDC-101 induces potent suppression of tumor growth and metastasis in anaplastic thyroid cancer

Zhang, L., Zhang, Y., Mehta, A., Boufraqech, M., Davis, S., Wang, J., Tian, Z., Yu, Z., Boxer, M. B., Kiefer, J. A., Copland, J. A., Smallridge, R. C., Li, Z., Shen, M. & Kebebew, E., 2015, In : Oncotarget. 6, 11, p. 9073-9085 13 p.

Research output: Contribution to journalArticle

Open Access
38 Scopus citations

Efatutazone, an oral PPAR- γ agonist, in combination with paclitaxel in anaplastic thyroid cancer: Results of a multicenter phase 1 trial

Smallridge, R. C., Copland, J. A., Brose, M. S., Wadsworth, J. T., Houvras, Y., Menefee, M. E., Bible, K. C., Shah, M. H., Gramza, A. W., Klopper, J. P., Marlow, L. A., Heckman, M. G. & Von Roemeling, R., Jun 2013, In : Journal of Clinical Endocrinology and Metabolism. 98, 6, p. 2392-2400 9 p.

Research output: Contribution to journalArticle

63 Scopus citations
Open Access
1 Scopus citations

Effects of ketamine-xylazine anesthesia on blood levels of luteinizing hormone and follicle stimulating hormone in rabbits

Mills, T. M. & Copland, J. A., Dec 1 1982, In : Laboratory animal science. 32, 6, p. 619-621 3 p.

Research output: Contribution to journalArticle

9 Scopus citations